iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053713

UUCD1 version

UUC-LoA-00237

Ensembl Protein ID

ENSLAFP00000005478.2

UniProt Accession

G3SYC4; G3SYC4_LOXAF

Protein Name

Uncharacterized protein

Gene Name

PAFAH1B1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000006527.2	ENSLAFT00000033166.1	ENSLAFP00000024227.1
ENSLAFG00000006527.2	ENSLAFT00000006527.2	ENSLAFP00000005478.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.20e-60	196.6	191	230
UBD/Beta-Prp	8.10e-95	317.8	108	411

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH   v+++a  ++ +++vs+s+D+tik+W++ tg ++k+
   Q: 191  GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVQTGYCVKT 230
           899*******99777********************99875 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 108  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 196
           5668888********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++
   Q: 197  SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 283
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd +++ 
   Q: 284  SWAPESsyssiseatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDFKNKR 372
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 373  CMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 411
           *****************.99*****************985 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

IEMKKKNRNE ILNRAIADYL RSNGYEEAYS VFKKEAELDM NEELDKKYAG LLEKKWTSVI 60
RLQKKVMELE SKLNEAKEEF TSGGPLGQKR DPKEWIPRPP EKYALSGHRS PVTRVIFHPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGCTCT CCCAGAGACA ACGAGATGAA CTGTAAGTTA CTCTGTTTTG TGCTTTAAAA 60
AAAAAATTCT TTCTCGTACG GGACAAAGCA CTAAATTAAA ATATAGTTTT GGGAGATTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000235--C:astral microtubule
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0031252--C:cell leading edge
GO:0005813--C:centrosome
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005875--C:microtubule associated complex
GO:0031514--C:motile cilium
GO:0005635--C:nuclear envelope
GO:0048471--C:perinuclear region of cytoplasm
GO:0032420--C:stereocilium
GO:0001675--P:acrosome assembly
GO:0030036--P:actin cytoskeleton organization
GO:0008344--P:adult locomotory behavior
GO:0001667--P:ameboidal-type cell migration
GO:0060117--P:auditory receptor cell development
GO:0048854--P:brain morphogenesis
GO:0051301--P:cell division
GO:0007268--P:chemical synaptic transmission
GO:0090102--P:cochlea development
GO:0021540--P:corpus callosum morphogenesis
GO:0043622--P:cortical microtubule organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0042249--P:establishment of planar polarity of embryonic epithelium
GO:0021766--P:hippocampus development
GO:0021819--P:layer formation in cerebral cortex
GO:0007611--P:learning or memory
GO:0051661--P:maintenance of centrosome location
GO:0090176--P:microtubule cytoskeleton organization involved in establishment of planar polarity
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0046329--P:negative regulation of JNK cascade
GO:0007405--P:neuroblast proliferation
GO:0050885--P:neuromuscular process controlling balance
GO:0001764--P:neuron migration
GO:0051081--P:nuclear envelope disassembly
GO:0036035--P:osteoclast development
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:0040019--P:positive regulation of embryonic development
GO:0009306--P:protein secretion
GO:0043087--P:regulation of GTPase activity
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0008090--P:retrograde axonal transport
GO:0019226--P:transmission of nerve impulse
GO:0047496--P:vesicle transport along microtubule

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	99.75	0.00e+00	833.00
IUUC-Apl-004024	Anas platyrhynchos	97.31	0.00e+00	834.00
IUUC-Aca-004564	Anolis carolinensis	96.58	0.00e+00	825.00
IUUC-Ago-007862	Ashbya gossypii	26.87	2.00e-36	146.00
IUUC-Acl-008360	Aspergillus clavatus	45.68	9.00e-103	367.00
IUUC-Afl-008502	Aspergillus flavus	45.69	8.00e-95	340.00
IUUC-Afu-008848	Aspergillus fumigatus	46.34	2.00e-104	372.00
IUUC-Ani-009173	Aspergillus nidulans	43.04	8.00e-90	323.00
IUUC-Ang-009873	Aspergillus niger	44.50	6.00e-93	334.00
IUUC-Aor-009973	Aspergillus oryzae	43.96	4.00e-90	324.00
IUUC-Ate-010523	Aspergillus terreus	41.21	6.00e-89	321.00
IUUC-Ame-010969	Astyanax mexicanus	92.91	0.00e+00	802.00
IUUC-Bgr-011972	Blumeria graminis	47.57	6.00e-103	367.00
IUUC-Bta-013106	Bos taurus	98.04	0.00e+00	837.00
IUUC-Bci-013615	Botrytis cinerea	44.50	1.00e-96	346.00
IUUC-Cel-018459	Caenorhabditis elegans	56.31	1.00e-145	508.00
IUUC-Cja-018755	Callithrix jacchus	98.29	0.00e+00	838.00
IUUC-Cfa-020749	Canis familiaris	98.04	0.00e+00	837.00
IUUC-Cpo-022371	Cavia porcellus	98.04	0.00e+00	837.00
IUUC-Cre-022578	Chlamydomonas reinhardtii	35.44	4.00e-50	191.00
IUUC-Csa-023524	Chlorocebus sabaeus	99.13	0.00e+00	720.00
IUUC-Cho-024764	Choloepus hoffmanni	88.95	0.00e+00	678.00
IUUC-Cin-025753	Ciona intestinalis	69.51	7.00e-176	609.00
IUUC-Csv-025817	Ciona savignyi	67.97	1.00e-178	619.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	45.99	2.00e-95	342.00
IUUC-Cne-027087	Cryptococcus neoformans	50.39	2.00e-110	392.00
IUUC-Dre-028314	Danio rerio	91.44	0.00e+00	797.00
IUUC-Dno-029050	Dasypus novemcinctus	97.80	0.00e+00	836.00
IUUC-Dor-030222	Dipodomys ordii	89.73	0.00e+00	754.00
IUUC-Dse-031164	Dothistroma septosporum	43.60	7.00e-100	357.00
IUUC-Dme-031745	Drosophila melanogaster	68.54	2.00e-167	581.00
IUUC-Ete-032508	Echinops telfairi	99.28	2.00e-168	585.00
IUUC-Eca-034288	Equus caballus	99.25	0.00e+00	829.00
IUUC-Eeu-034984	Erinaceus europaeus	89.49	0.00e+00	750.00
IUUC-Fca-036498	Felis catus	98.04	0.00e+00	837.00
IUUC-Fal-036920	Ficedula albicollis	97.31	0.00e+00	834.00
IUUC-Fox-037996	Fusarium oxysporum	46.36	2.00e-102	366.00
IUUC-Fso-038160	Fusarium solani	44.12	3.00e-97	348.00
IUUC-Gmo-038983	Gadus morhua	91.93	0.00e+00	792.00
IUUC-Ggr-040051	Gaeumannomyces graminis	46.11	1.00e-96	346.00
IUUC-Gga-040623	Gallus gallus	97.31	0.00e+00	834.00
IUUC-Gac-041613	Gasterosteus aculeatus	90.95	0.00e+00	788.00
IUUC-Ggo-045410	Gorilla gorilla	88.97	0.00e+00	724.00
IUUC-Hsa-046358	Homo sapiens	97.80	0.00e+00	835.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	98.04	0.00e+00	837.00
IUUC-Kpa-049351	Komagataella pastoris	29.22	2.00e-41	163.00
IUUC-Lch-049936	Latimeria chalumnae	94.87	0.00e+00	813.00
IUUC-Loc-052476	Lepisosteus oculatus	95.04	0.00e+00	806.00
IUUC-Lma-053170	Leptosphaeria maculans	48.42	3.00e-99	355.00
IUUC-Mcc-054628	Macaca mulatta	97.56	0.00e+00	834.00
IUUC-Meu-055927	Macropus eugenii	85.92	6.00e-140	489.00
IUUC-Mor-056962	Magnaporthe oryzae	45.12	5.00e-96	344.00
IUUC-Mpo-057583	Magnaporthe poae	46.15	2.00e-92	332.00
IUUC-Mla-058819	Melampsora laricipopulina	47.51	1.00e-115	410.00
IUUC-Mga-059945	Meleagris gallopavo	97.07	0.00e+00	833.00
IUUC-Mvi-060403	Microbotryum violaceum	48.76	5.00e-125	441.00
IUUC-Mmr-061289	Microcebus murinus	99.75	0.00e+00	833.00
IUUC-Mdo-061912	Monodelphis domestica	97.31	0.00e+00	831.00
IUUC-Mmu-063253	Mus musculus	98.04	0.00e+00	837.00
IUUC-Mpu-066638	Mustela putorius furo	98.04	0.00e+00	837.00
IUUC-Mlu-067267	Myotis lucifugus	99.50	0.00e+00	831.00
IUUC-Nfi-068571	Neosartorya fischeri	44.72	7.00e-97	347.00
IUUC-Ncr-068895	Neurospora crassa	50.13	7.00e-104	370.00
IUUC-Nle-069087	Nomascus leucogenys	97.60	0.00e+00	680.00
IUUC-Opr-070579	Ochotona princeps	97.80	0.00e+00	836.00
IUUC-Ont-072432	Oreochromis niloticus	92.67	0.00e+00	802.00
IUUC-Oan-073072	Ornithorhynchus anatinus	98.04	0.00e+00	837.00
IUUC-Ocu-074180	Oryctolagus cuniculus	97.80	0.00e+00	836.00
IUUC-Ola-086772	Oryzias latipes	92.18	0.00e+00	793.00
IUUC-Oga-088219	Otolemur garnettii	97.56	0.00e+00	835.00
IUUC-Oar-090394	Ovis aries	98.04	0.00e+00	837.00
IUUC-Ptr-091517	Pan troglodytes	98.04	0.00e+00	837.00
IUUC-Pan-092421	Papio anubis	97.56	0.00e+00	834.00
IUUC-Psi-093370	Pelodiscus sinensis	97.07	0.00e+00	832.00
IUUC-Pma-094319	Petromyzon marinus	88.54	0.00e+00	641.00
IUUC-Pno-094815	Phaeosphaeria nodorum	47.33	2.00e-102	365.00
IUUC-Pfo-097089	Poecilia formosa	91.69	0.00e+00	795.00
IUUC-Pab-098421	Pongo abelii	98.04	0.00e+00	837.00
IUUC-Pca-100120	Procavia capensis	72.35	9.00e-162	562.00
IUUC-Pva-102960	Pteropus vampyrus	97.80	0.00e+00	833.00
IUUC-Pgr-103538	Puccinia graminis	46.62	3.00e-115	408.00
IUUC-Ptt-103990	Puccinia triticina	40.96	3.00e-41	163.00
IUUC-Pte-104261	Pyrenophora teres	47.57	2.00e-102	365.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	47.82	9.00e-103	367.00
IUUC-Rno-105123	Rattus norvegicus	98.04	0.00e+00	837.00
IUUC-Sce-106208	Saccharomyces cerevisiae	29.77	3.00e-36	145.00
IUUC-Sha-107010	Sarcophilus harrisii	97.07	0.00e+00	829.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	32.32	1.00e-62	233.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	43.88	4.00e-97	348.00
IUUC-Sar-113309	Sorex araneus	99.00	0.00e+00	824.00
IUUC-Sre-115003	Sporisorium reilianum	48.86	1.00e-121	429.00
IUUC-Ssc-116148	Sus scrofa	98.04	0.00e+00	837.00
IUUC-Tgu-117299	Taeniopygia guttata	97.07	0.00e+00	831.00
IUUC-Tru-118179	Takifugu rubripes	90.22	0.00e+00	788.00
IUUC-Tsy-119493	Tarsius syrichta	96.58	0.00e+00	820.00
IUUC-Tni-120355	Tetraodon nigroviridis	91.20	0.00e+00	762.00
IUUC-Tre-121977	Trichoderma reesei	43.13	2.00e-99	355.00
IUUC-Tvi-122661	Trichoderma virens	43.67	4.00e-98	351.00
IUUC-Tme-127031	Tuber melanosporum	48.10	4.00e-101	361.00
IUUC-Tbe-127492	Tupaia belangeri	82.69	3.00e-115	407.00
IUUC-Ttr-128929	Tursiops truncatus	97.80	0.00e+00	834.00
IUUC-Uma-129347	Ustilago maydis	46.58	2.00e-118	419.00
IUUC-Vda-129837	Verticillium dahliae	45.54	6.00e-98	351.00
IUUC-Vpa-130532	Vicugna pacos	83.38	0.00e+00	646.00
IUUC-Xtr-131985	Xenopus tropicalis	95.60	0.00e+00	825.00
IUUC-Xma-133314	Xiphophorus maculatus	92.18	0.00e+00	796.00
IUUC-Yli-134403	Yarrowia lipolytica	40.81	9.00e-74	270.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence