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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063115
Ensembl Protein ID ENSMUSP00000033866.8
UniProt Accession Q91XD6; Q9CVA3; VPS36_MOUSE
Genbank Protein ID AAH10811.1; BAB25984.1
Protein Name Vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36
Genbank Nucleotide ID BC010811; AK008946
Gene Name Vps36
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031479.9 ENSMUST00000033866.8 ENSMUSP00000033866.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/PH/GLUE GLUE 15755741
Classification
Family E-value Score Start End
UBD/PH/GLUE 2.10e-74 249.2 1 138
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/PH/GLUE
   S: 1    mdrfvytealLeinetlvirqrsvkiydgdekikfdaGellLtthRLiWirdqkneevtlaipLsavvfieeeaaaigksakivvhlhp 89
           mdrfv+t++lLeinetlvi+qr+v++ydg+ekikfdaG+llL+thRLiW rdqkn+e+++aipLs++vfiee+aa+igksakivvhlhp
   Q: 1    MDRFVWTSGLLEINETLVIQQRGVRVYDGEEKIKFDAGTLLLSTHRLIW-RDQKNNECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHP 88
           9************************************************.*************************************** PP
   S: 90   arsdkePGpldsskasyiklsfkekgdiefyskLseeltaRaWeelevse 139
           a+s+kePGp++ssk+syi+lsfke+g+iefy++Lsee+t+R+We+++vs+
   Q: 89   APSNKEPGPFQSSKNSYIRLSFKEHGQIEFYRRLSEEMTQRRWETVPVSQ 138
           ************************************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
 Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Protein Sequence
(Fasta)
MDRFVWTSGL LEINETLVIQ QRGVRVYDGE EKIKFDAGTL LLSTHRLIWR DQKNNECCMA 60
IPLSQIVFIE EQAAGIGKSA KIVVHLHPAP SNKEPGPFQS SKNSYIRLSF KEHGQIEFYR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063115|UBD,GLUE|Mus musculus
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Nucleotide Sequence
(Fasta)
AGGGAGCGCC GCTCGCAGCC CGGGAGCACC GGCGAGCGGC AGAAGCCGGC CGGGTGGCGG 60
CCATGGACCG CTTCGTGTGG ACCAGCGGCC TCCTGGAGAT CAACGAGACC CTGGTTATCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063115|UBD,GLUE|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0813--Transport
Interpro

IPR007286--EAP30
IPR021648--GLUE_dom
IPR011993--PH_dom-like
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS51495--GLUE
Pfam

PF04157--EAP30
PF11605--Vps36_ESCRT-II
Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0000814--C:ESCRT II complex
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0031902--C:late endosome membrane
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0008022--F:protein C-terminus binding
GO:0043130--F:ubiquitin binding
GO:0016197--P:endosomal transport
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:70160
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000963 Aegilops tauschii 42.11 5.00e-35 140.00
IUUC-Aml-002313 Ailuropoda melanoleuca 95.85 0.00e+00 747.00
IUUC-Atr-003096 Amborella trichopoda 36.73 6.00e-15 74.70
IUUC-Apl-003218 Anas platyrhynchos 87.40 0.00e+00 680.00
IUUC-Aca-004580 Anolis carolinensis 88.34 0.00e+00 694.00
IUUC-Aly-006398 Arabidopsis lyrata 37.56 4.00e-59 222.00
IUUC-Ath-006907 Arabidopsis thaliana 38.50 3.00e-59 222.00
IUUC-Ago-007840 Ashbya gossypii 21.60 7.00e-03 35.80
IUUC-Acl-008117 Aspergillus clavatus 31.76 2.00e-36 147.00
IUUC-Afl-008595 Aspergillus flavus 33.23 2.00e-36 146.00
IUUC-Afu-008918 Aspergillus fumigatus 30.77 8.00e-35 141.00
IUUC-Ani-009206 Aspergillus nidulans 32.15 6.00e-36 145.00
IUUC-Ang-009784 Aspergillus niger 31.79 4.00e-33 136.00
IUUC-Aor-010126 Aspergillus oryzae 33.23 3.00e-36 146.00
IUUC-Ate-010303 Aspergillus terreus 32.11 3.00e-34 140.00
IUUC-Ame-011190 Astyanax mexicanus 83.51 0.00e+00 660.00
IUUC-Bgr-011979 Blumeria graminis 30.65 3.00e-32 133.00
IUUC-Bta-012661 Bos taurus 95.60 0.00e+00 743.00
IUUC-Bci-013982 Botrytis cinerea 32.33 5.00e-32 132.00
IUUC-Bdi-014753 Brachypodium distachyon 40.00 1.00e-50 194.00
IUUC-Bol-015465 Brassica oleracea 42.25 8.00e-50 191.00
IUUC-Bra-016794 Brassica rapa 43.08 5.00e-51 195.00
IUUC-Cel-018514 Caenorhabditis elegans 41.09 7.00e-82 297.00
IUUC-Cja-019285 Callithrix jacchus 94.63 0.00e+00 666.00
IUUC-Cfa-020746 Canis familiaris 95.60 0.00e+00 743.00
IUUC-Cpo-022005 Cavia porcellus 95.76 0.00e+00 680.00
IUUC-Cre-022686 Chlamydomonas reinhardtii 35.25 9.00e-33 135.00
IUUC-Csa-023520 Chlorocebus sabaeus 95.60 0.00e+00 744.00
IUUC-Cho-024957 Choloepus hoffmanni 90.67 0.00e+00 701.00
IUUC-Cin-025575 Ciona intestinalis 45.24 8.00e-08 48.10
IUUC-Csv-025942 Ciona savignyi 52.33 5.00e-109 387.00
IUUC-Cgl-026558 Colletotrichum gloeosporioides 32.44 1.00e-31 131.00
IUUC-Cne-026915 Cryptococcus neoformans 28.30 2.00e-24 107.00
IUUC-Cme-027099 Cyanidioschyzon merolae 24.68 4.00e-12 66.20
IUUC-Dre-027753 Danio rerio 83.25 0.00e+00 658.00
IUUC-Dno-029922 Dasypus novemcinctus 93.26 0.00e+00 728.00
IUUC-Dor-030643 Dipodomys ordii 88.60 0.00e+00 674.00
IUUC-Dse-031368 Dothistroma septosporum 32.81 1.00e-30 127.00
IUUC-Dme-031977 Drosophila melanogaster 44.28 3.00e-94 338.00
IUUC-Ete-033135 Echinops telfairi 72.80 2.00e-137 481.00
IUUC-Eca-033937 Equus caballus 94.35 0.00e+00 671.00
IUUC-Eeu-034483 Erinaceus europaeus 91.19 0.00e+00 733.00
IUUC-Fca-035496 Felis catus 94.92 0.00e+00 674.00
IUUC-Fal-036743 Ficedula albicollis 88.60 0.00e+00 698.00
IUUC-Fox-037685 Fusarium oxysporum 34.36 2.00e-27 117.00
IUUC-Fso-038421 Fusarium solani 30.51 2.00e-28 120.00
IUUC-Gmo-039456 Gadus morhua 78.07 2.00e-174 604.00
IUUC-Ggr-039763 Gaeumannomyces graminis 32.46 9.00e-37 148.00
IUUC-Gga-040556 Gallus gallus 87.56 0.00e+00 685.00
IUUC-Gac-041481 Gasterosteus aculeatus 79.17 5.00e-159 553.00
IUUC-Gma-044185 Glycine max 44.26 5.00e-53 201.00
IUUC-Ggo-044849 Gorilla gorilla 95.85 0.00e+00 744.00
IUUC-Hsa-046228 Homo sapiens 95.85 0.00e+00 744.00
IUUC-Hvu-047858 Hordeum vulgare 38.68 3.00e-13 68.90
IUUC-Itr-048068 Ictidomys tridecemlineatus 92.78 0.00e+00 717.00
IUUC-Kpa-049240 Komagataella pastoris 24.30 4.00e-06 46.20
IUUC-Lch-050293 Latimeria chalumnae 86.97 1.00e-125 441.00
IUUC-Lpe-051363 Leersia perrieri 45.08 6.00e-52 198.00
IUUC-Loc-052866 Lepisosteus oculatus 83.38 0.00e+00 635.00
IUUC-Lma-053139 Leptosphaeria maculans 28.93 6.00e-32 132.00
IUUC-Laf-053881 Loxodonta africana 88.60 0.00e+00 684.00
IUUC-Mcc-055158 Macaca mulatta 95.34 0.00e+00 743.00
IUUC-Meu-056126 Macropus eugenii 71.75 1.00e-132 465.00
IUUC-Mor-057092 Magnaporthe oryzae 31.45 3.00e-33 137.00
IUUC-Mpo-057629 Magnaporthe poae 32.78 5.00e-29 121.00
IUUC-Mtr-058039 Medicago truncatula 45.27 1.00e-53 204.00
IUUC-Mla-058913 Melampsora laricipopulina 30.10 1.00e-24 108.00
IUUC-Mga-059956 Meleagris gallopavo 87.56 0.00e+00 688.00
IUUC-Mvi-060570 Microbotryum violaceum 24.50 9.00e-19 88.60
IUUC-Mmr-061769 Microcebus murinus 95.48 0.00e+00 677.00
IUUC-Mdo-062751 Monodelphis domestica 89.34 0.00e+00 702.00
IUUC-Mac-064979 Musa acuminata 35.58 2.00e-53 202.00
IUUC-Mpu-066904 Mustela putorius furo 95.36 4.00e-136 476.00
IUUC-Mlu-067474 Myotis lucifugus 94.30 0.00e+00 733.00
IUUC-Nfi-068588 Neosartorya fischeri 31.06 5.00e-33 135.00
IUUC-Ncr-068855 Neurospora crassa 30.21 3.00e-28 120.00
IUUC-Nle-069660 Nomascus leucogenys 95.08 0.00e+00 738.00
IUUC-Opr-070695 Ochotona princeps 94.30 0.00e+00 735.00
IUUC-Ont-071837 Oreochromis niloticus 81.94 1.00e-173 602.00
IUUC-Oan-072903 Ornithorhynchus anatinus 91.57 0.00e+00 661.00
IUUC-Ocu-074833 Oryctolagus cuniculus 95.34 0.00e+00 746.00
IUUC-Oba-075899 Oryza barthii 45.42 4.00e-52 197.00
IUUC-Obr-076125 Oryza brachyantha 42.96 8.00e-56 211.00
IUUC-Ogl-077538 Oryza glaberrima 50.00 1.00e-32 134.00
IUUC-Ogu-078272 Oryza glumaepatula 45.08 5.00e-52 198.00
IUUC-Oin-079158 Oryza indica 44.77 1.00e-51 197.00
IUUC-Olo-080496 Oryza longistaminata 44.17 3.00e-48 185.00
IUUC-Ome-081440 Oryza meridionalis 44.77 6.00e-50 190.00
IUUC-Oni-083069 Oryza nivara 44.77 1.00e-51 197.00
IUUC-Opu-083838 Oryza punctata 45.53 1.00e-50 192.00
IUUC-Oru-084377 Oryza rufipogon 45.08 5.00e-52 198.00
IUUC-Osa-085976 Oryza sativa 45.08 5.00e-52 198.00
IUUC-Ola-086431 Oryzias latipes 83.51 5.00e-176 610.00
IUUC-Olu-087789 Ostreococcus lucimarinus 38.43 1.00e-38 152.00
IUUC-Oga-089152 Otolemur garnettii 95.08 0.00e+00 739.00
IUUC-Oar-089198 Ovis aries 95.48 0.00e+00 679.00
IUUC-Ptr-091123 Pan troglodytes 95.85 0.00e+00 744.00
IUUC-Pan-092866 Papio anubis 91.99 0.00e+00 712.00
IUUC-Psi-093384 Pelodiscus sinensis 92.23 0.00e+00 719.00
IUUC-Pno-094773 Phaeosphaeria nodorum 30.09 3.00e-27 116.00
IUUC-Ppa-095753 Physcomitrella patens 35.61 1.00e-55 211.00
IUUC-Pfo-096028 Poecilia formosa 81.94 5.00e-175 607.00
IUUC-Pop-098915 Populus trichocarpa 45.27 9.00e-53 201.00
IUUC-Pca-100422 Procavia capensis 91.81 0.00e+00 652.00
IUUC-Ppe-101564 Prunus persica 44.90 4.00e-54 205.00
IUUC-Pva-103019 Pteropus vampyrus 91.19 0.00e+00 699.00
IUUC-Pgr-103670 Puccinia graminis 28.68 1.00e-22 101.00
IUUC-Ptt-103958 Puccinia triticina 28.40 3.00e-21 96.30
IUUC-Pte-104343 Pyrenophora teres 31.80 8.00e-38 151.00
IUUC-Pyt-104554 Pyrenophora triticirepentis 31.59 2.00e-40 160.00
IUUC-Rno-105775 Rattus norvegicus 98.45 0.00e+00 759.00
IUUC-Sce-106148 Saccharomyces cerevisiae 21.66 5.00e-03 36.20
IUUC-Sha-106468 Sarcophilus harrisii 90.68 0.00e+00 649.00
IUUC-Sja-107850 Schizosaccharomyces japonicus 23.91 1.00e-16 81.30
IUUC-Spo-108225 Schizosaccharomyces pombe 24.14 2.00e-17 83.60
IUUC-Ssl-108412 Sclerotinia sclerotiorum 32.26 8.00e-31 128.00
IUUC-Smo-108898 Selaginella moellendorffii 36.41 5.00e-57 214.00
IUUC-Sit-110126 Setaria italica 35.58 3.00e-50 192.00
IUUC-Sly-110884 Solanum lycopersicum 36.34 4.00e-53 202.00
IUUC-Stu-112573 Solanum tuberosum 35.88 2.00e-53 203.00
IUUC-Sar-113114 Sorex araneus 89.55 4.00e-68 251.00
IUUC-Sbi-114331 Sorghum bicolor 30.22 1.00e-38 154.00
IUUC-Sre-115135 Sporisorium reilianum 22.91 4.00e-10 60.10
IUUC-Ssc-116158 Sus scrofa 96.11 0.00e+00 750.00
IUUC-Tgu-116962 Taeniopygia guttata 88.34 0.00e+00 667.00
IUUC-Tru-117567 Takifugu rubripes 81.94 3.00e-175 607.00
IUUC-Tsy-119357 Tarsius syrichta 79.06 2.00e-161 561.00
IUUC-Tni-120047 Tetraodon nigroviridis 81.38 2.00e-155 541.00
IUUC-Tca-121097 Theobroma cacao 44.44 3.00e-54 206.00
IUUC-Tre-122075 Trichoderma reesei 31.34 2.00e-33 137.00
IUUC-Tvi-122623 Trichoderma virens 32.84 3.00e-40 160.00
IUUC-Tae-123728 Triticum aestivum 43.62 5.00e-51 195.00
IUUC-Tur-125988 Triticum urartu 42.35 9.00e-41 160.00
IUUC-Tme-126936 Tuber melanosporum 30.79 1.00e-33 137.00
IUUC-Tbe-127481 Tupaia belangeri 66.67 3.00e-127 448.00
IUUC-Ttr-128160 Tursiops truncatus 94.30 0.00e+00 726.00
IUUC-Uma-129428 Ustilago maydis 25.25 4.00e-16 80.10
IUUC-Vda-129877 Verticillium dahliae 30.95 4.00e-30 126.00
IUUC-Vpa-130358 Vicugna pacos 95.20 0.00e+00 673.00
IUUC-Vvi-131406 Vitis vinifera 36.97 4.00e-57 215.00
IUUC-Xtr-132548 Xenopus tropicalis 83.98 0.00e+00 644.00
IUUC-Xma-133352 Xiphophorus maculatus 82.20 4.00e-175 607.00
IUUC-Yli-134466 Yarrowia lipolytica 29.55 5.00e-21 95.90
IUUC-Zma-135081 Zea mays 40.64 1.00e-51 197.00
Created Date 25-Jun-2017

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