iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059986

UUCD1 version

UUC-MeG-00535

Ensembl Protein ID

ENSMGAP00000012342.1

UniProt Accession

G1NGU6; G1NGU6_MELGA

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000011760.1	ENSMGAT00000013232.1	ENSMGAP00000012342.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-134	448.6	590	922

Active Site

Position(s)	Description	Evidence
891	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 590  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 677
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee++l++ f+v+ e+lg+++++eLk+gG+ni Vt+eNkeeY+ l++e
   Q: 678  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECNLEMYFCVDMELLGKVTSHELKSGGSNILVTEENKEEYIGLMAE 763
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l +F+e+ele+++cG++e+d+ d++++t y++ yt++s++i wFw++++e ++e r ++LqFv
   Q: 764  WRFSRGVREQTKAFLDGFNEVVPLQWLHYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIMWFWQFVKETDNEVRMRLLQFV 851
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 852  TGTCRLPLGGFAELMgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 922
           *********************************************************************96 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MATASPRTDT SNNHNGRLQM QVTVSSAKLK RKKNWFGTTF YTELTADGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATVD LKQALEIHNR KLEKVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATATGCAG AGGAGCAGGC TCCACATGGG CAGAACTTTG TCACGAGGTT GTCTCAGAAA 60
CTGTCTTGTG GGCTGCACTG GGCATGAGGA CTGAGAGATC AGAGGTAATG ATTAGTCTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	84.02	0.00e+00	1555.00
IUUC-Apl-003310	Anas platyrhynchos	95.35	0.00e+00	1722.00
IUUC-Aca-005388	Anolis carolinensis	83.82	0.00e+00	1518.00
IUUC-Ame-010992	Astyanax mexicanus	92.91	0.00e+00	857.00
IUUC-Bta-012857	Bos taurus	83.46	0.00e+00	1533.00
IUUC-Cel-018299	Caenorhabditis elegans	68.05	0.00e+00	849.00
IUUC-Cja-019448	Callithrix jacchus	83.37	0.00e+00	1555.00
IUUC-Cfa-020728	Canis familiaris	83.91	0.00e+00	1538.00
IUUC-Cpo-021635	Cavia porcellus	79.68	0.00e+00	1498.00
IUUC-Csa-023805	Chlorocebus sabaeus	85.32	0.00e+00	1192.00
IUUC-Cho-024943	Choloepus hoffmanni	72.60	0.00e+00	1014.00
IUUC-Cin-025212	Ciona intestinalis	74.27	0.00e+00	917.00
IUUC-Csv-026256	Ciona savignyi	73.18	0.00e+00	908.00
IUUC-Dre-028245	Danio rerio	73.10	0.00e+00	1245.00
IUUC-Dno-029618	Dasypus novemcinctus	83.05	0.00e+00	1538.00
IUUC-Dme-032041	Drosophila melanogaster	70.82	0.00e+00	902.00
IUUC-Ete-032779	Echinops telfairi	91.55	0.00e+00	1079.00
IUUC-Eca-033313	Equus caballus	82.61	0.00e+00	1514.00
IUUC-Eeu-035259	Erinaceus europaeus	75.49	0.00e+00	1364.00
IUUC-Fca-035420	Felis catus	82.72	0.00e+00	1541.00
IUUC-Fal-037335	Ficedula albicollis	93.41	0.00e+00	1721.00
IUUC-Gmo-039172	Gadus morhua	87.83	0.00e+00	1069.00
IUUC-Gga-040246	Gallus gallus	98.16	0.00e+00	1788.00
IUUC-Gac-042211	Gasterosteus aculeatus	92.96	0.00e+00	1179.00
IUUC-Ggo-045001	Gorilla gorilla	82.25	0.00e+00	1354.00
IUUC-Hsa-046544	Homo sapiens	82.76	0.00e+00	1544.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	82.12	0.00e+00	1495.00
IUUC-Lch-050398	Latimeria chalumnae	78.64	0.00e+00	1407.00
IUUC-Loc-052116	Lepisosteus oculatus	75.94	0.00e+00	1400.00
IUUC-Laf-053551	Loxodonta africana	82.96	0.00e+00	1510.00
IUUC-Mmr-060945	Microcebus murinus	79.83	0.00e+00	1469.00
IUUC-Mdo-063024	Monodelphis domestica	81.29	0.00e+00	1463.00
IUUC-Mmu-063202	Mus musculus	80.91	0.00e+00	1466.00
IUUC-Mpu-065773	Mustela putorius furo	83.73	0.00e+00	1538.00
IUUC-Nle-069188	Nomascus leucogenys	82.94	0.00e+00	1552.00
IUUC-Opr-070965	Ochotona princeps	80.56	0.00e+00	1479.00
IUUC-Ont-072226	Oreochromis niloticus	92.84	0.00e+00	1185.00
IUUC-Oan-073497	Ornithorhynchus anatinus	84.36	0.00e+00	1537.00
IUUC-Ocu-073891	Oryctolagus cuniculus	79.27	0.00e+00	1436.00
IUUC-Ola-087438	Oryzias latipes	89.49	0.00e+00	1178.00
IUUC-Oga-087922	Otolemur garnettii	82.22	0.00e+00	1516.00
IUUC-Oar-089317	Ovis aries	82.85	0.00e+00	1512.00
IUUC-Ptr-090484	Pan troglodytes	82.65	0.00e+00	1543.00
IUUC-Pan-092117	Papio anubis	82.61	0.00e+00	1543.00
IUUC-Psi-093338	Pelodiscus sinensis	89.83	0.00e+00	1657.00
IUUC-Pma-094279	Petromyzon marinus	74.43	0.00e+00	843.00
IUUC-Pfo-096171	Poecilia formosa	93.31	0.00e+00	1183.00
IUUC-Pab-098654	Pongo abelii	82.85	0.00e+00	1152.00
IUUC-Pva-102811	Pteropus vampyrus	74.59	0.00e+00	1324.00
IUUC-Rno-106125	Rattus norvegicus	80.97	0.00e+00	1483.00
IUUC-Sha-107243	Sarcophilus harrisii	83.12	0.00e+00	1529.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.39	7.00e-151	527.00
IUUC-Ssc-115368	Sus scrofa	82.90	0.00e+00	1517.00
IUUC-Tgu-117079	Taeniopygia guttata	93.41	0.00e+00	1689.00
IUUC-Tru-118062	Takifugu rubripes	71.06	0.00e+00	1358.00
IUUC-Tsy-119507	Tarsius syrichta	78.19	0.00e+00	1427.00
IUUC-Tni-120151	Tetraodon nigroviridis	69.35	0.00e+00	1315.00
IUUC-Ttr-129260	Tursiops truncatus	73.22	0.00e+00	1292.00
IUUC-Xtr-132877	Xenopus tropicalis	71.06	0.00e+00	1240.00
IUUC-Xma-133778	Xiphophorus maculatus	93.31	0.00e+00	1184.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence