iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-002356

Ensembl Protein ID

ENSAMEP00000009556.1

UniProt Accession

G1LR72; G1LR72_AILME

Genbank Protein ID

ENSAMEP00000009556

Protein Name

Presenilin

Genbank Nucleotide ID

ACTA01048941

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000009070.1	ENSAMET00000009968.1	ENSAMEP00000009556.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.80e-08	33.3	310	348

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 310  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 348
           89********************************99986 PP

Organism

Ailuropoda melanoleuca

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

PLATAAVLCC LCLQEDAPRS PVLLFPGASR GRAMLTFMAS DSEEEVCDER TSLMSAESPP 60
PRCCQEARQG LEDGGNAAQW RSQDSEDDLD EDADRYMCGG VPGQPSGLEE ELTLKYGAKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTGGCCA CTGCCGCAGT CCTTTGCTGC CTTTGCCTGC AGGAAGACGC ACCGAGGTCC 60
CCTGTGCTCC TTTTTCCAGG CGCTTCCCGA GGCAGGGCCA TGCTCACATT CATGGCCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003959	Anas platyrhynchos	70.97	1.00e-146	512.00
IUUC-Aca-005160	Anolis carolinensis	68.40	5.00e-137	480.00
IUUC-Ame-010686	Astyanax mexicanus	72.14	2.00e-131	462.00
IUUC-Bta-013097	Bos taurus	88.64	0.00e+00	640.00
IUUC-Cel-018553	Caenorhabditis elegans	49.26	4.00e-81	295.00
IUUC-Cja-018824	Callithrix jacchus	87.53	0.00e+00	669.00
IUUC-Cfa-020253	Canis familiaris	91.07	0.00e+00	685.00
IUUC-Cpo-021401	Cavia porcellus	88.00	0.00e+00	656.00
IUUC-Csa-023369	Chlorocebus sabaeus	89.06	0.00e+00	661.00
IUUC-Dre-028526	Danio rerio	65.02	2.00e-124	438.00
IUUC-Dno-029975	Dasypus novemcinctus	53.50	4.00e-107	381.00
IUUC-Dor-031127	Dipodomys ordii	83.74	2.00e-178	618.00
IUUC-Ete-033081	Echinops telfairi	84.40	4.00e-94	338.00
IUUC-Eca-034387	Equus caballus	88.13	2.00e-179	621.00
IUUC-Eeu-034846	Erinaceus europaeus	71.30	1.00e-127	449.00
IUUC-Fca-035396	Felis catus	90.29	0.00e+00	704.00
IUUC-Fal-037457	Ficedula albicollis	71.52	8.00e-144	503.00
IUUC-Gga-040706	Gallus gallus	70.55	6.00e-142	497.00
IUUC-Gac-042511	Gasterosteus aculeatus	60.72	9.00e-114	403.00
IUUC-Ggo-045338	Gorilla gorilla	87.02	0.00e+00	677.00
IUUC-Hsa-046455	Homo sapiens	87.02	0.00e+00	677.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	89.06	0.00e+00	662.00
IUUC-Lch-049638	Latimeria chalumnae	62.55	8.00e-124	437.00
IUUC-Loc-052427	Lepisosteus oculatus	67.70	1.00e-133	469.00
IUUC-Laf-053758	Loxodonta africana	82.26	0.00e+00	638.00
IUUC-Mcc-054755	Macaca mulatta	86.81	0.00e+00	674.00
IUUC-Mmr-060890	Microcebus murinus	87.50	0.00e+00	645.00
IUUC-Mdo-062197	Monodelphis domestica	73.70	8.00e-155	540.00
IUUC-Mmu-063823	Mus musculus	87.28	0.00e+00	650.00
IUUC-Mac-064858	Musa acuminata	43.86	1.00e-22	100.00
IUUC-Mpu-066181	Mustela putorius furo	91.29	0.00e+00	686.00
IUUC-Nle-069596	Nomascus leucogenys	87.59	6.00e-176	610.00
IUUC-Opr-070344	Ochotona princeps	85.90	0.00e+00	666.00
IUUC-Ont-071867	Oreochromis niloticus	65.17	2.00e-117	416.00
IUUC-Oan-073378	Ornithorhynchus anatinus	67.64	7.00e-129	453.00
IUUC-Ocu-074652	Oryctolagus cuniculus	86.59	1.00e-180	625.00
IUUC-Oba-075256	Oryza barthii	60.49	3.00e-16	79.70
IUUC-Ogu-078570	Oryza glumaepatula	60.49	4.00e-16	79.30
IUUC-Oin-079244	Oryza indica	60.49	3.00e-16	79.70
IUUC-Oni-082057	Oryza nivara	60.49	4.00e-16	79.30
IUUC-Oru-084618	Oryza rufipogon	60.49	4.00e-16	79.30
IUUC-Ola-086707	Oryzias latipes	58.33	1.00e-88	319.00
IUUC-Oga-088560	Otolemur garnettii	87.80	4.00e-178	617.00
IUUC-Oar-089200	Ovis aries	87.75	3.00e-177	614.00
IUUC-Ptr-090569	Pan troglodytes	89.06	0.00e+00	662.00
IUUC-Pan-091742	Papio anubis	89.06	0.00e+00	660.00
IUUC-Psi-093297	Pelodiscus sinensis	67.54	6.00e-114	404.00
IUUC-Pma-094612	Petromyzon marinus	71.24	1.00e-116	412.00
IUUC-Pab-098531	Pongo abelii	89.06	0.00e+00	661.00
IUUC-Pca-101120	Procavia capensis	84.33	0.00e+00	633.00
IUUC-Pva-102934	Pteropus vampyrus	79.56	2.00e-180	625.00
IUUC-Rno-106052	Rattus norvegicus	86.83	0.00e+00	665.00
IUUC-Sha-106876	Sarcophilus harrisii	73.13	7.00e-152	530.00
IUUC-Ssc-115380	Sus scrofa	89.96	0.00e+00	689.00
IUUC-Tgu-117280	Taeniopygia guttata	72.17	3.00e-145	508.00
IUUC-Tbe-127632	Tupaia belangeri	85.26	3.00e-158	551.00
IUUC-Ttr-129008	Tursiops truncatus	88.03	0.00e+00	658.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence