iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115368

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CU207251

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000006137.2	ENSSSCT00000006730.2	ENSSSCP00000006547.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-134	449.5	590	924

Active Site

Position(s)	Description	Evidence
893	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 590  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 677
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 678  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 763
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 764  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 851
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk......prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+      p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 852  TGTCRLPLGGFAELMglgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 924
           ***********************************************************************96 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MATASPRSDT SDNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGES KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATID LKQALLIHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAACTGTC ACACTGAAAC AATTTGTTTG TTTATAGGTT GTCTCCTCAC TAGACTATGA 60
GCGCCTTGAA AGAAGGAATC GTGTCTTGCT CATCTTTATA TCCCCAGTGT CTAGAACAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	94.05	0.00e+00	1740.00
IUUC-Apl-003310	Anas platyrhynchos	83.33	0.00e+00	1528.00
IUUC-Aca-005388	Anolis carolinensis	80.41	0.00e+00	1451.00
IUUC-Ago-007742	Ashbya gossypii	46.95	8.00e-156	543.00
IUUC-Acl-008273	Aspergillus clavatus	46.49	7.00e-152	531.00
IUUC-Afl-008713	Aspergillus flavus	45.48	7.00e-149	520.00
IUUC-Afu-009103	Aspergillus fumigatus	46.66	6.00e-153	534.00
IUUC-Ani-009259	Aspergillus nidulans	45.51	4.00e-149	521.00
IUUC-Ang-009738	Aspergillus niger	45.85	2.00e-150	526.00
IUUC-Ate-010529	Aspergillus terreus	46.23	3.00e-151	528.00
IUUC-Ame-010601	Astyanax mexicanus	74.58	0.00e+00	952.00
IUUC-Bgr-012148	Blumeria graminis	45.10	2.00e-146	512.00
IUUC-Bta-012857	Bos taurus	95.03	0.00e+00	1746.00
IUUC-Bci-013785	Botrytis cinerea	46.26	1.00e-148	520.00
IUUC-Cel-018299	Caenorhabditis elegans	67.13	0.00e+00	836.00
IUUC-Cja-019448	Callithrix jacchus	94.49	0.00e+00	1753.00
IUUC-Cfa-020728	Canis familiaris	94.81	0.00e+00	1740.00
IUUC-Cpo-021635	Cavia porcellus	89.32	0.00e+00	1668.00
IUUC-Csa-023805	Chlorocebus sabaeus	95.62	0.00e+00	1330.00
IUUC-Cho-024943	Choloepus hoffmanni	83.87	0.00e+00	1182.00
IUUC-Cin-025212	Ciona intestinalis	73.79	0.00e+00	905.00
IUUC-Csv-026256	Ciona savignyi	72.76	0.00e+00	899.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	46.76	1.00e-150	526.00
IUUC-Cne-026849	Cryptococcus neoformans	47.30	1.00e-153	536.00
IUUC-Dre-028245	Danio rerio	72.09	0.00e+00	1219.00
IUUC-Dno-029618	Dasypus novemcinctus	93.84	0.00e+00	1732.00
IUUC-Dor-030665	Dipodomys ordii	77.35	0.00e+00	1154.00
IUUC-Dse-031241	Dothistroma septosporum	45.90	1.00e-149	523.00
IUUC-Dme-032041	Drosophila melanogaster	69.90	0.00e+00	897.00
IUUC-Ete-032779	Echinops telfairi	94.91	0.00e+00	1114.00
IUUC-Eca-033313	Equus caballus	92.54	0.00e+00	1673.00
IUUC-Eeu-035259	Erinaceus europaeus	85.30	0.00e+00	1552.00
IUUC-Fca-035420	Felis catus	93.08	0.00e+00	1723.00
IUUC-Fal-037335	Ficedula albicollis	82.26	0.00e+00	1504.00
IUUC-Fox-037774	Fusarium oxysporum	46.62	8.00e-151	527.00
IUUC-Fso-038393	Fusarium solani	46.28	7.00e-150	524.00
IUUC-Gmo-039172	Gadus morhua	86.49	0.00e+00	1048.00
IUUC-Ggr-040107	Gaeumannomyces graminis	46.50	6.00e-150	524.00
IUUC-Gga-040246	Gallus gallus	83.17	0.00e+00	1529.00
IUUC-Gac-042211	Gasterosteus aculeatus	90.99	0.00e+00	1158.00
IUUC-Ggo-045001	Gorilla gorilla	93.61	0.00e+00	1550.00
IUUC-Hsa-046544	Homo sapiens	93.95	0.00e+00	1748.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	92.15	0.00e+00	1676.00
IUUC-Kpa-049273	Komagataella pastoris	47.43	1.00e-157	550.00
IUUC-Lch-050398	Latimeria chalumnae	93.92	0.00e+00	1160.00
IUUC-Loc-052116	Lepisosteus oculatus	93.71	0.00e+00	1177.00
IUUC-Laf-053551	Loxodonta africana	92.12	0.00e+00	1684.00
IUUC-Mor-057097	Magnaporthe oryzae	46.13	1.00e-149	523.00
IUUC-Mpo-057442	Magnaporthe poae	49.80	2.00e-139	490.00
IUUC-Mla-058996	Melampsora laricipopulina	50.41	5.00e-144	504.00
IUUC-Mga-059986	Meleagris gallopavo	83.10	0.00e+00	1528.00
IUUC-Mvi-060395	Microbotryum violaceum	49.90	4.00e-143	501.00
IUUC-Mmr-060945	Microcebus murinus	91.14	0.00e+00	1670.00
IUUC-Mdo-063024	Monodelphis domestica	82.06	0.00e+00	1458.00
IUUC-Mmu-063202	Mus musculus	89.95	0.00e+00	1613.00
IUUC-Mpu-065773	Mustela putorius furo	94.38	0.00e+00	1736.00
IUUC-Mlu-067373	Myotis lucifugus	96.49	0.00e+00	647.00
IUUC-Nfi-068427	Neosartorya fischeri	46.25	9.00e-153	533.00
IUUC-Ncr-068918	Neurospora crassa	45.36	8.00e-147	514.00
IUUC-Nle-069188	Nomascus leucogenys	94.38	0.00e+00	1753.00
IUUC-Opr-070965	Ochotona princeps	88.43	0.00e+00	1609.00
IUUC-Ont-072226	Oreochromis niloticus	91.22	0.00e+00	1162.00
IUUC-Oan-073497	Ornithorhynchus anatinus	86.29	0.00e+00	1530.00
IUUC-Ocu-073891	Oryctolagus cuniculus	89.52	0.00e+00	1630.00
IUUC-Ola-087438	Oryzias latipes	91.39	0.00e+00	1161.00
IUUC-Oga-087922	Otolemur garnettii	93.41	0.00e+00	1709.00
IUUC-Oar-089317	Ovis aries	93.63	0.00e+00	1714.00
IUUC-Ptr-090484	Pan troglodytes	93.84	0.00e+00	1748.00
IUUC-Pan-092117	Papio anubis	94.16	0.00e+00	1751.00
IUUC-Psi-093338	Pelodiscus sinensis	83.91	0.00e+00	1548.00
IUUC-Pma-094279	Petromyzon marinus	74.83	0.00e+00	842.00
IUUC-Pno-095118	Phaeosphaeria nodorum	44.32	3.00e-148	519.00
IUUC-Pfo-096171	Poecilia formosa	91.72	0.00e+00	1167.00
IUUC-Pab-098654	Pongo abelii	92.83	0.00e+00	1273.00
IUUC-Pca-100501	Procavia capensis	74.06	0.00e+00	889.00
IUUC-Pva-102811	Pteropus vampyrus	80.22	0.00e+00	1427.00
IUUC-Pte-104016	Pyrenophora teres	45.39	8.00e-147	514.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	45.39	8.00e-147	514.00
IUUC-Rno-106125	Rattus norvegicus	89.41	0.00e+00	1630.00
IUUC-Sce-106289	Saccharomyces cerevisiae	46.87	2.00e-155	543.00
IUUC-Sha-107243	Sarcophilus harrisii	85.28	0.00e+00	1534.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.49	2.00e-148	519.00
IUUC-Spo-108171	Schizosaccharomyces pombe	49.74	5.00e-157	548.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.51	3.00e-149	522.00
IUUC-Sar-113761	Sorex araneus	76.91	0.00e+00	963.00
IUUC-Sre-114929	Sporisorium reilianum	45.70	3.00e-150	525.00
IUUC-Tgu-117079	Taeniopygia guttata	82.15	0.00e+00	1496.00
IUUC-Tru-118062	Takifugu rubripes	71.78	0.00e+00	1338.00
IUUC-Tsy-119507	Tarsius syrichta	88.54	0.00e+00	1608.00
IUUC-Tni-120151	Tetraodon nigroviridis	91.20	0.00e+00	1156.00
IUUC-Tre-122203	Trichoderma reesei	46.22	2.00e-147	516.00
IUUC-Tvi-122595	Trichoderma virens	45.15	2.00e-148	519.00
IUUC-Tme-126897	Tuber melanosporum	47.86	2.00e-140	493.00
IUUC-Ttr-129260	Tursiops truncatus	85.73	0.00e+00	1519.00
IUUC-Uma-129332	Ustilago maydis	45.70	6.00e-144	504.00
IUUC-Vda-129753	Verticillium dahliae	45.33	3.00e-147	515.00
IUUC-Vpa-130390	Vicugna pacos	84.69	0.00e+00	949.00
IUUC-Xtr-132877	Xenopus tropicalis	70.50	0.00e+00	1198.00
IUUC-Xma-133778	Xiphophorus maculatus	91.72	0.00e+00	1165.00
IUUC-Yli-134668	Yarrowia lipolytica	44.57	7.00e-149	520.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence