iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-39	137.5	229	537

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaee.fsgyeqqDaqEf 95
           +Gl+N++ t ++N ++Q+L+ +++lr+++l   +e+ +     + k +l + + +l +++w   + k++vsp+e+l+a+ k++++ f+  +q D  Ef
   Q: 229  VGLNNIQKTEFVNVTIQSLMRVTPLRNFFLI--PENYQ-----HCKSPLGHRFGELTRKIWhaRNFKGQVSPHEFLQAVMKASKKrFRIGQQSDPVEF 319
           6******************************..55554.....45679*************999999**********998888777************ PP
   S: 96   laflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp.........gkeetkk 184
           +++ll++l+ +l                         ++ k  +s+i++ Fqg+l+     +  +n+  ++ pfl l l++p         +      
   Q: 320  MSWLLNTLHMDL-------------------------RTSKDASSIIHKCFQGELEVVKEYQGNENKEISRMPFLMLGLDLPppplfkdvmE------ 386
           ************.........................678999***************************************5554332222...... PP
   S: 185  e......slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts....peek 271
           +       l d+L++f  e   e    +  +     + a+ + ++ k P++L++h+ Rf  ++++ ++ek+ + v+fp + ++l+ +  s    pe +
   Q: 387  KniipqvALFDLLKKFDGETVTE----VVRP-----KLARMRYRVIKSPRYLMFHMVRF--KKNNFFKEKNPTLVNFPVKdMELRDYIPSlpraPE-G 472
           12333335556665555554444....2223.....3377889999*************..88999************999****88777666444.4 PP
   S: 272  qkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++++ kY+Lia +vH G+++ G + ++v+ ++++ W+++ D +V e+  + v+    s+aY+ +Y+++
   Q: 473  ENVCSKYNLIANIVHDGKPEDGYFRVFVQRKSQElWYEMQDLHVAETLPQMVEL---SEAYMQIYEQQ 537
           456***************************88889*******************...********985 PP

Organism

Arabidopsis thaliana

Protein Sequence
(Fasta)

MKGEREVKNG VSEEEREVKR KRVMERSDSP PPPLGFNNPL LPFANAYDDD NNQQNKSQTR 60
CNVVAKGEGN GNKVKGEAQV EVDDDEDDDD DASKGRGKHS RHVEVRRDCP YLDTVNRQVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCGAATAC GTCCTTGTAG ATTTTCACGC GTTTATAGTT TGCTTCGAGA AGCTTGAGGG 60
TATTAATGGT TATTCGATAA GTATCGGATC GTGAATACAG ATCAATTACT GAATACTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033809--USP39
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0000245--P:spliceosomal complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005683	Arabidopsis lyrata	90.54	0.00e+00	886.00
IUUC-Afl-008735	Aspergillus flavus	54.29	6.00e-43	167.00
IUUC-Bgr-011998	Blumeria graminis	43.35	1.00e-98	352.00
IUUC-Bol-015968	Brassica oleracea	96.65	0.00e+00	839.00
IUUC-Bra-017952	Brassica rapa	95.98	0.00e+00	833.00
IUUC-Cel-018491	Caenorhabditis elegans	45.41	2.00e-110	392.00
IUUC-Cre-022886	Chlamydomonas reinhardtii	52.80	3.00e-33	132.00
IUUC-Cin-025473	Ciona intestinalis	47.44	9.00e-35	139.00
IUUC-Cne-026802	Cryptococcus neoformans	42.83	2.00e-92	332.00
IUUC-Mla-059120	Melampsora laricipopulina	41.96	1.00e-97	350.00
IUUC-Ppa-095995	Physcomitrella patens	74.36	0.00e+00	700.00
IUUC-Pfo-096754	Poecilia formosa	51.52	1.00e-128	452.00
IUUC-Ppe-101699	Prunus persica	73.13	0.00e+00	716.00
IUUC-Sce-106368	Saccharomyces cerevisiae	27.97	3.00e-39	155.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence