iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073537

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01058961

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000006879.3	ENSOANT00000010966.1	ENSOANP00000010964.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.70e-107	358.6	779	1111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenp...kepkgellkslqklfeelwkskkkavsprellkalkkeaee 83
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++e++n++ +    ++kge+++++  ++++lw+++ +++sp++++ +++k++ +
   Q: 779  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnFYQEDINRQ-RsnlLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQ 864
           7******************************5334444433.3244899************************************** PP
   S: 84   fsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssr 165
           fsgy+qqD+qE+l fl+d+l+e+l+k +n ++++ee++d  +l+d      a+ k+k+ n+s+i+ lFqgq+ks+++cl+c+++s +
   Q: 865  FSGYSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENND--HLDDCraaelAWHKHKQLNESIIVALFQGQFKSTVQCLTCHKRSRT 949
           ************************885555555554444..3333344555************************************ PP
   S: 166  eepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkk 252
           +e f++lslp+ + +++   slqdcL+ f+kee+l+++n++yc++ck ++++ kk++++klP+vL +hLkRfs++ +   ++k++++
   Q: 950  FEAFMYLSLPLASTSKC---SLQDCLRLFSKEEKLTDNNRFYCSHCKTRRDSLKKIEIWKLPPVLLVHLKRFSYEGR--WKQKLQTS 1031
           ****************9...****************************************************99765..556***** PP
   S: 253  vefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           v+fple Ldls++++ ++++    k+Y+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1032 VDFPLEsLDLSQYVIGSKSS---LKRYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1111
           ****************7766...79*************************88888*******************...********8 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MPAVASGPKD LYLCSSLKDL NKKTEVKPEK ISTKSYIHSA LKIFKTAEES RLDRDEEKAY 60
VLYMKYVTVY NLIKIRPDFK QQQDYFHSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTGCTG TGGCCTCCGG ACCTAAAGAC CTCTACCTCT GTTCTTCACT GAAAGATCTT 60
AACAAGAAGA CAGAAGTTAA ACCAGAGAAA ATAAGTACCA AATCGTACGT ATGGTTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	76.28	0.00e+00	1535.00
IUUC-Apl-003226	Anas platyrhynchos	76.73	0.00e+00	897.00
IUUC-Aca-004936	Anolis carolinensis	87.50	0.00e+00	855.00
IUUC-Ago-007959	Ashbya gossypii	35.69	7.00e-53	201.00
IUUC-Acl-008102	Aspergillus clavatus	31.15	5.00e-51	196.00
IUUC-Afl-008604	Aspergillus flavus	30.05	2.00e-49	190.00
IUUC-Afu-009001	Aspergillus fumigatus	31.49	8.00e-51	195.00
IUUC-Ani-009291	Aspergillus nidulans	30.68	2.00e-49	190.00
IUUC-Ang-009844	Aspergillus niger	31.22	8.00e-49	188.00
IUUC-Aor-010098	Aspergillus oryzae	30.05	8.00e-49	188.00
IUUC-Ate-010585	Aspergillus terreus	30.49	3.00e-50	192.00
IUUC-Ame-010960	Astyanax mexicanus	78.33	5.00e-86	308.00
IUUC-Bta-013008	Bos taurus	80.59	0.00e+00	903.00
IUUC-Bol-015281	Brassica oleracea	38.87	4.00e-48	185.00
IUUC-Bra-017228	Brassica rapa	39.76	2.00e-50	192.00
IUUC-Cel-018482	Caenorhabditis elegans	34.69	8.00e-51	194.00
IUUC-Cja-019173	Callithrix jacchus	83.04	0.00e+00	945.00
IUUC-Cfa-021243	Canis familiaris	84.75	0.00e+00	954.00
IUUC-Cpo-021522	Cavia porcellus	74.71	0.00e+00	1486.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.67	4.00e-80	290.00
IUUC-Csa-023616	Chlorocebus sabaeus	83.19	0.00e+00	940.00
IUUC-Cho-024381	Choloepus hoffmanni	64.79	0.00e+00	1259.00
IUUC-Cin-025287	Ciona intestinalis	48.92	4.00e-97	348.00
IUUC-Csv-026253	Ciona savignyi	41.17	6.00e-87	315.00
IUUC-Cne-026821	Cryptococcus neoformans	39.94	3.00e-72	266.00
IUUC-Dre-028440	Danio rerio	68.03	0.00e+00	724.00
IUUC-Dno-029039	Dasypus novemcinctus	83.59	0.00e+00	968.00
IUUC-Dor-031043	Dipodomys ordii	90.95	7.00e-124	437.00
IUUC-Dse-031463	Dothistroma septosporum	29.07	3.00e-41	163.00
IUUC-Dme-032089	Drosophila melanogaster	44.91	9.00e-83	301.00
IUUC-Ete-033040	Echinops telfairi	70.03	0.00e+00	1308.00
IUUC-Eca-033449	Equus caballus	77.20	0.00e+00	1554.00
IUUC-Eeu-034693	Erinaceus europaeus	90.52	4.00e-122	432.00
IUUC-Fca-035794	Felis catus	92.03	0.00e+00	864.00
IUUC-Fal-037322	Ficedula albicollis	80.52	0.00e+00	906.00
IUUC-Gmo-038584	Gadus morhua	60.38	0.00e+00	656.00
IUUC-Gga-041188	Gallus gallus	81.15	0.00e+00	906.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.29	0.00e+00	729.00
IUUC-Ggo-045565	Gorilla gorilla	83.22	0.00e+00	946.00
IUUC-Hsa-046438	Homo sapiens	83.22	0.00e+00	946.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	75.07	0.00e+00	1486.00
IUUC-Kpa-049321	Komagataella pastoris	32.15	5.00e-47	181.00
IUUC-Lch-050485	Latimeria chalumnae	83.37	0.00e+00	856.00
IUUC-Loc-052769	Lepisosteus oculatus	72.34	0.00e+00	761.00
IUUC-Lma-053021	Leptosphaeria maculans	32.62	8.00e-53	201.00
IUUC-Laf-053432	Loxodonta africana	77.59	0.00e+00	907.00
IUUC-Mcc-055823	Macaca mulatta	83.22	0.00e+00	946.00
IUUC-Meu-056099	Macropus eugenii	94.80	6.00e-159	554.00
IUUC-Mla-059089	Melampsora laricipopulina	40.55	2.00e-70	260.00
IUUC-Mga-059739	Meleagris gallopavo	81.33	0.00e+00	909.00
IUUC-Mvi-060559	Microbotryum violaceum	41.19	1.00e-74	274.00
IUUC-Mmr-061158	Microcebus murinus	75.78	0.00e+00	1516.00
IUUC-Mdo-061801	Monodelphis domestica	87.50	0.00e+00	977.00
IUUC-Mmu-063665	Mus musculus	71.34	0.00e+00	1424.00
IUUC-Mpu-066738	Mustela putorius furo	74.00	0.00e+00	1516.00
IUUC-Mlu-067307	Myotis lucifugus	74.20	0.00e+00	1512.00
IUUC-Nfi-068410	Neosartorya fischeri	31.49	4.00e-51	196.00
IUUC-Nle-069314	Nomascus leucogenys	83.39	0.00e+00	949.00
IUUC-Opr-070378	Ochotona princeps	63.08	2.00e-143	502.00
IUUC-Ont-071545	Oreochromis niloticus	74.24	0.00e+00	756.00
IUUC-Ocu-074193	Oryctolagus cuniculus	75.22	0.00e+00	1519.00
IUUC-Ola-086622	Oryzias latipes	75.00	0.00e+00	736.00
IUUC-Oga-088271	Otolemur garnettii	80.17	0.00e+00	923.00
IUUC-Oar-090431	Ovis aries	80.94	0.00e+00	905.00
IUUC-Ptr-091339	Pan troglodytes	75.95	0.00e+00	1571.00
IUUC-Pan-091783	Papio anubis	70.89	0.00e+00	647.00
IUUC-Psi-093187	Pelodiscus sinensis	65.55	1.00e-158	553.00
IUUC-Pma-094626	Petromyzon marinus	58.47	9.00e-142	496.00
IUUC-Pno-094986	Phaeosphaeria nodorum	30.51	3.00e-38	153.00
IUUC-Pfo-096463	Poecilia formosa	75.56	0.00e+00	745.00
IUUC-Pab-097645	Pongo abelii	83.39	0.00e+00	948.00
IUUC-Pva-103222	Pteropus vampyrus	89.07	0.00e+00	707.00
IUUC-Pgr-103408	Puccinia graminis	35.58	2.00e-52	200.00
IUUC-Ptt-103699	Puccinia triticina	45.83	2.00e-66	247.00
IUUC-Pte-104348	Pyrenophora teres	29.13	4.00e-40	159.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	32.04	3.00e-51	196.00
IUUC-Rno-105510	Rattus norvegicus	71.61	0.00e+00	1449.00
IUUC-Sce-106166	Saccharomyces cerevisiae	33.70	5.00e-49	189.00
IUUC-Sha-106879	Sarcophilus harrisii	87.88	0.00e+00	959.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.08	4.00e-47	182.00
IUUC-Smo-108711	Selaginella moellendorffii	34.18	2.00e-47	182.00
IUUC-Sar-113019	Sorex araneus	72.87	0.00e+00	1469.00
IUUC-Sre-115031	Sporisorium reilianum	34.49	9.00e-68	251.00
IUUC-Ssc-116334	Sus scrofa	74.49	0.00e+00	1504.00
IUUC-Tgu-117062	Taeniopygia guttata	81.46	0.00e+00	910.00
IUUC-Tru-117908	Takifugu rubripes	73.02	0.00e+00	742.00
IUUC-Tsy-118867	Tarsius syrichta	76.30	0.00e+00	838.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.85	0.00e+00	728.00
IUUC-Tme-127144	Tuber melanosporum	39.55	3.00e-77	283.00
IUUC-Tbe-127877	Tupaia belangeri	92.81	6.00e-78	285.00
IUUC-Ttr-128580	Tursiops truncatus	81.83	0.00e+00	919.00
IUUC-Uma-129340	Ustilago maydis	35.58	2.00e-70	260.00
IUUC-Vpa-130541	Vicugna pacos	76.57	0.00e+00	1528.00
IUUC-Xtr-132161	Xenopus tropicalis	77.25	0.00e+00	790.00
IUUC-Xma-134271	Xiphophorus maculatus	75.35	0.00e+00	742.00
IUUC-Yli-134561	Yarrowia lipolytica	35.47	5.00e-59	222.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence