iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062653

UUCD1 version

UUC-MoD-00634

Ensembl Protein ID

ENSMODP00000008394.2

UniProt Accession

F7BTG6; F7BTG6_MONDO

Protein Name

Uncharacterized protein

Gene Name

HECTD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006780.2	ENSMODT00000008562.2	ENSMODP00000008394.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-102	341.8	449	787

Active Site

Position(s)	Description	Evidence
755	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f y+++++++++ + +      e+ + F+++G+l+g+a++++  ld+
   Q: 449  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFAYHKDSRCHWFSSFKC-----ENYSEFRLVGILMGLAVYNSITLDI 532
           589***************************************************88766.....679********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++++dl +++pel++ l+e++++ + ++ee  +  tf+v +e++g +k+++Lk+ G++ipV
   Q: 533  RFPPCCYKKLLSPpivpgdqntpvgicNVTIDDLYQIMPELAHGLNELLSY-DGNVEED-FYSTFQVFQEEFGIIKSYNLKSAGDKIPV 619
           *************777777776666666***********************.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l+v++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l+++t+y+g y +++ +i++Fw+v+ 
   Q: 620  TNQNRKEYVQLYVDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRNTQYDG-YVKTDLTIRYFWDVVL 707
           **********************************************************************76.**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  + +k++L+F+Tgs+r+P+gG+a+l+   f i+k ++s+++lP ++TCfn+L+LP+Y++k++lk+kL++ i++++gF+l+
   Q: 708  GFPLDLQKKLLHFTTGSDRVPVGGMADLN---FKISKhETSTNWLPVAHTCFNQLCLPPYKNKKELKQKLIIGISNSEGFGLE 787
           *****************************...9999977788**************************************985 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MNEDTRGPSQ AAAAATGAVE EKEKKEEEEK GKEEEREKLP PILTASSTAA SGAVERGAKG 60
QLSAFSSSIS AISQKKEVAE KRSSPPQPVI PNIKNVKDLP TICLDVRQKQ RLSIDSLSVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAGGAACTC ACTGTCTATG GCTTTGCCCC ACGAGAGATG CCTTTTCCAG CACTTCGAGA 60
AAAAGGGAAA AGCTGGTGGT ATTGGCTGAA TCCCTTGGGC GAGGTAGGAA GGAGAAACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mdo:100024451

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	88.50	0.00e+00	1327.00
IUUC-Apl-003589	Anas platyrhynchos	85.60	0.00e+00	1257.00
IUUC-Aca-004350	Anolis carolinensis	80.32	0.00e+00	1194.00
IUUC-Ago-007908	Ashbya gossypii	35.26	1.00e-79	291.00
IUUC-Acl-008288	Aspergillus clavatus	35.53	5.00e-95	343.00
IUUC-Afl-008402	Aspergillus flavus	34.38	3.00e-88	319.00
IUUC-Afu-008762	Aspergillus fumigatus	34.53	1.00e-91	331.00
IUUC-Ani-009176	Aspergillus nidulans	35.16	5.00e-89	322.00
IUUC-Ang-009791	Aspergillus niger	35.54	7.00e-90	325.00
IUUC-Aor-009921	Aspergillus oryzae	34.00	6.00e-88	318.00
IUUC-Ate-010295	Aspergillus terreus	35.38	7.00e-96	345.00
IUUC-Ame-010660	Astyanax mexicanus	80.94	5.00e-151	526.00
IUUC-Bgr-011981	Blumeria graminis	32.29	6.00e-90	326.00
IUUC-Bta-012945	Bos taurus	88.07	0.00e+00	1308.00
IUUC-Bci-013697	Botrytis cinerea	40.00	1.00e-77	285.00
IUUC-Cja-019263	Callithrix jacchus	86.38	0.00e+00	1288.00
IUUC-Cfa-020486	Canis familiaris	92.87	0.00e+00	1244.00
IUUC-Cpo-021755	Cavia porcellus	87.83	0.00e+00	1337.00
IUUC-Csa-023814	Chlorocebus sabaeus	87.11	0.00e+00	1228.00
IUUC-Cho-024980	Choloepus hoffmanni	71.95	0.00e+00	1032.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	42.70	1.00e-95	345.00
IUUC-Dre-028551	Danio rerio	74.63	0.00e+00	1120.00
IUUC-Dno-029497	Dasypus novemcinctus	88.35	0.00e+00	1206.00
IUUC-Dor-030867	Dipodomys ordii	76.60	0.00e+00	1101.00
IUUC-Dse-031239	Dothistroma septosporum	29.03	1.00e-85	311.00
IUUC-Ete-032902	Echinops telfairi	74.26	0.00e+00	1086.00
IUUC-Eca-033678	Equus caballus	88.57	0.00e+00	1321.00
IUUC-Eeu-035262	Erinaceus europaeus	74.82	0.00e+00	1001.00
IUUC-Fca-035590	Felis catus	89.25	0.00e+00	1338.00
IUUC-Fal-037123	Ficedula albicollis	81.43	0.00e+00	1202.00
IUUC-Fox-037941	Fusarium oxysporum	40.82	2.00e-99	357.00
IUUC-Fso-038388	Fusarium solani	41.47	8.00e-101	362.00
IUUC-Gmo-039553	Gadus morhua	65.83	0.00e+00	837.00
IUUC-Ggr-040110	Gaeumannomyces graminis	32.44	2.00e-95	343.00
IUUC-Gga-040406	Gallus gallus	84.72	0.00e+00	1295.00
IUUC-Gac-042141	Gasterosteus aculeatus	75.25	0.00e+00	1096.00
IUUC-Ggo-045504	Gorilla gorilla	86.32	0.00e+00	1293.00
IUUC-Hsa-045786	Homo sapiens	87.05	0.00e+00	1300.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	84.56	0.00e+00	1161.00
IUUC-Kpa-049152	Komagataella pastoris	32.31	9.00e-71	261.00
IUUC-Lch-049824	Latimeria chalumnae	79.60	0.00e+00	1075.00
IUUC-Loc-052173	Lepisosteus oculatus	77.87	0.00e+00	1176.00
IUUC-Laf-054017	Loxodonta africana	89.74	0.00e+00	1266.00
IUUC-Mcc-055713	Macaca mulatta	87.18	0.00e+00	1298.00
IUUC-Meu-056212	Macropus eugenii	71.87	2.00e-121	429.00
IUUC-Mor-057045	Magnaporthe oryzae	36.02	3.00e-88	320.00
IUUC-Mla-059187	Melampsora laricipopulina	43.95	1.00e-86	313.00
IUUC-Mga-059884	Meleagris gallopavo	78.56	0.00e+00	1134.00
IUUC-Mmr-061344	Microcebus murinus	88.42	0.00e+00	1320.00
IUUC-Mmu-063775	Mus musculus	84.77	0.00e+00	1231.00
IUUC-Mpu-066069	Mustela putorius furo	91.69	0.00e+00	1255.00
IUUC-Mlu-067925	Myotis lucifugus	88.84	0.00e+00	1308.00
IUUC-Nfi-068439	Neosartorya fischeri	34.75	2.00e-91	331.00
IUUC-Ncr-068903	Neurospora crassa	30.59	2.00e-91	331.00
IUUC-Nle-070046	Nomascus leucogenys	86.59	0.00e+00	1318.00
IUUC-Opr-071085	Ochotona princeps	77.52	2.00e-134	472.00
IUUC-Ont-072126	Oreochromis niloticus	72.78	0.00e+00	1136.00
IUUC-Oan-072933	Ornithorhynchus anatinus	89.81	0.00e+00	1184.00
IUUC-Ocu-073800	Oryctolagus cuniculus	92.30	0.00e+00	1250.00
IUUC-Ola-086988	Oryzias latipes	75.58	0.00e+00	1099.00
IUUC-Oga-088117	Otolemur garnettii	92.76	0.00e+00	1093.00
IUUC-Oar-089371	Ovis aries	88.84	0.00e+00	1284.00
IUUC-Ptr-090551	Pan troglodytes	87.87	0.00e+00	1266.00
IUUC-Pan-092067	Papio anubis	87.65	0.00e+00	1304.00
IUUC-Psi-092963	Pelodiscus sinensis	85.98	0.00e+00	1271.00
IUUC-Pfo-096562	Poecilia formosa	74.17	0.00e+00	1095.00
IUUC-Pab-098680	Pongo abelii	87.18	0.00e+00	1300.00
IUUC-Pca-100986	Procavia capensis	72.67	0.00e+00	850.00
IUUC-Pva-102219	Pteropus vampyrus	73.62	0.00e+00	1001.00
IUUC-Pgr-103315	Puccinia graminis	35.70	5.00e-92	332.00
IUUC-Ptt-103736	Puccinia triticina	41.28	9.00e-92	331.00
IUUC-Rno-105270	Rattus norvegicus	84.11	0.00e+00	1238.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.89	8.00e-68	252.00
IUUC-Sha-106819	Sarcophilus harrisii	93.61	0.00e+00	1390.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.11	3.00e-84	306.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	30.95	7.00e-81	295.00
IUUC-Sar-113134	Sorex araneus	79.73	0.00e+00	1154.00
IUUC-Ssc-115441	Sus scrofa	88.57	0.00e+00	1303.00
IUUC-Tgu-117166	Taeniopygia guttata	83.31	0.00e+00	1232.00
IUUC-Tsy-118898	Tarsius syrichta	75.88	0.00e+00	1031.00
IUUC-Tre-122108	Trichoderma reesei	38.76	2.00e-87	317.00
IUUC-Tvi-122644	Trichoderma virens	39.31	3.00e-93	337.00
IUUC-Tme-127004	Tuber melanosporum	34.56	2.00e-98	354.00
IUUC-Tbe-127292	Tupaia belangeri	72.65	0.00e+00	998.00
IUUC-Ttr-128352	Tursiops truncatus	84.90	0.00e+00	1237.00
IUUC-Vda-129969	Verticillium dahliae	40.00	2.00e-90	327.00
IUUC-Vpa-130218	Vicugna pacos	84.56	0.00e+00	919.00
IUUC-Xtr-132594	Xenopus tropicalis	78.50	0.00e+00	1143.00
IUUC-Xma-134157	Xiphophorus maculatus	73.81	0.00e+00	1018.00
IUUC-Yli-134470	Yarrowia lipolytica	34.68	7.00e-75	275.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence