iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000010747.1	ENSPSIT00000012467.1	ENSPSIP00000012406.1
ENSPSIG00000010747.1	ENSPSIT00000012482.1	ENSPSIP00000012421.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-96	324.0	1657	2036

Active Site

Position(s)	Description	Evidence
2003	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnp..dsglknp..................ehlklFe 72
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + n+  +++++n                   ++   F+
   Q: 1657 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGNQegTKYIHNLqglfalpfgrtakpahiaKVKMKFR 1742
           56899***********.**********************766664444433330033444448999999**********9999**** PP
   S: 73   flGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es..................... 130
           flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                     
   Q: 1743 FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFNIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletlnmngc 1829
           *******************************654444**************999999855555511555666666444444444433 PP
   S: 131  dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFtee 212
           ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F +e
   Q: 1830 SVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPE 1904
           3333............35555588999************************************************************ PP
   S: 213  elellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....d 292
           el++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f+se+++ fLqFvTgs+rlP+gGf++l+p l+++rk     +
   Q: 1905 ELDQLLCGSktDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSSFDSEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfestE 1991
           ********97778999999999999***********************************************************988 PP
   S: 293  asddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           + dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1992 NPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2036
           888***************************************985 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDTV GGRSHLGQAK HKAHSPPESK KSISKAPKVQ 60
SNTTSEQSRG HFSKRGCSSS AIIIPQEDPD RVSTSEKQRT GQVPKKDHSR GVKRSASPDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGGTAG TGTCTAGAAA GGGTATGTCC CTTCAGGAGA CAGGTGCCAA TGTCCAACCG 60
GCCTAATAAC AATCCAGGGG GGTCACTGCG ACGTTCACAG AGGAACACTG CTGGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.54	5.00e-126	446.00
IUUC-Aml-001502	Ailuropoda melanoleuca	95.40	0.00e+00	3561.00
IUUC-Atr-002821	Amborella trichopoda	37.30	6.00e-117	416.00
IUUC-Apl-003531	Anas platyrhynchos	93.98	0.00e+00	3471.00
IUUC-Aly-005962	Arabidopsis lyrata	38.80	9.00e-115	409.00
IUUC-Ath-006636	Arabidopsis thaliana	38.80	8.00e-114	405.00
IUUC-Ago-007875	Ashbya gossypii	35.87	2.00e-81	297.00
IUUC-Acl-008242	Aspergillus clavatus	36.31	1.00e-114	408.00
IUUC-Afl-008736	Aspergillus flavus	38.60	9.00e-111	395.00
IUUC-Afu-008812	Aspergillus fumigatus	35.70	3.00e-115	410.00
IUUC-Ani-009407	Aspergillus nidulans	36.67	3.00e-111	397.00
IUUC-Ang-009763	Aspergillus niger	39.59	6.00e-106	379.00
IUUC-Aor-009941	Aspergillus oryzae	30.88	1.00e-113	404.00
IUUC-Ate-010459	Aspergillus terreus	33.33	2.00e-86	314.00
IUUC-Ame-011761	Astyanax mexicanus	87.61	0.00e+00	2942.00
IUUC-Bgr-012265	Blumeria graminis	35.16	2.00e-104	374.00
IUUC-Bta-013070	Bos taurus	92.30	0.00e+00	3453.00
IUUC-Bci-013890	Botrytis cinerea	39.32	6.00e-103	369.00
IUUC-Bdi-014046	Brachypodium distachyon	37.90	4.00e-121	429.00
IUUC-Bol-015942	Brassica oleracea	43.85	2.00e-113	404.00
IUUC-Bra-016849	Brassica rapa	40.86	5.00e-113	403.00
IUUC-Cja-019046	Callithrix jacchus	93.64	0.00e+00	3554.00
IUUC-Cfa-020521	Canis familiaris	93.63	0.00e+00	3451.00
IUUC-Cpo-021639	Cavia porcellus	91.25	0.00e+00	3434.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.08	3.00e-90	325.00
IUUC-Csa-023231	Chlorocebus sabaeus	93.43	0.00e+00	3543.00
IUUC-Cho-024380	Choloepus hoffmanni	87.61	0.00e+00	3237.00
IUUC-Cin-025482	Ciona intestinalis	51.02	8.00e-160	556.00
IUUC-Csv-026121	Ciona savignyi	48.70	0.00e+00	1536.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.54	4.00e-111	396.00
IUUC-Cne-026857	Cryptococcus neoformans	40.94	2.00e-94	341.00
IUUC-Cme-027226	Cyanidioschyzon merolae	34.94	9.00e-75	275.00
IUUC-Dre-028174	Danio rerio	87.50	0.00e+00	2985.00
IUUC-Dor-030939	Dipodomys ordii	87.49	0.00e+00	1406.00
IUUC-Dse-031444	Dothistroma septosporum	37.55	3.00e-105	377.00
IUUC-Dme-032162	Drosophila melanogaster	63.41	8.00e-158	552.00
IUUC-Ete-032345	Echinops telfairi	89.85	0.00e+00	2236.00
IUUC-Eca-033229	Equus caballus	94.71	0.00e+00	3485.00
IUUC-Eeu-035205	Erinaceus europaeus	82.95	0.00e+00	2984.00
IUUC-Fca-036444	Felis catus	94.72	0.00e+00	3540.00
IUUC-Fal-037131	Ficedula albicollis	95.16	0.00e+00	3549.00
IUUC-Fox-038035	Fusarium oxysporum	36.12	1.00e-109	390.00
IUUC-Fso-038320	Fusarium solani	36.46	8.00e-110	392.00
IUUC-Gmo-039497	Gadus morhua	88.38	0.00e+00	3010.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.75	1.00e-107	385.00
IUUC-Gga-041021	Gallus gallus	95.40	0.00e+00	3567.00
IUUC-Gac-042474	Gasterosteus aculeatus	81.69	0.00e+00	3062.00
IUUC-Gma-043060	Glycine max	38.92	9.00e-121	428.00
IUUC-Ggo-044855	Gorilla gorilla	93.64	0.00e+00	3553.00
IUUC-Hsa-046147	Homo sapiens	91.72	0.00e+00	3454.00
IUUC-Hvu-047775	Hordeum vulgare	38.39	6.00e-124	439.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	91.45	0.00e+00	3372.00
IUUC-Kpa-049098	Komagataella pastoris	37.50	5.00e-85	310.00
IUUC-Lch-049818	Latimeria chalumnae	85.09	0.00e+00	3079.00
IUUC-Lpe-051017	Leersia perrieri	38.03	3.00e-118	420.00
IUUC-Loc-051777	Lepisosteus oculatus	87.17	0.00e+00	3330.00
IUUC-Lma-052990	Leptosphaeria maculans	34.80	5.00e-112	399.00
IUUC-Laf-053727	Loxodonta africana	95.30	0.00e+00	3551.00
IUUC-Mcc-055799	Macaca mulatta	91.98	0.00e+00	3448.00
IUUC-Meu-056065	Macropus eugenii	93.44	0.00e+00	2076.00
IUUC-Mor-057054	Magnaporthe oryzae	38.49	2.00e-106	381.00
IUUC-Mpo-057417	Magnaporthe poae	39.17	2.00e-108	387.00
IUUC-Mtr-057849	Medicago truncatula	37.16	2.00e-113	404.00
IUUC-Mla-058870	Melampsora laricipopulina	42.37	6.00e-107	382.00
IUUC-Mga-059580	Meleagris gallopavo	96.52	0.00e+00	3123.00
IUUC-Mvi-060507	Microbotryum violaceum	40.74	1.00e-115	412.00
IUUC-Mmr-060816	Microcebus murinus	93.38	0.00e+00	3536.00
IUUC-Mdo-062866	Monodelphis domestica	92.32	0.00e+00	3335.00
IUUC-Mmu-063906	Mus musculus	91.73	0.00e+00	3434.00
IUUC-Mac-064675	Musa acuminata	39.56	7.00e-113	401.00
IUUC-Mpu-066199	Mustela putorius furo	92.41	0.00e+00	3430.00
IUUC-Mlu-067110	Myotis lucifugus	91.97	0.00e+00	3431.00
IUUC-Nfi-068482	Neosartorya fischeri	35.70	7.00e-115	409.00
IUUC-Ncr-068906	Neurospora crassa	39.13	5.00e-109	389.00
IUUC-Nle-069410	Nomascus leucogenys	94.37	0.00e+00	3543.00
IUUC-Opr-070401	Ochotona princeps	84.25	0.00e+00	2984.00
IUUC-Ont-072100	Oreochromis niloticus	82.41	0.00e+00	3106.00
IUUC-Oan-073121	Ornithorhynchus anatinus	94.09	0.00e+00	3597.00
IUUC-Ocu-074623	Oryctolagus cuniculus	92.27	0.00e+00	3460.00
IUUC-Oba-075380	Oryza barthii	31.60	3.00e-117	416.00
IUUC-Obr-076915	Oryza brachyantha	37.22	6.00e-119	422.00
IUUC-Ogl-077055	Oryza glaberrima	38.16	2.00e-118	421.00
IUUC-Ogu-078892	Oryza glumaepatula	40.95	4.00e-113	402.00
IUUC-Oin-079256	Oryza indica	37.97	3.00e-117	417.00
IUUC-Olo-080343	Oryza longistaminata	37.97	1.00e-117	417.00
IUUC-Ome-081422	Oryza meridionalis	37.97	2.00e-117	417.00
IUUC-Oni-083047	Oryza nivara	41.13	5.00e-115	409.00
IUUC-Opu-083641	Oryza punctata	36.15	4.00e-111	396.00
IUUC-Oru-084439	Oryza rufipogon	40.95	1.00e-113	404.00
IUUC-Osa-085972	Oryza sativa	38.16	1.00e-116	413.00
IUUC-Ola-087173	Oryzias latipes	81.16	0.00e+00	3044.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	8.00e-88	317.00
IUUC-Oga-087908	Otolemur garnettii	93.35	0.00e+00	3544.00
IUUC-Oar-090277	Ovis aries	91.20	0.00e+00	3442.00
IUUC-Ptr-091543	Pan troglodytes	91.72	0.00e+00	3455.00
IUUC-Pan-092243	Papio anubis	91.93	0.00e+00	3449.00
IUUC-Pno-094891	Phaeosphaeria nodorum	39.96	4.00e-112	400.00
IUUC-Ppa-095181	Physcomitrella patens	37.05	2.00e-108	386.00
IUUC-Pfo-096267	Poecilia formosa	82.25	0.00e+00	3049.00
IUUC-Pab-098072	Pongo abelii	94.66	0.00e+00	3554.00
IUUC-Pop-099190	Populus trichocarpa	37.00	4.00e-116	413.00
IUUC-Pca-100311	Procavia capensis	88.59	0.00e+00	3171.00
IUUC-Ppe-101284	Prunus persica	37.57	7.00e-116	412.00
IUUC-Pva-102215	Pteropus vampyrus	93.23	0.00e+00	1323.00
IUUC-Pgr-103694	Puccinia graminis	39.58	1.00e-104	375.00
IUUC-Ptt-103916	Puccinia triticina	39.44	4.00e-98	353.00
IUUC-Pte-104346	Pyrenophora teres	39.07	9.00e-110	392.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.14	4.00e-110	393.00
IUUC-Rno-105315	Rattus norvegicus	91.35	0.00e+00	3405.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.00	2.00e-70	261.00
IUUC-Sha-106835	Sarcophilus harrisii	94.64	0.00e+00	3605.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.98	9.00e-96	345.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.74	2.00e-95	344.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.52	3.00e-106	380.00
IUUC-Smo-108776	Selaginella moellendorffii	43.47	1.00e-113	405.00
IUUC-Sit-110717	Setaria italica	38.12	2.00e-120	427.00
IUUC-Sly-111469	Solanum lycopersicum	39.37	7.00e-122	432.00
IUUC-Stu-112896	Solanum tuberosum	37.66	1.00e-104	374.00
IUUC-Sar-113224	Sorex araneus	84.63	0.00e+00	1837.00
IUUC-Sbi-114313	Sorghum bicolor	38.02	3.00e-123	436.00
IUUC-Sre-114993	Sporisorium reilianum	33.38	2.00e-99	358.00
IUUC-Ssc-115535	Sus scrofa	88.14	0.00e+00	3301.00
IUUC-Tgu-117493	Taeniopygia guttata	96.70	0.00e+00	2850.00
IUUC-Tru-118669	Takifugu rubripes	82.80	0.00e+00	3067.00
IUUC-Tsy-119373	Tarsius syrichta	91.13	0.00e+00	1799.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.98	0.00e+00	868.00
IUUC-Tca-121779	Theobroma cacao	38.39	9.00e-115	409.00
IUUC-Tre-122195	Trichoderma reesei	35.99	3.00e-106	380.00
IUUC-Tvi-122650	Trichoderma virens	35.93	7.00e-109	389.00
IUUC-Tae-123580	Triticum aestivum	38.29	1.00e-123	437.00
IUUC-Tur-126295	Triticum urartu	38.39	6.00e-126	445.00
IUUC-Tme-126964	Tuber melanosporum	40.28	6.00e-106	379.00
IUUC-Tbe-128149	Tupaia belangeri	82.79	0.00e+00	1231.00
IUUC-Ttr-128165	Tursiops truncatus	93.88	0.00e+00	2992.00
IUUC-Uma-129365	Ustilago maydis	36.17	1.00e-88	322.00
IUUC-Vda-129725	Verticillium dahliae	40.35	9.00e-109	389.00
IUUC-Vpa-130678	Vicugna pacos	96.08	0.00e+00	2620.00
IUUC-Vvi-131147	Vitis vinifera	39.40	1.00e-121	431.00
IUUC-Xtr-132636	Xenopus tropicalis	87.29	0.00e+00	3248.00
IUUC-Xma-133458	Xiphophorus maculatus	82.40	0.00e+00	3090.00
IUUC-Yli-134481	Yarrowia lipolytica	39.17	4.00e-97	349.00
IUUC-Zma-135657	Zea mays	38.79	4.00e-121	429.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence