iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120355

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Lissencephaly-1 homolog

Genbank Nucleotide ID

CAAE01015036

Gene Name

pafah1b1b (1 of many); pafah1b1; lis1; GSTENG00033355001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000017966.1	ENSTNIT00000021361.1	ENSTNIP00000021128.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-60	197.6	148	186
UBD/Beta-Prp	4.00e-92	308.8	107	410

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           gHtdsv +++f  +++ll+s+s D tik+WD+ ++ +++
   Q: 148  GHTDSVQDISFdlTGKLLASCSADMTIKLWDFQSFECIR 186
           8**********9666*******************99987 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+ +gk+l+++s D+tik+wd+++++c++t++gh+++v
   Q: 107  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDLTGKLLASCSADMTIKLWDFQSFECIRTMHGHDHNV 195
           5678889********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd+++s+s+d+t ++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++++++  +l++ h++ v+++
   Q: 196  SSVAIMPNGDHIISASRDKTMKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f+p ++++v++++D+++riWd++++ 
   Q: 283  SWAPESahptildatsseskksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHPGGKFIVTCADDKTLRIWDYKNKR 371
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl  h++ v+s ++ +   +++v+gs d++v++w+++
   Q: 372  CMKTLCAHEHFVTSLDF-HKAAPYVVTGSVDQTVKVWECR 410
           *****************.999****************985 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.

Protein Sequence
(Fasta)

MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDNN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVSQKRD PKEWIPRPPE RYALSGHRSP VTRVIFHPVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGCTGT CACAACGGCA ACGAGATGAA CTGTAAGTGG CCCACACCTC TTTCCTAAGC 60
GTGTGTGTGT GTGTGTGTGT GTGTGAGATC TGCTGCTGTT GTGCCACAAT GATACGTGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

KEGG

tng:GSTEN00033355G001

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	92.98	0.00e+00	785.00
IUUC-Apl-004024	Anas platyrhynchos	93.17	0.00e+00	807.00
IUUC-Aca-004564	Anolis carolinensis	92.93	0.00e+00	800.00
IUUC-Acl-008360	Aspergillus clavatus	46.55	9.00e-105	373.00
IUUC-Afu-008848	Aspergillus fumigatus	46.57	9.00e-106	377.00
IUUC-Ani-009173	Aspergillus nidulans	43.18	2.00e-89	322.00
IUUC-Ang-009873	Aspergillus niger	44.05	6.00e-92	330.00
IUUC-Ate-010523	Aspergillus terreus	41.60	1.00e-88	320.00
IUUC-Ame-010969	Astyanax mexicanus	95.12	0.00e+00	824.00
IUUC-Bgr-011972	Blumeria graminis	47.02	8.00e-104	370.00
IUUC-Bta-013106	Bos taurus	93.17	0.00e+00	807.00
IUUC-Bci-013615	Botrytis cinerea	45.06	1.00e-98	353.00
IUUC-Cel-018459	Caenorhabditis elegans	55.96	1.00e-147	515.00
IUUC-Cja-018755	Callithrix jacchus	90.73	0.00e+00	787.00
IUUC-Cfa-020749	Canis familiaris	93.17	0.00e+00	807.00
IUUC-Cpo-022371	Cavia porcellus	93.17	0.00e+00	807.00
IUUC-Cre-022578	Chlamydomonas reinhardtii	35.76	3.00e-51	195.00
IUUC-Csa-023524	Chlorocebus sabaeus	91.88	0.00e+00	676.00
IUUC-Cho-024764	Choloepus hoffmanni	82.75	0.00e+00	637.00
IUUC-Cin-025753	Ciona intestinalis	71.29	0.00e+00	626.00
IUUC-Csv-025817	Ciona savignyi	70.24	0.00e+00	639.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	47.27	1.00e-97	350.00
IUUC-Cne-027087	Cryptococcus neoformans	49.61	8.00e-110	390.00
IUUC-Dre-028314	Danio rerio	94.39	0.00e+00	821.00
IUUC-Dno-029050	Dasypus novemcinctus	92.93	0.00e+00	806.00
IUUC-Dor-030222	Dipodomys ordii	85.12	0.00e+00	724.00
IUUC-Dse-031164	Dothistroma septosporum	42.89	4.00e-99	354.00
IUUC-Dme-031745	Drosophila melanogaster	70.32	8.00e-175	605.00
IUUC-Ete-032508	Echinops telfairi	77.32	0.00e+00	648.00
IUUC-Eca-034288	Equus caballus	92.48	0.00e+00	780.00
IUUC-Eeu-034984	Erinaceus europaeus	84.88	0.00e+00	721.00
IUUC-Fca-036498	Felis catus	93.17	0.00e+00	807.00
IUUC-Fal-036920	Ficedula albicollis	93.17	0.00e+00	807.00
IUUC-Fox-037996	Fusarium oxysporum	45.43	2.00e-102	365.00
IUUC-Fso-038160	Fusarium solani	43.36	6.00e-96	344.00
IUUC-Gmo-038983	Gadus morhua	94.63	0.00e+00	817.00
IUUC-Ggr-040051	Gaeumannomyces graminis	45.11	1.00e-96	346.00
IUUC-Gga-040623	Gallus gallus	93.17	0.00e+00	807.00
IUUC-Gac-041613	Gasterosteus aculeatus	97.32	0.00e+00	838.00
IUUC-Ggo-045410	Gorilla gorilla	82.71	0.00e+00	682.00
IUUC-Hsa-046358	Homo sapiens	93.17	0.00e+00	806.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	93.17	0.00e+00	807.00
IUUC-Lch-049936	Latimeria chalumnae	93.17	0.00e+00	806.00
IUUC-Loc-052476	Lepisosteus oculatus	94.49	0.00e+00	795.00
IUUC-Lma-053170	Leptosphaeria maculans	45.71	3.00e-98	351.00
IUUC-Laf-053713	Loxodonta africana	91.20	0.00e+00	788.00
IUUC-Mcc-054628	Macaca mulatta	92.68	0.00e+00	804.00
IUUC-Meu-055927	Macropus eugenii	79.78	9.00e-131	459.00
IUUC-Mor-056962	Magnaporthe oryzae	44.12	3.00e-96	345.00
IUUC-Mla-058819	Melampsora laricipopulina	47.31	7.00e-117	413.00
IUUC-Mga-059945	Meleagris gallopavo	92.93	0.00e+00	806.00
IUUC-Mvi-060403	Microbotryum violaceum	50.00	8.00e-129	453.00
IUUC-Mmr-061289	Microcebus murinus	92.98	0.00e+00	785.00
IUUC-Mdo-061912	Monodelphis domestica	92.44	0.00e+00	799.00
IUUC-Mmu-063253	Mus musculus	93.17	0.00e+00	807.00
IUUC-Mpu-066638	Mustela putorius furo	93.17	0.00e+00	807.00
IUUC-Mlu-067267	Myotis lucifugus	91.67	0.00e+00	790.00
IUUC-Nfi-068571	Neosartorya fischeri	45.39	1.00e-98	353.00
IUUC-Ncr-068895	Neurospora crassa	48.53	3.00e-104	372.00
IUUC-Nle-069087	Nomascus leucogenys	93.13	0.00e+00	656.00
IUUC-Opr-070579	Ochotona princeps	92.93	0.00e+00	806.00
IUUC-Ont-072432	Oreochromis niloticus	96.83	0.00e+00	834.00
IUUC-Oan-073072	Ornithorhynchus anatinus	93.17	0.00e+00	807.00
IUUC-Ocu-074180	Oryctolagus cuniculus	92.93	0.00e+00	806.00
IUUC-Ola-086772	Oryzias latipes	96.83	0.00e+00	837.00
IUUC-Oga-088219	Otolemur garnettii	90.95	0.00e+00	786.00
IUUC-Oar-090394	Ovis aries	93.17	0.00e+00	807.00
IUUC-Ptr-091517	Pan troglodytes	93.17	0.00e+00	807.00
IUUC-Pan-092421	Papio anubis	92.68	0.00e+00	804.00
IUUC-Psi-093370	Pelodiscus sinensis	92.93	0.00e+00	805.00
IUUC-Pma-094319	Petromyzon marinus	86.53	0.00e+00	638.00
IUUC-Pno-094815	Phaeosphaeria nodorum	46.30	4.00e-102	364.00
IUUC-Pfo-097089	Poecilia formosa	97.07	0.00e+00	839.00
IUUC-Pab-098421	Pongo abelii	93.17	0.00e+00	807.00
IUUC-Pca-100120	Procavia capensis	68.56	5.00e-154	536.00
IUUC-Pva-102960	Pteropus vampyrus	92.93	0.00e+00	802.00
IUUC-Pgr-103538	Puccinia graminis	46.53	4.00e-117	414.00
IUUC-Ptt-103990	Puccinia triticina	42.28	2.00e-44	173.00
IUUC-Pte-104261	Pyrenophora teres	46.54	4.00e-102	364.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	46.78	1.00e-102	366.00
IUUC-Rno-105123	Rattus norvegicus	93.17	0.00e+00	807.00
IUUC-Sce-106208	Saccharomyces cerevisiae	28.11	2.00e-36	146.00
IUUC-Sha-107010	Sarcophilus harrisii	92.20	0.00e+00	798.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	32.80	3.00e-65	242.00
IUUC-Spo-108357	Schizosaccharomyces pombe	28.46	2.00e-31	130.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	45.19	4.00e-99	354.00
IUUC-Sar-113309	Sorex araneus	92.23	0.00e+00	775.00
IUUC-Sre-115003	Sporisorium reilianum	49.09	2.00e-123	435.00
IUUC-Ssc-116148	Sus scrofa	93.17	0.00e+00	807.00
IUUC-Tgu-117299	Taeniopygia guttata	92.93	0.00e+00	804.00
IUUC-Tru-117721	Takifugu rubripes	98.54	0.00e+00	846.00
IUUC-Tsy-119493	Tarsius syrichta	92.44	0.00e+00	796.00
IUUC-Tre-121977	Trichoderma reesei	42.80	1.00e-99	356.00
IUUC-Tvi-122661	Trichoderma virens	43.20	4.00e-99	354.00
IUUC-Tme-127031	Tuber melanosporum	48.17	5.00e-102	364.00
IUUC-Tbe-127492	Tupaia belangeri	60.56	9.00e-121	426.00
IUUC-Ttr-128929	Tursiops truncatus	93.17	0.00e+00	805.00
IUUC-Uma-129347	Ustilago maydis	48.17	2.00e-123	435.00
IUUC-Vda-129837	Verticillium dahliae	45.67	6.00e-100	357.00
IUUC-Vpa-130532	Vicugna pacos	79.53	1.00e-179	622.00
IUUC-Xtr-131985	Xenopus tropicalis	92.93	0.00e+00	806.00
IUUC-Xma-133314	Xiphophorus maculatus	97.07	0.00e+00	838.00
IUUC-Yli-134403	Yarrowia lipolytica	39.15	2.00e-74	272.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence