iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-106878

Ensembl Protein ID

ENSSHAP00000021633.1

UniProt Accession

G3X1S8; G3X1S8_SARHA

Genbank Protein ID

ENSSHAP00000021633

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01023350

Gene Name

PTK6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000018321.1	ENSSHAT00000021807.1	ENSSHAP00000021633.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.20e-10	40.5	12	70

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk.elegk...rGlfPenFve 60
           k++   l+d+ea ++deL++++Gd  +v    e+ e+W+k++k +++g+   +G +P+n+ +
   Q: 12   KYLYVSLWDFEARTEDELSFQAGDHFYVT---EKKEDWWKATKlDAAGRslgEGYVPHNYLA 70
           566778**********************7...999*******98555553337*******86 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MDSRSLSHLG PKYLYVSLWD FEARTEDELS FQAGDHFYVT EKKEDWWKAT KLDAAGRSLG 60
EGYVPHNYLA EEETMETEPW FFGQISRSEA LHRLLAGENG TGTFLIRISE KTGADYVLSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGAGCCT GCTAGGTTTG TGGCAATCAC CTACTCCTAG TTGAGATGTT CTATAAGGGT 60
GAGACCCAGA GATCAGCTGG GGCAATTCTC CGTTGTCAAA ATACTTAAAA GTTCCCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0016477--P:cell migration
GO:0071300--P:cellular response to retinoic acid
GO:0060575--P:intestinal epithelial cell differentiation
GO:0045926--P:negative regulation of growth
GO:0061099--P:negative regulation of protein tyrosine kinase activity
GO:0010976--P:positive regulation of neuron projection development
GO:0046777--P:protein autophosphorylation
GO:0042503--P:tyrosine phosphorylation of Stat3 protein
GO:0042506--P:tyrosine phosphorylation of Stat5 protein

KEGG

shr:100916163

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cre-022669	Chlamydomonas reinhardtii	29.46	4.00e-20	92.00
IUUC-Gac-042486	Gasterosteus aculeatus	45.48	3.00e-116	411.00
IUUC-Meu-056656	Macropus eugenii	92.94	0.00e+00	853.00
IUUC-Ont-071657	Oreochromis niloticus	46.01	9.00e-111	393.00
IUUC-Oba-075594	Oryza barthii	34.26	2.00e-21	97.80
IUUC-Ogl-077631	Oryza glaberrima	34.26	2.00e-21	97.80
IUUC-Ogu-078578	Oryza glumaepatula	34.26	2.00e-21	97.80
IUUC-Oin-079434	Oryza indica	34.26	2.00e-21	97.80
IUUC-Olo-080520	Oryza longistaminata	34.26	9.00e-22	98.60
IUUC-Ome-081162	Oryza meridionalis	34.26	3.00e-21	97.10
IUUC-Osa-086179	Oryza sativa	34.26	2.00e-21	97.40

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence