iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108285

Ensembl Protein ID

SPAC1486.02c.1:pep

UniProt Accession

Q9UTK7; DSC2_SCHPO

Genbank Protein ID

CAB62412.1

Protein Name

DSC E3 ubiquitin ligase complex subunit 2; Defective for SREBP cleavage protein 2; RING-type E3 ubiquitin transferase DSC2; UBA domain-containing protein 14

Genbank Nucleotide ID

CU329670

Gene Name

dsc2; ucp14; SPAC1486.02c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC1486.02c	SPAC1486.02c.1	SPAC1486.02c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	21504829; 12672455

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	2.30e-05	22.5	330	367

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlve.MGFdreealqaLraannnleaAveyLld 40
           +e+ ++  +  M  +r +a+qaL +  n++++Ave+Ll+
   Q: 330  REEDINTVQTiMQTSRAQAIQALSQ-TNDVQRAVELLLE 367
           67788888888999***********.7**********97 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.

Protein Sequence
(Fasta)

MSSANIVPSN MGITKFLLLT ISTSSVVAGV FALKPFFHIN FGLHLLSHYQ YWRILLWQFI 60
YWNSTEVFQA LFIIYQARDV ERLLGSHRFA SFCVYMFILG MFVTPIFSFL YSLLFKNLDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATACTAGG GATATGCGTT TTCCATAGCA ATCATGTCTA GCGCCAATAT TGGTATGTTA 60
ATGACTAGTT AAACGATATT TTTTATTCTT TTTGTTTTTC TTTTAGAGCT TCATTTGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR022764--Peptidase_S54_rhomboid_dom

Gene Ontology

GO:0044695--C:Dsc E3 ubiquitin ligase complex
GO:0016021--C:integral component of membrane
GO:0031228--C:intrinsic component of Golgi membrane
GO:0016740--F:transferase activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:1900039--P:positive regulation of cellular response to hypoxia
GO:0016485--P:protein processing
GO:0016567--P:protein ubiquitination
GO:0060049--P:regulation of protein glycosylation
GO:0035103--P:sterol regulatory element binding protein cleavage

KEGG

spo:SPAC1486.02c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000266	Aegilops tauschii	41.67	1.80e-01	25.40
IUUC-Aml-002272	Ailuropoda melanoleuca	24.84	3.00e-04	37.40
IUUC-Atr-002884	Amborella trichopoda	28.87	3.00e-07	46.60
IUUC-Apl-004075	Anas platyrhynchos	23.40	8.00e-05	39.30
IUUC-Aly-006411	Arabidopsis lyrata	22.73	9.00e-10	55.50
IUUC-Ath-007083	Arabidopsis thaliana	22.73	1.00e-09	54.70
IUUC-Ago-007789	Ashbya gossypii	26.74	2.00e-06	44.30
IUUC-Acl-008340	Aspergillus clavatus	35.64	3.00e-08	50.40
IUUC-Afu-009037	Aspergillus fumigatus	32.39	1.00e-09	55.10
IUUC-Ang-009777	Aspergillus niger	32.52	9.00e-20	88.20
IUUC-Ame-010961	Astyanax mexicanus	37.21	1.00e-03	33.10
IUUC-Bgr-012021	Blumeria graminis	30.47	6.00e-24	102.00
IUUC-Bci-013918	Botrytis cinerea	36.06	5.00e-28	115.00
IUUC-Bdi-014098	Brachypodium distachyon	25.47	3.00e-10	57.00
IUUC-Bol-015531	Brassica oleracea	22.01	3.00e-08	50.40
IUUC-Bra-017340	Brassica rapa	22.40	1.00e-09	55.10
IUUC-Cel-018544	Caenorhabditis elegans	24.66	8.80e-02	28.90
IUUC-Cja-018818	Callithrix jacchus	26.58	6.00e-05	39.70
IUUC-Cre-022898	Chlamydomonas reinhardtii	23.08	3.00e-03	33.50
IUUC-Csa-024015	Chlorocebus sabaeus	25.93	2.00e-04	37.70
IUUC-Cho-024706	Choloepus hoffmanni	23.65	9.00e-05	38.90
IUUC-Cin-025284	Ciona intestinalis	44.68	5.60e-02	31.20
IUUC-Cgl-026433	Colletotrichum gloeosporioides	31.60	4.00e-26	109.00
IUUC-Cne-026916	Cryptococcus neoformans	31.58	9.00e-17	79.00
IUUC-Dre-027633	Danio rerio	26.47	2.00e-06	45.10
IUUC-Dno-029418	Dasypus novemcinctus	26.28	3.00e-06	44.30
IUUC-Dor-030432	Dipodomys ordii	26.58	3.00e-05	40.80
IUUC-Dse-031426	Dothistroma septosporum	34.31	7.00e-23	98.60
IUUC-Dme-031801	Drosophila melanogaster	33.85	8.70e-02	31.60
IUUC-Eca-034280	Equus caballus	25.50	2.00e-05	41.20
IUUC-Eeu-034998	Erinaceus europaeus	26.17	7.00e-07	45.80
IUUC-Fca-036332	Felis catus	25.17	3.00e-05	40.80
IUUC-Fox-037932	Fusarium oxysporum	33.17	8.00e-27	111.00
IUUC-Fso-038343	Fusarium solani	32.69	1.00e-20	91.30
IUUC-Ggr-039926	Gaeumannomyces graminis	32.86	1.00e-27	114.00
IUUC-Gac-041765	Gasterosteus aculeatus	24.78	3.00e-06	43.90
IUUC-Gma-043546	Glycine max	22.97	2.00e-08	51.20
IUUC-Hvu-047737	Hordeum vulgare	26.25	4.00e-10	56.20
IUUC-Kpa-049248	Komagataella pastoris	28.83	5.00e-12	62.80
IUUC-Lch-049713	Latimeria chalumnae	27.62	9.30e-02	30.00
IUUC-Lpe-050798	Leersia perrieri	25.83	1.00e-08	51.60
IUUC-Loc-052511	Lepisosteus oculatus	25.84	2.00e-06	44.70
IUUC-Laf-053414	Loxodonta africana	24.52	1.00e-04	38.90
IUUC-Mcc-055111	Macaca mulatta	25.93	2.00e-04	37.70
IUUC-Meu-056905	Macropus eugenii	28.09	3.00e-04	37.40
IUUC-Mor-057083	Magnaporthe oryzae	33.65	5.00e-26	109.00
IUUC-Mpo-057326	Magnaporthe poae	32.39	2.00e-26	110.00
IUUC-Mtr-057918	Medicago truncatula	22.51	4.00e-09	53.10
IUUC-Mla-058868	Melampsora laricipopulina	29.19	2.00e-08	50.40
IUUC-Mvi-060380	Microbotryum violaceum	29.81	1.00e-14	72.00
IUUC-Mmr-061267	Microcebus murinus	28.44	7.00e-05	39.30
IUUC-Mdo-062640	Monodelphis domestica	25.50	9.00e-06	42.40
IUUC-Mmu-063305	Mus musculus	25.93	7.00e-06	42.70
IUUC-Mac-065255	Musa acuminata	22.68	1.00e-10	58.50
IUUC-Mpu-066519	Mustela putorius furo	25.52	2.00e-05	41.20
IUUC-Nfi-068304	Neosartorya fischeri	27.56	1.00e-13	68.20
IUUC-Ncr-068703	Neurospora crassa	33.82	8.00e-28	115.00
IUUC-Nle-070130	Nomascus leucogenys	33.33	4.00e-04	36.60
IUUC-Opr-070252	Ochotona princeps	24.66	8.00e-05	39.30
IUUC-Oan-072843	Ornithorhynchus anatinus	35.29	2.00e-03	33.50
IUUC-Ocu-073940	Oryctolagus cuniculus	24.69	3.00e-05	40.40
IUUC-Oba-075447	Oryza barthii	23.12	1.00e-08	51.60
IUUC-Obr-076812	Oryza brachyantha	25.00	6.00e-10	55.80
IUUC-Ogl-077322	Oryza glaberrima	25.33	1.00e-08	51.60
IUUC-Ogu-078996	Oryza glumaepatula	25.33	1.00e-08	51.60
IUUC-Oin-080171	Oryza indica	23.46	7.00e-09	52.40
IUUC-Olo-081041	Oryza longistaminata	25.87	4.00e-08	51.20
IUUC-Ome-081238	Oryza meridionalis	25.16	7.00e-09	52.00
IUUC-Oni-082310	Oryza nivara	25.33	8.00e-09	52.00
IUUC-Opu-083755	Oryza punctata	24.38	2.00e-09	54.70
IUUC-Oru-084586	Oryza rufipogon	25.33	7.00e-09	52.40
IUUC-Osa-085870	Oryza sativa	23.12	1.00e-08	51.60
IUUC-Ola-086401	Oryzias latipes	33.33	3.10e-01	29.30
IUUC-Olu-087791	Ostreococcus lucimarinus	22.99	2.40e-02	30.00
IUUC-Oga-088600	Otolemur garnettii	26.80	1.00e-05	42.00
IUUC-Pno-095028	Phaeosphaeria nodorum	29.63	2.00e-21	94.00
IUUC-Ppa-095918	Physcomitrella patens	23.87	1.00e-08	51.20
IUUC-Pab-097915	Pongo abelii	26.09	1.00e-04	39.30
IUUC-Pop-099311	Populus trichocarpa	22.73	2.00e-09	53.90
IUUC-Ppe-101164	Prunus persica	23.03	3.00e-11	60.10
IUUC-Pva-102466	Pteropus vampyrus	25.17	2.00e-05	41.60
IUUC-Pgr-103488	Puccinia graminis	29.66	3.00e-09	53.50
IUUC-Pte-104413	Pyrenophora teres	30.80	2.00e-18	84.00
IUUC-Pyt-104659	Pyrenophora triticirepentis	28.82	1.00e-17	80.90
IUUC-Rno-105226	Rattus norvegicus	25.77	1.00e-04	38.50
IUUC-Sce-106268	Saccharomyces cerevisiae	21.92	2.00e-08	50.80
IUUC-Sja-107960	Schizosaccharomyces japonicus	35.36	2.00e-59	220.00
IUUC-Ssl-108440	Sclerotinia sclerotiorum	36.54	2.00e-30	124.00
IUUC-Smo-108945	Selaginella moellendorffii	25.00	2.00e-05	41.20
IUUC-Sit-109805	Setaria italica	24.84	3.00e-11	60.10
IUUC-Sly-111445	Solanum lycopersicum	21.89	3.00e-07	47.00
IUUC-Stu-112541	Solanum tuberosum	23.32	5.00e-07	46.20
IUUC-Sar-113380	Sorex araneus	33.33	5.00e-03	32.70
IUUC-Sbi-113948	Sorghum bicolor	25.16	3.00e-11	60.10
IUUC-Sre-114903	Sporisorium reilianum	31.79	3.00e-15	73.60
IUUC-Ssc-115286	Sus scrofa	35.56	8.00e-04	35.40
IUUC-Tru-118110	Takifugu rubripes	24.24	3.00e-06	44.30
IUUC-Tsy-118933	Tarsius syrichta	32.08	1.00e-03	35.00
IUUC-Tni-119811	Tetraodon nigroviridis	23.68	4.00e-07	47.00
IUUC-Tca-121053	Theobroma cacao	24.32	9.00e-09	52.00
IUUC-Tre-122152	Trichoderma reesei	33.17	9.00e-26	108.00
IUUC-Tvi-122334	Trichoderma virens	30.29	1.00e-24	104.00
IUUC-Tae-124151	Triticum aestivum	25.62	6.00e-10	55.80
IUUC-Tur-126868	Triticum urartu	25.17	3.00e-09	53.10
IUUC-Tme-127059	Tuber melanosporum	34.65	8.00e-32	128.00
IUUC-Ttr-128543	Tursiops truncatus	25.33	8.00e-05	39.30
IUUC-Uma-129462	Ustilago maydis	28.84	4.00e-16	77.00
IUUC-Vda-129740	Verticillium dahliae	32.54	4.00e-25	106.00
IUUC-Vvi-131299	Vitis vinifera	26.62	1.00e-11	61.60
IUUC-Xtr-132867	Xenopus tropicalis	23.71	2.00e-06	44.70
IUUC-Yli-134415	Yarrowia lipolytica	32.67	2.00e-26	110.00
IUUC-Zma-135390	Zea mays	25.16	9.00e-11	58.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence