iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098247

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Nitric oxide synthase-interacting protein

Genbank Nucleotide ID

ABGA01391568

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000010255.2	ENSPPYT00000011923.2	ENSPPYP00000011480.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.20e-16	58.6	74	113

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 74   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 113
           567789*****************************99887 PP

Organism

Pongo abelii

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

AGRKWAKRRG KIALLSGVGA QLKKRPRDWE SFVRMTRHGK NCTAGAVYTY HEKKKDTAAS 60
GYGTQNIRLS RDAVKDFDCC CLSLQPCHDP VVTPDGYLYE REAILEYILH QKKEIARQMK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCTGGGCG GAAGTGGGCG AAGCGGAGGG GGAAAATAGC GCTCCTTTCC GGTGTCGGGG 60
CACAGTTGAA GAAGCGACCG AGGGACTGGG AGTCGTTCGT GAGGTGAGTT GGAGGCGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0051001--P:negative regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-16	81.30
IUUC-Aml-002069	Ailuropoda melanoleuca	89.81	4.00e-161	560.00
IUUC-Atr-002661	Amborella trichopoda	32.53	3.00e-31	128.00
IUUC-Aca-004630	Anolis carolinensis	76.08	9.00e-137	479.00
IUUC-Aly-006316	Arabidopsis lyrata	30.39	5.00e-29	121.00
IUUC-Ath-007000	Arabidopsis thaliana	30.07	1.00e-28	120.00
IUUC-Acl-008175	Aspergillus clavatus	34.51	2.00e-06	47.00
IUUC-Afl-008440	Aspergillus flavus	34.19	3.00e-06	46.20
IUUC-Afu-009012	Aspergillus fumigatus	34.78	9.00e-07	47.80
IUUC-Ani-009153	Aspergillus nidulans	30.40	5.00e-03	35.40
IUUC-Ang-009556	Aspergillus niger	34.78	2.00e-06	46.60
IUUC-Aor-009892	Aspergillus oryzae	34.19	3.00e-06	45.80
IUUC-Ame-011874	Astyanax mexicanus	63.46	7.00e-110	390.00
IUUC-Bgr-012090	Blumeria graminis	27.46	5.00e-07	48.50
IUUC-Bta-012956	Bos taurus	94.37	5.00e-169	586.00
IUUC-Bci-013897	Botrytis cinerea	42.50	1.00e-09	57.40
IUUC-Bdi-014968	Brachypodium distachyon	30.41	9.00e-34	137.00
IUUC-Bol-015578	Brassica oleracea	31.05	1.00e-33	136.00
IUUC-Bra-017234	Brassica rapa	31.05	1.00e-33	136.00
IUUC-Cel-018637	Caenorhabditis elegans	39.51	5.00e-56	211.00
IUUC-Cja-019632	Callithrix jacchus	98.01	9.00e-177	612.00
IUUC-Cfa-020192	Canis familiaris	91.64	0.00e+00	631.00
IUUC-Cpo-021939	Cavia porcellus	89.04	3.00e-155	540.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	34.22	3.00e-43	168.00
IUUC-Csa-023802	Chlorocebus sabaeus	98.51	0.00e+00	680.00
IUUC-Cho-024637	Choloepus hoffmanni	74.65	1.00e-79	288.00
IUUC-Cin-025180	Ciona intestinalis	51.99	5.00e-86	310.00
IUUC-Csv-026206	Ciona savignyi	54.42	7.00e-43	166.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	24.03	2.00e-11	63.50
IUUC-Cne-026827	Cryptococcus neoformans	36.36	1.00e-06	47.40
IUUC-Dre-028092	Danio rerio	65.26	9.00e-117	412.00
IUUC-Dno-029501	Dasypus novemcinctus	79.82	1.00e-140	492.00
IUUC-Dor-030542	Dipodomys ordii	90.76	4.00e-163	566.00
IUUC-Dse-031188	Dothistroma septosporum	23.60	7.00e-15	74.70
IUUC-Dme-031734	Drosophila melanogaster	48.54	6.00e-79	287.00
IUUC-Eca-033577	Equus caballus	93.69	4.00e-169	587.00
IUUC-Fca-035761	Felis catus	93.36	2.00e-167	580.00
IUUC-Fox-037703	Fusarium oxysporum	27.20	2.00e-14	73.20
IUUC-Fso-038208	Fusarium solani	27.45	2.00e-13	69.70
IUUC-Gmo-038523	Gadus morhua	59.90	5.00e-61	226.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	8.00e-10	57.80
IUUC-Gac-042621	Gasterosteus aculeatus	60.38	5.00e-109	387.00
IUUC-Gma-042698	Glycine max	31.16	1.00e-32	133.00
IUUC-Ggo-045357	Gorilla gorilla	100.00	1.00e-179	621.00
IUUC-Hsa-046195	Homo sapiens	100.00	1.00e-179	621.00
IUUC-Hvu-047174	Hordeum vulgare	30.74	9.00e-35	140.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	94.02	6.00e-163	566.00
IUUC-Lch-050569	Latimeria chalumnae	68.93	3.00e-116	411.00
IUUC-Lpe-050992	Leersia perrieri	35.47	4.00e-23	102.00
IUUC-Loc-052522	Lepisosteus oculatus	69.67	1.00e-115	409.00
IUUC-Lma-053254	Leptosphaeria maculans	25.17	5.00e-13	68.60
IUUC-Laf-053397	Loxodonta africana	94.06	4.00e-168	583.00
IUUC-Mcc-054681	Macaca mulatta	98.20	0.00e+00	676.00
IUUC-Meu-056723	Macropus eugenii	83.17	8.00e-151	525.00
IUUC-Mor-056961	Magnaporthe oryzae	25.81	6.00e-12	65.10
IUUC-Mpo-057359	Magnaporthe poae	24.44	5.00e-07	48.10
IUUC-Mtr-058063	Medicago truncatula	32.08	4.00e-34	138.00
IUUC-Mla-059004	Melampsora laricipopulina	29.71	1.00e-25	109.00
IUUC-Mvi-060460	Microbotryum violaceum	29.46	3.00e-26	112.00
IUUC-Mmr-060847	Microcebus murinus	97.01	9.00e-175	605.00
IUUC-Mdo-062480	Monodelphis domestica	83.83	4.00e-151	526.00
IUUC-Mmu-063809	Mus musculus	90.70	1.00e-161	561.00
IUUC-Mac-064870	Musa acuminata	31.51	9.00e-34	137.00
IUUC-Mpu-066322	Mustela putorius furo	92.79	2.00e-174	605.00
IUUC-Mlu-067556	Myotis lucifugus	91.12	2.00e-156	544.00
IUUC-Nfi-068440	Neosartorya fischeri	35.09	1.00e-06	47.80
IUUC-Ncr-068898	Neurospora crassa	38.46	1.00e-07	50.80
IUUC-Nle-070049	Nomascus leucogenys	99.68	0.00e+00	649.00
IUUC-Opr-070972	Ochotona princeps	87.87	2.00e-154	537.00
IUUC-Ont-071682	Oreochromis niloticus	66.23	2.00e-117	414.00
IUUC-Oan-073296	Ornithorhynchus anatinus	71.74	3.00e-33	133.00
IUUC-Ocu-074218	Oryctolagus cuniculus	88.93	2.00e-133	468.00
IUUC-Oba-075284	Oryza barthii	31.85	2.00e-33	135.00
IUUC-Obr-076651	Oryza brachyantha	31.85	4.00e-36	145.00
IUUC-Ogl-077899	Oryza glaberrima	31.85	2.00e-33	135.00
IUUC-Ogu-078477	Oryza glumaepatula	32.19	1.00e-33	136.00
IUUC-Oin-080011	Oryza indica	31.85	2.00e-33	135.00
IUUC-Olo-080545	Oryza longistaminata	31.40	1.00e-26	114.00
IUUC-Ome-081543	Oryza meridionalis	31.85	2.00e-33	135.00
IUUC-Oni-082955	Oryza nivara	31.85	2.00e-33	135.00
IUUC-Opu-083565	Oryza punctata	31.85	1.00e-33	137.00
IUUC-Oru-084474	Oryza rufipogon	31.85	2.00e-33	135.00
IUUC-Osa-085913	Oryza sativa	31.85	2.00e-33	135.00
IUUC-Ola-086851	Oryzias latipes	67.11	7.00e-120	423.00
IUUC-Olu-087724	Ostreococcus lucimarinus	32.38	1.00e-11	63.50
IUUC-Oga-087970	Otolemur garnettii	94.70	3.00e-170	590.00
IUUC-Oar-089756	Ovis aries	90.76	3.00e-157	546.00
IUUC-Ptr-091485	Pan troglodytes	98.67	7.00e-176	609.00
IUUC-Pan-091832	Papio anubis	99.67	5.00e-179	619.00
IUUC-Pma-094551	Petromyzon marinus	61.56	3.00e-106	377.00
IUUC-Pno-094830	Phaeosphaeria nodorum	34.31	9.00e-09	54.30
IUUC-Ppa-095255	Physcomitrella patens	30.00	2.00e-32	132.00
IUUC-Pfo-096373	Poecilia formosa	65.36	5.00e-117	413.00
IUUC-Pop-099186	Populus trichocarpa	31.16	1.00e-31	129.00
IUUC-Pca-100677	Procavia capensis	89.82	2.00e-136	477.00
IUUC-Ppe-101403	Prunus persica	30.38	4.00e-32	131.00
IUUC-Pva-103000	Pteropus vampyrus	93.36	6.00e-168	582.00
IUUC-Pgr-103663	Puccinia graminis	30.25	4.00e-31	129.00
IUUC-Ptt-103712	Puccinia triticina	40.00	5.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	25.70	8.00e-17	80.90
IUUC-Pyt-104579	Pyrenophora triticirepentis	25.09	4.00e-10	58.90
IUUC-Rno-106069	Rattus norvegicus	91.69	6.00e-163	566.00
IUUC-Sha-106553	Sarcophilus harrisii	82.84	9.00e-150	522.00
IUUC-Smo-108874	Selaginella moellendorffii	31.77	2.00e-37	149.00
IUUC-Sit-110307	Setaria italica	31.85	6.00e-33	134.00
IUUC-Sly-111094	Solanum lycopersicum	33.11	3.00e-34	138.00
IUUC-Stu-112363	Solanum tuberosum	32.34	3.00e-34	138.00
IUUC-Sar-113480	Sorex araneus	92.36	1.00e-154	538.00
IUUC-Sbi-113939	Sorghum bicolor	31.85	2.00e-33	135.00
IUUC-Ssc-115644	Sus scrofa	94.68	4.00e-170	590.00
IUUC-Tru-118781	Takifugu rubripes	66.12	3.00e-120	424.00
IUUC-Tni-119672	Tetraodon nigroviridis	75.86	1.00e-35	140.00
IUUC-Tca-121795	Theobroma cacao	31.85	5.00e-36	144.00
IUUC-Tre-122037	Trichoderma reesei	36.36	3.00e-08	52.80
IUUC-Tvi-122524	Trichoderma virens	27.15	1.00e-16	80.50
IUUC-Tae-122828	Triticum aestivum	31.08	6.00e-35	140.00
IUUC-Tur-126387	Triticum urartu	31.01	2.00e-28	120.00
IUUC-Tme-127111	Tuber melanosporum	40.00	2.00e-09	56.60
IUUC-Ttr-128227	Tursiops truncatus	93.02	2.00e-166	577.00
IUUC-Vda-129924	Verticillium dahliae	26.25	7.00e-14	71.20
IUUC-Vpa-130802	Vicugna pacos	95.51	2.00e-44	172.00
IUUC-Vvi-131105	Vitis vinifera	32.88	2.00e-34	139.00
IUUC-Xtr-132830	Xenopus tropicalis	65.73	4.00e-122	430.00
IUUC-Xma-133618	Xiphophorus maculatus	65.79	3.00e-111	394.00
IUUC-Zma-135389	Zea mays	31.51	1.00e-32	133.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence