iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020074

Ensembl Protein ID

ENSCAFP00000031755.2

UniProt Accession

Q6RH31; Q6RH32; PSN1_CANLF

Genbank Protein ID

AAR97724.1; AAR97725.1

Protein Name

Presenilin-1; Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12

Genbank Nucleotide ID

AY498704; AY498705

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000016815.4	ENSCAFT00000036386.3	ENSCAFP00000031755.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.20e-08	35.1	271	309

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ +  
   Q: 271  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVS 309
           89****************************999998876 PP

Organism

Canis familiaris

Functional Description
(View)

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity).

Protein Sequence
(Fasta)

MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DSREQHSSER RRRGNPEPLS NGRPQGSSHQ 60
VVEQDDEEDE ELTLKYGAKH VIMLFVPVTL CMVVVVATIK SVSFYTRKDG QLIYTPFTED 120

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Nucleotide Sequence
(Fasta)

ACCTAATCTG GGAGCCTGCA AGTGACAGCT GCCTGCGAGG TCCTTAGAAA GCTTGGCCTG 60
GAGGAGAACA CATGAAAGAA AGGTTTGTTT TTGCTGAATA TAATTTATGA AAGTGTTTAA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0042982--P:amyloid precursor protein metabolic process
GO:0006915--P:apoptotic process
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0007155--P:cell adhesion
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis

KEGG

cfa:403408

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	36.60	1.00e-24	108.00
IUUC-Aml-001648	Ailuropoda melanoleuca	96.44	1.00e-172	598.00
IUUC-Atr-003039	Amborella trichopoda	31.90	5.00e-39	155.00
IUUC-Apl-003727	Anas platyrhynchos	83.40	0.00e+00	626.00
IUUC-Aca-004582	Anolis carolinensis	81.57	0.00e+00	638.00
IUUC-Aly-005455	Arabidopsis lyrata	29.60	2.00e-32	133.00
IUUC-Ath-006730	Arabidopsis thaliana	32.21	4.00e-35	142.00
IUUC-Ame-011500	Astyanax mexicanus	73.46	3.00e-150	525.00
IUUC-Bta-013026	Bos taurus	91.00	0.00e+00	728.00
IUUC-Bdi-014196	Brachypodium distachyon	32.71	9.00e-30	124.00
IUUC-Bol-015841	Brassica oleracea	36.51	8.00e-33	134.00
IUUC-Bra-017580	Brassica rapa	34.80	1.00e-30	127.00
IUUC-Cel-018553	Caenorhabditis elegans	53.69	1.00e-94	340.00
IUUC-Cja-019994	Callithrix jacchus	95.51	0.00e+00	681.00
IUUC-Cpo-022237	Cavia porcellus	92.94	0.00e+00	697.00
IUUC-Csa-023537	Chlorocebus sabaeus	94.22	0.00e+00	759.00
IUUC-Cho-024735	Choloepus hoffmanni	81.45	0.00e+00	667.00
IUUC-Cin-025780	Ciona intestinalis	62.91	1.00e-125	442.00
IUUC-Csv-025967	Ciona savignyi	63.70	6.00e-121	427.00
IUUC-Dre-028689	Danio rerio	78.45	4.00e-145	507.00
IUUC-Dno-029758	Dasypus novemcinctus	91.04	0.00e+00	720.00
IUUC-Dor-030609	Dipodomys ordii	72.38	8.00e-170	590.00
IUUC-Dme-031929	Drosophila melanogaster	55.80	3.00e-111	395.00
IUUC-Ete-032487	Echinops telfairi	81.90	3.00e-82	298.00
IUUC-Eeu-035134	Erinaceus europaeus	92.83	8.00e-147	512.00
IUUC-Fca-036243	Felis catus	95.94	0.00e+00	756.00
IUUC-Fal-036600	Ficedula albicollis	83.37	0.00e+00	631.00
IUUC-Gmo-038550	Gadus morhua	66.16	4.00e-114	404.00
IUUC-Gga-040993	Gallus gallus	84.01	0.00e+00	639.00
IUUC-Gac-042342	Gasterosteus aculeatus	67.47	7.00e-132	463.00
IUUC-Gma-043822	Glycine max	39.19	3.00e-25	109.00
IUUC-Ggo-044859	Gorilla gorilla	91.93	1.00e-161	562.00
IUUC-Hsa-046822	Homo sapiens	94.00	0.00e+00	757.00
IUUC-Hvu-047141	Hordeum vulgare	36.27	6.00e-26	112.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	94.10	2.00e-156	545.00
IUUC-Lch-049946	Latimeria chalumnae	71.00	4.00e-147	514.00
IUUC-Lpe-051132	Leersia perrieri	33.33	7.00e-31	128.00
IUUC-Laf-053979	Loxodonta africana	88.74	0.00e+00	630.00
IUUC-Mcc-055682	Macaca mulatta	94.00	0.00e+00	757.00
IUUC-Meu-056004	Macropus eugenii	76.60	9.00e-156	543.00
IUUC-Mtr-058392	Medicago truncatula	33.98	8.00e-31	127.00
IUUC-Mga-059466	Meleagris gallopavo	83.58	0.00e+00	637.00
IUUC-Mmr-061538	Microcebus murinus	76.66	1.00e-162	566.00
IUUC-Mdo-062122	Monodelphis domestica	87.69	0.00e+00	691.00
IUUC-Mmu-063176	Mus musculus	90.79	0.00e+00	710.00
IUUC-Mpu-065927	Mustela putorius furo	96.14	0.00e+00	752.00
IUUC-Mlu-067079	Myotis lucifugus	94.23	0.00e+00	776.00
IUUC-Nle-070180	Nomascus leucogenys	94.00	0.00e+00	757.00
IUUC-Opr-070847	Ochotona princeps	87.20	0.00e+00	663.00
IUUC-Ont-071846	Oreochromis niloticus	76.73	4.00e-147	514.00
IUUC-Oan-072783	Ornithorhynchus anatinus	84.05	1.00e-135	476.00
IUUC-Ocu-074527	Oryctolagus cuniculus	92.08	0.00e+00	740.00
IUUC-Oba-075256	Oryza barthii	34.86	3.00e-29	122.00
IUUC-Obr-076302	Oryza brachyantha	32.45	4.00e-29	122.00
IUUC-Ogl-077097	Oryza glaberrima	33.80	5.00e-30	125.00
IUUC-Ogu-078570	Oryza glumaepatula	34.10	5.00e-30	125.00
IUUC-Oin-079244	Oryza indica	33.85	2.00e-29	123.00
IUUC-Olo-080484	Oryza longistaminata	37.14	5.00e-25	108.00
IUUC-Ome-081814	Oryza meridionalis	34.08	1.00e-30	127.00
IUUC-Oni-082057	Oryza nivara	33.85	2.00e-29	123.00
IUUC-Opu-084176	Oryza punctata	33.93	2.00e-30	126.00
IUUC-Oru-084618	Oryza rufipogon	34.10	7.00e-30	124.00
IUUC-Osa-085602	Oryza sativa	33.85	5.00e-30	125.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.69	3.00e-48	185.00
IUUC-Oar-090348	Ovis aries	93.80	0.00e+00	772.00
IUUC-Ptr-091060	Pan troglodytes	94.00	0.00e+00	757.00
IUUC-Pan-091855	Papio anubis	85.65	0.00e+00	661.00
IUUC-Psi-093505	Pelodiscus sinensis	82.94	0.00e+00	636.00
IUUC-Pfo-097396	Poecilia formosa	75.80	2.00e-152	531.00
IUUC-Pab-098591	Pongo abelii	93.36	0.00e+00	744.00
IUUC-Pop-099661	Populus trichocarpa	33.42	5.00e-33	135.00
IUUC-Pca-101029	Procavia capensis	88.06	0.00e+00	681.00
IUUC-Ppe-101495	Prunus persica	32.81	5.00e-38	152.00
IUUC-Pva-102244	Pteropus vampyrus	87.18	0.00e+00	688.00
IUUC-Rno-105861	Rattus norvegicus	90.19	0.00e+00	681.00
IUUC-Sha-107045	Sarcophilus harrisii	88.09	0.00e+00	688.00
IUUC-Smo-109325	Selaginella moellendorffii	35.14	3.00e-37	149.00
IUUC-Sit-110624	Setaria italica	34.58	1.00e-27	117.00
IUUC-Stu-112433	Solanum tuberosum	34.93	8.00e-34	137.00
IUUC-Sar-113169	Sorex araneus	89.27	6.00e-145	507.00
IUUC-Sbi-114305	Sorghum bicolor	33.54	4.00e-26	112.00
IUUC-Ssc-115766	Sus scrofa	93.59	0.00e+00	734.00
IUUC-Tgu-116469	Taeniopygia guttata	88.79	1.00e-142	498.00
IUUC-Tru-117732	Takifugu rubripes	76.31	2.00e-145	508.00
IUUC-Tsy-119624	Tarsius syrichta	84.22	0.00e+00	659.00
IUUC-Tni-119852	Tetraodon nigroviridis	71.65	9.00e-137	479.00
IUUC-Tca-121865	Theobroma cacao	33.17	3.00e-37	149.00
IUUC-Tae-125925	Triticum aestivum	35.60	1.00e-26	114.00
IUUC-Tur-126237	Triticum urartu	35.95	1.00e-25	110.00
IUUC-Tbe-128148	Tupaia belangeri	85.11	2.00e-169	588.00
IUUC-Ttr-128793	Tursiops truncatus	93.38	0.00e+00	728.00
IUUC-Vpa-130625	Vicugna pacos	76.45	6.00e-164	570.00
IUUC-Vvi-131312	Vitis vinifera	33.42	1.00e-35	144.00
IUUC-Xtr-131790	Xenopus tropicalis	78.13	4.00e-158	550.00
IUUC-Xma-133377	Xiphophorus maculatus	75.47	3.00e-150	524.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence