iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054892

UUCD1 version

UUC-MaM-01123

Ensembl Protein ID

ENSMMUP00000006932.2

UniProt Accession

F7BWU9; F7BWU9_MACMU

Genbank Protein ID

AFE64482.1; AFI38547.1; EHH21154.1

Protein Name

Putative uncharacterized protein; Ubiquitin carboxyl-terminal hydrolase 30

Genbank Nucleotide ID

JSUE03007717; JV048476; CM001263

Gene Name

USP30; EGK_04157

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000005237.3	ENSMMUT00000007375.3	ENSMMUP00000006932.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-71	241.5	69	501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgy 87
           Gl NlgNtC+mNS+LQ Ls++p + + l e +++ +++++++ +++ l+ +l +l+++l     +++++ + + ll++l+++  ++s++
   Q: 69   GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYTRDQKEPPSHQYLSLTLLHLLKALScqeVTDDEVLDASCLLDVLRMYRWQISSF 157
           9*****************************77777777777889999************888899999********************* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvs.sr 165
           e+qDa+E+++++ ++le+e    ++ +++++++ ++ e+++e          + + ++++n+   ++ F+g+l+s+++c++c+++s +r
   Q: 158  EEQDAHELFHVITSSLEDER--DRQPRVTHLFDVHSLEQQSEitpkqitcrtRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSpVR 244
           *******************9..668888889998888888888999999999999********************************** PP
   S: 166  eepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhLkRfsf 239
           +++f +lsl++p  +  ++++l++cL++f + e++++   + c++c+               ++++ +k+lkl klP++L++hL+R s+
   Q: 245  FDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRD---VVCDNCTkieakgtlngekvehQRTTFVKQLKLGKLPQCLCIHLQRLSW 330
           ***********************************97...9******8888888888888777777*********************** PP
   S: 240  seeqksrekinkkvefpleLdlspfcts..........peekqke............................................ 274
           s++ + + k +++v+f++ L ++ +  +          p     +                                            
   Q: 331  SSH-GTPLKRHEHVQFNEFLMMDIYKYHllghkpsqhnP-----Klnknpgptlelqdgpgaptpvlnqpgapktqifmngacspsllp 413
           998.8888*********8877775444444556555551.....144455555666666666666666666666666666677777777 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvlfY 335
                              ++ ++L+avvvH+G ++sGH+v+y ++         ++++Wl ++D++V++ + +evl+   s+aY+lfY
   Q: 414  tlsapmpfplpvvpdysssTYLFRLMAVVVHHGDMHSGHFVTYRRSppsarnplsTSNQWLWVSDDTVRKASLQEVLS---SSAYLLFY 499
           77777777777777777669999***********************9999988888999*******************...******** PP
   S: 336  kr 337
           +r
   Q: 500  ER 501
           98 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MLSSRAEAAM TAADRAIQRF LRTGAAVRYK VMKNWGVIGG IAAALAAGIY VIWGPITERK 60
KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFIRWLEEFT SQYTRDQKEP PSHQYLSLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCAATGC TGAGCTCACG GGCCGAGGCG GCGATGACCG CGGCCGACAG GGCCATCCAG 60
CGCTTCCTGA GGACCGGGGC GGCCGTCAGG TGAGATTTTG GGGGGCGGGG CGGCCGAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:706607

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	29.04	2.00e-17	83.60
IUUC-Aml-001733	Ailuropoda melanoleuca	93.46	0.00e+00	880.00
IUUC-Atr-002510	Amborella trichopoda	24.28	2.00e-20	94.00
IUUC-Apl-003645	Anas platyrhynchos	71.48	2.00e-107	381.00
IUUC-Aca-004583	Anolis carolinensis	68.42	1.00e-24	103.00
IUUC-Aly-005754	Arabidopsis lyrata	26.43	2.00e-22	100.00
IUUC-Ath-007622	Arabidopsis thaliana	26.54	5.00e-23	102.00
IUUC-Ame-010896	Astyanax mexicanus	62.71	9.00e-156	543.00
IUUC-Bta-012321	Bos taurus	91.88	0.00e+00	865.00
IUUC-Bdi-014795	Brachypodium distachyon	27.92	1.00e-18	88.20
IUUC-Bol-015637	Brassica oleracea	26.86	2.00e-23	103.00
IUUC-Bra-016801	Brassica rapa	24.95	1.00e-23	104.00
IUUC-Cel-018308	Caenorhabditis elegans	28.10	7.00e-38	151.00
IUUC-Cja-018826	Callithrix jacchus	98.46	0.00e+00	973.00
IUUC-Cfa-021206	Canis familiaris	91.35	0.00e+00	885.00
IUUC-Cpo-021343	Cavia porcellus	93.61	0.00e+00	871.00
IUUC-Csa-023419	Chlorocebus sabaeus	99.61	0.00e+00	981.00
IUUC-Cho-024475	Choloepus hoffmanni	89.82	9.00e-140	490.00
IUUC-Cgl-026621	Colletotrichum gloeosporioides	20.79	1.00e-11	65.10
IUUC-Cne-027061	Cryptococcus neoformans	24.71	4.00e-10	60.10
IUUC-Dre-027563	Danio rerio	59.68	7.00e-160	556.00
IUUC-Dno-029929	Dasypus novemcinctus	93.62	0.00e+00	916.00
IUUC-Dor-030166	Dipodomys ordii	83.37	0.00e+00	759.00
IUUC-Dme-031627	Drosophila melanogaster	35.29	9.00e-37	148.00
IUUC-Ete-032634	Echinops telfairi	80.85	0.00e+00	700.00
IUUC-Eca-033968	Equus caballus	94.29	0.00e+00	855.00
IUUC-Eeu-035279	Erinaceus europaeus	81.71	2.00e-58	219.00
IUUC-Fca-036525	Felis catus	94.20	0.00e+00	910.00
IUUC-Fal-036606	Ficedula albicollis	74.61	4.00e-161	560.00
IUUC-Gmo-038726	Gadus morhua	56.80	3.00e-143	501.00
IUUC-Gga-040718	Gallus gallus	74.94	2.00e-162	565.00
IUUC-Gac-042645	Gasterosteus aculeatus	57.65	5.00e-151	527.00
IUUC-Gma-042890	Glycine max	25.47	8.00e-26	111.00
IUUC-Ggo-045021	Gorilla gorilla	99.61	0.00e+00	979.00
IUUC-Hsa-045832	Homo sapiens	99.61	0.00e+00	979.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	95.51	0.00e+00	875.00
IUUC-Lch-050662	Latimeria chalumnae	70.76	0.00e+00	629.00
IUUC-Lpe-051078	Leersia perrieri	26.48	4.00e-31	129.00
IUUC-Loc-052611	Lepisosteus oculatus	66.27	2.00e-179	622.00
IUUC-Lma-053048	Leptosphaeria maculans	20.51	6.00e-16	79.30
IUUC-Laf-053752	Loxodonta africana	93.06	0.00e+00	847.00
IUUC-Meu-056673	Macropus eugenii	75.26	2.00e-165	574.00
IUUC-Mor-057143	Magnaporthe oryzae	20.33	1.00e-07	52.00
IUUC-Mtr-057976	Medicago truncatula	26.51	3.00e-32	133.00
IUUC-Mla-058970	Melampsora laricipopulina	23.34	4.00e-20	92.80
IUUC-Mga-059543	Meleagris gallopavo	76.60	0.00e+00	672.00
IUUC-Mmr-061534	Microcebus murinus	95.55	0.00e+00	915.00
IUUC-Mdo-062140	Monodelphis domestica	69.76	1.00e-168	586.00
IUUC-Mmu-063673	Mus musculus	89.75	0.00e+00	852.00
IUUC-Mpu-066328	Mustela putorius furo	92.84	0.00e+00	869.00
IUUC-Mlu-067938	Myotis lucifugus	93.62	0.00e+00	919.00
IUUC-Nle-069426	Nomascus leucogenys	98.87	0.00e+00	878.00
IUUC-Opr-070796	Ochotona princeps	85.99	1.00e-124	439.00
IUUC-Ont-072248	Oreochromis niloticus	57.92	2.00e-156	545.00
IUUC-Oan-072916	Ornithorhynchus anatinus	80.12	0.00e+00	775.00
IUUC-Ocu-074459	Oryctolagus cuniculus	88.21	0.00e+00	674.00
IUUC-Oba-075765	Oryza barthii	27.40	4.00e-30	125.00
IUUC-Obr-076005	Oryza brachyantha	27.03	1.00e-30	127.00
IUUC-Ogl-077916	Oryza glaberrima	27.65	1.00e-33	137.00
IUUC-Ogu-078263	Oryza glumaepatula	27.40	6.00e-31	129.00
IUUC-Oin-080096	Oryza indica	28.10	1.00e-24	107.00
IUUC-Ome-081928	Oryza meridionalis	27.45	5.00e-32	132.00
IUUC-Oni-082424	Oryza nivara	27.40	7.00e-31	128.00
IUUC-Oru-085117	Oryza rufipogon	27.40	7.00e-31	128.00
IUUC-Ola-087429	Oryzias latipes	57.45	1.00e-148	519.00
IUUC-Oga-087981	Otolemur garnettii	95.36	0.00e+00	905.00
IUUC-Oar-089927	Ovis aries	91.30	0.00e+00	858.00
IUUC-Ptr-090878	Pan troglodytes	99.61	0.00e+00	979.00
IUUC-Pan-092698	Papio anubis	100.00	0.00e+00	985.00
IUUC-Psi-093451	Pelodiscus sinensis	77.48	0.00e+00	727.00
IUUC-Ppa-096015	Physcomitrella patens	25.53	1.00e-09	58.90
IUUC-Pfo-096096	Poecilia formosa	58.17	6.00e-154	537.00
IUUC-Pab-098676	Pongo abelii	98.26	0.00e+00	957.00
IUUC-Pca-100418	Procavia capensis	96.93	1.00e-131	463.00
IUUC-Ppe-101898	Prunus persica	24.47	9.00e-25	108.00
IUUC-Pva-103018	Pteropus vampyrus	92.07	0.00e+00	886.00
IUUC-Pgr-103423	Puccinia graminis	26.78	7.00e-10	59.70
IUUC-Pte-104330	Pyrenophora teres	21.76	7.00e-15	75.90
IUUC-Pyt-104518	Pyrenophora triticirepentis	21.64	1.00e-16	81.60
IUUC-Rno-105708	Rattus norvegicus	88.78	0.00e+00	842.00
IUUC-Sha-106971	Sarcophilus harrisii	79.92	0.00e+00	788.00
IUUC-Sit-110442	Setaria italica	26.61	8.00e-28	118.00
IUUC-Sly-110928	Solanum lycopersicum	24.08	8.00e-16	78.60
IUUC-Stu-112223	Solanum tuberosum	25.07	4.00e-17	82.80
IUUC-Ssc-116397	Sus scrofa	91.49	0.00e+00	863.00
IUUC-Tgu-117446	Taeniopygia guttata	70.39	0.00e+00	645.00
IUUC-Tru-118268	Takifugu rubripes	59.08	2.00e-143	501.00
IUUC-Tsy-119484	Tarsius syrichta	92.91	9.00e-54	204.00
IUUC-Tni-119735	Tetraodon nigroviridis	53.32	5.00e-122	431.00
IUUC-Tca-121660	Theobroma cacao	24.48	5.00e-28	119.00
IUUC-Tae-125383	Triticum aestivum	27.89	2.00e-29	124.00
IUUC-Tur-126458	Triticum urartu	27.31	2.00e-26	113.00
IUUC-Tbe-127740	Tupaia belangeri	88.97	0.00e+00	816.00
IUUC-Ttr-129273	Tursiops truncatus	90.33	0.00e+00	850.00
IUUC-Vvi-131177	Vitis vinifera	25.78	2.00e-27	116.00
IUUC-Xtr-132374	Xenopus tropicalis	66.47	8.00e-175	606.00
IUUC-Xma-133267	Xiphophorus maculatus	60.72	2.00e-157	549.00
IUUC-Yli-134571	Yarrowia lipolytica	23.53	4.00e-12	66.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence