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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106407
UUCD1 version UUC-SaC-00065
Ensembl Protein ID YOL133W
UniProt Accession Q08273; D6W1T5; RBX1_YEAST
Genbank Protein ID CAA64737.1; CAA99155.1; DAA10651.1
Protein Name RING-box protein HRT1; E3 ubiquitin-protein ligase complex SCF subunit HRT1; High level expression reduces Ty3 transposition protein 1; Regulator of cullins protein 1
Genbank Nucleotide ID X95465; Z74876; BK006948
Gene Name HRT1; RBX1; ROC1; YOL133W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YOL133W YOL133W YOL133W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFUniProtBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19390082; 18704118
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.50e-11 41.3 55 110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplv..................lpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC++++++ p++                  + C+H+fh++C++kw       ++++ CPl+
   Q: 55   CAICRNHIME-PCIecqpkamtdtdnecvaawGVCNHAFHLHCINKW------IKTRDACPLD 110
           ********99.88656666666666666566688*************......********97 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. Recruits the E2 ubiquitin-conjugating enzyme CDC34/UBC3 to the complex and brings it into close proximity to the substrate. Also stimulates CDC34/UBC3 autoubiquitination and promotes the neddylation of CDC53 and RTT101. Component of the SCF(CDC4) ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor SIC1 and for the G1-to-S phase transition. Component of the RTT101(MMS1-MMS22) ubiquitin ligase that promotes fork progression through damaged DNA or natural pause sites. Component of the CRL3(ELA1) ubiquitin ligase required for ubiquitinaton of RPB1, the largest subunit of RNA polymerase II (Pol II), which targets Pol II for proteasomal degradation in DNA-damaged cells.
 Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. Recruits the E2 ubiquitin-conjugating enzyme CDC34/UBC3 to the complex and brings it into close proximity to the substrate. Also stimulates CDC34/UBC3 autoubiquitination and promotes the neddylation of CDC53 and RTT101. Component of the SCF(CDC4) ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor SIC1 and for the G1-to-S phase transition. Component of the RTT101(MMS1-MMS22) ubiquitin ligase that promotes fork progression through damaged DNA or natural pause sites. Component of the CRL3(ELA1) ubiquitin ligase required for ubiquitinaton of RPB1, the largest subunit of RNA polymerase II (Pol II), which targets Pol II for proteasomal degradation in DNA-damaged cells.
Protein Sequence
(Fasta)
MSNEVDRMDV DEDESQNIAQ SSNQSAPVET KKKRFEIKKW TAVAFWSWDI AVDNCAICRN 60
HIMEPCIECQ PKAMTDTDNE CVAAWGVCNH AFHLHCINKW IKTRDACPLD NQPWQLARCG 120
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Protein Fasta Sequence


>IUUC-Sce-106407|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAGCAACG AAGTTGACAG GATGGATGTT GATGAAGATG AATCGCAAAA TATTGCGCAA 60
AGCTCAAACC AAAGTGCGCC AGTGGAAACC AAAAAGAAGA GATTTGAAAT TAAGAAATGG 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106407|E3,RING|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0035361--C:Cul8-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006281--P:DNA repair
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG sce:YOL133W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001798 Ailuropoda melanoleuca 54.17 9.00e-36 139.00
IUUC-Atr-002900 Amborella trichopoda 63.00 7.00e-36 140.00
IUUC-Apl-003762 Anas platyrhynchos 66.23 4.00e-30 119.00
IUUC-Aca-005328 Anolis carolinensis 57.89 1.00e-35 139.00
IUUC-Aly-005923 Arabidopsis lyrata 65.91 1.00e-34 135.00
IUUC-Ath-007535 Arabidopsis thaliana 62.92 5.00e-33 130.00
IUUC-Ago-007991 Ashbya gossypii 71.93 2.00e-46 174.00
IUUC-Acl-008332 Aspergillus clavatus 64.44 2.00e-35 138.00
IUUC-Afl-008537 Aspergillus flavus 64.37 5.00e-34 134.00
IUUC-Afu-008985 Aspergillus fumigatus 64.44 2.00e-35 138.00
IUUC-Ani-009342 Aspergillus nidulans 64.44 1.00e-35 139.00
IUUC-Ang-009778 Aspergillus niger 64.37 5.00e-34 134.00
IUUC-Aor-009918 Aspergillus oryzae 64.37 5.00e-34 134.00
IUUC-Ame-010935 Astyanax mexicanus 46.07 2.00e-21 92.00
IUUC-Bgr-012224 Blumeria graminis 60.40 1.00e-36 142.00
IUUC-Bta-012426 Bos taurus 56.14 9.00e-36 139.00
IUUC-Bci-013839 Botrytis cinerea 64.77 2.00e-34 135.00
IUUC-Bdi-014575 Brachypodium distachyon 67.05 5.00e-35 137.00
IUUC-Bol-015671 Brassica oleracea 64.84 1.00e-35 139.00
IUUC-Bra-017034 Brassica rapa 64.84 1.00e-35 139.00
IUUC-Cel-018195 Caenorhabditis elegans 60.82 3.00e-35 137.00
IUUC-Cja-018788 Callithrix jacchus 56.76 2.00e-35 137.00
IUUC-Cfa-020188 Canis familiaris 46.07 2.00e-21 91.70
IUUC-Cpo-021365 Cavia porcellus 56.14 9.00e-36 139.00
IUUC-Cre-022904 Chlamydomonas reinhardtii 57.47 3.00e-26 108.00
IUUC-Csa-024198 Chlorocebus sabaeus 56.14 9.00e-36 139.00
IUUC-Cho-024539 Choloepus hoffmanni 46.07 2.00e-21 92.40
IUUC-Cin-025449 Ciona intestinalis 59.62 5.00e-37 143.00
IUUC-Csv-026356 Ciona savignyi 44.19 3.00e-19 84.00
IUUC-Cgl-026522 Colletotrichum gloeosporioides 51.75 4.00e-36 140.00
IUUC-Cne-027067 Cryptococcus neoformans 59.52 2.00e-29 119.00
IUUC-Cme-027268 Cyanidioschyzon merolae 55.26 2.00e-34 135.00
IUUC-Dre-027434 Danio rerio 57.02 4.00e-36 140.00
IUUC-Dno-029252 Dasypus novemcinctus 53.39 7.00e-35 136.00
IUUC-Dor-030861 Dipodomys ordii 44.95 3.00e-23 97.80
IUUC-Dse-031355 Dothistroma septosporum 63.33 3.00e-35 137.00
IUUC-Dme-031585 Drosophila melanogaster 58.41 1.00e-36 142.00
IUUC-Ete-033111 Echinops telfairi 34.23 5.00e-14 67.40
IUUC-Eca-033758 Equus caballus 56.14 9.00e-36 139.00
IUUC-Fca-035586 Felis catus 56.14 9.00e-36 139.00
IUUC-Fal-037097 Ficedula albicollis 63.75 1.00e-30 121.00
IUUC-Fox-037881 Fusarium oxysporum 62.20 2.00e-30 121.00
IUUC-Fso-038373 Fusarium solani 60.00 2.00e-35 138.00
IUUC-Gmo-039457 Gadus morhua 58.72 2.00e-35 138.00
IUUC-Ggr-039970 Gaeumannomyces graminis 62.50 2.00e-33 132.00
IUUC-Gga-040328 Gallus gallus 56.14 9.00e-36 139.00
IUUC-Gac-041578 Gasterosteus aculeatus 57.02 4.00e-36 140.00
IUUC-Gma-042692 Glycine max 65.91 2.00e-34 134.00
IUUC-Ggo-045314 Gorilla gorilla 41.44 4.00e-22 94.40
IUUC-Hsa-046279 Homo sapiens 56.14 9.00e-36 139.00
IUUC-Hvu-047597 Hordeum vulgare 65.93 3.00e-35 138.00
IUUC-Itr-048227 Ictidomys tridecemlineatus 55.93 5.00e-36 140.00
IUUC-Kpa-049330 Komagataella pastoris 64.44 1.00e-36 142.00
IUUC-Lch-049667 Latimeria chalumnae 57.02 4.00e-36 140.00
IUUC-Loc-052481 Lepisosteus oculatus 42.34 7.00e-22 93.20
IUUC-Lma-053052 Leptosphaeria maculans 64.52 3.00e-36 141.00
IUUC-Laf-053827 Loxodonta africana 57.80 3.00e-35 137.00
IUUC-Mcc-055208 Macaca mulatta 56.14 9.00e-36 139.00
IUUC-Meu-056143 Macropus eugenii 63.41 8.00e-31 122.00
IUUC-Mor-057158 Magnaporthe oryzae 63.64 4.00e-34 134.00
IUUC-Mpo-057409 Magnaporthe poae 62.50 2.00e-33 132.00
IUUC-Mtr-058505 Medicago truncatula 65.91 2.00e-34 135.00
IUUC-Mla-059071 Melampsora laricipopulina 52.76 8.00e-35 136.00
IUUC-Mga-059797 Meleagris gallopavo 56.14 9.00e-36 139.00
IUUC-Mvi-060401 Microbotryum violaceum 52.50 8.00e-36 140.00
IUUC-Mmr-061077 Microcebus murinus 56.14 9.00e-36 139.00
IUUC-Mdo-062218 Monodelphis domestica 56.14 9.00e-36 139.00
IUUC-Mmu-064224 Mus musculus 56.14 9.00e-36 139.00
IUUC-Mac-064737 Musa acuminata 65.91 2.00e-34 135.00
IUUC-Mpu-066572 Mustela putorius furo 56.14 9.00e-36 139.00
IUUC-Mlu-067821 Myotis lucifugus 56.14 9.00e-36 139.00
IUUC-Nfi-068412 Neosartorya fischeri 64.44 2.00e-35 138.00
IUUC-Nle-069309 Nomascus leucogenys 56.14 9.00e-36 139.00
IUUC-Opr-070307 Ochotona princeps 56.14 9.00e-36 139.00
IUUC-Ont-071677 Oreochromis niloticus 57.52 6.00e-36 140.00
IUUC-Oan-072926 Ornithorhynchus anatinus 64.56 3.00e-30 120.00
IUUC-Oba-075405 Oryza barthii 67.05 8.00e-35 136.00
IUUC-Obr-076843 Oryza brachyantha 67.05 5.00e-35 137.00
IUUC-Ogl-077608 Oryza glaberrima 67.05 8.00e-35 136.00
IUUC-Ogu-078316 Oryza glumaepatula 67.05 7.00e-35 136.00
IUUC-Oin-079918 Oryza indica 43.85 3.00e-28 115.00
IUUC-Olo-080968 Oryza longistaminata 67.92 9.00e-19 82.00
IUUC-Ome-081246 Oryza meridionalis 64.77 7.00e-34 133.00
IUUC-Oni-082052 Oryza nivara 67.05 8.00e-35 136.00
IUUC-Opu-084035 Oryza punctata 55.56 4.00e-36 140.00
IUUC-Oru-084941 Oryza rufipogon 67.05 8.00e-35 136.00
IUUC-Osa-085800 Oryza sativa 67.05 8.00e-35 136.00
IUUC-Ola-087352 Oryzias latipes 57.02 3.00e-36 140.00
IUUC-Olu-087676 Ostreococcus lucimarinus 48.84 3.00e-23 97.80
IUUC-Oga-088880 Otolemur garnettii 56.14 9.00e-36 139.00
IUUC-Oar-089286 Ovis aries 54.17 8.00e-36 139.00
IUUC-Ptr-091402 Pan troglodytes 56.14 9.00e-36 139.00
IUUC-Pan-091687 Papio anubis 55.26 8.00e-35 136.00
IUUC-Psi-093640 Pelodiscus sinensis 57.52 3.00e-36 141.00
IUUC-Pma-094723 Petromyzon marinus 62.65 5.00e-31 122.00
IUUC-Pno-094822 Phaeosphaeria nodorum 59.80 1.00e-36 142.00
IUUC-Ppa-095730 Physcomitrella patens 64.89 5.00e-36 140.00
IUUC-Pfo-096055 Poecilia formosa 57.02 4.00e-36 140.00
IUUC-Pab-098577 Pongo abelii 56.14 9.00e-36 139.00
IUUC-Pop-099697 Populus trichocarpa 57.41 3.00e-36 141.00
IUUC-Pca-100719 Procavia capensis 56.14 9.00e-36 139.00
IUUC-Ppe-101429 Prunus persica 60.00 4.00e-37 144.00
IUUC-Pva-102548 Pteropus vampyrus 46.07 2.00e-21 92.00
IUUC-Pgr-103470 Puccinia graminis 55.17 2.00e-36 142.00
IUUC-Ptt-103909 Puccinia triticina 53.57 2.00e-22 95.50
IUUC-Pte-104144 Pyrenophora teres 62.37 5.00e-33 130.00
IUUC-Pyt-104533 Pyrenophora triticirepentis 61.86 3.00e-36 140.00
IUUC-Rno-105912 Rattus norvegicus 56.14 9.00e-36 139.00
IUUC-Sha-107549 Sarcophilus harrisii 56.14 9.00e-36 139.00
IUUC-Sja-108003 Schizosaccharomyces japonicus 57.55 2.00e-34 135.00
IUUC-Spo-108091 Schizosaccharomyces pombe 58.42 2.00e-34 134.00
IUUC-Ssl-108634 Sclerotinia sclerotiorum 64.77 2.00e-34 135.00
IUUC-Smo-109406 Selaginella moellendorffii 66.67 2.00e-34 135.00
IUUC-Sit-110419 Setaria italica 64.04 5.00e-34 134.00
IUUC-Sly-111256 Solanum lycopersicum 52.89 9.00e-35 136.00
IUUC-Stu-112567 Solanum tuberosum 54.55 6.00e-36 140.00
IUUC-Sar-112957 Sorex araneus 44.83 2.00e-20 89.00
IUUC-Sbi-113799 Sorghum bicolor 67.05 6.00e-35 137.00
IUUC-Sre-115142 Sporisorium reilianum 60.19 4.00e-35 137.00
IUUC-Tgu-116923 Taeniopygia guttata 65.38 3.00e-30 120.00
IUUC-Tru-117710 Takifugu rubripes 56.48 1.00e-35 139.00
IUUC-Tsy-119251 Tarsius syrichta 46.07 2.00e-21 92.00
IUUC-Tni-119934 Tetraodon nigroviridis 57.52 2.00e-36 142.00
IUUC-Tca-121820 Theobroma cacao 66.29 4.00e-35 137.00
IUUC-Tre-122212 Trichoderma reesei 53.10 7.00e-31 123.00
IUUC-Tvi-122357 Trichoderma virens 53.10 6.00e-36 140.00
IUUC-Tae-125834 Triticum aestivum 67.05 5.00e-35 137.00
IUUC-Tur-125958 Triticum urartu 65.91 4.00e-34 133.00
IUUC-Tme-126940 Tuber melanosporum 56.64 4.00e-36 140.00
IUUC-Tbe-127918 Tupaia belangeri 63.41 8.00e-31 122.00
IUUC-Ttr-128306 Tursiops truncatus 63.41 8.00e-31 122.00
IUUC-Uma-129482 Ustilago maydis 58.25 5.00e-34 133.00
IUUC-Vda-129917 Verticillium dahliae 55.56 1.00e-36 142.00
IUUC-Vpa-130142 Vicugna pacos 55.96 2.00e-32 127.00
IUUC-Vvi-130957 Vitis vinifera 65.91 2.00e-34 135.00
IUUC-Xtr-132382 Xenopus tropicalis 45.98 4.00e-21 90.10
IUUC-Xma-133061 Xiphophorus maculatus 57.02 4.00e-36 140.00
IUUC-Yli-134542 Yarrowia lipolytica 61.05 2.00e-34 134.00
IUUC-Zma-135160 Zea mays 67.05 7.00e-35 136.00
Created Date 25-Jun-2017

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