iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033661

UUCD1 version

UUC-EqC-01027

Ensembl Protein ID

ENSECAP00000014363.1

UniProt Accession

F6YHA4; F6YHA4_HORSE

Protein Name

Uncharacterized protein

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000016554.1	ENSECAT00000017668.1	ENSECAP00000014363.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-115	384.7	536	1253

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 536  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 622
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 623  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 707
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 708  FLYLPVPLPQKQKVLPVfyfarephskpikflvsiskenssasevldsisqsvhvkpenlrlteviknrfhrvflpshsldtvspsd 794
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 795  vllcfellspelakervvvlevqqrpqvpsiriskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 881
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 882  lvsvpasrltyarlaqllegyarfsvsvfqppfqpgrmalesqgpgcttllstssleagdserdpvqlpelqlvtpvaegdtgvpra 968
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 969  waapdrgpvpsmsgvssemlasgpvevgslpagervsrpeaavpgyqhpseamnahtpqffiykidasnreqrledkgdtplelgdd 1055
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1056 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1142
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1143 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1226
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1227 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1253
           ****************...********996 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MSGGASATGP RRGPPGLEEA TSKKKQKDRA NQESKNGDPR RASTPREEQT KEELLLDWRQ 60
SADEVIVKLR VGAGPLRLEE VDAAFTDTDC VVRLPGGRQW GGVFYAEIES SCTKVQARKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGGCG GGGCCAGTGC CACAGGCCCG AGGAGAGGGC CTCCAGGACT GGAGGAGGCC 60
ACCAGTAAGA AGAAGCAAAA GGATCGAGCA AACCAGGAGA GCAAGAATGG AGATCCTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	92.82	0.00e+00	2303.00
IUUC-Apl-003368	Anas platyrhynchos	67.18	0.00e+00	1682.00
IUUC-Aca-004267	Anolis carolinensis	67.71	0.00e+00	1658.00
IUUC-Ame-010970	Astyanax mexicanus	70.25	0.00e+00	1332.00
IUUC-Bta-012905	Bos taurus	90.86	0.00e+00	2269.00
IUUC-Cel-018257	Caenorhabditis elegans	43.48	6.00e-91	329.00
IUUC-Cja-018789	Callithrix jacchus	89.07	0.00e+00	2342.00
IUUC-Cfa-021004	Canis familiaris	91.47	0.00e+00	2296.00
IUUC-Cpo-021529	Cavia porcellus	90.35	0.00e+00	2313.00
IUUC-Csa-024035	Chlorocebus sabaeus	92.08	0.00e+00	2301.00
IUUC-Cho-025036	Choloepus hoffmanni	88.14	0.00e+00	1241.00
IUUC-Cin-025451	Ciona intestinalis	43.41	2.00e-86	314.00
IUUC-Csv-025931	Ciona savignyi	36.59	1.00e-111	397.00
IUUC-Dre-028556	Danio rerio	68.12	0.00e+00	1319.00
IUUC-Dno-029240	Dasypus novemcinctus	88.91	0.00e+00	2169.00
IUUC-Dor-030495	Dipodomys ordii	94.68	0.00e+00	1259.00
IUUC-Ete-032741	Echinops telfairi	92.53	0.00e+00	1854.00
IUUC-Eeu-034648	Erinaceus europaeus	92.93	0.00e+00	830.00
IUUC-Fca-035646	Felis catus	91.42	0.00e+00	2265.00
IUUC-Fal-037094	Ficedula albicollis	67.66	0.00e+00	1767.00
IUUC-Gmo-038869	Gadus morhua	71.62	0.00e+00	836.00
IUUC-Gga-041170	Gallus gallus	66.23	0.00e+00	1707.00
IUUC-Gac-041901	Gasterosteus aculeatus	64.32	0.00e+00	1311.00
IUUC-Ggo-044708	Gorilla gorilla	89.64	0.00e+00	2389.00
IUUC-Hsa-046791	Homo sapiens	94.75	0.00e+00	2051.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	88.83	0.00e+00	2305.00
IUUC-Lch-050456	Latimeria chalumnae	51.88	0.00e+00	1204.00
IUUC-Loc-052861	Lepisosteus oculatus	59.16	0.00e+00	1132.00
IUUC-Laf-053788	Loxodonta africana	93.17	0.00e+00	2326.00
IUUC-Mcc-055693	Macaca mulatta	88.02	0.00e+00	2286.00
IUUC-Meu-055921	Macropus eugenii	78.72	0.00e+00	1519.00
IUUC-Mga-059879	Meleagris gallopavo	69.13	0.00e+00	1708.00
IUUC-Mmr-060802	Microcebus murinus	91.96	0.00e+00	2402.00
IUUC-Mdo-061856	Monodelphis domestica	82.22	0.00e+00	1620.00
IUUC-Mmu-063874	Mus musculus	91.84	0.00e+00	2319.00
IUUC-Mpu-066166	Mustela putorius furo	91.09	0.00e+00	2271.00
IUUC-Nle-070161	Nomascus leucogenys	89.50	0.00e+00	2400.00
IUUC-Opr-071015	Ochotona princeps	93.06	0.00e+00	1915.00
IUUC-Ont-072308	Oreochromis niloticus	69.25	0.00e+00	1360.00
IUUC-Oan-072723	Ornithorhynchus anatinus	66.19	0.00e+00	1639.00
IUUC-Ocu-073938	Oryctolagus cuniculus	89.76	0.00e+00	2232.00
IUUC-Ola-086375	Oryzias latipes	69.56	0.00e+00	1326.00
IUUC-Oga-088297	Otolemur garnettii	90.54	0.00e+00	2325.00
IUUC-Oar-089675	Ovis aries	95.15	0.00e+00	1658.00
IUUC-Ptr-091621	Pan troglodytes	94.66	0.00e+00	2056.00
IUUC-Pan-092118	Papio anubis	88.88	0.00e+00	2303.00
IUUC-Pfo-097246	Poecilia formosa	74.69	0.00e+00	929.00
IUUC-Pab-098551	Pongo abelii	94.13	0.00e+00	2018.00
IUUC-Pca-100158	Procavia capensis	89.11	0.00e+00	2284.00
IUUC-Pva-103160	Pteropus vampyrus	95.66	0.00e+00	2385.00
IUUC-Rno-105355	Rattus norvegicus	92.26	0.00e+00	2365.00
IUUC-Sha-107057	Sarcophilus harrisii	76.63	0.00e+00	1754.00
IUUC-Sar-113011	Sorex araneus	91.55	0.00e+00	1506.00
IUUC-Ssc-115761	Sus scrofa	90.90	0.00e+00	2311.00
IUUC-Tgu-116956	Taeniopygia guttata	62.80	0.00e+00	827.00
IUUC-Tru-118739	Takifugu rubripes	67.88	0.00e+00	1343.00
IUUC-Tsy-118827	Tarsius syrichta	87.32	0.00e+00	1271.00
IUUC-Tni-119921	Tetraodon nigroviridis	59.94	0.00e+00	1397.00
IUUC-Tbe-128017	Tupaia belangeri	92.29	0.00e+00	1955.00
IUUC-Ttr-128869	Tursiops truncatus	94.85	0.00e+00	2385.00
IUUC-Vpa-130427	Vicugna pacos	96.15	0.00e+00	929.00
IUUC-Xtr-132734	Xenopus tropicalis	61.04	0.00e+00	1532.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence