iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000131979.18	ENST00000543643.6	ENSP00000444011.2
ENSG00000131979.18	ENST00000491895.6	ENSP00000419045.2
ENSG00000131979.18	ENST00000536224.2	ENSP00000445246.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	22984419

Organism

Homo sapiens

Functional Description
(View)

Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.

Protein Sequence
(Fasta)

MEKGPVRAPA EKPRGARCSN GFPERDPPRP GPSRPAEKPP RPEAKSAQPA DGWKGERPRS 60
EEDNELNLPN LAAAYSSILS SLGENPQRQG LLKTPWRAAS AMQFFTKGYQ ETISDVLNDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAGGAGG CGCGGCCGGG CTTTCCAGCC TGTGGCCGCT CCCGGCTCGG AGTGTGATCT 60
AAGCAGGTTG CGTACCTTCC TCAGGTGACT CCGGCCACAG CCCATTGTCC GCGGCCACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0021--Allosteric enzyme
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-1023--Dystonia
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0908--Parkinsonism
KW-0586--Phenylketonuria
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0783--Tetrahydrobiopterin biosynthesis
KW-0862--Zinc

Interpro

IPR001474--GTP_CycHdrlase_I
IPR018234--GTP_CycHdrlase_I_CS
IPR020602--GTP_CycHdrlase_I_dom

PROSITE

PS00859--GTP_CYCLOHYDROL_1_1
PS00860--GTP_CYCLOHYDROL_1_2

Pfam

PF01227--GTP_cyclohydroI

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0044306--C:neuron projection terminus
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0005509--F:calcium ion binding
GO:0050662--F:coenzyme binding
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0051019--F:mitogen-activated protein kinase binding
GO:0042803--F:protein homodimerization activity
GO:0008270--F:zinc ion binding
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042416--P:dopamine biosynthetic process
GO:0045776--P:negative regulation of blood pressure
GO:0050884--P:neuromuscular process controlling posture
GO:0006809--P:nitric oxide biosynthetic process
GO:0010460--P:positive regulation of heart rate
GO:0051000--P:positive regulation of nitric-oxide synthase activity
GO:0051291--P:protein heterooligomerization
GO:0051260--P:protein homooligomerization
GO:0042559--P:pteridine-containing compound biosynthetic process
GO:0008217--P:regulation of blood pressure
GO:0014916--P:regulation of lung blood pressure
GO:0050999--P:regulation of nitric-oxide synthase activity
GO:2000121--P:regulation of removal of superoxide radicals
GO:0034341--P:response to interferon-gamma
GO:0032496--P:response to lipopolysaccharide
GO:0048265--P:response to pain
GO:0034612--P:response to tumor necrosis factor
GO:0006729--P:tetrahydrobiopterin biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process
GO:0042311--P:vasodilation

KEGG

hsa:2643

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002530	Amborella trichopoda	33.65	3.00e-26	112.00
IUUC-Apl-004135	Anas platyrhynchos	91.79	2.00e-104	370.00
IUUC-Aca-005252	Anolis carolinensis	75.63	6.00e-87	313.00
IUUC-Aly-006454	Arabidopsis lyrata	40.70	5.00e-30	125.00
IUUC-Ath-006744	Arabidopsis thaliana	40.84	2.00e-29	123.00
IUUC-Ago-007744	Ashbya gossypii	69.71	3.00e-70	258.00
IUUC-Acl-008058	Aspergillus clavatus	59.50	2.00e-71	262.00
IUUC-Afl-008668	Aspergillus flavus	61.00	4.00e-73	268.00
IUUC-Afu-008935	Aspergillus fumigatus	59.50	2.00e-71	262.00
IUUC-Ani-009207	Aspergillus nidulans	61.00	2.00e-73	269.00
IUUC-Ang-009686	Aspergillus niger	65.17	1.00e-70	259.00
IUUC-Aor-010202	Aspergillus oryzae	61.00	3.00e-73	268.00
IUUC-Ate-010518	Aspergillus terreus	55.46	3.00e-72	265.00
IUUC-Ame-010958	Astyanax mexicanus	69.53	1.00e-93	335.00
IUUC-Bgr-012060	Blumeria graminis	51.98	2.00e-64	238.00
IUUC-Bta-012416	Bos taurus	91.20	8.00e-122	429.00
IUUC-Bci-013811	Botrytis cinerea	50.42	2.00e-67	249.00
IUUC-Bdi-014794	Brachypodium distachyon	38.15	2.00e-22	100.00
IUUC-Bol-015182	Brassica oleracea	39.59	2.00e-30	126.00
IUUC-Bra-016764	Brassica rapa	38.50	5.00e-29	122.00
IUUC-Cel-018345	Caenorhabditis elegans	71.74	2.00e-80	291.00
IUUC-Cja-019848	Callithrix jacchus	100.00	3.00e-79	286.00
IUUC-Cfa-020630	Canis familiaris	96.40	2.00e-128	451.00
IUUC-Cpo-021420	Cavia porcellus	91.87	1.00e-104	372.00
IUUC-Cre-022618	Chlamydomonas reinhardtii	41.36	1.00e-33	136.00
IUUC-Csa-023403	Chlorocebus sabaeus	92.80	8.00e-125	439.00
IUUC-Cho-024907	Choloepus hoffmanni	93.20	2.00e-129	454.00
IUUC-Cin-025120	Ciona intestinalis	64.29	1.00e-68	252.00
IUUC-Csv-026259	Ciona savignyi	72.00	4.00e-78	283.00
IUUC-Cgl-026508	Colletotrichum gloeosporioides	55.45	2.00e-66	245.00
IUUC-Cne-026810	Cryptococcus neoformans	64.55	6.00e-72	265.00
IUUC-Cme-027139	Cyanidioschyzon merolae	49.46	1.00e-49	189.00
IUUC-Dre-028815	Danio rerio	88.00	7.00e-105	373.00
IUUC-Dno-029017	Dasypus novemcinctus	93.75	4.00e-125	440.00
IUUC-Dor-030417	Dipodomys ordii	97.78	2.00e-76	276.00
IUUC-Dse-031187	Dothistroma septosporum	64.09	1.00e-69	256.00
IUUC-Dme-031615	Drosophila melanogaster	76.50	7.00e-74	270.00
IUUC-Ete-032727	Echinops telfairi	75.96	7.00e-86	309.00
IUUC-Eca-033487	Equus caballus	97.83	9.00e-78	281.00
IUUC-Eeu-034696	Erinaceus europaeus	86.80	4.00e-117	414.00
IUUC-Fca-035975	Felis catus	98.72	6.00e-41	158.00
IUUC-Fal-037439	Ficedula albicollis	97.32	2.00e-85	307.00
IUUC-Fox-037781	Fusarium oxysporum	59.55	1.00e-64	239.00
IUUC-Fso-038377	Fusarium solani	57.46	6.00e-63	234.00
IUUC-Gmo-038945	Gadus morhua	73.96	1.00e-83	302.00
IUUC-Ggr-039834	Gaeumannomyces graminis	53.47	6.00e-65	240.00
IUUC-Gga-040495	Gallus gallus	84.32	1.00e-111	395.00
IUUC-Gac-042306	Gasterosteus aculeatus	83.89	2.00e-103	368.00
IUUC-Gma-043539	Glycine max	32.86	2.00e-30	127.00
IUUC-Ggo-045597	Gorilla gorilla	87.50	1.00e-113	402.00
IUUC-Hvu-047298	Hordeum vulgare	32.65	3.00e-26	113.00
IUUC-Itr-048997	Ictidomys tridecemlineatus	94.27	2.00e-106	378.00
IUUC-Kpa-049319	Komagataella pastoris	59.38	3.00e-74	271.00
IUUC-Lch-049771	Latimeria chalumnae	77.64	5.00e-107	380.00
IUUC-Lpe-050904	Leersia perrieri	36.73	2.00e-25	110.00
IUUC-Loc-052063	Lepisosteus oculatus	83.33	1.00e-108	385.00
IUUC-Lma-053280	Leptosphaeria maculans	45.89	1.00e-48	187.00
IUUC-Laf-054214	Loxodonta africana	97.20	3.00e-136	477.00
IUUC-Mcc-054778	Macaca mulatta	98.80	8.00e-139	486.00
IUUC-Meu-056598	Macropus eugenii	95.65	4.00e-34	138.00
IUUC-Mor-056989	Magnaporthe oryzae	55.45	3.00e-65	241.00
IUUC-Mpo-057591	Magnaporthe poae	54.95	3.00e-66	244.00
IUUC-Mtr-057924	Medicago truncatula	36.02	5.00e-32	132.00
IUUC-Mla-058931	Melampsora laricipopulina	60.80	8.00e-69	253.00
IUUC-Mga-060001	Meleagris gallopavo	97.10	4.00e-78	282.00
IUUC-Mvi-060513	Microbotryum violaceum	66.85	8.00e-69	253.00
IUUC-Mmr-061725	Microcebus murinus	96.00	1.00e-132	465.00
IUUC-Mdo-062715	Monodelphis domestica	84.21	1.00e-121	429.00
IUUC-Mmu-063203	Mus musculus	89.17	1.00e-119	422.00
IUUC-Mac-065392	Musa acuminata	38.56	9.00e-37	147.00
IUUC-Mpu-066174	Mustela putorius furo	97.17	2.00e-122	431.00
IUUC-Mlu-067883	Myotis lucifugus	99.28	5.00e-79	285.00
IUUC-Nfi-068317	Neosartorya fischeri	59.50	2.00e-71	262.00
IUUC-Ncr-068822	Neurospora crassa	55.94	4.00e-67	248.00
IUUC-Nle-069231	Nomascus leucogenys	99.60	3.00e-140	490.00
IUUC-Opr-070417	Ochotona princeps	99.26	7.00e-77	278.00
IUUC-Ont-072168	Oreochromis niloticus	80.91	1.00e-104	372.00
IUUC-Oan-072690	Ornithorhynchus anatinus	98.72	6.00e-41	158.00
IUUC-Ocu-074537	Oryctolagus cuniculus	95.20	7.00e-126	442.00
IUUC-Oba-075333	Oryza barthii	33.16	3.00e-26	112.00
IUUC-Obr-076255	Oryza brachyantha	37.29	8.00e-26	110.00
IUUC-Ogl-077792	Oryza glaberrima	33.16	1.00e-26	113.00
IUUC-Ogu-078354	Oryza glumaepatula	33.16	6.00e-26	112.00
IUUC-Oin-079934	Oryza indica	33.16	9.00e-26	111.00
IUUC-Olo-080643	Oryza longistaminata	37.36	1.00e-24	107.00
IUUC-Ome-081632	Oryza meridionalis	36.99	9.00e-26	111.00
IUUC-Oni-083004	Oryza nivara	33.16	1.00e-25	111.00
IUUC-Opu-083899	Oryza punctata	36.73	8.00e-26	111.00
IUUC-Oru-084386	Oryza rufipogon	33.16	7.00e-26	112.00
IUUC-Osa-085665	Oryza sativa	37.36	9.00e-25	107.00
IUUC-Ola-086577	Oryzias latipes	76.29	2.00e-88	318.00
IUUC-Olu-087867	Ostreococcus lucimarinus	43.39	1.00e-36	146.00
IUUC-Oga-088652	Otolemur garnettii	91.60	1.00e-112	399.00
IUUC-Oar-089965	Ovis aries	96.14	4.00e-119	420.00
IUUC-Ptr-090833	Pan troglodytes	100.00	1.00e-140	492.00
IUUC-Psi-093542	Pelodiscus sinensis	67.51	2.00e-86	311.00
IUUC-Pma-094423	Petromyzon marinus	84.72	2.00e-71	261.00
IUUC-Pno-095091	Phaeosphaeria nodorum	64.61	8.00e-69	253.00
IUUC-Ppa-096013	Physcomitrella patens	40.51	1.00e-28	121.00
IUUC-Pfo-097146	Poecilia formosa	79.24	7.00e-108	383.00
IUUC-Pab-098744	Pongo abelii	100.00	1.00e-140	492.00
IUUC-Pop-099917	Populus trichocarpa	37.27	6.00e-27	115.00
IUUC-Pca-100111	Procavia capensis	95.20	9.00e-134	469.00
IUUC-Ppe-101984	Prunus persica	40.10	7.00e-29	121.00
IUUC-Pva-103078	Pteropus vampyrus	93.60	3.00e-135	474.00
IUUC-Pgr-103438	Puccinia graminis	51.28	2.00e-66	245.00
IUUC-Ptt-103875	Puccinia triticina	63.69	1.00e-66	246.00
IUUC-Pte-104180	Pyrenophora teres	63.19	2.00e-68	252.00
IUUC-Pyt-104552	Pyrenophora triticirepentis	63.19	2.00e-68	253.00
IUUC-Rno-105506	Rattus norvegicus	92.50	7.00e-132	462.00
IUUC-Sce-106375	Saccharomyces cerevisiae	57.53	2.00e-68	251.00
IUUC-Sha-107585	Sarcophilus harrisii	95.65	3.00e-77	279.00
IUUC-Sja-107871	Schizosaccharomyces japonicus	61.54	3.00e-71	261.00
IUUC-Spo-108282	Schizosaccharomyces pombe	56.09	4.00e-71	260.00
IUUC-Smo-109561	Selaginella moellendorffii	40.93	2.00e-31	130.00
IUUC-Sit-110577	Setaria italica	37.89	6.00e-27	115.00
IUUC-Sly-111719	Solanum lycopersicum	38.36	1.00e-27	117.00
IUUC-Stu-112752	Solanum tuberosum	38.51	7.00e-29	121.00
IUUC-Sar-113701	Sorex araneus	85.94	1.00e-126	445.00
IUUC-Sbi-114308	Sorghum bicolor	37.31	1.00e-27	117.00
IUUC-Sre-115125	Sporisorium reilianum	64.67	7.00e-70	257.00
IUUC-Tgu-117039	Taeniopygia guttata	97.83	3.00e-78	283.00
IUUC-Tru-117939	Takifugu rubripes	78.72	4.00e-106	377.00
IUUC-Tsy-118852	Tarsius syrichta	85.19	1.00e-62	231.00
IUUC-Tni-120356	Tetraodon nigroviridis	81.57	5.00e-105	373.00
IUUC-Tca-121422	Theobroma cacao	34.87	3.00e-29	123.00
IUUC-Tre-122035	Trichoderma reesei	56.44	5.00e-68	250.00
IUUC-Tvi-122649	Trichoderma virens	56.44	2.00e-68	252.00
IUUC-Tae-124146	Triticum aestivum	32.65	2.00e-27	116.00
IUUC-Tme-127015	Tuber melanosporum	55.91	5.00e-68	251.00
IUUC-Tbe-128024	Tupaia belangeri	85.93	3.00e-63	233.00
IUUC-Ttr-128474	Tursiops truncatus	92.00	7.00e-135	473.00
IUUC-Uma-129655	Ustilago maydis	65.22	4.00e-71	261.00
IUUC-Vda-129970	Verticillium dahliae	56.06	2.00e-65	242.00
IUUC-Vpa-130564	Vicugna pacos	98.52	9.00e-77	278.00
IUUC-Vvi-131597	Vitis vinifera	40.11	2.00e-29	124.00
IUUC-Xtr-132201	Xenopus tropicalis	79.34	1.00e-110	392.00
IUUC-Xma-133679	Xiphophorus maculatus	79.24	7.00e-108	383.00
IUUC-Yli-134489	Yarrowia lipolytica	59.24	5.00e-72	264.00
IUUC-Zma-135058	Zea mays	39.69	5.00e-29	122.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence