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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063444
Ensembl Protein ID ENSMUSP00000099785.4
UniProt Accession P54731; Q6P1F8; FAF1_MOUSE
Genbank Protein ID AAA92091.1; CAM13709.1; CAM13709.1; CAM16845.1; CAM16845.1; EDL30696.1; AAH65098.1
Protein Name FAS-associated factor 1
Genbank Nucleotide ID U39643; AL627188; AL627392; AL627392; AL627188; CH466527; BC065098
Gene Name Faf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000010517.7 ENSMUST00000102724.4 ENSMUSP00000099785.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 21411632; 23307929
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 2.10e-07 32.0 5 45
ULD/UDP/UFD/UBX 1.40e-19 71.5 569 645
ULD/UDP/UBQ/UBQ_Other 3.20e-09 37.6 110 169
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 1    sededkleqlve.MGF.dreealqaLraannnleaAveyLl 39
           +++e++l+ +++ +G+ + +ea++ L+++n++l aA++ ++
   Q: 5    MDREMILADFQAcTGIeNIDEAITLLEQNNWDLVAAINGVI 45
           689**********************************9875 PP
   

   ULD/UDP/UFD/UBX
   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++ ++l+iR+p+G++l+r+F +s++l+ +++fv+ ++++++d+F+L+s+fPrr++++ + +++l e +L+p+++l++
   Q: 569  AEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVA-SKGFPWDEFKLLSTFPRRDVTQLDPNKSLLEVNLFPQETLFL 645
           56799******************************.****************************************97 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 12   eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL...eddktLadyglkdgstihll 70
           + ++ ++ s+tV+e+K+ +e +l ip+   ++++kG      ed   L++++l+ ++ +++l
   Q: 110  NVDVVLEDSCTVGEIKQILENELQIPVP--KMLLKGWKTgdvEDSTVLKSLHLPKNNSLYVL 169
           5566678999****************55..688887776666***************99987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain (By similarity). Specifically interacts with the cytoplasmic domain of FAS.
 Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain (By similarity). Specifically interacts with the cytoplasmic domain of FAS.
Protein Sequence
(Fasta)
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSDFGGET 60
MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML DFRVEYRDRN VDVVLEDSCT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063444|UBD,UBA;ULD,UBQ_Other;ULD,UBX|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGGGCGGA GGCGGCGGCC GGGGAGGAAG CGGAGGAGGC GGAGGCGGCT GTGGCGTTGG 60
CCCGCCTGCT CCTTCTCTCG CTTTCCCCGC CCCCGTCGGG TTTGCCGTGG CTGGAGGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063444|UBD,UBA;ULD,UBQ_Other;ULD,UBX|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR033043--FAF1_UBX
IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
PROSITE

PS50033--UBX
Pfam

PF00789--UBX
SMART

SM00594--UAS
SM00166--UBX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031072--F:heat shock protein binding
GO:0051059--F:NF-kappaB binding
GO:0019904--F:protein domain specific binding
GO:0019901--F:protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0006915--P:apoptotic process
GO:0008219--P:cell death
GO:0007253--P:cytoplasmic sequestering of NF-kappaB
GO:0010942--P:positive regulation of cell death
GO:1902043--P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0031334--P:positive regulation of protein complex assembly
GO:0030155--P:regulation of cell adhesion
GO:0042176--P:regulation of protein catabolic process
KEGG mmu:14084
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002153 Ailuropoda melanoleuca 96.30 0.00e+00 1221.00
IUUC-Apl-004127 Anas platyrhynchos 89.81 0.00e+00 1127.00
IUUC-Aca-005188 Anolis carolinensis 89.17 0.00e+00 1121.00
IUUC-Ame-010696 Astyanax mexicanus 76.65 0.00e+00 867.00
IUUC-Bta-012965 Bos taurus 96.46 0.00e+00 1216.00
IUUC-Cel-018420 Caenorhabditis elegans 29.12 2.00e-29 124.00
IUUC-Cja-019128 Callithrix jacchus 95.71 0.00e+00 1234.00
IUUC-Cfa-021201 Canis familiaris 96.46 0.00e+00 908.00
IUUC-Cpo-021475 Cavia porcellus 96.05 0.00e+00 905.00
IUUC-Csa-024076 Chlorocebus sabaeus 96.46 0.00e+00 1219.00
IUUC-Cho-025067 Choloepus hoffmanni 82.90 0.00e+00 1052.00
IUUC-Cin-025663 Ciona intestinalis 42.94 2.00e-67 249.00
IUUC-Csv-025894 Ciona savignyi 34.24 5.00e-70 258.00
IUUC-Dre-027508 Danio rerio 74.52 0.00e+00 937.00
IUUC-Dno-029336 Dasypus novemcinctus 95.69 0.00e+00 1196.00
IUUC-Dor-030218 Dipodomys ordii 89.98 0.00e+00 1105.00
IUUC-Dme-031581 Drosophila melanogaster 32.78 1.00e-92 334.00
IUUC-Ete-032860 Echinops telfairi 74.12 0.00e+00 669.00
IUUC-Eca-034321 Equus caballus 97.34 0.00e+00 1050.00
IUUC-Eeu-034844 Erinaceus europaeus 74.12 2.00e-144 506.00
IUUC-Fca-036575 Felis catus 98.40 0.00e+00 729.00
IUUC-Fal-037128 Ficedula albicollis 90.17 0.00e+00 1147.00
IUUC-Gmo-038694 Gadus morhua 73.05 0.00e+00 898.00
IUUC-Gga-040826 Gallus gallus 90.48 0.00e+00 1154.00
IUUC-Gac-042125 Gasterosteus aculeatus 74.77 0.00e+00 966.00
IUUC-Ggo-045254 Gorilla gorilla 96.31 0.00e+00 1220.00
IUUC-Hsa-046722 Homo sapiens 96.15 0.00e+00 1219.00
IUUC-Itr-048149 Ictidomys tridecemlineatus 96.55 9.00e-102 362.00
IUUC-Lch-050312 Latimeria chalumnae 80.58 0.00e+00 670.00
IUUC-Loc-051990 Lepisosteus oculatus 80.79 0.00e+00 961.00
IUUC-Laf-054375 Loxodonta africana 97.35 0.00e+00 726.00
IUUC-Mcc-054627 Macaca mulatta 95.92 0.00e+00 1187.00
IUUC-Meu-056611 Macropus eugenii 70.85 2.00e-130 459.00
IUUC-Mga-059400 Meleagris gallopavo 88.17 0.00e+00 1128.00
IUUC-Mmr-060882 Microcebus murinus 95.99 0.00e+00 1185.00
IUUC-Mdo-061874 Monodelphis domestica 90.77 0.00e+00 1167.00
IUUC-Mpu-065713 Mustela putorius furo 95.90 0.00e+00 1181.00
IUUC-Mlu-068122 Myotis lucifugus 95.48 0.00e+00 1153.00
IUUC-Nle-069025 Nomascus leucogenys 95.85 0.00e+00 1209.00
IUUC-Opr-071089 Ochotona princeps 86.13 0.00e+00 1093.00
IUUC-Ont-072421 Oreochromis niloticus 74.40 0.00e+00 947.00
IUUC-Oan-073092 Ornithorhynchus anatinus 86.83 0.00e+00 845.00
IUUC-Ola-086497 Oryzias latipes 75.11 0.00e+00 958.00
IUUC-Oga-088854 Otolemur garnettii 95.99 0.00e+00 1207.00
IUUC-Oar-090120 Ovis aries 96.62 0.00e+00 1193.00
IUUC-Ptr-091554 Pan troglodytes 96.31 0.00e+00 1220.00
IUUC-Pan-091985 Papio anubis 96.00 0.00e+00 1190.00
IUUC-Psi-093548 Pelodiscus sinensis 90.09 0.00e+00 1082.00
IUUC-Pma-094123 Petromyzon marinus 52.45 1.00e-52 198.00
IUUC-Pfo-096729 Poecilia formosa 73.89 0.00e+00 947.00
IUUC-Pab-097810 Pongo abelii 96.46 0.00e+00 1222.00
IUUC-Pca-101079 Procavia capensis 88.80 0.00e+00 897.00
IUUC-Pva-102534 Pteropus vampyrus 88.31 0.00e+00 923.00
IUUC-Ptt-103866 Puccinia triticina 36.14 2.80e-01 30.40
IUUC-Rno-105127 Rattus norvegicus 98.86 0.00e+00 1133.00
IUUC-Sha-106667 Sarcophilus harrisii 92.20 0.00e+00 1023.00
IUUC-Ssl-108656 Sclerotinia sclerotiorum 24.56 2.50e-02 32.30
IUUC-Sar-113424 Sorex araneus 82.37 0.00e+00 649.00
IUUC-Ssc-115974 Sus scrofa 95.75 0.00e+00 1162.00
IUUC-Tgu-116495 Taeniopygia guttata 90.17 0.00e+00 1149.00
IUUC-Tru-118727 Takifugu rubripes 72.46 0.00e+00 927.00
IUUC-Tsy-118906 Tarsius syrichta 91.22 0.00e+00 1097.00
IUUC-Tni-119717 Tetraodon nigroviridis 74.85 0.00e+00 944.00
IUUC-Tbe-127849 Tupaia belangeri 82.44 0.00e+00 721.00
IUUC-Ttr-128660 Tursiops truncatus 92.18 0.00e+00 1149.00
IUUC-Vpa-130359 Vicugna pacos 96.85 0.00e+00 1195.00
IUUC-Xtr-132212 Xenopus tropicalis 82.49 0.00e+00 721.00
Created Date 25-Jun-2017

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