iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	15772280

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	5.80e-08	33.9	60	122
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.10e-07	31.1	158	188

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 7    vg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
            + +++f+ah +vLaa+S+v   l+++  +++  +   +i++v +e++  +++FlY++  +e+e
   Q: 60   TDnKSHFPAHSSVLAAASPVIATLLNQSRDKNG-NTYLKIHGVPCEAVYMFIRFLYSSCYEEEE 122
           55689********************88887766.9999*******************9888765 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eN++++l++A+ +d ++ + ++l++++k Fk
   Q: 158  ENVIDVLQLARNCDVTRICFVCLSMVIKDFK 188
           9****************************97 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Essential for female and male gametophyte development.

Protein Sequence
(Fasta)

MSSSTKNIPK PPPLPCITYQ RFQSSTRKPS SLMRLVPKEA LETWDKLFKE GSGADTYVET 60
DNKSHFPAHS SVLAAASPVI ATLLNQSRDK NGNTYLKIHG VPCEAVYMFI RFLYSSCYEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAACTTTGA TCTTTGGTGC AATTGAAGAT CAGCCATATG TATTTCAACC TTATATTATC 60
CCCCAAATCA TTCCAACTTT TATTTTATAA ACATTCGTGG CCTTCATTTT TCCACTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR000197--Znf_TAZ

PROSITE

PS50097--BTB
PS50134--ZF_TAZ

Pfam

PF00651--BTB
PF02135--zf-TAZ

SMART

SM00225--BTB
SM00551--ZnF_TAZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0005516--F:calmodulin binding
GO:0004402--F:histone acetyltransferase activity
GO:0003712--F:transcription cofactor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0009553--P:embryo sac development
GO:0009555--P:pollen development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009409--P:response to cold
GO:0009723--P:response to ethylene
GO:0042542--P:response to hydrogen peroxide
GO:0009751--P:response to salicylic acid
GO:0009651--P:response to salt stress

KEGG

ath:AT1G05690

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006091	Arabidopsis lyrata	93.65	0.00e+00	646.00
IUUC-Bol-015181	Brassica oleracea	73.77	4.00e-138	483.00
IUUC-Bra-017836	Brassica rapa	73.84	1.00e-136	478.00
IUUC-Dme-031937	Drosophila melanogaster	27.78	3.00e-07	48.50
IUUC-Fox-038026	Fusarium oxysporum	29.76	4.00e-02	32.00
IUUC-Mpo-057564	Magnaporthe poae	32.35	6.70e-02	30.00
IUUC-Pop-100073	Populus trichocarpa	62.36	2.00e-128	451.00
IUUC-Ppe-101511	Prunus persica	67.71	2.00e-114	405.00
IUUC-Pgr-103542	Puccinia graminis	32.08	3.40e-01	30.80
IUUC-Sly-111228	Solanum lycopersicum	54.38	6.00e-91	326.00
IUUC-Stu-112299	Solanum tuberosum	58.17	6.00e-114	403.00
IUUC-Tca-121794	Theobroma cacao	63.23	9.00e-116	409.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence