iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/ZnF_A20	1.10e-20	73.6	8	42

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           +p+++lC++gCgfYGnp+tng+CS+Cy+e+l+r++
   Q: 8    TPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQ 42
           69*******************************96 PP

Organism

Rattus norvegicus

Functional Description
(View)

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity).

Protein Sequence
(Fasta)

MAQETNQTPG PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QQNSGRMSPM GTASGSNSPT 60
SDSASVQRAD ATLNNCEGAA GSTSEKSRNV PVAALPVTQQ MTEMSISRED KITSPKTEVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCGCCCGG CGTCGCGCGC CAGCTCGCTA GTGCATCCGG GCCCCGCAGG GTAAGTGGCG 60
CGAGCCGGGA CGGCGCGGGG GCGGGAGCAC GCCCGATCAG CGAGCACAAA GACCGGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002653--Znf_A20
IPR000058--Znf_AN1

PROSITE

PS51036--ZF_A20
PS51039--ZF_AN1

Pfam

PF01754--zf-A20
PF01428--zf-AN1

SMART

SM00259--ZnF_A20
SM00154--ZnF_AN1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0060324--P:face development
GO:0010761--P:fibroblast migration
GO:0001701--P:in utero embryonic development
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0003016--P:respiratory system process
GO:0048705--P:skeletal system morphogenesis
GO:0048745--P:smooth muscle tissue development
GO:0001944--P:vasculature development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001163	Aegilops tauschii	32.85	1.00e-25	108.00
IUUC-Aml-002088	Ailuropoda melanoleuca	97.65	5.00e-101	359.00
IUUC-Atr-002750	Amborella trichopoda	66.13	2.00e-22	98.60
IUUC-Apl-003370	Anas platyrhynchos	91.12	5.00e-98	349.00
IUUC-Aca-004848	Anolis carolinensis	90.14	2.00e-90	324.00
IUUC-Aly-006499	Arabidopsis lyrata	30.54	6.00e-21	93.60
IUUC-Ame-011611	Astyanax mexicanus	63.55	6.00e-56	209.00
IUUC-Bta-012511	Bos taurus	97.65	7.00e-101	359.00
IUUC-Bdi-014584	Brachypodium distachyon	35.21	3.00e-30	124.00
IUUC-Cel-018374	Caenorhabditis elegans	35.98	4.00e-31	127.00
IUUC-Cja-019481	Callithrix jacchus	98.12	9.00e-101	359.00
IUUC-Cfa-020427	Canis familiaris	98.12	6.00e-101	359.00
IUUC-Cpo-021969	Cavia porcellus	98.12	5.00e-101	359.00
IUUC-Cre-022706	Chlamydomonas reinhardtii	58.06	2.00e-20	91.70
IUUC-Csa-024124	Chlorocebus sabaeus	98.12	6.00e-101	359.00
IUUC-Cho-024982	Choloepus hoffmanni	87.32	6.00e-96	342.00
IUUC-Cin-025685	Ciona intestinalis	43.06	2.00e-35	141.00
IUUC-Dre-028143	Danio rerio	65.14	1.00e-72	265.00
IUUC-Dno-029194	Dasypus novemcinctus	97.18	2.00e-100	358.00
IUUC-Dor-031104	Dipodomys ordii	98.12	4.00e-101	360.00
IUUC-Ete-032527	Echinops telfairi	96.71	8.00e-100	355.00
IUUC-Eca-034160	Equus caballus	98.59	1.00e-101	361.00
IUUC-Eeu-034800	Erinaceus europaeus	96.71	6.00e-86	309.00
IUUC-Fca-035481	Felis catus	98.12	6.00e-101	359.00
IUUC-Fal-036728	Ficedula albicollis	81.17	2.00e-100	357.00
IUUC-Gmo-039236	Gadus morhua	67.14	2.00e-71	261.00
IUUC-Gga-040753	Gallus gallus	81.31	2.00e-82	298.00
IUUC-Gac-042356	Gasterosteus aculeatus	65.89	3.00e-67	247.00
IUUC-Gma-043085	Glycine max	34.80	2.00e-26	111.00
IUUC-Ggo-044975	Gorilla gorilla	97.65	2.00e-100	358.00
IUUC-Hsa-046465	Homo sapiens	98.12	6.00e-101	359.00
IUUC-Hvu-047179	Hordeum vulgare	36.76	3.00e-28	117.00
IUUC-Itr-047997	Ictidomys tridecemlineatus	95.77	2.00e-97	348.00
IUUC-Lch-049431	Latimeria chalumnae	84.72	7.00e-88	316.00
IUUC-Lpe-051068	Leersia perrieri	33.49	3.00e-26	111.00
IUUC-Loc-051838	Lepisosteus oculatus	72.35	6.00e-79	286.00
IUUC-Laf-054572	Loxodonta africana	98.12	5.00e-108	383.00
IUUC-Meu-056305	Macropus eugenii	95.96	3.00e-92	330.00
IUUC-Mtr-058809	Medicago truncatula	35.29	6.00e-27	113.00
IUUC-Mga-059903	Meleagris gallopavo	80.37	3.00e-81	294.00
IUUC-Mdo-062494	Monodelphis domestica	96.24	1.00e-102	365.00
IUUC-Mmu-063632	Mus musculus	99.06	4.00e-101	360.00
IUUC-Mac-064854	Musa acuminata	33.97	3.00e-25	107.00
IUUC-Mpu-065918	Mustela putorius furo	97.65	5.00e-101	359.00
IUUC-Mlu-067594	Myotis lucifugus	97.65	6.00e-101	359.00
IUUC-Nle-069326	Nomascus leucogenys	95.77	3.00e-103	367.00
IUUC-Opr-071113	Ochotona princeps	95.77	3.00e-99	354.00
IUUC-Ont-071860	Oreochromis niloticus	66.67	3.00e-72	264.00
IUUC-Oan-073601	Ornithorhynchus anatinus	91.55	8.00e-87	312.00
IUUC-Ocu-073952	Oryctolagus cuniculus	98.12	2.00e-100	358.00
IUUC-Oba-075600	Oryza barthii	33.49	4.00e-27	114.00
IUUC-Obr-076269	Oryza brachyantha	34.45	6.00e-27	114.00
IUUC-Ogl-077456	Oryza glaberrima	33.49	4.00e-27	114.00
IUUC-Ogu-078105	Oryza glumaepatula	33.49	4.00e-27	114.00
IUUC-Oin-079326	Oryza indica	33.49	4.00e-27	114.00
IUUC-Olo-081039	Oryza longistaminata	33.49	4.00e-27	114.00
IUUC-Ome-081197	Oryza meridionalis	33.49	6.00e-27	113.00
IUUC-Oni-082851	Oryza nivara	33.49	4.00e-27	114.00
IUUC-Opu-083820	Oryza punctata	33.01	3.00e-27	114.00
IUUC-Oru-084563	Oryza rufipogon	33.49	4.00e-27	114.00
IUUC-Osa-085931	Oryza sativa	33.49	4.00e-27	114.00
IUUC-Ola-087109	Oryzias latipes	67.76	2.00e-78	285.00
IUUC-Oga-088394	Otolemur garnettii	97.18	1.00e-100	358.00
IUUC-Oar-089649	Ovis aries	97.65	7.00e-101	359.00
IUUC-Pan-092692	Papio anubis	98.12	6.00e-101	359.00
IUUC-Psi-093090	Pelodiscus sinensis	92.49	4.00e-86	310.00
IUUC-Pma-094271	Petromyzon marinus	49.78	2.00e-55	208.00
IUUC-Pfo-096087	Poecilia formosa	66.82	3.00e-69	254.00
IUUC-Pab-098585	Pongo abelii	98.12	6.00e-101	359.00
IUUC-Pop-099528	Populus trichocarpa	37.02	2.00e-26	111.00
IUUC-Pca-100951	Procavia capensis	97.91	9.00e-87	312.00
IUUC-Ppe-101886	Prunus persica	33.98	3.00e-27	114.00
IUUC-Pva-102118	Pteropus vampyrus	98.59	5.00e-101	360.00
IUUC-Pyt-104769	Pyrenophora triticirepentis	33.33	7.00e-04	37.70
IUUC-Sha-106942	Sarcophilus harrisii	95.77	9.00e-105	372.00
IUUC-Sit-110684	Setaria italica	35.89	1.00e-29	122.00
IUUC-Sly-111440	Solanum lycopersicum	36.06	2.00e-27	115.00
IUUC-Stu-112819	Solanum tuberosum	36.76	3.00e-26	110.00
IUUC-Sar-113241	Sorex araneus	98.12	8.00e-101	358.00
IUUC-Sbi-114497	Sorghum bicolor	36.67	9.00e-28	115.00
IUUC-Ssc-115824	Sus scrofa	98.59	2.00e-101	361.00
IUUC-Tgu-116588	Taeniopygia guttata	92.02	5.00e-107	379.00
IUUC-Tru-118060	Takifugu rubripes	65.12	7.00e-72	263.00
IUUC-Tsy-119054	Tarsius syrichta	89.67	9.00e-86	309.00
IUUC-Tni-120082	Tetraodon nigroviridis	65.73	1.00e-75	275.00
IUUC-Tca-120932	Theobroma cacao	33.80	7.00e-26	109.00
IUUC-Tae-123386	Triticum aestivum	36.76	4.00e-28	117.00
IUUC-Tur-126864	Triticum urartu	34.30	3.00e-27	115.00
IUUC-Tbe-127974	Tupaia belangeri	96.57	7.00e-82	295.00
IUUC-Ttr-129163	Tursiops truncatus	98.11	1.00e-99	355.00
IUUC-Vpa-130351	Vicugna pacos	97.64	6.00e-100	356.00
IUUC-Vvi-131696	Vitis vinifera	34.31	2.00e-25	108.00
IUUC-Xtr-132723	Xenopus tropicalis	87.32	2.00e-91	327.00
IUUC-Xma-134104	Xiphophorus maculatus	67.61	6.00e-72	263.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence