iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000008215.4	ENSCAFT00000049155.2	ENSCAFP00000042631.1
ENSCAFG00000008215.4	ENSCAFT00000013084.4	ENSCAFP00000012107.3
ENSCAFG00000008215.4	ENSCAFT00000045246.1	ENSCAFP00000040179.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-64	217.9	169	654

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 169  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 256
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 257  DSQQQDVSEFTHKLLDWLEDAFQM------------------RAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 325
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    ++++++klP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 326  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTKLPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 403
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 404  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvedidassppsgstpqtlpstteq 492
           ****8888888888888888888888888888888888888888888888887777777777777777777777777777777655555 PP
   S: 268  ...peekqke............................................................................... 274
              p     +                                                                               
   Q: 493  qgvP-----Sselpstspasiaaissrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrti 576
           5550.....05555555555666666666666666666666666666666666666666777777777777777777778888888888 PP
   S: 275  ..........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                     ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 577  elmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRENrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 654
           8888888888**************************965556***************99997779************6 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDAQILQQAL KDSNGNLELA VAFLTAKNAK 60
TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNCGCCG 60
GCCGCCATTG CCTTCGAGCC TGGCTGGCGG GGGCGCTGTC CTCCCCGGCG GTCCGCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	95.81	0.00e+00	2109.00
IUUC-Apl-004030	Anas platyrhynchos	83.00	0.00e+00	1893.00
IUUC-Aca-004753	Anolis carolinensis	65.33	0.00e+00	1059.00
IUUC-Acl-008164	Aspergillus clavatus	24.88	3.00e-17	84.30
IUUC-Ani-009503	Aspergillus nidulans	32.82	5.00e-12	67.00
IUUC-Ame-010624	Astyanax mexicanus	71.43	0.00e+00	1152.00
IUUC-Bta-013166	Bos taurus	96.26	0.00e+00	1441.00
IUUC-Cel-018346	Caenorhabditis elegans	28.21	3.00e-30	127.00
IUUC-Cja-019150	Callithrix jacchus	97.24	0.00e+00	2135.00
IUUC-Cpo-021807	Cavia porcellus	92.97	0.00e+00	2144.00
IUUC-Csa-023388	Chlorocebus sabaeus	97.21	0.00e+00	2135.00
IUUC-Cho-024343	Choloepus hoffmanni	98.19	1.00e-155	544.00
IUUC-Cin-025302	Ciona intestinalis	37.73	3.00e-97	348.00
IUUC-Csv-025911	Ciona savignyi	34.10	6.00e-128	451.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.32	1.00e-10	62.80
IUUC-Dre-028016	Danio rerio	75.39	0.00e+00	1704.00
IUUC-Dno-029495	Dasypus novemcinctus	94.97	0.00e+00	2150.00
IUUC-Dor-030948	Dipodomys ordii	81.26	0.00e+00	1506.00
IUUC-Fca-035876	Felis catus	98.56	0.00e+00	1499.00
IUUC-Fal-036762	Ficedula albicollis	83.93	0.00e+00	1118.00
IUUC-Fox-037752	Fusarium oxysporum	23.60	3.00e-15	78.20
IUUC-Gmo-039490	Gadus morhua	72.60	0.00e+00	1605.00
IUUC-Gga-040817	Gallus gallus	84.85	0.00e+00	1962.00
IUUC-Gac-042473	Gasterosteus aculeatus	72.21	0.00e+00	1625.00
IUUC-Ggo-044939	Gorilla gorilla	92.71	0.00e+00	2007.00
IUUC-Hsa-046204	Homo sapiens	97.56	0.00e+00	1464.00
IUUC-Kpa-049349	Komagataella pastoris	27.75	8.00e-10	60.10
IUUC-Lch-049572	Latimeria chalumnae	79.01	0.00e+00	1769.00
IUUC-Loc-052070	Lepisosteus oculatus	78.02	0.00e+00	1737.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	4.00e-12	67.80
IUUC-Laf-054426	Loxodonta africana	96.67	0.00e+00	1321.00
IUUC-Mcc-055858	Macaca mulatta	97.33	0.00e+00	2167.00
IUUC-Mga-059808	Meleagris gallopavo	85.23	0.00e+00	1354.00
IUUC-Mmr-060987	Microcebus murinus	97.24	0.00e+00	2127.00
IUUC-Mmu-064245	Mus musculus	92.68	0.00e+00	1458.00
IUUC-Mpu-066304	Mustela putorius furo	98.56	0.00e+00	2157.00
IUUC-Mlu-067139	Myotis lucifugus	96.07	0.00e+00	1490.00
IUUC-Nfi-068458	Neosartorya fischeri	24.00	2.00e-17	85.50
IUUC-Nle-069075	Nomascus leucogenys	97.82	0.00e+00	1466.00
IUUC-Ont-072150	Oreochromis niloticus	73.57	0.00e+00	1699.00
IUUC-Oan-073054	Ornithorhynchus anatinus	79.77	0.00e+00	1750.00
IUUC-Ocu-074102	Oryctolagus cuniculus	94.97	0.00e+00	2149.00
IUUC-Ola-086529	Oryzias latipes	69.58	0.00e+00	1554.00
IUUC-Oga-088939	Otolemur garnettii	94.49	0.00e+00	1452.00
IUUC-Oar-090266	Ovis aries	96.49	0.00e+00	2116.00
IUUC-Ptr-090546	Pan troglodytes	97.43	0.00e+00	1461.00
IUUC-Pan-092311	Papio anubis	97.24	0.00e+00	2166.00
IUUC-Psi-093459	Pelodiscus sinensis	90.71	0.00e+00	1181.00
IUUC-Pfo-096726	Poecilia formosa	73.89	0.00e+00	1689.00
IUUC-Pab-097608	Pongo abelii	94.14	0.00e+00	2020.00
IUUC-Pca-100718	Procavia capensis	82.35	0.00e+00	1449.00
IUUC-Pva-103150	Pteropus vampyrus	91.67	0.00e+00	1534.00
IUUC-Rno-105727	Rattus norvegicus	93.84	0.00e+00	1422.00
IUUC-Sha-107051	Sarcophilus harrisii	89.11	0.00e+00	1370.00
IUUC-Sar-113097	Sorex araneus	85.39	0.00e+00	1871.00
IUUC-Sre-115145	Sporisorium reilianum	24.53	3.00e-11	65.10
IUUC-Ssc-115877	Sus scrofa	93.65	0.00e+00	1429.00
IUUC-Tgu-117473	Taeniopygia guttata	76.11	0.00e+00	1707.00
IUUC-Tru-118135	Takifugu rubripes	66.43	0.00e+00	1421.00
IUUC-Tsy-119471	Tarsius syrichta	89.49	0.00e+00	1870.00
IUUC-Tni-120139	Tetraodon nigroviridis	69.92	0.00e+00	1009.00
IUUC-Tbe-127549	Tupaia belangeri	87.92	0.00e+00	1891.00
IUUC-Ttr-128896	Tursiops truncatus	90.57	0.00e+00	1975.00
IUUC-Vda-129742	Verticillium dahliae	24.19	3.00e-12	68.20
IUUC-Vpa-130500	Vicugna pacos	92.32	0.00e+00	1328.00
IUUC-Xtr-132896	Xenopus tropicalis	81.25	0.00e+00	1277.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence