iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000036698.4	ENSRNOT00000054973.3	ENSRNOP00000051856.3
ENSRNOG00000036698.4	ENSRNOT00000080188.1	ENSRNOP00000068982.1

Annotation

mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	10811609; 12411482; 19182904

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	1.10e-12	47.6	581	608

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +a+WaC++CTf+N+P +++CemCs pR+
   Q: 581  SAMWACQHCTFMNQPGTGHCEMCSLPRT 608
           78************************95 PP

Organism

Rattus norvegicus

Functional Description
(View)

The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (PubMed:10811609, PubMed:11740563, PubMed:11781570, PubMed:12411482, PubMed:12644454, PubMed:14636562). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1L, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).

Protein Sequence
(Fasta)

MAERIIIRVQ SPDGVKRITA TKRETAATFL KKVAKEFGFQ NNGFSVYINR NKTGEITASS 60
SKSLHLLKIK HGDLLFLFPS SLAGPSSEME TSTSVGLKAF GAPHVVEDEI DQYLSKQDGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCTGAGG CCGAGGCCGG GGCTGCGAGG CGTTGGGAAC AGGCGGCGCA GCGGGGGCCA 60
GCCGGAGGCA GGAGCGCGCC GGCATGGCCG AGAGGATCGT GAGGTGCGGC GGTCGGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016563--Npl4
IPR007717--NPL4_C
IPR024682--Npl4_Ub-like_dom
IPR007716--NPL4_Zn-bd_put
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF05021--NPL4
PF11543--UN_NPL4
PF05020--zf-NPL4

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0036501--C:UFD1-NPL4 complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0051117--F:ATPase binding
GO:0032403--F:protein complex binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0007030--P:Golgi organization
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:140639

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000460	Aegilops tauschii	28.04	2.00e-15	76.60
IUUC-Aml-002268	Ailuropoda melanoleuca	97.18	0.00e+00	1204.00
IUUC-Atr-002939	Amborella trichopoda	28.78	5.00e-19	89.00
IUUC-Apl-003496	Anas platyrhynchos	89.02	0.00e+00	1082.00
IUUC-Aca-005230	Anolis carolinensis	90.97	0.00e+00	1167.00
IUUC-Aly-006056	Arabidopsis lyrata	30.12	6.00e-23	101.00
IUUC-Ath-006993	Arabidopsis thaliana	27.86	4.00e-21	95.90
IUUC-Ago-007954	Ashbya gossypii	36.63	2.00e-79	290.00
IUUC-Acl-008208	Aspergillus clavatus	32.38	8.00e-90	324.00
IUUC-Afl-008574	Aspergillus flavus	36.07	2.00e-89	323.00
IUUC-Afu-008825	Aspergillus fumigatus	34.65	2.00e-97	349.00
IUUC-Ani-009495	Aspergillus nidulans	39.49	5.00e-93	335.00
IUUC-Ang-009762	Aspergillus niger	33.72	3.00e-88	319.00
IUUC-Aor-010199	Aspergillus oryzae	35.54	8.00e-88	318.00
IUUC-Ate-010592	Aspergillus terreus	37.19	4.00e-92	332.00
IUUC-Ame-011587	Astyanax mexicanus	72.98	2.00e-103	369.00
IUUC-Bgr-012124	Blumeria graminis	33.17	2.00e-89	323.00
IUUC-Bta-013312	Bos taurus	97.04	0.00e+00	1239.00
IUUC-Bci-013648	Botrytis cinerea	32.85	7.00e-96	344.00
IUUC-Bdi-014326	Brachypodium distachyon	28.73	3.00e-16	79.30
IUUC-Bol-016294	Brassica oleracea	28.74	6.00e-21	95.10
IUUC-Bra-017023	Brassica rapa	28.74	4.00e-21	95.50
IUUC-Cel-018713	Caenorhabditis elegans	43.44	4.00e-130	458.00
IUUC-Cja-018869	Callithrix jacchus	96.55	0.00e+00	1217.00
IUUC-Cfa-020757	Canis familiaris	97.52	0.00e+00	1220.00
IUUC-Cpo-022390	Cavia porcellus	98.18	0.00e+00	1207.00
IUUC-Csa-023366	Chlorocebus sabaeus	97.04	0.00e+00	1243.00
IUUC-Cho-024455	Choloepus hoffmanni	79.10	0.00e+00	840.00
IUUC-Cin-025638	Ciona intestinalis	48.83	8.00e-147	513.00
IUUC-Csv-026310	Ciona savignyi	44.04	4.00e-133	468.00
IUUC-Cgl-026685	Colletotrichum gloeosporioides	33.23	7.00e-89	321.00
IUUC-Cne-026794	Cryptococcus neoformans	29.18	2.00e-71	263.00
IUUC-Cme-027248	Cyanidioschyzon merolae	27.22	5.00e-16	79.00
IUUC-Dre-027689	Danio rerio	80.54	0.00e+00	1043.00
IUUC-Dno-030004	Dasypus novemcinctus	96.05	0.00e+00	1219.00
IUUC-Dor-030585	Dipodomys ordii	97.13	0.00e+00	986.00
IUUC-Dse-031202	Dothistroma septosporum	33.11	2.00e-89	323.00
IUUC-Dme-032092	Drosophila melanogaster	47.94	6.00e-177	614.00
IUUC-Ete-033009	Echinops telfairi	96.53	2.00e-99	355.00
IUUC-Eca-034001	Equus caballus	96.88	0.00e+00	1243.00
IUUC-Eeu-034485	Erinaceus europaeus	81.33	0.00e+00	839.00
IUUC-Fca-036128	Felis catus	96.55	0.00e+00	1178.00
IUUC-Fal-037523	Ficedula albicollis	90.80	0.00e+00	1169.00
IUUC-Fox-037802	Fusarium oxysporum	33.83	1.00e-94	340.00
IUUC-Fso-038152	Fusarium solani	33.06	7.00e-94	338.00
IUUC-Gmo-038486	Gadus morhua	75.16	0.00e+00	956.00
IUUC-Ggr-039916	Gaeumannomyces graminis	37.24	2.00e-85	310.00
IUUC-Gga-041208	Gallus gallus	92.12	0.00e+00	1188.00
IUUC-Gac-042304	Gasterosteus aculeatus	77.85	0.00e+00	984.00
IUUC-Gma-044178	Glycine max	27.27	8.00e-16	78.20
IUUC-Ggo-045236	Gorilla gorilla	93.53	0.00e+00	1179.00
IUUC-Hsa-046334	Homo sapiens	96.88	0.00e+00	1240.00
IUUC-Hvu-047323	Hordeum vulgare	26.70	1.00e-08	53.10
IUUC-Itr-047878	Ictidomys tridecemlineatus	98.37	0.00e+00	733.00
IUUC-Lch-050302	Latimeria chalumnae	82.46	0.00e+00	1058.00
IUUC-Lpe-051362	Leersia perrieri	28.94	3.00e-18	85.90
IUUC-Loc-052548	Lepisosteus oculatus	82.85	0.00e+00	1026.00
IUUC-Lma-053092	Leptosphaeria maculans	33.18	3.00e-95	343.00
IUUC-Laf-053911	Loxodonta africana	96.88	0.00e+00	1234.00
IUUC-Mcc-055830	Macaca mulatta	96.67	0.00e+00	1217.00
IUUC-Meu-056460	Macropus eugenii	58.93	4.00e-149	521.00
IUUC-Mor-057189	Magnaporthe oryzae	36.69	4.00e-88	318.00
IUUC-Mpo-057366	Magnaporthe poae	37.97	1.00e-85	311.00
IUUC-Mtr-057834	Medicago truncatula	26.76	2.00e-17	83.20
IUUC-Mla-059190	Melampsora laricipopulina	33.00	1.00e-85	311.00
IUUC-Mga-060036	Meleagris gallopavo	91.89	0.00e+00	1176.00
IUUC-Mvi-060275	Microbotryum violaceum	34.80	1.00e-79	290.00
IUUC-Mmr-061300	Microcebus murinus	97.51	0.00e+00	1233.00
IUUC-Mdo-062911	Monodelphis domestica	96.17	0.00e+00	1057.00
IUUC-Mmu-063916	Mus musculus	99.51	0.00e+00	1239.00
IUUC-Mac-065601	Musa acuminata	26.75	2.00e-11	63.90
IUUC-Mpu-065912	Mustela putorius furo	96.37	0.00e+00	1209.00
IUUC-Mlu-067965	Myotis lucifugus	95.52	0.00e+00	1193.00
IUUC-Nfi-068465	Neosartorya fischeri	34.81	9.00e-98	351.00
IUUC-Ncr-068936	Neurospora crassa	33.50	1.00e-92	334.00
IUUC-Nle-069570	Nomascus leucogenys	96.55	0.00e+00	1235.00
IUUC-Opr-071097	Ochotona princeps	91.99	0.00e+00	922.00
IUUC-Ont-071430	Oreochromis niloticus	79.71	0.00e+00	1030.00
IUUC-Oan-073709	Ornithorhynchus anatinus	82.00	0.00e+00	793.00
IUUC-Ocu-074875	Oryctolagus cuniculus	92.22	0.00e+00	1153.00
IUUC-Oba-075214	Oryza barthii	28.21	4.00e-18	85.90
IUUC-Obr-076758	Oryza brachyantha	28.78	7.00e-18	84.30
IUUC-Ogl-077665	Oryza glaberrima	28.21	4.00e-18	85.90
IUUC-Ogu-078899	Oryza glumaepatula	28.21	4.00e-18	85.90
IUUC-Oin-079167	Oryza indica	28.21	4.00e-18	85.90
IUUC-Olo-080451	Oryza longistaminata	28.21	2.00e-18	85.90
IUUC-Ome-081836	Oryza meridionalis	28.06	4.00e-18	85.90
IUUC-Oni-083019	Oryza nivara	28.21	4.00e-18	85.90
IUUC-Opu-083122	Oryza punctata	28.26	2.00e-18	86.70
IUUC-Oru-084900	Oryza rufipogon	28.21	4.00e-18	85.90
IUUC-Osa-086054	Oryza sativa	28.21	4.00e-18	85.90
IUUC-Ola-087077	Oryzias latipes	68.95	0.00e+00	857.00
IUUC-Olu-087601	Ostreococcus lucimarinus	25.95	7.00e-06	45.10
IUUC-Oga-088049	Otolemur garnettii	83.17	0.00e+00	1039.00
IUUC-Oar-089678	Ovis aries	96.70	0.00e+00	1233.00
IUUC-Ptr-091380	Pan troglodytes	96.63	0.00e+00	1135.00
IUUC-Pan-092821	Papio anubis	95.70	0.00e+00	1220.00
IUUC-Psi-093074	Pelodiscus sinensis	92.57	0.00e+00	1177.00
IUUC-Pma-094102	Petromyzon marinus	69.03	0.00e+00	906.00
IUUC-Pno-094987	Phaeosphaeria nodorum	34.26	9.00e-94	338.00
IUUC-Ppa-095368	Physcomitrella patens	27.93	3.00e-18	85.90
IUUC-Pfo-097245	Poecilia formosa	81.18	0.00e+00	1000.00
IUUC-Pab-098763	Pongo abelii	97.35	0.00e+00	1237.00
IUUC-Pop-099355	Populus trichocarpa	30.26	1.00e-14	73.60
IUUC-Ppe-101990	Prunus persica	28.48	3.00e-18	86.30
IUUC-Pva-102308	Pteropus vampyrus	88.76	0.00e+00	962.00
IUUC-Pgr-103626	Puccinia graminis	32.38	7.00e-81	295.00
IUUC-Pte-104100	Pyrenophora teres	33.06	5.00e-90	325.00
IUUC-Pyt-104482	Pyrenophora triticirepentis	36.82	8.00e-91	328.00
IUUC-Sce-106145	Saccharomyces cerevisiae	34.41	7.00e-92	331.00
IUUC-Sha-106647	Sarcophilus harrisii	95.59	0.00e+00	1192.00
IUUC-Sja-107972	Schizosaccharomyces japonicus	35.53	1.00e-86	314.00
IUUC-Spo-108281	Schizosaccharomyces pombe	34.43	1.00e-91	330.00
IUUC-Ssl-108617	Sclerotinia sclerotiorum	37.61	3.00e-91	329.00
IUUC-Smo-108933	Selaginella moellendorffii	30.46	8.00e-19	88.20
IUUC-Sit-110083	Setaria italica	29.18	1.00e-16	81.30
IUUC-Sly-111645	Solanum lycopersicum	26.33	9.00e-17	81.30
IUUC-Stu-112422	Solanum tuberosum	26.33	6.00e-17	82.00
IUUC-Sbi-113987	Sorghum bicolor	28.94	2.00e-17	83.20
IUUC-Sre-115095	Sporisorium reilianum	37.88	3.00e-80	293.00
IUUC-Ssc-116141	Sus scrofa	95.18	0.00e+00	1094.00
IUUC-Tgu-117492	Taeniopygia guttata	90.87	0.00e+00	863.00
IUUC-Tru-118463	Takifugu rubripes	78.12	0.00e+00	977.00
IUUC-Tsy-118993	Tarsius syrichta	88.19	0.00e+00	1002.00
IUUC-Tni-119896	Tetraodon nigroviridis	79.97	0.00e+00	985.00
IUUC-Tca-121169	Theobroma cacao	28.12	9.00e-20	91.30
IUUC-Tre-122046	Trichoderma reesei	33.00	5.00e-91	328.00
IUUC-Tvi-122415	Trichoderma virens	33.56	1.00e-91	330.00
IUUC-Tae-123514	Triticum aestivum	28.04	1.00e-15	77.40
IUUC-Tur-126703	Triticum urartu	45.45	1.00e+00	27.30
IUUC-Tme-127123	Tuber melanosporum	36.49	8.00e-103	367.00
IUUC-Tbe-127629	Tupaia belangeri	91.09	1.00e-156	546.00
IUUC-Ttr-128476	Tursiops truncatus	86.59	0.00e+00	971.00
IUUC-Uma-129492	Ustilago maydis	34.09	4.00e-83	302.00
IUUC-Vda-129702	Verticillium dahliae	36.55	5.00e-89	322.00
IUUC-Vvi-131090	Vitis vinifera	30.41	3.00e-14	72.80
IUUC-Xtr-131786	Xenopus tropicalis	85.78	0.00e+00	1081.00
IUUC-Xma-133997	Xiphophorus maculatus	78.32	0.00e+00	994.00
IUUC-Yli-134537	Yarrowia lipolytica	35.27	2.00e-90	326.00
IUUC-Zma-134847	Zea mays	29.72	1.00e-18	87.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence