iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000002929.5	ENSGALT00000004623.5	ENSGALP00000004614.5
ENSGALG00000002929.5	ENSGALT00000075489.1	ENSGALP00000051483.1
ENSGALG00000002929.5	ENSGALT00000058935.1	ENSGALP00000050394.1
ENSGALG00000002929.5	ENSGALT00000064768.1	ENSGALP00000054718.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-96	323.8	1681	2060

Active Site

Position(s)	Description	Evidence
2027	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp..................ehlklFe 72
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++++n                   ++   F+
   Q: 1681 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLANPKgsQEGTKYIHNLqglfalpfgrtakpahiaKVKMKFR 1766
           56899***********.**********************766663333330023334444448999999**********9999**** PP
   S: 73   flGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikenaes........................... 130
           flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp ++ks+  +++ + +                           
   Q: 1767 FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFSIDPVVAKSIYHLEDIVRQkkrleqdktqtkeslqyaletltmngc 1853
           *******************************654444*************9999999833344555556666667554444555544 PP
   S: 131  dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFtee 212
           ++e+            +     l+   + eLk gG+++pVt+ N+eeY +lv+ + l+eg+++q+++fr+Gf++v+pl++l++F +e
   Q: 1854 SVED------------LgldftLPGFPNIELKKGGKDTPVTIHNLEEYLRLVIFWALNEGVARQFDSFRDGFESVFPLSHLQYFYPE 1928
           4444............24444478999************************************************************ PP
   S: 213  elellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....d 292
           ele+l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f+se+++ fLqFvTgs+rlP+gGf++l+p l+++rk     +
   Q: 1929 ELEQLLCGSktDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSSFDSEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfestE 2015
           ********97778999999999999***********************************************************988 PP
   S: 293  asddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           + dd lPs++TC+nyLkLP+Ys+ ei++ekLl+A +e+ ++F+ls
   Q: 2016 NPDDFLPSVMTCVNYLKLPDYSTIEIMREKLLIAAREGqQSFHLS 2060
           888***************************************985 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDAA GGRSHLGQAK HKAHSPPESR KSISKTPKVQ 60
SNTTSEQSKG HFSKRGCSSS AVLIPQEDSE RVSTSEKQKT GQVPKKDNSR GVKRSASPDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTCACACT CAACTAAAAT GTTTAAAAGC AGTATTCTGG TGAGTAAATA ACACTTCTAG 60
TACTTCTTAA AAGCTTGCAT GTTTTCAGCT CGTGGTAATT AAAGGGAACT TATTGTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.83	5.00e-127	449.00
IUUC-Aml-001502	Ailuropoda melanoleuca	93.81	0.00e+00	3526.00
IUUC-Atr-002821	Amborella trichopoda	37.30	4.00e-117	416.00
IUUC-Apl-003531	Anas platyrhynchos	94.84	0.00e+00	3505.00
IUUC-Aly-005962	Arabidopsis lyrata	38.71	3.00e-115	410.00
IUUC-Ath-006636	Arabidopsis thaliana	38.57	5.00e-115	409.00
IUUC-Ago-007875	Ashbya gossypii	36.20	2.00e-82	300.00
IUUC-Acl-008242	Aspergillus clavatus	36.05	3.00e-114	407.00
IUUC-Afl-008736	Aspergillus flavus	38.29	9.00e-111	395.00
IUUC-Afu-008812	Aspergillus fumigatus	35.25	2.00e-115	411.00
IUUC-Ani-009407	Aspergillus nidulans	37.12	3.00e-111	397.00
IUUC-Ang-009763	Aspergillus niger	39.78	2.00e-106	381.00
IUUC-Aor-009941	Aspergillus oryzae	31.00	5.00e-114	405.00
IUUC-Ate-010459	Aspergillus terreus	33.95	3.00e-87	317.00
IUUC-Ame-011761	Astyanax mexicanus	88.98	0.00e+00	3018.00
IUUC-Bgr-012265	Blumeria graminis	35.31	4.00e-105	376.00
IUUC-Bta-013070	Bos taurus	90.80	0.00e+00	3428.00
IUUC-Bci-013890	Botrytis cinerea	39.92	1.00e-103	372.00
IUUC-Bdi-014046	Brachypodium distachyon	38.47	5.00e-124	439.00
IUUC-Bol-015942	Brassica oleracea	41.21	4.00e-115	410.00
IUUC-Bra-016849	Brassica rapa	44.23	9.00e-115	409.00
IUUC-Cja-019046	Callithrix jacchus	92.17	0.00e+00	3502.00
IUUC-Cfa-020521	Canis familiaris	91.83	0.00e+00	3409.00
IUUC-Cpo-021639	Cavia porcellus	89.72	0.00e+00	3402.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.08	1.00e-90	326.00
IUUC-Csa-023231	Chlorocebus sabaeus	94.49	0.00e+00	3576.00
IUUC-Cho-024380	Choloepus hoffmanni	89.74	0.00e+00	2079.00
IUUC-Cin-025482	Ciona intestinalis	51.21	1.00e-160	559.00
IUUC-Csv-026121	Ciona savignyi	48.52	0.00e+00	1542.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.34	8.00e-112	399.00
IUUC-Cne-026857	Cryptococcus neoformans	39.89	8.00e-96	345.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.34	2.00e-74	275.00
IUUC-Dre-028174	Danio rerio	88.92	0.00e+00	3070.00
IUUC-Dor-030939	Dipodomys ordii	85.15	0.00e+00	1395.00
IUUC-Dse-031444	Dothistroma septosporum	39.11	6.00e-106	379.00
IUUC-Dme-032162	Drosophila melanogaster	67.73	2.00e-174	607.00
IUUC-Ete-032345	Echinops telfairi	87.71	0.00e+00	2222.00
IUUC-Eca-033229	Equus caballus	92.99	0.00e+00	3449.00
IUUC-Eeu-035205	Erinaceus europaeus	80.75	0.00e+00	2956.00
IUUC-Fca-036444	Felis catus	93.09	0.00e+00	3511.00
IUUC-Fal-037131	Ficedula albicollis	98.40	0.00e+00	3680.00
IUUC-Fox-038035	Fusarium oxysporum	36.42	3.00e-111	395.00
IUUC-Fso-038320	Fusarium solani	36.06	7.00e-111	395.00
IUUC-Gmo-039497	Gadus morhua	87.17	0.00e+00	3007.00
IUUC-Ggr-040057	Gaeumannomyces graminis	39.10	4.00e-108	387.00
IUUC-Gac-042474	Gasterosteus aculeatus	80.62	0.00e+00	3055.00
IUUC-Gma-043060	Glycine max	39.06	5.00e-122	433.00
IUUC-Ggo-044855	Gorilla gorilla	92.17	0.00e+00	3501.00
IUUC-Hsa-046147	Homo sapiens	90.32	0.00e+00	3410.00
IUUC-Hvu-047775	Hordeum vulgare	38.69	5.00e-125	442.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	92.70	0.00e+00	3415.00
IUUC-Kpa-049098	Komagataella pastoris	38.29	3.00e-86	314.00
IUUC-Lch-049818	Latimeria chalumnae	85.95	0.00e+00	3141.00
IUUC-Lpe-051017	Leersia perrieri	38.75	9.00e-120	425.00
IUUC-Loc-051777	Lepisosteus oculatus	88.52	0.00e+00	3387.00
IUUC-Lma-052990	Leptosphaeria maculans	36.32	8.00e-116	412.00
IUUC-Laf-053727	Loxodonta africana	93.47	0.00e+00	3509.00
IUUC-Mcc-055799	Macaca mulatta	93.04	0.00e+00	3487.00
IUUC-Meu-056065	Macropus eugenii	93.00	0.00e+00	2072.00
IUUC-Mor-057054	Magnaporthe oryzae	38.97	2.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.36	2.00e-109	391.00
IUUC-Mtr-057849	Medicago truncatula	37.64	2.00e-114	407.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	9.00e-108	385.00
IUUC-Mga-059580	Meleagris gallopavo	98.31	0.00e+00	3177.00
IUUC-Mvi-060507	Microbotryum violaceum	40.55	1.00e-115	412.00
IUUC-Mmr-060816	Microcebus murinus	94.68	0.00e+00	3587.00
IUUC-Mdo-062866	Monodelphis domestica	93.06	0.00e+00	3386.00
IUUC-Mmu-063906	Mus musculus	92.69	0.00e+00	3491.00
IUUC-Mac-064675	Musa acuminata	39.16	3.00e-114	405.00
IUUC-Mpu-066199	Mustela putorius furo	93.28	0.00e+00	3480.00
IUUC-Mlu-067110	Myotis lucifugus	92.84	0.00e+00	3473.00
IUUC-Nfi-068482	Neosartorya fischeri	35.25	4.00e-115	410.00
IUUC-Ncr-068906	Neurospora crassa	39.51	5.00e-110	393.00
IUUC-Nle-069410	Nomascus leucogenys	92.89	0.00e+00	3493.00
IUUC-Opr-070401	Ochotona princeps	83.20	0.00e+00	1882.00
IUUC-Ont-072100	Oreochromis niloticus	83.25	0.00e+00	3179.00
IUUC-Oan-073121	Ornithorhynchus anatinus	95.10	0.00e+00	3656.00
IUUC-Ocu-074623	Oryctolagus cuniculus	93.33	0.00e+00	3521.00
IUUC-Oba-075380	Oryza barthii	38.08	3.00e-115	409.00
IUUC-Obr-076915	Oryza brachyantha	38.20	4.00e-121	430.00
IUUC-Ogl-077055	Oryza glaberrima	38.87	7.00e-120	425.00
IUUC-Ogu-078892	Oryza glumaepatula	40.57	4.00e-115	409.00
IUUC-Oin-079256	Oryza indica	38.26	4.00e-118	419.00
IUUC-Olo-080343	Oryza longistaminata	37.83	5.00e-118	419.00
IUUC-Ome-081422	Oryza meridionalis	37.83	4.00e-118	420.00
IUUC-Oni-083047	Oryza nivara	40.89	3.00e-116	413.00
IUUC-Opu-083641	Oryza punctata	40.18	6.00e-112	399.00
IUUC-Oru-084439	Oryza rufipogon	40.71	2.00e-115	410.00
IUUC-Osa-085972	Oryza sativa	38.58	6.00e-118	417.00
IUUC-Ola-087173	Oryzias latipes	81.58	0.00e+00	3093.00
IUUC-Olu-087871	Ostreococcus lucimarinus	37.67	2.00e-89	322.00
IUUC-Oga-087908	Otolemur garnettii	92.22	0.00e+00	3514.00
IUUC-Oar-090277	Ovis aries	92.11	0.00e+00	3492.00
IUUC-Ptr-091543	Pan troglodytes	90.32	0.00e+00	3409.00
IUUC-Pan-092243	Papio anubis	93.09	0.00e+00	3488.00
IUUC-Psi-093150	Pelodiscus sinensis	95.40	0.00e+00	3638.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.84	1.00e-115	412.00
IUUC-Ppa-095181	Physcomitrella patens	41.75	1.00e-106	380.00
IUUC-Pfo-096267	Poecilia formosa	88.81	0.00e+00	3065.00
IUUC-Pab-098072	Pongo abelii	93.18	0.00e+00	3502.00
IUUC-Pop-099190	Populus trichocarpa	37.52	1.00e-116	415.00
IUUC-Pca-100311	Procavia capensis	87.14	0.00e+00	3143.00
IUUC-Ppe-101284	Prunus persica	37.86	5.00e-117	416.00
IUUC-Pva-102215	Pteropus vampyrus	90.05	0.00e+00	1288.00
IUUC-Pgr-103694	Puccinia graminis	40.48	8.00e-105	375.00
IUUC-Ptt-103916	Puccinia triticina	38.80	1.00e-98	355.00
IUUC-Pte-104346	Pyrenophora teres	39.63	2.00e-111	397.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.89	3.00e-112	400.00
IUUC-Rno-105315	Rattus norvegicus	92.65	0.00e+00	3450.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.26	3.00e-71	263.00
IUUC-Sha-106835	Sarcophilus harrisii	95.46	0.00e+00	3661.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.98	4.00e-96	346.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.74	4.00e-96	346.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.12	3.00e-107	383.00
IUUC-Smo-109590	Selaginella moellendorffii	42.54	2.00e-111	397.00
IUUC-Sit-110717	Setaria italica	37.83	9.00e-121	428.00
IUUC-Sly-111469	Solanum lycopersicum	39.08	2.00e-122	434.00
IUUC-Stu-112896	Solanum tuberosum	37.95	4.00e-105	375.00
IUUC-Sar-113224	Sorex araneus	82.89	0.00e+00	1820.00
IUUC-Sbi-114313	Sorghum bicolor	38.14	4.00e-124	440.00
IUUC-Sre-114993	Sporisorium reilianum	33.10	2.00e-98	355.00
IUUC-Ssc-115535	Sus scrofa	89.05	0.00e+00	3351.00
IUUC-Tgu-117493	Taeniopygia guttata	96.70	0.00e+00	2864.00
IUUC-Tru-118669	Takifugu rubripes	81.26	0.00e+00	3047.00
IUUC-Tsy-119373	Tarsius syrichta	90.65	0.00e+00	1798.00
IUUC-Tni-120049	Tetraodon nigroviridis	78.53	0.00e+00	877.00
IUUC-Tca-121779	Theobroma cacao	38.90	5.00e-116	413.00
IUUC-Tre-122195	Trichoderma reesei	35.90	2.00e-107	384.00
IUUC-Tvi-122650	Trichoderma virens	35.93	3.00e-109	390.00
IUUC-Tae-123580	Triticum aestivum	38.58	5.00e-125	441.00
IUUC-Tur-126295	Triticum urartu	38.69	5.00e-127	449.00
IUUC-Tme-126964	Tuber melanosporum	40.48	5.00e-107	383.00
IUUC-Tbe-128149	Tupaia belangeri	82.00	0.00e+00	1226.00
IUUC-Ttr-128165	Tursiops truncatus	92.11	0.00e+00	2977.00
IUUC-Uma-129365	Ustilago maydis	35.18	5.00e-88	320.00
IUUC-Vda-129725	Verticillium dahliae	40.88	3.00e-109	390.00
IUUC-Vpa-130678	Vicugna pacos	93.88	0.00e+00	2603.00
IUUC-Vvi-131147	Vitis vinifera	39.40	7.00e-123	436.00
IUUC-Xtr-132636	Xenopus tropicalis	87.77	0.00e+00	3272.00
IUUC-Xma-133458	Xiphophorus maculatus	83.54	0.00e+00	3160.00
IUUC-Yli-134481	Yarrowia lipolytica	39.17	9.00e-98	352.00
IUUC-Zma-135657	Zea mays	38.47	1.00e-122	434.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence