iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106550

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AEFK01198508

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000011852.1	ENSSHAT00000013977.1	ENSSHAP00000013860.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.90e-27	94.0	1024	1075

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
            C+vC +++++e+ +++C++C++w+H+ C +l+ e+e++n  +  + C+ Cr
   Q: 1024 TCPVCSRNYREEDLILQCRQCDRWMHAVCQNLNTEDEVENVADigFDCTMCR 1075
           6********************************999999999899******8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MDGLETAETE NPVETAEVKE QSAEEDGDTE VDSNKQLTPA LQRSVSEEST SSTVSVGVEA 60
KISEQLCAFC YCGERSSLGQ GELKQFSPTP EFITTWKKQP LNKKDIGDNS DGTSEKIQNA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCGAAAC AGAGGAAAAA CGACAGTGGA GGATGATGAT AGCATGGATG GGTTAGAGAC 60
GGCAGAAACA GAAAACCCTG TTGAAACAGG TAATATTTTA GGAATCCTAT TAAATGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	72.93	0.00e+00	4450.00
IUUC-Apl-003311	Anas platyrhynchos	70.42	0.00e+00	4212.00
IUUC-Aca-004705	Anolis carolinensis	63.71	0.00e+00	3868.00
IUUC-Bta-012322	Bos taurus	70.02	0.00e+00	4154.00
IUUC-Bra-017422	Brassica rapa	32.46	2.00e-26	114.00
IUUC-Cel-018354	Caenorhabditis elegans	35.96	3.00e-64	241.00
IUUC-Cja-019983	Callithrix jacchus	73.16	0.00e+00	4601.00
IUUC-Cfa-020903	Canis familiaris	71.52	0.00e+00	4482.00
IUUC-Cpo-021732	Cavia porcellus	68.47	0.00e+00	4190.00
IUUC-Csa-023083	Chlorocebus sabaeus	76.82	0.00e+00	6386.00
IUUC-Cho-024469	Choloepus hoffmanni	71.13	0.00e+00	1904.00
IUUC-Dre-028110	Danio rerio	47.67	0.00e+00	1964.00
IUUC-Dor-030569	Dipodomys ordii	66.59	0.00e+00	2354.00
IUUC-Dme-031590	Drosophila melanogaster	34.35	5.00e-71	263.00
IUUC-Eca-033945	Equus caballus	74.30	0.00e+00	4337.00
IUUC-Fca-035922	Felis catus	71.48	0.00e+00	4302.00
IUUC-Gmo-039403	Gadus morhua	52.66	0.00e+00	1199.00
IUUC-Gac-041896	Gasterosteus aculeatus	47.56	0.00e+00	1358.00
IUUC-Ggo-044812	Gorilla gorilla	71.26	0.00e+00	4458.00
IUUC-Hsa-046595	Homo sapiens	73.84	0.00e+00	4647.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	71.28	0.00e+00	4376.00
IUUC-Lch-050086	Latimeria chalumnae	55.80	0.00e+00	3201.00
IUUC-Loc-052891	Lepisosteus oculatus	64.98	0.00e+00	2047.00
IUUC-Laf-054348	Loxodonta africana	74.84	0.00e+00	2746.00
IUUC-Mcc-054868	Macaca mulatta	73.66	0.00e+00	4528.00
IUUC-Meu-056322	Macropus eugenii	87.18	0.00e+00	1758.00
IUUC-Mga-059541	Meleagris gallopavo	70.24	0.00e+00	4255.00
IUUC-Mmr-061092	Microcebus murinus	75.95	0.00e+00	6313.00
IUUC-Mdo-062610	Monodelphis domestica	87.04	0.00e+00	2394.00
IUUC-Mmu-063666	Mus musculus	70.53	0.00e+00	4233.00
IUUC-Mpu-066366	Mustela putorius furo	70.30	0.00e+00	3999.00
IUUC-Mlu-068201	Myotis lucifugus	70.72	0.00e+00	3524.00
IUUC-Nle-069232	Nomascus leucogenys	76.65	0.00e+00	6358.00
IUUC-Opr-070625	Ochotona princeps	62.79	0.00e+00	1007.00
IUUC-Ont-072401	Oreochromis niloticus	52.51	0.00e+00	1180.00
IUUC-Oan-072945	Ornithorhynchus anatinus	77.34	0.00e+00	6210.00
IUUC-Ocu-074920	Oryctolagus cuniculus	74.97	0.00e+00	6237.00
IUUC-Ola-086436	Oryzias latipes	43.91	0.00e+00	1855.00
IUUC-Oga-088637	Otolemur garnettii	70.99	0.00e+00	3578.00
IUUC-Oar-089363	Ovis aries	68.88	0.00e+00	4102.00
IUUC-Ptr-091527	Pan troglodytes	73.79	0.00e+00	4666.00
IUUC-Pan-092102	Papio anubis	71.04	0.00e+00	4315.00
IUUC-Pma-094252	Petromyzon marinus	38.79	9.00e-176	611.00
IUUC-Pfo-096288	Poecilia formosa	47.75	0.00e+00	1501.00
IUUC-Pab-098241	Pongo abelii	71.18	0.00e+00	2341.00
IUUC-Pca-100103	Procavia capensis	91.56	0.00e+00	1358.00
IUUC-Pva-102238	Pteropus vampyrus	68.66	0.00e+00	2224.00
IUUC-Rno-105395	Rattus norvegicus	60.34	0.00e+00	841.00
IUUC-Sar-113183	Sorex araneus	88.20	1.00e-153	539.00
IUUC-Tgu-116677	Taeniopygia guttata	68.83	0.00e+00	3836.00
IUUC-Tru-118037	Takifugu rubripes	46.60	0.00e+00	1456.00
IUUC-Tsy-118932	Tarsius syrichta	72.30	0.00e+00	2751.00
IUUC-Tni-119970	Tetraodon nigroviridis	47.06	0.00e+00	1411.00
IUUC-Ttr-129051	Tursiops truncatus	71.16	0.00e+00	4221.00
IUUC-Vda-129876	Verticillium dahliae	52.08	9.00e-09	55.50
IUUC-Vpa-130236	Vicugna pacos	68.03	0.00e+00	1519.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence