iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.10e-32	109.6	115	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd..vqpevfrallkFlYtgklde 67
           +Dv++vv g+ f+ah+++L a+S +F ++++++++    k+ v+++   + p +f all++lYtg+ld+
   Q: 115  SDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKG---KSVVVLRHplINPVAFGALLQYLYTGRLDI 180
           6*****************************999985...4699999889******************96 PP

Organism

Rattus norvegicus

Functional Description
(View)

May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity).

Protein Sequence
(Fasta)

MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE LVRYLLANGA 60
RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY YDDFLQRLLE QGIHSDVVFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTACATCC GGCCGGGCAC AGACAACTCC TGAGATCGCT CGGCCGGGGG TCCAGCCTCT 60
TTCGCCATGG ACACTAGCGA CCTGTTTGCC AGCTGCAGGA AGGGGGACGT GGGCCGTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0251--Elongation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB

Pfam

PF12796--Ank_2
PF00651--BTB

SMART

SM00248--ANK
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003746--F:translation elongation factor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

rno:297432

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000443	Aegilops tauschii	25.93	6.00e-20	92.00
IUUC-Aml-001651	Ailuropoda melanoleuca	93.93	0.00e+00	870.00
IUUC-Atr-002929	Amborella trichopoda	27.73	1.00e-24	107.00
IUUC-Apl-003737	Anas platyrhynchos	77.83	0.00e+00	688.00
IUUC-Aca-005362	Anolis carolinensis	77.41	0.00e+00	717.00
IUUC-Aly-005560	Arabidopsis lyrata	31.07	4.00e-52	199.00
IUUC-Ath-007684	Arabidopsis thaliana	31.28	5.00e-53	202.00
IUUC-Acl-008196	Aspergillus clavatus	38.71	4.00e-24	106.00
IUUC-Afl-008477	Aspergillus flavus	29.68	3.00e-38	153.00
IUUC-Afu-009053	Aspergillus fumigatus	36.53	1.00e-23	105.00
IUUC-Ang-009825	Aspergillus niger	31.39	2.00e-41	163.00
IUUC-Aor-010132	Aspergillus oryzae	29.68	3.00e-38	153.00
IUUC-Ate-010330	Aspergillus terreus	27.54	3.00e-33	136.00
IUUC-Ame-010691	Astyanax mexicanus	65.56	3.00e-162	564.00
IUUC-Bgr-012002	Blumeria graminis	27.62	1.00e-33	138.00
IUUC-Bta-012987	Bos taurus	83.05	0.00e+00	735.00
IUUC-Bci-013710	Botrytis cinerea	28.03	1.00e-30	128.00
IUUC-Bdi-014977	Brachypodium distachyon	50.57	9.00e-19	88.60
IUUC-Bol-016212	Brassica oleracea	32.09	1.00e-52	201.00
IUUC-Bra-016855	Brassica rapa	31.73	2.00e-50	193.00
IUUC-Cja-019303	Callithrix jacchus	93.72	0.00e+00	888.00
IUUC-Cfa-020840	Canis familiaris	93.72	0.00e+00	888.00
IUUC-Cpo-021992	Cavia porcellus	92.89	0.00e+00	857.00
IUUC-Csa-023233	Chlorocebus sabaeus	94.35	0.00e+00	870.00
IUUC-Cin-025170	Ciona intestinalis	43.90	4.00e-93	335.00
IUUC-Csv-026159	Ciona savignyi	45.74	3.00e-114	405.00
IUUC-Cgl-026440	Colletotrichum gloeosporioides	28.38	2.00e-37	150.00
IUUC-Cme-027271	Cyanidioschyzon merolae	30.70	6.00e-25	109.00
IUUC-Dre-027436	Danio rerio	70.08	0.00e+00	689.00
IUUC-Dno-029837	Dasypus novemcinctus	91.43	0.00e+00	704.00
IUUC-Dse-031307	Dothistroma septosporum	25.59	3.00e-24	107.00
IUUC-Ete-032833	Echinops telfairi	87.24	0.00e+00	825.00
IUUC-Eca-034247	Equus caballus	93.72	0.00e+00	884.00
IUUC-Fca-035764	Felis catus	93.91	0.00e+00	853.00
IUUC-Fal-036709	Ficedula albicollis	77.26	0.00e+00	712.00
IUUC-Fox-037679	Fusarium oxysporum	27.08	5.00e-32	132.00
IUUC-Fso-038182	Fusarium solani	28.44	2.00e-34	140.00
IUUC-Gmo-038709	Gadus morhua	61.05	4.00e-171	594.00
IUUC-Ggr-039933	Gaeumannomyces graminis	26.61	7.00e-25	108.00
IUUC-Gga-040642	Gallus gallus	77.41	0.00e+00	725.00
IUUC-Gac-041542	Gasterosteus aculeatus	63.56	0.00e+00	632.00
IUUC-Gma-044195	Glycine max	32.74	2.00e-50	193.00
IUUC-Ggo-045298	Gorilla gorilla	93.91	0.00e+00	854.00
IUUC-Hsa-045733	Homo sapiens	94.56	0.00e+00	896.00
IUUC-Hvu-047766	Hordeum vulgare	30.99	2.00e-09	56.60
IUUC-Itr-048809	Ictidomys tridecemlineatus	85.40	0.00e+00	672.00
IUUC-Kpa-049236	Komagataella pastoris	26.78	5.00e-28	119.00
IUUC-Lch-050088	Latimeria chalumnae	71.12	0.00e+00	629.00
IUUC-Lpe-051044	Leersia perrieri	26.02	1.00e-22	101.00
IUUC-Loc-052787	Lepisosteus oculatus	70.77	0.00e+00	699.00
IUUC-Lma-053329	Leptosphaeria maculans	36.65	5.00e-23	102.00
IUUC-Laf-054099	Loxodonta africana	92.26	0.00e+00	842.00
IUUC-Mcc-055242	Macaca mulatta	93.19	0.00e+00	837.00
IUUC-Meu-056512	Macropus eugenii	77.62	0.00e+00	675.00
IUUC-Mor-057053	Magnaporthe oryzae	27.19	1.00e-21	98.20
IUUC-Mpo-057397	Magnaporthe poae	26.20	3.00e-23	103.00
IUUC-Mtr-058594	Medicago truncatula	30.09	7.00e-47	181.00
IUUC-Mga-059397	Meleagris gallopavo	76.96	0.00e+00	691.00
IUUC-Mmr-061427	Microcebus murinus	78.35	2.00e-103	368.00
IUUC-Mdo-061956	Monodelphis domestica	77.92	0.00e+00	677.00
IUUC-Mmu-063506	Mus musculus	98.33	0.00e+00	906.00
IUUC-Mac-065218	Musa acuminata	28.76	5.00e-44	172.00
IUUC-Mpu-066102	Mustela putorius furo	93.93	0.00e+00	882.00
IUUC-Mlu-067293	Myotis lucifugus	83.89	0.00e+00	758.00
IUUC-Nfi-068356	Neosartorya fischeri	31.67	2.00e-39	157.00
IUUC-Ncr-068884	Neurospora crassa	24.69	3.00e-19	90.10
IUUC-Nle-069809	Nomascus leucogenys	94.77	0.00e+00	896.00
IUUC-Opr-070691	Ochotona princeps	94.77	0.00e+00	833.00
IUUC-Ont-072314	Oreochromis niloticus	65.27	0.00e+00	649.00
IUUC-Oan-073035	Ornithorhynchus anatinus	74.53	8.00e-171	593.00
IUUC-Ocu-073868	Oryctolagus cuniculus	93.91	0.00e+00	799.00
IUUC-Oba-075254	Oryza barthii	26.65	3.00e-23	103.00
IUUC-Obr-076877	Oryza brachyantha	26.56	5.00e-25	109.00
IUUC-Ogu-078108	Oryza glumaepatula	27.04	3.00e-23	103.00
IUUC-Olo-081059	Oryza longistaminata	27.04	1.00e-23	103.00
IUUC-Oni-082081	Oryza nivara	26.65	8.00e-23	102.00
IUUC-Opu-083551	Oryza punctata	26.25	3.00e-21	96.70
IUUC-Oru-085228	Oryza rufipogon	26.73	7.00e-23	102.00
IUUC-Osa-085844	Oryza sativa	26.73	7.00e-23	102.00
IUUC-Ola-086680	Oryzias latipes	65.06	0.00e+00	644.00
IUUC-Oga-088474	Otolemur garnettii	94.98	0.00e+00	883.00
IUUC-Oar-090327	Ovis aries	81.96	2.00e-148	518.00
IUUC-Ptr-090511	Pan troglodytes	91.83	8.00e-155	539.00
IUUC-Pan-092758	Papio anubis	94.56	0.00e+00	871.00
IUUC-Psi-093772	Pelodiscus sinensis	75.13	8.00e-155	539.00
IUUC-Pma-094548	Petromyzon marinus	63.57	4.00e-154	537.00
IUUC-Pno-094959	Phaeosphaeria nodorum	31.39	2.00e-18	87.80
IUUC-Ppa-095931	Physcomitrella patens	34.47	5.00e-35	142.00
IUUC-Pfo-096211	Poecilia formosa	64.72	0.00e+00	649.00
IUUC-Pab-098352	Pongo abelii	86.19	0.00e+00	791.00
IUUC-Pop-099552	Populus trichocarpa	31.91	1.00e-49	191.00
IUUC-Pca-100943	Procavia capensis	88.84	5.00e-108	384.00
IUUC-Ppe-101944	Prunus persica	31.55	3.00e-50	192.00
IUUC-Pva-102566	Pteropus vampyrus	86.19	0.00e+00	772.00
IUUC-Pte-104208	Pyrenophora teres	28.98	1.00e-36	148.00
IUUC-Pyt-104617	Pyrenophora triticirepentis	34.53	1.00e-26	114.00
IUUC-Sce-106261	Saccharomyces cerevisiae	27.29	1.00e-31	130.00
IUUC-Sha-107095	Sarcophilus harrisii	82.05	0.00e+00	740.00
IUUC-Sja-107811	Schizosaccharomyces japonicus	28.39	4.00e-38	152.00
IUUC-Spo-108277	Schizosaccharomyces pombe	30.60	5.00e-41	162.00
IUUC-Ssl-108583	Sclerotinia sclerotiorum	29.03	2.00e-31	130.00
IUUC-Smo-108744	Selaginella moellendorffii	31.09	2.00e-32	133.00
IUUC-Sit-110191	Setaria italica	29.79	1.00e-40	160.00
IUUC-Sly-110836	Solanum lycopersicum	29.61	1.00e-45	177.00
IUUC-Stu-112766	Solanum tuberosum	29.27	1.00e-44	174.00
IUUC-Sbi-114848	Sorghum bicolor	30.02	6.00e-41	162.00
IUUC-Ssc-115778	Sus scrofa	85.62	0.00e+00	764.00
IUUC-Tgu-117174	Taeniopygia guttata	77.41	0.00e+00	719.00
IUUC-Tru-117645	Takifugu rubripes	60.79	3.00e-171	594.00
IUUC-Tsy-119394	Tarsius syrichta	92.72	5.00e-155	540.00
IUUC-Tni-120500	Tetraodon nigroviridis	59.01	7.00e-164	570.00
IUUC-Tca-121738	Theobroma cacao	31.20	3.00e-48	186.00
IUUC-Tre-121929	Trichoderma reesei	28.21	1.00e-29	125.00
IUUC-Tvi-122627	Trichoderma virens	28.90	3.00e-36	146.00
IUUC-Tae-125436	Triticum aestivum	27.85	5.00e-38	152.00
IUUC-Tme-126911	Tuber melanosporum	25.51	6.00e-21	95.90
IUUC-Ttr-128844	Tursiops truncatus	84.75	0.00e+00	707.00
IUUC-Vda-129922	Verticillium dahliae	27.61	2.00e-33	137.00
IUUC-Vvi-131681	Vitis vinifera	29.12	2.00e-45	177.00
IUUC-Xtr-132110	Xenopus tropicalis	71.71	0.00e+00	682.00
IUUC-Xma-132990	Xiphophorus maculatus	65.48	0.00e+00	655.00
IUUC-Yli-134395	Yarrowia lipolytica	29.25	1.00e-34	141.00
IUUC-Zma-135189	Zea mays	29.65	9.00e-39	154.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence