iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	23951086

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.60e-07	30.1	215	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e f+ g   + +pC+H+fh dC+  w       s + +CP+Cr
   Q: 215  CAVCTEVFEAGieGREMPCKHIFHGDCIVPW------LSIRNSCPVCR 256
           ****99996553366799*************......**********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid-dependent drought stress responses (PubMed:22405823). Involved in the positive regulation of responses to salt and osmotic stresses during seed germination and early seedling development (PubMed:23951086). Possesses E3 ubiquitin ligase activity in vitro (PubMed:22405823, PubMed:23951086).

Protein Sequence
(Fasta)

MMPNSRSATI TPTTESTTTT TTTTTTLTTS YWCYSCTRFI SVWEDQDANA GVLCPYCNGG 60
FIEEIEDSSN STVAAIPAST PEVRSVEETH RSIIRRRRSN RRTSFNPVIV LHGGGGGGAG 120

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Nucleotide Sequence
(Fasta)

ACATATACAA GAACACATTT ACATCATTTC CAAAATTCAA AGATTTATAT TATATATTTC 60
ACATCAATAC AAATAGATCT TTTACCTTCT TTTTCTTTTC TAATTTGGGG TCAAATGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0938--Abscisic acid signaling pathway
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR010543--DUF1117
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF06547--DUF1117
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009738--P:abscisic acid-activated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0009737--P:response to abscisic acid
GO:0010200--P:response to chitin
GO:0009414--P:response to water deprivation

KEGG

ath:AT3G46620

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006461	Arabidopsis lyrata	91.18	3.00e-166	577.00
IUUC-Bol-016362	Brassica oleracea	80.05	2.00e-142	498.00
IUUC-Bra-017869	Brassica rapa	76.63	8.00e-135	472.00
IUUC-Hvu-047236	Hordeum vulgare	61.14	2.00e-48	185.00
IUUC-Mac-065278	Musa acuminata	52.32	4.00e-65	240.00
IUUC-Mpu-066689	Mustela putorius furo	44.55	4.00e-20	89.70
IUUC-Mlu-067441	Myotis lucifugus	54.05	1.00e-18	85.10
IUUC-Olo-080227	Oryza longistaminata	34.71	3.00e-36	145.00
IUUC-Ppe-101788	Prunus persica	52.73	1.00e-71	263.00
IUUC-Ssc-115694	Sus scrofa	40.48	6.00e-20	89.40
IUUC-Vvi-131530	Vitis vinifera	54.10	6.00e-61	228.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence