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Tag Content
iUUCD ID IUUC-Ago-007936
Ensembl Protein ID AAS52850
UniProt Accession Q756T5; NACA_ASHGO
Genbank Protein ID AAS52850.1
Protein Name Nascent polypeptide-associated complex subunit alpha; Alpha-NAC
Genbank Nucleotide ID AE016818
Gene Name EGD2; AER168C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AGOS_AER168C AAS52850 AAS52850
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 55.62 2.00e-39 156.00 IUUC-Sce-106371
UBD/Alpha-Helix/UBA 40.72 1.00e-25 109.00 IUUC-Spo-108121
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Ashbya gossypii
Functional Description
(View)

Functional Description


     Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
 Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
Protein Sequence
(Fasta)
MSEIPENSKV SIYSKNEKKA RELIQKFSMK PMPGITRVTF RKKNNQIFAI DNPDVYKTQG 60
GNYVVFGEPK VDDFTRRLAR AQQQAASAAK DPQSIQADMA AAAAAPAAPA APAAAPEEDE 120
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Protein Fasta Sequence


>IUUC-Ago-007936|UBD,UBA|Ashbya gossypii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCAGAAA TTCCAGAGAA CTCCAAAGTT TCTATCTACA GCAAGAATGA GAAGAAGGCT 60
AGAGAATTGA TTCAGAAATT CTCTATGAAG CCAATGCCTG GCATCACAAG GGTGACATTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ago-007936|UBD,UBA|Ashbya gossypii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom
PROSITE

PS51151--NAC_AB
Pfam

PF01849--NAC
SMART

SM01407--NAC
Gene Ontology

GO:0005854--C:nascent polypeptide-associated complex
GO:0005634--C:nucleus
GO:0070300--F:phosphatidic acid binding
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0070273--F:phosphatidylinositol-4-phosphate binding
GO:0051083--P:'de novo' cotranslational protein folding
GO:0006620--P:posttranslational protein targeting to membrane
KEGG ago:AGOS_AER168C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000480 Aegilops tauschii 37.24 8.00e-20 87.80
IUUC-Aml-002185 Ailuropoda melanoleuca 42.58 2.00e-23 102.00
IUUC-Atr-002586 Amborella trichopoda 32.70 4.00e-10 55.80
IUUC-Apl-003190 Anas platyrhynchos 40.13 8.00e-20 87.00
IUUC-Aca-005265 Anolis carolinensis 41.67 5.00e-21 91.70
IUUC-Aly-006488 Arabidopsis lyrata 43.36 4.00e-21 92.40
IUUC-Ath-007378 Arabidopsis thaliana 66.67 2.00e-09 53.50
IUUC-Acl-008036 Aspergillus clavatus 48.57 4.00e-17 79.00
IUUC-Afl-008462 Aspergillus flavus 48.61 2.00e-18 83.20
IUUC-Afu-008832 Aspergillus fumigatus 50.00 6.00e-16 75.10
IUUC-Ani-009246 Aspergillus nidulans 48.61 1.00e-17 80.90
IUUC-Ang-009808 Aspergillus niger 48.57 5.00e-17 78.60
IUUC-Aor-009972 Aspergillus oryzae 48.61 2.00e-18 83.20
IUUC-Ame-011674 Astyanax mexicanus 37.82 7.00e-22 94.70
IUUC-Bgr-012162 Blumeria graminis 50.79 2.00e-15 73.20
IUUC-Bta-012508 Bos taurus 37.18 6.00e-21 91.70
IUUC-Bci-013643 Botrytis cinerea 50.00 4.00e-16 75.50
IUUC-Bdi-014854 Brachypodium distachyon 44.90 6.00e-09 51.60
IUUC-Bol-015132 Brassica oleracea 38.89 1.00e-16 77.40
IUUC-Bra-017540 Brassica rapa 40.56 5.00e-15 72.00
IUUC-Cel-018111 Caenorhabditis elegans 36.77 3.00e-24 102.00
IUUC-Cja-019846 Callithrix jacchus 41.03 1.00e-23 103.00
IUUC-Cfa-020429 Canis familiaris 37.82 3.00e-21 92.40
IUUC-Cpo-021659 Cavia porcellus 40.00 7.00e-23 100.00
IUUC-Cre-022679 Chlamydomonas reinhardtii 43.87 1.00e-25 107.00
IUUC-Csa-023260 Chlorocebus sabaeus 41.94 1.00e-23 103.00
IUUC-Cho-024869 Choloepus hoffmanni 69.44 3.00e-09 52.80
IUUC-Cin-025166 Ciona intestinalis 40.38 4.00e-21 92.00
IUUC-Csv-026284 Ciona savignyi 39.31 3.00e-16 75.10
IUUC-Cgl-026520 Colletotrichum gloeosporioides 44.24 7.00e-25 104.00
IUUC-Cne-026920 Cryptococcus neoformans 41.10 1.00e-14 70.90
IUUC-Cme-027301 Cyanidioschyzon merolae 36.75 7.00e-17 78.20
IUUC-Dre-027840 Danio rerio 41.29 2.00e-23 99.80
IUUC-Dno-029367 Dasypus novemcinctus 43.23 3.00e-23 102.00
IUUC-Dor-030962 Dipodomys ordii 37.18 7.00e-21 91.30
IUUC-Dme-032061 Drosophila melanogaster 47.62 8.00e-14 68.20
IUUC-Ete-033075 Echinops telfairi 42.07 2.00e-19 89.40
IUUC-Eca-034049 Equus caballus 36.54 2.00e-20 89.70
IUUC-Eeu-034673 Erinaceus europaeus 37.82 5.00e-21 92.00
IUUC-Fca-035429 Felis catus 41.94 6.00e-24 104.00
IUUC-Fal-037006 Ficedula albicollis 37.82 6.00e-22 95.10
IUUC-Fox-037704 Fusarium oxysporum 47.95 2.00e-16 76.60
IUUC-Fso-038247 Fusarium solani 46.58 4.00e-17 79.00
IUUC-Gmo-039002 Gadus morhua 40.48 8.00e-25 104.00
IUUC-Ggr-039888 Gaeumannomyces graminis 45.95 2.00e-16 76.60
IUUC-Gga-040237 Gallus gallus 37.18 5.00e-21 91.70
IUUC-Gac-041800 Gasterosteus aculeatus 38.71 3.00e-20 90.90
IUUC-Gma-043275 Glycine max 40.00 2.00e-20 89.70
IUUC-Ggo-045163 Gorilla gorilla 41.29 6.00e-27 111.00
IUUC-Hsa-045795 Homo sapiens 37.18 1.00e-18 87.40
IUUC-Hvu-047376 Hordeum vulgare 41.26 1.00e-18 84.00
IUUC-Itr-048152 Ictidomys tridecemlineatus 37.82 5.00e-21 92.00
IUUC-Kpa-049166 Komagataella pastoris 46.15 4.00e-33 132.00
IUUC-Lch-050076 Latimeria chalumnae 38.46 1.00e-21 94.00
IUUC-Lpe-051258 Leersia perrieri 41.96 3.00e-17 79.70
IUUC-Loc-052292 Lepisosteus oculatus 37.91 5.00e-21 92.40
IUUC-Lma-053293 Leptosphaeria maculans 45.95 2.00e-17 80.10
IUUC-Laf-054393 Loxodonta africana 41.94 1.00e-24 103.00
IUUC-Mcc-054632 Macaca mulatta 37.18 2.00e-18 87.00
IUUC-Meu-056242 Macropus eugenii 46.03 1.00e-13 67.80
IUUC-Mor-057099 Magnaporthe oryzae 47.30 6.00e-17 78.20
IUUC-Mpo-057543 Magnaporthe poae 43.08 9.00e-13 63.90
IUUC-Mtr-058112 Medicago truncatula 38.71 4.00e-22 95.50
IUUC-Mla-059166 Melampsora laricipopulina 39.62 1.00e-22 96.70
IUUC-Mga-060195 Meleagris gallopavo 41.29 3.00e-22 96.30
IUUC-Mvi-060390 Microbotryum violaceum 32.30 3.00e-13 65.90
IUUC-Mmr-061475 Microcebus murinus 42.58 6.00e-24 104.00
IUUC-Mdo-062474 Monodelphis domestica 40.65 2.00e-23 103.00
IUUC-Mmu-063984 Mus musculus 37.18 4.00e-18 86.30
IUUC-Mac-065175 Musa acuminata 41.26 5.00e-23 98.60
IUUC-Mpu-066751 Mustela putorius furo 42.58 2.00e-23 103.00
IUUC-Mlu-068234 Myotis lucifugus 37.82 5.00e-21 92.00
IUUC-Nfi-068541 Neosartorya fischeri 50.00 6.00e-16 75.10
IUUC-Ncr-068830 Neurospora crassa 50.00 1.00e-18 84.00
IUUC-Nle-069126 Nomascus leucogenys 37.18 6.00e-21 92.00
IUUC-Opr-070742 Ochotona princeps 41.67 4.00e-21 92.00
IUUC-Ont-071828 Oreochromis niloticus 40.00 4.00e-21 92.40
IUUC-Oan-073462 Ornithorhynchus anatinus 46.03 3.00e-12 65.90
IUUC-Ocu-074890 Oryctolagus cuniculus 40.00 1.00e-23 103.00
IUUC-Oba-075995 Oryza barthii 43.36 2.00e-22 96.30
IUUC-Obr-076668 Oryza brachyantha 40.00 6.00e-21 91.70
IUUC-Ogl-077445 Oryza glaberrima 43.36 2.00e-22 96.30
IUUC-Ogu-078606 Oryza glumaepatula 43.36 2.00e-22 96.30
IUUC-Oin-079287 Oryza indica 43.36 2.00e-22 96.30
IUUC-Olo-080686 Oryza longistaminata 37.20 2.00e-18 83.20
IUUC-Ome-081567 Oryza meridionalis 42.07 3.00e-22 95.10
IUUC-Oni-082873 Oryza nivara 43.36 2.00e-22 96.30
IUUC-Opu-083291 Oryza punctata 41.38 1.00e-21 94.00
IUUC-Oru-085045 Oryza rufipogon 42.07 3.00e-22 95.10
IUUC-Osa-086102 Oryza sativa 42.66 3.00e-22 96.30
IUUC-Ola-087531 Oryzias latipes 42.31 9.00e-22 94.40
IUUC-Olu-087895 Ostreococcus lucimarinus 33.79 3.00e-17 78.20
IUUC-Oga-088239 Otolemur garnettii 37.82 5.00e-21 92.00
IUUC-Oar-090371 Ovis aries 43.23 1.00e-23 103.00
IUUC-Ptr-090481 Pan troglodytes 42.58 9.00e-20 90.90
IUUC-Pan-092210 Papio anubis 41.94 3.00e-23 102.00
IUUC-Psi-093905 Pelodiscus sinensis 42.58 4.00e-22 95.90
IUUC-Pma-094702 Petromyzon marinus 41.29 3.00e-21 92.80
IUUC-Pno-094927 Phaeosphaeria nodorum 45.95 3.00e-17 79.30
IUUC-Ppa-095389 Physcomitrella patens 47.54 1.00e-14 70.50
IUUC-Pfo-096744 Poecilia formosa 41.29 2.00e-21 93.60
IUUC-Pab-098044 Pongo abelii 37.82 5.00e-21 92.00
IUUC-Pop-099384 Populus trichocarpa 41.29 2.00e-25 106.00
IUUC-Pca-100355 Procavia capensis 41.29 1.00e-20 93.20
IUUC-Ppe-101786 Prunus persica 39.86 3.00e-22 96.30
IUUC-Pva-102494 Pteropus vampyrus 37.82 6.00e-21 91.70
IUUC-Pgr-103303 Puccinia graminis 34.76 7.00e-19 84.70
IUUC-Ptt-103748 Puccinia triticina 47.73 1.00e-06 44.30
IUUC-Pte-104368 Pyrenophora teres 46.48 9.00e-17 77.80
IUUC-Pyt-104542 Pyrenophora triticirepentis 46.48 1.00e-16 77.40
IUUC-Rno-105387 Rattus norvegicus 37.18 7.00e-18 85.50
IUUC-Sce-106371 Saccharomyces cerevisiae 55.62 3.00e-40 155.00
IUUC-Sha-107189 Sarcophilus harrisii 37.82 5.00e-21 92.00
IUUC-Sja-107942 Schizosaccharomyces japonicus 37.72 1.00e-21 93.60
IUUC-Spo-108121 Schizosaccharomyces pombe 40.72 3.00e-26 108.00
IUUC-Ssl-108595 Sclerotinia sclerotiorum 48.61 4.00e-17 79.00
IUUC-Smo-108783 Selaginella moellendorffii 41.10 4.00e-20 89.00
IUUC-Sit-110180 Setaria italica 39.16 1.00e-21 93.60
IUUC-Sly-110957 Solanum lycopersicum 37.75 1.00e-20 90.10
IUUC-Stu-112873 Solanum tuberosum 37.09 3.00e-20 89.40
IUUC-Sar-113668 Sorex araneus 71.43 4.00e-09 52.40
IUUC-Sbi-114328 Sorghum bicolor 40.56 2.00e-23 99.80
IUUC-Sre-115220 Sporisorium reilianum 39.68 2.00e-11 59.70
IUUC-Ssc-116119 Sus scrofa 37.82 5.00e-21 92.00
IUUC-Tgu-116528 Taeniopygia guttata 37.91 2.00e-21 93.20
IUUC-Tru-117538 Takifugu rubripes 37.18 7.00e-22 94.70
IUUC-Tsy-118855 Tarsius syrichta 69.44 3.00e-09 52.80
IUUC-Tni-120134 Tetraodon nigroviridis 42.31 5.00e-22 95.50
IUUC-Tca-121524 Theobroma cacao 41.26 1.00e-22 97.40
IUUC-Tre-121915 Trichoderma reesei 47.95 3.00e-15 72.80
IUUC-Tvi-122411 Trichoderma virens 47.83 1.00e-13 67.40
IUUC-Tae-123448 Triticum aestivum 40.56 9.00e-19 84.30
IUUC-Tur-126728 Triticum urartu 37.24 2.00e-19 87.00
IUUC-Tme-126875 Tuber melanosporum 40.66 5.00e-17 78.20
IUUC-Tbe-127759 Tupaia belangeri 36.99 1.00e-14 70.50
IUUC-Ttr-129124 Tursiops truncatus 42.11 1.00e-20 94.00
IUUC-Uma-129551 Ustilago maydis 37.58 1.00e-19 87.00
IUUC-Vda-129992 Verticillium dahliae 43.79 7.00e-27 111.00
IUUC-Vpa-130096 Vicugna pacos 37.18 3.00e-19 86.30
IUUC-Vvi-130940 Vitis vinifera 41.26 2.00e-17 79.70
IUUC-Xtr-132904 Xenopus tropicalis 40.65 3.00e-22 96.30
IUUC-Xma-133842 Xiphophorus maculatus 41.29 3.00e-21 92.80
IUUC-Yli-134485 Yarrowia lipolytica 39.27 4.00e-24 102.00
IUUC-Zma-135748 Zea mays 40.56 1.00e-22 97.40
Created Date 25-Jun-2017

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