iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/Other	UBD/ZnF/Other	19182904

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
UBD/ZnF/NZF	34.41	2.00e-90	331.00	IUUC-Mmu-063916
UBD/ZnF/NZF	34.41	1.00e-90	331.00	IUUC-Rno-105582

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD.

Protein Sequence
(Fasta)

MLIRFRSKNG THRVSCQEND LFGTVIEKLV GNLDPNADVD TFTVCEKPGQ GIHAVSELAD 60
RTVMDLGLKH GDMLILNYSD KPANEKDGVN VEIGSVGIDS KGIRQHRYGP LRIKELAVDE 120

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Nucleotide Sequence
(Fasta)

ATGCTTATCA GATTTAGATC AAAAAACGGT ACACACAGGG TTTCTTGTCA AGAAAACGAC 60
CTTTTCGGAA CGGTCATTGA AAAGTTGGTG GGTAATCTGG ACCCCAATGC CGATGTCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR016563--Npl4
IPR007717--NPL4_C
IPR007716--NPL4_Zn-bd_put
IPR029071--Ubiquitin-rel_dom

Pfam

PF05021--NPL4
PF05020--zf-NPL4

Gene Ontology

GO:0036266--C:Cdc48p-Npl4p-Vms1p AAA ATPase complex
GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0031965--C:nuclear membrane
GO:0042175--C:nuclear outer membrane-endoplasmic reticulum membrane network
GO:0048471--C:perinuclear region of cytoplasm
GO:1990112--C:RQC complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0072671--P:mitochondria-associated ubiquitin-dependent protein catabolic process
GO:0051228--P:mitotic spindle disassembly
GO:0051028--P:mRNA transport
GO:0051974--P:negative regulation of telomerase activity
GO:0070651--P:nonfunctional rRNA decay
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YBR170C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000460	Aegilops tauschii	22.22	6.00e-05	40.00
IUUC-Aml-002268	Ailuropoda melanoleuca	33.62	9.00e-92	328.00
IUUC-Atr-002939	Amborella trichopoda	28.85	1.00e-05	42.40
IUUC-Apl-003496	Anas platyrhynchos	37.31	1.00e-91	328.00
IUUC-Aca-005230	Anolis carolinensis	34.36	9.00e-96	342.00
IUUC-Aly-005413	Arabidopsis lyrata	27.01	4.00e-06	43.90
IUUC-Ath-007051	Arabidopsis thaliana	27.74	2.00e-06	45.10
IUUC-Ago-007954	Ashbya gossypii	60.38	0.00e+00	706.00
IUUC-Acl-008208	Aspergillus clavatus	43.56	2.00e-144	503.00
IUUC-Afl-008574	Aspergillus flavus	44.74	1.00e-145	508.00
IUUC-Afu-008825	Aspergillus fumigatus	44.98	1.00e-150	524.00
IUUC-Ani-009495	Aspergillus nidulans	43.18	5.00e-145	506.00
IUUC-Ang-009762	Aspergillus niger	44.17	4.00e-144	503.00
IUUC-Aor-010199	Aspergillus oryzae	44.57	7.00e-145	505.00
IUUC-Ate-010592	Aspergillus terreus	45.04	1.00e-141	494.00
IUUC-Ame-011438	Astyanax mexicanus	40.99	1.00e-30	123.00
IUUC-Bgr-012124	Blumeria graminis	42.76	1.00e-139	488.00
IUUC-Bta-013312	Bos taurus	34.19	1.00e-94	338.00
IUUC-Bci-013648	Botrytis cinerea	43.96	4.00e-149	519.00
IUUC-Bdi-014326	Brachypodium distachyon	22.33	3.00e-07	47.80
IUUC-Bol-016294	Brassica oleracea	26.95	2.00e-07	48.10
IUUC-Bra-017023	Brassica rapa	27.66	2.00e-07	48.10
IUUC-Cel-018206	Caenorhabditis elegans	37.71	2.00e-87	314.00
IUUC-Cja-018869	Callithrix jacchus	34.24	7.00e-95	339.00
IUUC-Cfa-020757	Canis familiaris	33.73	3.00e-92	330.00
IUUC-Cpo-022390	Cavia porcellus	34.64	8.00e-94	335.00
IUUC-Csa-023366	Chlorocebus sabaeus	34.07	1.00e-94	338.00
IUUC-Cho-024455	Choloepus hoffmanni	33.86	1.00e-66	245.00
IUUC-Cin-025638	Ciona intestinalis	28.45	9.00e-59	219.00
IUUC-Csv-026310	Ciona savignyi	28.33	4.00e-58	216.00
IUUC-Cgl-026685	Colletotrichum gloeosporioides	44.41	8.00e-143	498.00
IUUC-Cne-026794	Cryptococcus neoformans	34.20	4.00e-107	380.00
IUUC-Cme-027248	Cyanidioschyzon merolae	23.21	3.00e-06	44.70
IUUC-Dre-027689	Danio rerio	33.56	8.00e-89	319.00
IUUC-Dno-030004	Dasypus novemcinctus	33.73	1.00e-93	335.00
IUUC-Dor-030585	Dipodomys ordii	36.15	4.00e-88	316.00
IUUC-Dse-031202	Dothistroma septosporum	43.76	5.00e-139	485.00
IUUC-Dme-032092	Drosophila melanogaster	36.08	2.00e-89	321.00
IUUC-Ete-033009	Echinops telfairi	38.46	2.00e-29	121.00
IUUC-Eca-034001	Equus caballus	33.73	1.00e-94	338.00
IUUC-Eeu-034485	Erinaceus europaeus	27.50	6.00e-53	199.00
IUUC-Fca-036128	Felis catus	37.61	4.00e-91	327.00
IUUC-Fal-037523	Ficedula albicollis	34.92	3.00e-95	340.00
IUUC-Fox-037802	Fusarium oxysporum	44.33	7.00e-151	525.00
IUUC-Fso-038152	Fusarium solani	45.00	5.00e-153	532.00
IUUC-Gmo-038486	Gadus morhua	36.34	4.00e-84	303.00
IUUC-Ggr-039916	Gaeumannomyces graminis	43.81	1.00e-146	511.00
IUUC-Gga-041208	Gallus gallus	34.98	8.00e-96	342.00
IUUC-Gac-042304	Gasterosteus aculeatus	32.26	2.00e-82	297.00
IUUC-Gma-044007	Glycine max	27.63	3.00e-05	41.20
IUUC-Ggo-045236	Gorilla gorilla	33.11	1.00e-88	318.00
IUUC-Hsa-046334	Homo sapiens	34.24	1.00e-94	338.00
IUUC-Itr-047878	Ictidomys tridecemlineatus	36.90	6.00e-66	242.00
IUUC-Lch-050302	Latimeria chalumnae	32.35	3.00e-87	313.00
IUUC-Lpe-051362	Leersia perrieri	22.68	5.00e-05	40.40
IUUC-Loc-052548	Lepisosteus oculatus	36.50	6.00e-92	329.00
IUUC-Lma-053092	Leptosphaeria maculans	45.01	2.00e-145	508.00
IUUC-Laf-053911	Loxodonta africana	33.90	3.00e-95	340.00
IUUC-Mcc-055830	Macaca mulatta	34.13	3.00e-94	337.00
IUUC-Meu-056460	Macropus eugenii	32.82	1.00e-11	62.40
IUUC-Mor-057189	Magnaporthe oryzae	45.37	8.00e-153	531.00
IUUC-Mpo-057366	Magnaporthe poae	43.97	1.00e-145	507.00
IUUC-Mtr-057834	Medicago truncatula	29.09	2.00e-04	38.50
IUUC-Mla-059190	Melampsora laricipopulina	41.46	2.00e-124	437.00
IUUC-Mga-060036	Meleagris gallopavo	34.70	3.00e-94	337.00
IUUC-Mvi-060275	Microbotryum violaceum	35.24	7.00e-109	385.00
IUUC-Mmr-061300	Microcebus murinus	34.30	9.00e-95	338.00
IUUC-Mdo-062911	Monodelphis domestica	35.11	4.00e-93	333.00
IUUC-Mmu-063916	Mus musculus	34.41	6.00e-93	332.00
IUUC-Mac-065601	Musa acuminata	28.57	1.00e-03	35.80
IUUC-Mpu-065912	Mustela putorius furo	33.73	1.00e-92	332.00
IUUC-Mlu-067965	Myotis lucifugus	33.28	2.00e-93	334.00
IUUC-Nfi-068465	Neosartorya fischeri	44.98	4.00e-151	526.00
IUUC-Ncr-068936	Neurospora crassa	43.39	2.00e-146	510.00
IUUC-Nle-069570	Nomascus leucogenys	34.07	1.00e-94	338.00
IUUC-Opr-071097	Ochotona princeps	36.31	4.00e-83	300.00
IUUC-Ont-071430	Oreochromis niloticus	33.39	7.00e-90	322.00
IUUC-Oan-073709	Ornithorhynchus anatinus	30.99	3.00e-60	224.00
IUUC-Ocu-074875	Oryctolagus cuniculus	32.76	5.00e-86	310.00
IUUC-Oba-075214	Oryza barthii	22.47	1.00e-05	42.40
IUUC-Obr-076758	Oryza brachyantha	21.52	1.00e-04	38.50
IUUC-Ogl-077665	Oryza glaberrima	22.47	1.00e-05	42.40
IUUC-Ogu-078899	Oryza glumaepatula	22.47	1.00e-05	42.40
IUUC-Oin-079167	Oryza indica	22.47	1.00e-05	42.40
IUUC-Olo-080451	Oryza longistaminata	22.47	5.00e-06	42.70
IUUC-Ome-081836	Oryza meridionalis	22.78	1.00e-05	42.40
IUUC-Oni-083019	Oryza nivara	22.47	1.00e-05	42.40
IUUC-Opu-083122	Oryza punctata	22.55	8.00e-06	42.70
IUUC-Oru-084900	Oryza rufipogon	22.47	1.00e-05	42.40
IUUC-Osa-086054	Oryza sativa	22.47	1.00e-05	42.40
IUUC-Ola-087077	Oryzias latipes	32.79	1.00e-74	272.00
IUUC-Oga-088049	Otolemur garnettii	34.35	5.00e-77	280.00
IUUC-Oar-089678	Ovis aries	34.19	1.00e-94	338.00
IUUC-Ptr-091380	Pan troglodytes	34.13	2.00e-94	338.00
IUUC-Pan-092821	Papio anubis	34.07	4.00e-92	330.00
IUUC-Psi-093074	Pelodiscus sinensis	33.68	1.00e-94	338.00
IUUC-Pma-094102	Petromyzon marinus	32.39	6.00e-86	309.00
IUUC-Pno-094987	Phaeosphaeria nodorum	43.38	5.00e-142	496.00
IUUC-Ppa-095368	Physcomitrella patens	38.36	6.00e-05	39.70
IUUC-Pfo-097245	Poecilia formosa	34.08	2.00e-90	324.00
IUUC-Pab-098763	Pongo abelii	34.13	3.00e-94	337.00
IUUC-Pop-099355	Populus trichocarpa	23.91	5.00e-04	36.60
IUUC-Pca-100730	Procavia capensis	40.91	3.90e-01	27.30
IUUC-Ppe-101990	Prunus persica	27.88	2.00e-04	38.10
IUUC-Pva-102308	Pteropus vampyrus	30.92	5.00e-73	266.00
IUUC-Pgr-103553	Puccinia graminis	41.60	2.00e-124	437.00
IUUC-Pte-104100	Pyrenophora teres	42.62	9.00e-141	491.00
IUUC-Pyt-104482	Pyrenophora triticirepentis	43.07	5.00e-141	492.00
IUUC-Rno-105582	Rattus norvegicus	34.41	6.00e-93	332.00
IUUC-Sha-106647	Sarcophilus harrisii	34.59	2.00e-95	341.00
IUUC-Sja-107972	Schizosaccharomyces japonicus	44.67	3.00e-139	486.00
IUUC-Spo-108281	Schizosaccharomyces pombe	41.98	4.00e-133	466.00
IUUC-Ssl-108617	Sclerotinia sclerotiorum	43.36	4.00e-148	516.00
IUUC-Smo-108933	Selaginella moellendorffii	23.03	2.00e-07	48.10
IUUC-Sit-110083	Setaria italica	23.27	6.00e-08	50.10
IUUC-Sly-111645	Solanum lycopersicum	30.77	5.00e-05	40.00
IUUC-Stu-112422	Solanum tuberosum	30.77	3.00e-05	40.80
IUUC-Sbi-113987	Sorghum bicolor	25.93	5.00e-05	40.40
IUUC-Sre-115095	Sporisorium reilianum	38.92	8.00e-122	429.00
IUUC-Ssc-116141	Sus scrofa	36.43	2.00e-91	327.00
IUUC-Tgu-117492	Taeniopygia guttata	35.67	3.00e-81	293.00
IUUC-Tru-118463	Takifugu rubripes	32.43	2.00e-88	318.00
IUUC-Tsy-118993	Tarsius syrichta	29.76	8.00e-70	255.00
IUUC-Tni-119896	Tetraodon nigroviridis	33.39	8.00e-88	315.00
IUUC-Tca-121169	Theobroma cacao	27.88	1.00e-04	38.90
IUUC-Tre-122046	Trichoderma reesei	44.28	7.00e-150	521.00
IUUC-Tvi-122415	Trichoderma virens	43.85	8.00e-147	511.00
IUUC-Tae-125503	Triticum aestivum	25.93	8.00e-05	39.30
IUUC-Tme-127123	Tuber melanosporum	47.15	2.00e-154	537.00
IUUC-Tbe-127629	Tupaia belangeri	32.11	2.00e-39	155.00
IUUC-Ttr-128476	Tursiops truncatus	29.86	1.00e-71	261.00
IUUC-Uma-129492	Ustilago maydis	40.26	1.00e-124	438.00
IUUC-Vda-129702	Verticillium dahliae	44.30	2.00e-141	493.00
IUUC-Vpa-130726	Vicugna pacos	37.50	3.20e-01	27.30
IUUC-Vvi-131090	Vitis vinifera	28.85	6.00e-05	39.70
IUUC-Xtr-131786	Xenopus tropicalis	33.96	4.00e-91	326.00
IUUC-Xma-133997	Xiphophorus maculatus	33.06	5.00e-89	319.00
IUUC-Yli-134537	Yarrowia lipolytica	48.89	7.00e-153	531.00
IUUC-Zma-134847	Zea mays	21.90	5.00e-06	43.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence