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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063835
UUCD1 version UUC-MuM-00445
Ensembl Protein ID ENSMUSP00000090476.5
UniProt Accession Q5NCP0; B2KGH3; Q6DI76; Q8BME0; Q8C191; Q8K0X4; RNF43_MOUSE
Genbank Protein ID BAC26097.1; BAC28018.1; CAI35141.1; CAI35141.1; CAI35962.1; CAI35962.1; CAQ52071.1; AAH29717.1; AAH75707.1
Protein Name E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43
Genbank Nucleotide ID AK028750; AK032782; AL596086; AL604022; AL604022; AL596086; CU393486; BC029717; BC075707
Gene Name Rnf43
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034177.15 ENSMUST00000092800.11 ENSMUSP00000090476.5
ENSMUSG00000034177.15 ENSMUST00000121782.8 ENSMUSP00000112748.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexHINT
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.40e-07 33.0 272 312
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiCle+f++g  ++v +C H fh++C+  w       +++ +CPlC
   Q: 272  CAICLEEFSEGqeLRVISCLHEFHRTCVDPW------LYQHRTCPLC 312
           ********55444******************......********** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Protein Sequence
(Fasta)
MSGGHQLQLA VLWPWLLMAT LHAGFGHTGR VLAAAVESER SAEQKAVIRV IPLKMDPTGK 60
LNLTLEGVFA GVAEVTPAEG KLMQSHPLYL CNASDDDNLE PGFISIVKLE SPRRAPRPCL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063835|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATCCAGAAT TGTCTTTCTT GAAAGGAAGC ACTTCAACCC TGCCTCCTCC TGAACTTCCA 60
AGTCCGTCCA TGATTCAGGG ATACCGTCTT CTCCCTCTGG GATATTCTGT GATTTGGGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063835|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0005635--C:nuclear envelope
GO:0005109--F:frizzled binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089--P:stem cell proliferation
GO:0038018--P:Wnt receptor catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG mmu:207742
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001826 Ailuropoda melanoleuca 79.03 0.00e+00 986.00
IUUC-Apl-003222 Anas platyrhynchos 63.54 4.00e-137 481.00
IUUC-Ath-007583 Arabidopsis thaliana 41.10 1.00e-11 62.40
IUUC-Ame-011450 Astyanax mexicanus 47.13 4.00e-51 196.00
IUUC-Bta-012714 Bos taurus 79.03 0.00e+00 996.00
IUUC-Cel-018318 Caenorhabditis elegans 60.00 1.00e-15 77.80
IUUC-Cja-018949 Callithrix jacchus 83.64 2.00e-94 337.00
IUUC-Cfa-021169 Canis familiaris 75.25 0.00e+00 963.00
IUUC-Cpo-022010 Cavia porcellus 90.43 5.00e-163 568.00
IUUC-Csa-023712 Chlorocebus sabaeus 76.36 0.00e+00 791.00
IUUC-Dre-027851 Danio rerio 45.21 1.00e-56 213.00
IUUC-Dno-029646 Dasypus novemcinctus 72.48 0.00e+00 846.00
IUUC-Dor-030965 Dipodomys ordii 71.66 0.00e+00 919.00
IUUC-Ete-033153 Echinops telfairi 73.98 0.00e+00 885.00
IUUC-Eca-034222 Equus caballus 82.47 0.00e+00 1023.00
IUUC-Eeu-035320 Erinaceus europaeus 72.17 3.00e-79 290.00
IUUC-Fca-036163 Felis catus 79.87 0.00e+00 1029.00
IUUC-Fal-037463 Ficedula albicollis 60.62 4.00e-109 389.00
IUUC-Fox-037754 Fusarium oxysporum 41.89 7.00e-12 63.90
IUUC-Gmo-039022 Gadus morhua 47.00 3.00e-39 154.00
IUUC-Gga-040209 Gallus gallus 59.16 1.00e-118 421.00
IUUC-Ggo-045644 Gorilla gorilla 80.43 0.00e+00 1012.00
IUUC-Hsa-045983 Homo sapiens 80.18 0.00e+00 1040.00
IUUC-Itr-049074 Ictidomys tridecemlineatus 82.58 0.00e+00 1071.00
IUUC-Loc-052503 Lepisosteus oculatus 39.56 5.00e-62 232.00
IUUC-Laf-054039 Loxodonta africana 79.51 0.00e+00 1011.00
IUUC-Mcc-054760 Macaca mulatta 79.54 0.00e+00 1006.00
IUUC-Meu-055948 Macropus eugenii 61.25 0.00e+00 630.00
IUUC-Mtr-058712 Medicago truncatula 32.06 1.00e-12 66.20
IUUC-Mga-060022 Meleagris gallopavo 65.47 3.00e-77 282.00
IUUC-Mmr-061100 Microcebus murinus 81.96 0.00e+00 1065.00
IUUC-Mdo-062909 Monodelphis domestica 68.44 0.00e+00 838.00
IUUC-Mpu-066916 Mustela putorius furo 79.16 0.00e+00 992.00
IUUC-Mlu-067234 Myotis lucifugus 78.96 0.00e+00 994.00
IUUC-Nle-069493 Nomascus leucogenys 80.05 0.00e+00 1024.00
IUUC-Oan-073037 Ornithorhynchus anatinus 81.86 3.00e-96 345.00
IUUC-Ocu-074655 Oryctolagus cuniculus 79.80 0.00e+00 1019.00
IUUC-Ola-087097 Oryzias latipes 43.98 2.00e-56 213.00
IUUC-Oga-088134 Otolemur garnettii 79.80 0.00e+00 1063.00
IUUC-Oar-089606 Ovis aries 71.92 0.00e+00 942.00
IUUC-Ptr-090726 Pan troglodytes 80.18 0.00e+00 1025.00
IUUC-Pan-091958 Papio anubis 79.80 0.00e+00 1011.00
IUUC-Psi-093208 Pelodiscus sinensis 56.64 3.00e-132 465.00
IUUC-Pfo-096209 Poecilia formosa 43.94 5.00e-55 209.00
IUUC-Pab-097950 Pongo abelii 87.17 0.00e+00 749.00
IUUC-Pca-100229 Procavia capensis 73.57 0.00e+00 944.00
IUUC-Pva-102480 Pteropus vampyrus 77.76 0.00e+00 987.00
IUUC-Rno-104862 Rattus norvegicus 92.48 0.00e+00 1305.00
IUUC-Sha-107577 Sarcophilus harrisii 69.96 0.00e+00 868.00
IUUC-Stu-112205 Solanum tuberosum 31.82 1.00e-13 69.30
IUUC-Sar-113693 Sorex araneus 69.42 0.00e+00 823.00
IUUC-Tgu-116568 Taeniopygia guttata 64.15 4.00e-110 391.00
IUUC-Tru-118126 Takifugu rubripes 46.33 1.00e-52 201.00
IUUC-Tni-120241 Tetraodon nigroviridis 45.48 5.00e-43 168.00
IUUC-Tbe-128106 Tupaia belangeri 90.91 6.00e-132 464.00
IUUC-Ttr-128832 Tursiops truncatus 81.92 0.00e+00 789.00
IUUC-Vvi-131349 Vitis vinifera 58.70 2.00e-13 68.60
Created Date 25-Jun-2017

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