iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133497

Ensembl Protein ID

ENSXMAP00000009389.1

UniProt Accession

M4A4J5; M4A4J5_XIPMA

Genbank Protein ID

ENSXMAP00000009389

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01038311

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000009354.1	ENSXMAT00000009403.1	ENSXMAP00000009389.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-120	402.7	1494	1962

Active Site

Position(s)	Description	Evidence
1931	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 1494 HADRKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgfyvqrscglfpapfpqdsee 1579
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp s++f+kll                                                  
   Q: 1580 leRITKLFHFLGIFLAKCIQDNRLVDLPVSQPFFKLLcmgdiksnmskllyqsrgsppghgperahlqallsevqseasteesqety 1666
           *************************************************99999999999999999999999999999999988888 PP
   S: 101  .........................lgkklsledleevdpelykslkeikena.......es......................... 130
                                     +  l+++d++ v+p+++ +lke+ke+a       +s                         
   Q: 1667 svgsfdedsksefimdppkrkppawYHGILTWDDFQLVNPHRATFLKEVKELAvkrrqilSSkslsedekntrlqdlmlrnpmgsgp 1753
           88888887777777666665555555557***********************97666655005666677788999999999999*** PP
   S: 131  ..dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeele 215
             +ie+lgl+++f++s+++ g  +++ Lkp+G++++Vt eN+eeYv+l++++++++gi++q+eaf+eGfn+v+p+e+ls+F+++e++
   Q: 1754 plSIEDLGLNFQFCPSSKVHGFSAVD-LKPNGDDEMVTVENAEEYVELMFDFCMHTGIQKQMEAFKEGFNQVFPMEKLSSFSHKEVQ 1839
           ****************9988888777.************************************************************ PP
   S: 216  llicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlP 299
           +++cG+  ++++++d+ + t+ k gyt+dsp++q+F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++P
   Q: 1840 MVLCGNqsPSWNADDIINYTEPKLGYTRDSPGFQRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDSSYP 1926
           ******7777888888888888***************************************************************** PP
   S: 300  ssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           s+nTC++yLkLPeYss++i++e+Ll+A++e kgF+l+
   Q: 1927 SVNTCVHYLKLPEYSSEDIMRERLLAATME-KGFHLN 1962
           ******************************.****86 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MLGEALYTFR ISKLYGISLQ EDEVQEDAKE VQQGKPYHWR DWSIIRGRDC LYIWSDAAAL 60
ELSNGSNGWF RFILDGKLAT MYSSGSPEGG SDSSESRSEF LEKLQRARSQ VKPVTASQPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTACGAT ATGCTGGGGG AAGCCCTGTA CACTTTTCGA ATTAGTAAAC TGTATGGGAT 60
TTCCCTGCAG GAGGACGAGG TTCAGGAAGA TGCTAAGGAA GTCCAGCAGG GGAAGCCGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	78.66	0.00e+00	2725.00
IUUC-Apl-003493	Anas platyrhynchos	79.32	0.00e+00	2726.00
IUUC-Aca-004521	Anolis carolinensis	83.56	0.00e+00	1451.00
IUUC-Ame-011258	Astyanax mexicanus	82.70	0.00e+00	1431.00
IUUC-Bta-012835	Bos taurus	78.66	0.00e+00	2735.00
IUUC-Cel-018153	Caenorhabditis elegans	36.35	5.00e-133	470.00
IUUC-Cja-019174	Callithrix jacchus	77.78	0.00e+00	2662.00
IUUC-Cfa-021115	Canis familiaris	78.81	0.00e+00	2729.00
IUUC-Cpo-022382	Cavia porcellus	77.66	0.00e+00	2699.00
IUUC-Csa-023230	Chlorocebus sabaeus	78.87	0.00e+00	2730.00
IUUC-Cho-024711	Choloepus hoffmanni	76.06	0.00e+00	1282.00
IUUC-Cin-025342	Ciona intestinalis	49.10	0.00e+00	629.00
IUUC-Csv-026031	Ciona savignyi	49.72	0.00e+00	685.00
IUUC-Dre-027435	Danio rerio	83.71	0.00e+00	2914.00
IUUC-Dno-029954	Dasypus novemcinctus	79.11	0.00e+00	2730.00
IUUC-Dor-030734	Dipodomys ordii	76.85	0.00e+00	1160.00
IUUC-Dme-031739	Drosophila melanogaster	56.78	0.00e+00	842.00
IUUC-Ete-033192	Echinops telfairi	93.58	9.00e-48	185.00
IUUC-Eca-033434	Equus caballus	78.21	0.00e+00	2701.00
IUUC-Eeu-035031	Erinaceus europaeus	91.74	8.00e-47	182.00
IUUC-Fca-035998	Felis catus	76.34	0.00e+00	2608.00
IUUC-Fal-037468	Ficedula albicollis	81.12	0.00e+00	1430.00
IUUC-Gmo-038495	Gadus morhua	89.12	0.00e+00	873.00
IUUC-Gga-040736	Gallus gallus	83.75	0.00e+00	1445.00
IUUC-Gac-041777	Gasterosteus aculeatus	88.17	0.00e+00	1718.00
IUUC-Ggo-044677	Gorilla gorilla	76.01	0.00e+00	2586.00
IUUC-Hsa-045879	Homo sapiens	78.87	0.00e+00	2730.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	78.82	0.00e+00	2731.00
IUUC-Lch-050444	Latimeria chalumnae	81.72	0.00e+00	1464.00
IUUC-Loc-051986	Lepisosteus oculatus	80.75	0.00e+00	2874.00
IUUC-Laf-054230	Loxodonta africana	78.77	0.00e+00	2700.00
IUUC-Mcc-054787	Macaca mulatta	78.87	0.00e+00	2730.00
IUUC-Meu-056502	Macropus eugenii	83.88	0.00e+00	1032.00
IUUC-Mga-059409	Meleagris gallopavo	71.48	0.00e+00	1546.00
IUUC-Mmr-061667	Microcebus murinus	77.89	0.00e+00	2701.00
IUUC-Mdo-061960	Monodelphis domestica	79.35	0.00e+00	2720.00
IUUC-Mmu-063941	Mus musculus	77.99	0.00e+00	2695.00
IUUC-Mpu-065939	Mustela putorius furo	78.92	0.00e+00	2732.00
IUUC-Mlu-068112	Myotis lucifugus	78.61	0.00e+00	2696.00
IUUC-Nle-069001	Nomascus leucogenys	78.82	0.00e+00	2728.00
IUUC-Opr-071222	Ochotona princeps	83.52	0.00e+00	874.00
IUUC-Ont-072101	Oreochromis niloticus	88.77	0.00e+00	3088.00
IUUC-Oan-072814	Ornithorhynchus anatinus	79.65	0.00e+00	2741.00
IUUC-Ocu-074011	Oryctolagus cuniculus	78.82	0.00e+00	2731.00
IUUC-Ola-086412	Oryzias latipes	87.42	0.00e+00	3008.00
IUUC-Oar-089668	Ovis aries	78.71	0.00e+00	2729.00
IUUC-Ptr-090517	Pan troglodytes	78.45	0.00e+00	2695.00
IUUC-Pan-091849	Papio anubis	78.27	0.00e+00	2700.00
IUUC-Psi-093390	Pelodiscus sinensis	78.24	0.00e+00	1316.00
IUUC-Pma-094628	Petromyzon marinus	81.26	0.00e+00	974.00
IUUC-Ppa-095264	Physcomitrella patens	32.19	2.00e-79	291.00
IUUC-Pfo-097075	Poecilia formosa	94.90	0.00e+00	1705.00
IUUC-Pab-098176	Pongo abelii	78.87	0.00e+00	2730.00
IUUC-Pca-101123	Procavia capensis	70.88	0.00e+00	1797.00
IUUC-Pva-103008	Pteropus vampyrus	77.49	0.00e+00	1197.00
IUUC-Rno-105885	Rattus norvegicus	78.73	0.00e+00	2727.00
IUUC-Sha-107048	Sarcophilus harrisii	79.04	0.00e+00	2721.00
IUUC-Sar-113071	Sorex araneus	93.58	2.00e-47	184.00
IUUC-Ssc-115963	Sus scrofa	79.21	0.00e+00	2728.00
IUUC-Tgu-117167	Taeniopygia guttata	76.61	0.00e+00	2087.00
IUUC-Tru-118626	Takifugu rubripes	87.01	0.00e+00	3063.00
IUUC-Tsy-119504	Tarsius syrichta	80.25	0.00e+00	1367.00
IUUC-Tni-119877	Tetraodon nigroviridis	86.87	0.00e+00	3008.00
IUUC-Ttr-128394	Tursiops truncatus	76.61	0.00e+00	2397.00
IUUC-Vpa-130280	Vicugna pacos	77.00	0.00e+00	2509.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence