iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000009094.1	ENSLACT00000010403.1	ENSLACP00000010325.1
ENSLACG00000009094.1	ENSLACT00000010404.1	ENSLACP00000010326.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-122	408.1	1254	1586

Active Site

Position(s)	Description	Evidence
1554	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1254 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1339
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1340 AFFTRPFYKGLLRISCDLSDLEYLDEEFHQSLQWMKDN---DINDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1422
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1423 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1509
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1510 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1586
           **************************************************************************985 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQLR YTLSPENLQS LVSQNSMAEN LNFQRANSDT DLVTSDSRSS 60
LTASMYEYTL GLSQNLIIYW DIKEEVDPTD WIGLYHIDEN SPANVWDSKN RGVNGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATGAAAGGC AGCGGCTCAG AGCAGAATGA CGCAGAGGAA ACACGTTTCA AAGCAACTGG 60
ATCCTGTCAA TATAATCCAG CTCCTGACCT GACTTGGGAA TCCGTGCTTC CCGTATTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

lcm:102365712

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	76.94	0.00e+00	2452.00
IUUC-Apl-003935	Anas platyrhynchos	79.89	0.00e+00	2511.00
IUUC-Aca-004558	Anolis carolinensis	79.56	0.00e+00	2490.00
IUUC-Ame-010893	Astyanax mexicanus	89.45	0.00e+00	1321.00
IUUC-Bta-013093	Bos taurus	89.91	0.00e+00	1489.00
IUUC-Cel-018137	Caenorhabditis elegans	42.29	2.00e-91	330.00
IUUC-Cja-019651	Callithrix jacchus	76.96	0.00e+00	2311.00
IUUC-Cfa-021232	Canis familiaris	92.68	0.00e+00	1537.00
IUUC-Cpo-021770	Cavia porcellus	74.92	0.00e+00	2398.00
IUUC-Csa-023970	Chlorocebus sabaeus	78.20	0.00e+00	2436.00
IUUC-Cho-024512	Choloepus hoffmanni	71.83	0.00e+00	2165.00
IUUC-Csv-026127	Ciona savignyi	66.02	6.00e-157	546.00
IUUC-Dre-028275	Danio rerio	84.73	0.00e+00	1476.00
IUUC-Dno-029963	Dasypus novemcinctus	76.78	0.00e+00	2313.00
IUUC-Dor-030282	Dipodomys ordii	66.47	0.00e+00	1446.00
IUUC-Dme-032217	Drosophila melanogaster	70.78	0.00e+00	653.00
IUUC-Ete-033132	Echinops telfairi	77.88	0.00e+00	1190.00
IUUC-Eca-033978	Equus caballus	77.88	0.00e+00	2448.00
IUUC-Eeu-035278	Erinaceus europaeus	95.25	0.00e+00	731.00
IUUC-Fca-036157	Felis catus	77.94	0.00e+00	2415.00
IUUC-Fal-037110	Ficedula albicollis	77.61	0.00e+00	2222.00
IUUC-Gmo-039291	Gadus morhua	73.55	0.00e+00	1157.00
IUUC-Gga-040821	Gallus gallus	79.85	0.00e+00	2505.00
IUUC-Gac-042181	Gasterosteus aculeatus	83.11	0.00e+00	1423.00
IUUC-Ggo-044862	Gorilla gorilla	77.65	0.00e+00	2323.00
IUUC-Hsa-046219	Homo sapiens	78.02	0.00e+00	2464.00
IUUC-Loc-052648	Lepisosteus oculatus	86.32	0.00e+00	1507.00
IUUC-Laf-054005	Loxodonta africana	77.67	0.00e+00	2441.00
IUUC-Mcc-055314	Macaca mulatta	77.95	0.00e+00	2427.00
IUUC-Meu-056356	Macropus eugenii	55.10	0.00e+00	851.00
IUUC-Mga-060074	Meleagris gallopavo	79.60	0.00e+00	2413.00
IUUC-Mmr-061526	Microcebus murinus	77.89	0.00e+00	2443.00
IUUC-Mdo-063017	Monodelphis domestica	78.21	0.00e+00	2434.00
IUUC-Mmu-064165	Mus musculus	77.60	0.00e+00	2418.00
IUUC-Mpu-065835	Mustela putorius furo	89.17	0.00e+00	1471.00
IUUC-Mlu-067709	Myotis lucifugus	75.42	0.00e+00	2352.00
IUUC-Nle-069308	Nomascus leucogenys	78.02	0.00e+00	2429.00
IUUC-Opr-070330	Ochotona princeps	65.60	0.00e+00	1951.00
IUUC-Ont-071345	Oreochromis niloticus	86.67	0.00e+00	1450.00
IUUC-Ocu-074775	Oryctolagus cuniculus	76.25	0.00e+00	2197.00
IUUC-Ola-087225	Oryzias latipes	82.66	0.00e+00	1356.00
IUUC-Oga-088177	Otolemur garnettii	76.36	0.00e+00	2361.00
IUUC-Oar-089452	Ovis aries	77.89	0.00e+00	2448.00
IUUC-Ptr-090806	Pan troglodytes	78.08	0.00e+00	2440.00
IUUC-Pan-091838	Papio anubis	77.71	0.00e+00	2316.00
IUUC-Psi-094090	Pelodiscus sinensis	80.10	0.00e+00	2480.00
IUUC-Pfo-096520	Poecilia formosa	66.81	0.00e+00	1489.00
IUUC-Pab-098405	Pongo abelii	78.02	0.00e+00	2435.00
IUUC-Pca-100441	Procavia capensis	70.39	0.00e+00	1802.00
IUUC-Pva-102324	Pteropus vampyrus	92.32	0.00e+00	1532.00
IUUC-Rno-105943	Rattus norvegicus	77.27	0.00e+00	2461.00
IUUC-Sha-106985	Sarcophilus harrisii	75.78	0.00e+00	2031.00
IUUC-Sar-113505	Sorex araneus	89.27	0.00e+00	1449.00
IUUC-Ssc-115439	Sus scrofa	69.52	0.00e+00	1488.00
IUUC-Tgu-117078	Taeniopygia guttata	86.36	0.00e+00	1649.00
IUUC-Tru-118671	Takifugu rubripes	81.86	0.00e+00	1445.00
IUUC-Tsy-119379	Tarsius syrichta	72.97	0.00e+00	704.00
IUUC-Tni-120619	Tetraodon nigroviridis	85.98	0.00e+00	1420.00
IUUC-Tbe-127975	Tupaia belangeri	72.63	0.00e+00	1927.00
IUUC-Ttr-128469	Tursiops truncatus	72.28	0.00e+00	2172.00
IUUC-Vpa-130498	Vicugna pacos	68.44	0.00e+00	2003.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence