iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012424

Ensembl Protein ID

ENSBTAP00000020230.5

UniProt Accession

A6H720; A6H720_BOVIN

Genbank Protein ID

AAI46084.1

Protein Name

NCK2 protein

Genbank Nucleotide ID

DAAA02031065

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015205.5	ENSBTAT00000020230.5	ENSBTAP00000020230.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.30e-45	152.0	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL++ kG++++viek e+d +W+++ ++++g+ Gl+P+n+v+ l+
   Q: 197  LQVVQTLYPFSSVTEEELNFDKGETMEVIEKPENDPEWWRC-RNARGQVGLVPKNYVVVLS 256
           679**************************************.5**************9886 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN IKDTLGLGRT RRKTSARDAS PTPSTDAEFP ANGGGADRIY DLSIPAVVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCAGGTGC AGTCAGCTGA GGAACTCAGC CTTTGAGGAG CTCTGTGTTG TGTGTCACCT 60
CTCGTAACTG GGTGCCGAAG GTGAGTGTGG CTTTCCGCCT GAGACAGGCA GGAGGAGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

bta:526430

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	90.00	0.00e+00	692.00
IUUC-Apl-003456	Anas platyrhynchos	85.26	0.00e+00	666.00
IUUC-Aca-005105	Anolis carolinensis	85.00	0.00e+00	667.00
IUUC-Ame-010966	Astyanax mexicanus	77.08	1.00e-169	588.00
IUUC-Cel-018144	Caenorhabditis elegans	42.72	3.00e-78	285.00
IUUC-Cja-019898	Callithrix jacchus	89.21	0.00e+00	688.00
IUUC-Cfa-020830	Canis familiaris	90.53	0.00e+00	694.00
IUUC-Cpo-021487	Cavia porcellus	86.58	0.00e+00	637.00
IUUC-Csa-023693	Chlorocebus sabaeus	89.21	0.00e+00	689.00
IUUC-Cin-025348	Ciona intestinalis	36.66	1.00e-66	246.00
IUUC-Dre-028334	Danio rerio	78.33	3.00e-174	604.00
IUUC-Dno-028973	Dasypus novemcinctus	87.37	0.00e+00	677.00
IUUC-Dor-031003	Dipodomys ordii	87.37	0.00e+00	642.00
IUUC-Ete-032792	Echinops telfairi	78.91	6.00e-174	603.00
IUUC-Eca-033656	Equus caballus	90.00	0.00e+00	691.00
IUUC-Fca-036347	Felis catus	90.00	0.00e+00	692.00
IUUC-Fal-037095	Ficedula albicollis	85.00	0.00e+00	668.00
IUUC-Gmo-039410	Gadus morhua	72.52	1.00e-161	562.00
IUUC-Gga-040155	Gallus gallus	85.26	0.00e+00	667.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.99	8.00e-166	576.00
IUUC-Ggo-044805	Gorilla gorilla	89.47	0.00e+00	690.00
IUUC-Hsa-046585	Homo sapiens	89.47	0.00e+00	689.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	88.16	0.00e+00	663.00
IUUC-Lch-049795	Latimeria chalumnae	82.63	0.00e+00	643.00
IUUC-Loc-051985	Lepisosteus oculatus	82.37	0.00e+00	630.00
IUUC-Laf-054228	Loxodonta africana	87.37	0.00e+00	675.00
IUUC-Mcc-055402	Macaca mulatta	89.21	0.00e+00	689.00
IUUC-Mga-059374	Meleagris gallopavo	85.26	0.00e+00	667.00
IUUC-Mmr-061453	Microcebus murinus	89.21	0.00e+00	687.00
IUUC-Mdo-063080	Monodelphis domestica	84.74	0.00e+00	664.00
IUUC-Mmu-063529	Mus musculus	87.89	0.00e+00	659.00
IUUC-Mpu-066815	Mustela putorius furo	90.00	0.00e+00	692.00
IUUC-Mlu-067132	Myotis lucifugus	85.57	6.00e-147	513.00
IUUC-Nle-069371	Nomascus leucogenys	89.47	0.00e+00	689.00
IUUC-Opr-070948	Ochotona princeps	87.53	0.00e+00	641.00
IUUC-Ont-071410	Oreochromis niloticus	74.31	2.00e-162	565.00
IUUC-Oan-073304	Ornithorhynchus anatinus	82.68	6.00e-147	513.00
IUUC-Ocu-074783	Oryctolagus cuniculus	88.95	0.00e+00	667.00
IUUC-Ola-086808	Oryzias latipes	73.78	4.00e-158	550.00
IUUC-Oga-088391	Otolemur garnettii	89.47	0.00e+00	671.00
IUUC-Oar-090025	Ovis aries	90.96	2.00e-178	617.00
IUUC-Ptr-090975	Pan troglodytes	89.47	0.00e+00	689.00
IUUC-Pan-092287	Papio anubis	89.21	0.00e+00	689.00
IUUC-Psi-093413	Pelodiscus sinensis	85.53	0.00e+00	669.00
IUUC-Pfo-097129	Poecilia formosa	75.38	1.00e-165	575.00
IUUC-Pab-098756	Pongo abelii	89.47	0.00e+00	689.00
IUUC-Pca-100235	Procavia capensis	76.05	1.00e-172	598.00
IUUC-Pva-102294	Pteropus vampyrus	86.32	0.00e+00	656.00
IUUC-Rno-105090	Rattus norvegicus	87.89	0.00e+00	658.00
IUUC-Sha-107521	Sarcophilus harrisii	84.74	0.00e+00	667.00
IUUC-Sit-110528	Setaria italica	52.17	1.10e+00	27.30
IUUC-Sar-113697	Sorex araneus	88.02	0.00e+00	655.00
IUUC-Ssc-115958	Sus scrofa	95.51	4.00e-178	616.00
IUUC-Tgu-116559	Taeniopygia guttata	83.16	0.00e+00	642.00
IUUC-Tru-117677	Takifugu rubripes	75.95	2.00e-164	571.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.49	9.00e-163	566.00
IUUC-Tbe-127931	Tupaia belangeri	86.39	1.00e-163	568.00
IUUC-Ttr-128993	Tursiops truncatus	94.68	0.00e+00	679.00
IUUC-Xtr-132543	Xenopus tropicalis	77.95	9.00e-179	619.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence