iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000161677.11	ENST00000601423.5	ENSP00000472116.1
ENSG00000161677.11	ENST00000595669.5	ENSP00000468860.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/Josephin	Josephin	19615732

Classification

Family	E-value	Score	Start	End
DUB/Josephin	9.50e-96	320.4	1	188

Active Site

Position(s)	Description	Evidence
24	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU00331}
125	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}

Domain Profile

DUB/Josephin

   S: 1    msqvpgaqaapesiyhekqrrelCalhalnnvlqdelfsreeldeiakrldeeerlqPskslldtGnydvnvisaalkvlGleavwfdkrre 92
           msq+pgaq++p+++yhe+qr+elCa+halnnvlq++lfs+e++dei+krl++++rl+P++sll+tGnydvnvi+aal++lGl+avw+d+rr+
   Q: 1    MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQLFSQEAADEICKRLAPDSRLNPHRSLLGTGNYDVNVIMAALQGLGLAAVWWDRRRP 92
           8******************************************************************************************* PP
   S: 93   lqklaldnvlgfilnlpsslslgllklplkkqhWvtvrkvgkayynldsklkaPeligdetelrkflakllqqkyselllvvkeevedkesd 184
           l++lal++vlg+ilnlps++slgll+lpl+++hWv++r+v+++yynldskl+aPe++gde+ +r+fla++l+q+++e+llvv++eve+k+s+
   Q: 93   LSQLALPQVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQGLCEVLLVVTKEVEEKGSW 184
           ******************************************************************************************** PP
   S: 185  qrld 188
           +r+d
   Q: 185  LRTD 188
           **97 PP

Organism

Homo sapiens

Functional Description
(View)

Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.

Protein Sequence
(Fasta)

MSQAPGAQPS PPTVYHERQR LELCAVHALN NVLQQQLFSQ EAADEICKRL APDSRLNPHR 60
SLLGTGNYDV NVIMAALQGL GLAAVWWDRR RPLSQLALPQ VLGLILNLPS PVSLGLLSLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCTAGGCC CGACGGCCGA CTTCAGGGCC ACGCGGCCCG GGCGTTCCGT GTGGAGCAGG 60
AGTCCCGCGG GGCCCCACGG GAGTCGTAGT CCGGCGCGCG GGGATCACCG GGAGCTGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR006155--Josephin

PROSITE

PS50957--JOSEPHIN

Pfam

PF02099--Josephin

SMART

SM01246--Josephin

Gene Ontology

GO:0005829--C:cytosol
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination

KEGG

hsa:126119

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000785	Aegilops tauschii	37.08	3.00e-25	108.00
IUUC-Aml-001650	Ailuropoda melanoleuca	96.81	2.00e-82	298.00
IUUC-Atr-002584	Amborella trichopoda	40.83	7.00e-26	111.00
IUUC-Aca-004833	Anolis carolinensis	70.11	1.00e-71	262.00
IUUC-Aly-005621	Arabidopsis lyrata	38.54	2.00e-30	126.00
IUUC-Ath-007306	Arabidopsis thaliana	39.41	2.00e-29	123.00
IUUC-Ame-010835	Astyanax mexicanus	65.91	4.00e-68	250.00
IUUC-Bta-012918	Bos taurus	96.57	1.00e-72	265.00
IUUC-Bdi-014128	Brachypodium distachyon	37.08	1.00e-26	112.00
IUUC-Bol-015647	Brassica oleracea	41.44	5.00e-32	130.00
IUUC-Bra-017811	Brassica rapa	39.08	6.00e-29	120.00
IUUC-Cel-018568	Caenorhabditis elegans	40.35	5.00e-39	153.00
IUUC-Cja-019837	Callithrix jacchus	99.43	3.00e-76	277.00
IUUC-Cfa-021001	Canis familiaris	96.79	5.00e-81	293.00
IUUC-Cpo-021340	Cavia porcellus	94.86	3.00e-72	264.00
IUUC-Csa-023069	Chlorocebus sabaeus	97.71	3.00e-75	273.00
IUUC-Csv-026011	Ciona savignyi	57.30	1.00e-57	216.00
IUUC-Cme-027180	Cyanidioschyzon merolae	30.47	1.00e-07	50.10
IUUC-Dre-028459	Danio rerio	63.69	7.00e-68	249.00
IUUC-Dno-029569	Dasypus novemcinctus	98.40	3.00e-83	300.00
IUUC-Dor-030570	Dipodomys ordii	94.15	5.00e-76	276.00
IUUC-Dme-032124	Drosophila melanogaster	50.87	8.00e-43	166.00
IUUC-Fca-036089	Felis catus	96.81	7.00e-82	296.00
IUUC-Gmo-038493	Gadus morhua	64.57	7.00e-64	236.00
IUUC-Gac-041579	Gasterosteus aculeatus	65.36	2.00e-68	251.00
IUUC-Gma-043620	Glycine max	42.78	5.00e-33	133.00
IUUC-Ggo-045508	Gorilla gorilla	100.00	6.00e-85	306.00
IUUC-Hvu-047184	Hordeum vulgare	39.33	4.00e-26	110.00
IUUC-Itr-048074	Ictidomys tridecemlineatus	98.86	9.00e-76	275.00
IUUC-Lch-050506	Latimeria chalumnae	64.74	7.00e-68	249.00
IUUC-Lpe-051421	Leersia perrieri	38.76	9.00e-28	116.00
IUUC-Mcc-054840	Macaca mulatta	98.29	7.00e-76	276.00
IUUC-Meu-056539	Macropus eugenii	88.20	5.00e-76	276.00
IUUC-Mtr-058745	Medicago truncatula	40.11	1.00e-32	132.00
IUUC-Mmu-063463	Mus musculus	95.19	1.00e-78	285.00
IUUC-Mac-065631	Musa acuminata	39.38	2.00e-25	110.00
IUUC-Mpu-066337	Mustela putorius furo	95.74	2.00e-81	294.00
IUUC-Nle-069739	Nomascus leucogenys	98.29	1.00e-75	275.00
IUUC-Ont-072050	Oreochromis niloticus	64.80	8.00e-63	232.00
IUUC-Oba-075401	Oryza barthii	37.64	1.00e-27	116.00
IUUC-Obr-076916	Oryza brachyantha	37.64	1.00e-26	112.00
IUUC-Ogl-077194	Oryza glaberrima	37.64	1.00e-27	116.00
IUUC-Ogu-078532	Oryza glumaepatula	37.64	1.00e-27	116.00
IUUC-Oin-079562	Oryza indica	35.85	6.00e-23	100.00
IUUC-Olo-080503	Oryza longistaminata	37.64	1.00e-27	115.00
IUUC-Ome-081997	Oryza meridionalis	38.20	8.00e-28	116.00
IUUC-Oni-082854	Oryza nivara	36.11	1.00e-26	112.00
IUUC-Opu-083984	Oryza punctata	37.08	3.00e-27	114.00
IUUC-Oru-084655	Oryza rufipogon	37.57	1.00e-26	113.00
IUUC-Osa-085854	Oryza sativa	37.64	1.00e-27	116.00
IUUC-Ola-086805	Oryzias latipes	64.25	1.00e-66	245.00
IUUC-Oga-088741	Otolemur garnettii	92.55	7.00e-68	249.00
IUUC-Oar-089548	Ovis aries	96.57	1.00e-72	265.00
IUUC-Ptr-091101	Pan troglodytes	88.83	4.00e-83	300.00
IUUC-Pan-092144	Papio anubis	98.29	7.00e-76	276.00
IUUC-Ppa-095444	Physcomitrella patens	33.70	7.00e-23	100.00
IUUC-Pfo-097459	Poecilia formosa	65.71	2.00e-67	248.00
IUUC-Pca-100200	Procavia capensis	87.30	1.00e-81	295.00
IUUC-Ppe-102087	Prunus persica	41.71	2.00e-33	135.00
IUUC-Pva-102585	Pteropus vampyrus	95.53	7.00e-76	276.00
IUUC-Rno-105654	Rattus norvegicus	93.58	3.00e-76	277.00
IUUC-Smo-109138	Selaginella moellendorffii	48.76	7.00e-21	93.20
IUUC-Sit-110826	Setaria italica	39.89	1.00e-28	119.00
IUUC-Sly-111452	Solanum lycopersicum	38.42	5.00e-28	117.00
IUUC-Stu-112215	Solanum tuberosum	38.33	3.00e-28	117.00
IUUC-Sbi-114786	Sorghum bicolor	39.33	3.00e-29	121.00
IUUC-Ssc-115298	Sus scrofa	97.14	7.00e-74	269.00
IUUC-Tru-118437	Takifugu rubripes	63.69	3.00e-67	247.00
IUUC-Tni-120715	Tetraodon nigroviridis	64.80	1.00e-62	231.00
IUUC-Tca-121220	Theobroma cacao	39.38	4.00e-29	122.00
IUUC-Tae-123012	Triticum aestivum	37.08	3.00e-25	108.00
IUUC-Tur-126618	Triticum urartu	38.21	9.00e-17	79.70
IUUC-Ttr-128359	Tursiops truncatus	73.14	3.00e-43	167.00
IUUC-Vvi-131246	Vitis vinifera	35.68	3.00e-29	121.00
IUUC-Xtr-132462	Xenopus tropicalis	62.50	4.00e-66	243.00
IUUC-Xma-134148	Xiphophorus maculatus	64.25	6.00e-67	246.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence