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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064338
UUCD1 version UUC-MuM-00520
Ensembl Protein ID ENSMUSP00000002502.5
UniProt Accession Q6PCN7; O35596; O35597; Q80VT6; HLTF_MOUSE
Genbank Protein ID AAB64175.1; AAB63915.1; AAH39796.1; AAH57116.1; AAH59240.1
Protein Name Helicase-like transcription factor; P113; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3; TNF-response element-binding protein
Genbank Nucleotide ID AF010138; AF010600; BC039796; BC057116; BC059240
Gene Name Hltf; Smarca3; Snf2l3; Zbu1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000002428.12 ENSMUST00000002502.11 ENSMUSP00000002502.5
ENSMUSG00000002428.12 ENSMUST00000143005.7 ENSMUSP00000116570.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 31.59 4.00e-76 281.00 IUUC-Sce-106396
E3 activity/RING/RING 32.55 3.00e-78 288.00 IUUC-Spo-108026
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA (By similarity).
 Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA (By similarity).
Protein Sequence
(Fasta)
MSYTFTRGPV WKYSQSVQYG SHENIPRLSY STFLPHFEFQ DIIPPDDFLT SDEEQDLVLF 60
GTMRGQVVGL RYYTGVVNNN EMVALQREPN NPYDKNAIKV NNVNGNQVGH IKREIAAAVA 120
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Protein Fasta Sequence


>IUUC-Mmu-064338|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GGTTTCTCAG ACTGTTGCAG GAAGGAGTGG TGTGGACACG TCTCACCGGG CGGACGCGGC 60
CTGGCGGTTC TGATTTGGAT TCCGGCGCCT GGGCCACGAC GCCTTGAGGA GCTTTATCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064338|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014905--HIRAN
IPR030065--HLTF
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00271--Helicase_C
PF08797--HIRAN
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00490--HELICc
SM00910--HIRAN
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0004386--F:helicase activity
GO:0003723--F:RNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006301--P:postreplication repair
GO:0000209--P:protein polyubiquitination
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
KEGG mmu:20585
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000167 Aegilops tauschii 37.86 4.00e-108 385.00
IUUC-Aml-001237 Ailuropoda melanoleuca 83.56 0.00e+00 1627.00
IUUC-Atr-003058 Amborella trichopoda 38.56 7.00e-108 385.00
IUUC-Apl-003679 Anas platyrhynchos 30.67 8.00e-34 139.00
IUUC-Aca-004994 Anolis carolinensis 61.79 0.00e+00 1181.00
IUUC-Aly-005898 Arabidopsis lyrata 42.41 3.00e-120 426.00
IUUC-Ath-007559 Arabidopsis thaliana 41.09 1.00e-120 427.00
IUUC-Ago-007997 Ashbya gossypii 34.11 5.00e-77 283.00
IUUC-Acl-008053 Aspergillus clavatus 35.10 3.00e-80 293.00
IUUC-Afl-008697 Aspergillus flavus 35.48 1.00e-86 314.00
IUUC-Afu-008767 Aspergillus fumigatus 35.18 1.00e-86 314.00
IUUC-Ani-009435 Aspergillus nidulans 35.75 3.00e-88 320.00
IUUC-Ang-009635 Aspergillus niger 36.87 2.00e-86 313.00
IUUC-Aor-010130 Aspergillus oryzae 35.89 1.00e-87 318.00
IUUC-Ate-010582 Aspergillus terreus 34.40 6.00e-78 285.00
IUUC-Ame-011743 Astyanax mexicanus 60.00 0.00e+00 653.00
IUUC-Bgr-012147 Blumeria graminis 34.14 2.00e-82 301.00
IUUC-Bta-013391 Bos taurus 82.06 0.00e+00 1628.00
IUUC-Bci-013741 Botrytis cinerea 33.51 2.00e-82 300.00
IUUC-Bdi-014267 Brachypodium distachyon 39.79 9.00e-119 421.00
IUUC-Bol-016075 Brassica oleracea 42.12 1.00e-120 427.00
IUUC-Bra-017057 Brassica rapa 42.30 2.00e-120 427.00
IUUC-Cja-019685 Callithrix jacchus 83.15 0.00e+00 1709.00
IUUC-Cfa-020485 Canis familiaris 84.21 0.00e+00 1636.00
IUUC-Cpo-021361 Cavia porcellus 85.05 0.00e+00 1023.00
IUUC-Cre-022824 Chlamydomonas reinhardtii 29.35 6.00e-64 239.00
IUUC-Csa-023894 Chlorocebus sabaeus 83.75 0.00e+00 1657.00
IUUC-Cho-024891 Choloepus hoffmanni 91.01 0.00e+00 713.00
IUUC-Csv-026168 Ciona savignyi 28.45 2.00e-52 201.00
IUUC-Cgl-026606 Colletotrichum gloeosporioides 33.50 2.00e-87 317.00
IUUC-Cne-026829 Cryptococcus neoformans 37.44 4.00e-94 339.00
IUUC-Cme-027110 Cyanidioschyzon merolae 33.68 1.00e-88 321.00
IUUC-Dre-027867 Danio rerio 62.15 0.00e+00 721.00
IUUC-Dno-029517 Dasypus novemcinctus 82.56 0.00e+00 1609.00
IUUC-Dor-030590 Dipodomys ordii 77.67 0.00e+00 630.00
IUUC-Dse-031564 Dothistroma septosporum 37.66 5.00e-76 278.00
IUUC-Dme-031815 Drosophila melanogaster 31.57 3.00e-55 210.00
IUUC-Ete-032421 Echinops telfairi 68.69 0.00e+00 891.00
IUUC-Eca-034058 Equus caballus 83.58 0.00e+00 1613.00
IUUC-Eeu-034597 Erinaceus europaeus 66.80 0.00e+00 1228.00
IUUC-Fca-035390 Felis catus 83.81 0.00e+00 1614.00
IUUC-Fal-037486 Ficedula albicollis 32.78 2.00e-37 150.00
IUUC-Fox-037751 Fusarium oxysporum 38.02 3.00e-86 313.00
IUUC-Fso-038179 Fusarium solani 34.22 2.00e-85 311.00
IUUC-Gmo-038544 Gadus morhua 56.29 0.00e+00 679.00
IUUC-Ggr-039735 Gaeumannomyces graminis 32.00 5.00e-73 270.00
IUUC-Gga-040472 Gallus gallus 33.55 3.00e-37 150.00
IUUC-Gac-042401 Gasterosteus aculeatus 51.40 0.00e+00 968.00
IUUC-Gma-044315 Glycine max 37.95 6.00e-100 358.00
IUUC-Ggo-045628 Gorilla gorilla 82.94 0.00e+00 1627.00
IUUC-Hsa-045930 Homo sapiens 83.65 0.00e+00 1655.00
IUUC-Hvu-047747 Hordeum vulgare 37.68 3.00e-108 386.00
IUUC-Itr-048493 Ictidomys tridecemlineatus 84.21 0.00e+00 1678.00
IUUC-Kpa-049087 Komagataella pastoris 34.80 3.00e-83 303.00
IUUC-Lch-050617 Latimeria chalumnae 59.10 0.00e+00 1063.00
IUUC-Lpe-051724 Leersia perrieri 41.77 5.00e-121 429.00
IUUC-Loc-052785 Lepisosteus oculatus 64.87 0.00e+00 772.00
IUUC-Lma-052956 Leptosphaeria maculans 31.63 1.00e-76 281.00
IUUC-Laf-054309 Loxodonta africana 81.07 0.00e+00 1533.00
IUUC-Mcc-055493 Macaca mulatta 83.68 0.00e+00 1644.00
IUUC-Meu-056270 Macropus eugenii 73.15 0.00e+00 865.00
IUUC-Mor-056943 Magnaporthe oryzae 36.33 1.00e-93 337.00
IUUC-Mpo-057407 Magnaporthe poae 32.39 1.00e-77 285.00
IUUC-Mtr-058172 Medicago truncatula 42.16 1.00e-115 410.00
IUUC-Mla-059170 Melampsora laricipopulina 32.51 1.00e-74 274.00
IUUC-Mga-059553 Meleagris gallopavo 32.89 5.00e-37 150.00
IUUC-Mvi-060365 Microbotryum violaceum 34.52 1.00e-85 311.00
IUUC-Mmr-061043 Microcebus murinus 82.42 0.00e+00 1565.00
IUUC-Mdo-062919 Monodelphis domestica 76.24 0.00e+00 1403.00
IUUC-Mac-065666 Musa acuminata 37.33 3.00e-90 327.00
IUUC-Mpu-066781 Mustela putorius furo 83.61 0.00e+00 1627.00
IUUC-Mlu-068076 Myotis lucifugus 81.80 0.00e+00 1601.00
IUUC-Nfi-068386 Neosartorya fischeri 35.36 2.00e-84 307.00
IUUC-Ncr-068858 Neurospora crassa 37.18 4.00e-91 329.00
IUUC-Nle-069947 Nomascus leucogenys 83.45 0.00e+00 1650.00
IUUC-Opr-070388 Ochotona princeps 75.07 0.00e+00 1503.00
IUUC-Ont-071782 Oreochromis niloticus 61.08 0.00e+00 673.00
IUUC-Oan-073331 Ornithorhynchus anatinus 74.32 0.00e+00 1247.00
IUUC-Ocu-074705 Oryctolagus cuniculus 83.81 0.00e+00 1619.00
IUUC-Oba-075881 Oryza barthii 41.64 2.00e-119 423.00
IUUC-Obr-076344 Oryza brachyantha 40.85 5.00e-115 408.00
IUUC-Ogl-076957 Oryza glaberrima 41.64 2.00e-119 423.00
IUUC-Ogu-078648 Oryza glumaepatula 41.12 8.00e-114 404.00
IUUC-Oin-079449 Oryza indica 41.08 1.00e-114 407.00
IUUC-Olo-080721 Oryza longistaminata 41.08 7.00e-115 407.00
IUUC-Ome-081579 Oryza meridionalis 40.56 8.00e-114 404.00
IUUC-Oni-083054 Oryza nivara 41.08 1.00e-114 407.00
IUUC-Opu-083706 Oryza punctata 41.11 6.00e-115 408.00
IUUC-Oru-085259 Oryza rufipogon 41.08 1.00e-114 407.00
IUUC-Osa-085568 Oryza sativa 41.53 3.00e-102 366.00
IUUC-Ola-086830 Oryzias latipes 57.12 6.00e-178 618.00
IUUC-Olu-087669 Ostreococcus lucimarinus 28.06 9.00e-55 209.00
IUUC-Oga-088120 Otolemur garnettii 78.46 0.00e+00 1477.00
IUUC-Oar-089293 Ovis aries 82.11 0.00e+00 1636.00
IUUC-Ptr-091418 Pan troglodytes 83.65 0.00e+00 1654.00
IUUC-Pan-092579 Papio anubis 81.75 0.00e+00 1226.00
IUUC-Psi-093626 Pelodiscus sinensis 68.22 0.00e+00 1164.00
IUUC-Pno-094841 Phaeosphaeria nodorum 38.76 7.00e-88 318.00
IUUC-Ppa-095291 Physcomitrella patens 45.96 3.00e-140 493.00
IUUC-Pfo-096540 Poecilia formosa 58.89 0.00e+00 688.00
IUUC-Pab-098010 Pongo abelii 83.65 0.00e+00 1652.00
IUUC-Pop-099320 Populus trichocarpa 36.45 1.00e-106 381.00
IUUC-Pca-100648 Procavia capensis 72.35 0.00e+00 1376.00
IUUC-Ppe-102077 Prunus persica 42.80 5.00e-104 372.00
IUUC-Pva-102896 Pteropus vampyrus 85.03 0.00e+00 847.00
IUUC-Pgr-103403 Puccinia graminis 31.46 1.00e-74 275.00
IUUC-Ptt-103966 Puccinia triticina 31.51 3.00e-73 270.00
IUUC-Pte-104242 Pyrenophora teres 32.16 5.00e-78 286.00
IUUC-Pyt-104728 Pyrenophora triticirepentis 31.88 2.00e-76 280.00
IUUC-Rno-106130 Rattus norvegicus 88.66 0.00e+00 1810.00
IUUC-Sce-106396 Saccharomyces cerevisiae 32.17 7.00e-75 276.00
IUUC-Sha-107221 Sarcophilus harrisii 76.24 0.00e+00 1408.00
IUUC-Sja-107985 Schizosaccharomyces japonicus 33.28 2.00e-85 311.00
IUUC-Spo-108026 Schizosaccharomyces pombe 32.91 1.00e-80 295.00
IUUC-Ssl-108388 Sclerotinia sclerotiorum 34.19 1.00e-83 305.00
IUUC-Smo-109629 Selaginella moellendorffii 43.34 3.00e-129 456.00
IUUC-Sit-109770 Setaria italica 42.07 1.00e-118 421.00
IUUC-Sly-111908 Solanum lycopersicum 38.64 4.00e-108 386.00
IUUC-Stu-112600 Solanum tuberosum 38.18 6.00e-107 382.00
IUUC-Sar-113719 Sorex araneus 83.92 0.00e+00 1548.00
IUUC-Sbi-114616 Sorghum bicolor 36.41 9.00e-106 378.00
IUUC-Sre-114938 Sporisorium reilianum 30.20 2.00e-76 280.00
IUUC-Ssc-116186 Sus scrofa 83.58 0.00e+00 1669.00
IUUC-Tru-117768 Takifugu rubripes 58.21 0.00e+00 642.00
IUUC-Tsy-118957 Tarsius syrichta 77.52 0.00e+00 1480.00
IUUC-Tni-120618 Tetraodon nigroviridis 51.40 0.00e+00 966.00
IUUC-Tca-121146 Theobroma cacao 38.59 3.00e-108 386.00
IUUC-Tre-121896 Trichoderma reesei 35.60 6.00e-92 332.00
IUUC-Tvi-122492 Trichoderma virens 37.17 5.00e-88 319.00
IUUC-Tae-123773 Triticum aestivum 39.89 1.00e-106 380.00
IUUC-Tur-125999 Triticum urartu 38.41 3.00e-109 389.00
IUUC-Tme-126953 Tuber melanosporum 33.57 2.00e-85 311.00
IUUC-Tbe-127612 Tupaia belangeri 72.75 0.00e+00 681.00
IUUC-Ttr-128243 Tursiops truncatus 77.65 0.00e+00 1163.00
IUUC-Uma-129441 Ustilago maydis 30.22 7.00e-77 282.00
IUUC-Vda-129933 Verticillium dahliae 34.88 6.00e-84 305.00
IUUC-Vpa-130672 Vicugna pacos 84.27 0.00e+00 1539.00
IUUC-Vvi-131204 Vitis vinifera 42.96 3.00e-123 436.00
IUUC-Xtr-132730 Xenopus tropicalis 60.16 0.00e+00 1207.00
IUUC-Xma-133384 Xiphophorus maculatus 60.37 0.00e+00 699.00
IUUC-Yli-134350 Yarrowia lipolytica 31.12 4.00e-76 279.00
IUUC-Zma-134966 Zea mays 42.99 2.00e-127 449.00
Created Date 25-Jun-2017

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