iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-74	251.3	478	810

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee.fsgyeqqDaqEflafll 100
           +Gl N+gNtC+m ++LQcL+++p l+e + +  + +k+n +++ ++kg ++  +++l   +w+++ +a+ p+++l+ ++++  + +s  +q+Da+Ef  fll
   Q: 478  VGLFNMGNTCFMSATLQCLFQTPGLAEVFTKkVFVSKVNTQSRLGSKGVISAGFASLSDMIWNGTFTAIRPSRFLQLFSDTVYQpLSDGRQHDASEFQIFLL 579
           69***************************998899********************************************9887779**************** PP
   S: 101  dqleeelkkeknkpkeeeeeedkselsde..aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeel 200
           d+l+e+ ++ ++ + e+  +     +++     +k+ + + s++++l++  + s+i+cl+c+ +s ++e+++ +s+++p+++++   sl+ cL+s +++ +l
   Q: 580  DALHEDTNQAQRISFEQNYHGGAGIAKEAadFLKKHYQFSLSPVNRLLGSITVSEIRCLTCGASSATFEENTIISVEIPSNSSC---SLDMCLRSHFSQTKL 678
           *******8855555555444333322222225678888888******************************************9...*************** PP
   S: 201  egenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn 301
           +g+ +++c+kck+ + ++++ kl++ P+v+i+hLkRf     ++  ek++  v+f    +d++p++++   ++  k  Y+L+a   H G l+sGHY+a++ +
   Q: 679  DGDSRWNCPKCKEPRASTRTSKLWQPPPVMIIHLKRF--ALFNGDFEKNTAAVTFETArFDVRPYLHEMAPAE--KPVYKLYAATLHNGRLNSGHYTAVASH 776
           *************************************..34445667*********999*********66555..9************************** PP
   S: 302  .ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +++kWl+fdDs Vt+++  +v     s aY+lfYkr
   Q: 777  lRSDKWLRFDDSVVTPCENFKVDP---SLAYILFYKR 810
           55556*******************...********98 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MNSSGLQFTS MTELLATCSL TEQQTRQFEQ KSLDVVYQSL KNLQGSAEKA RGDLEQQYRL 60
LMKAGELGNI ITKSSKFARW KQNTANAALF YADFEKVVRE ASNLQSVLNI KYENLVRRAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTCGCC GAAATTTCGC AATTTTTCAG TCATTTTCTT CCAATTTCAC ACGAAAAATC 60
GATTTTCAGC GGGTTTTCTG TCAATTTCAA ATGAAAAATG AACTCATCCG GACTTCAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS50235--USP_3

Pfam

PF00443--UCH
PF08969--USP8_dimer

Gene Ontology

GO:0005769--C:early endosome
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_E01B7.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	33.82	5.00e-52	198.00
IUUC-Apl-003226	Anas platyrhynchos	34.40	2.00e-53	203.00
IUUC-Aca-004936	Anolis carolinensis	33.72	8.00e-51	194.00
IUUC-Ago-007959	Ashbya gossypii	28.49	1.00e-38	153.00
IUUC-Acl-008102	Aspergillus clavatus	30.65	1.00e-36	147.00
IUUC-Afl-008604	Aspergillus flavus	30.00	9.00e-37	147.00
IUUC-Afu-009001	Aspergillus fumigatus	29.48	4.00e-35	142.00
IUUC-Ani-009291	Aspergillus nidulans	28.53	3.00e-35	142.00
IUUC-Ang-009844	Aspergillus niger	30.14	2.00e-36	146.00
IUUC-Aor-010098	Aspergillus oryzae	30.05	8.00e-37	147.00
IUUC-Ate-010585	Aspergillus terreus	30.71	6.00e-38	151.00
IUUC-Bta-013008	Bos taurus	34.11	1.00e-52	200.00
IUUC-Bra-017228	Brassica rapa	28.11	1.00e-32	132.00
IUUC-Cja-019173	Callithrix jacchus	33.82	3.00e-52	199.00
IUUC-Cfa-021243	Canis familiaris	33.82	5.00e-52	198.00
IUUC-Cpo-021522	Cavia porcellus	33.82	1.00e-51	197.00
IUUC-Csa-023616	Chlorocebus sabaeus	33.82	1.00e-51	197.00
IUUC-Cin-025287	Ciona intestinalis	31.17	4.00e-40	159.00
IUUC-Csv-026253	Ciona savignyi	31.39	2.00e-35	143.00
IUUC-Dre-028440	Danio rerio	31.58	8.00e-48	184.00
IUUC-Dno-029039	Dasypus novemcinctus	33.82	5.00e-52	198.00
IUUC-Dse-031463	Dothistroma septosporum	27.61	4.00e-34	139.00
IUUC-Dme-032089	Drosophila melanogaster	31.71	2.00e-49	189.00
IUUC-Eca-033449	Equus caballus	33.82	1.00e-53	204.00
IUUC-Fca-035794	Felis catus	33.82	2.00e-51	194.00
IUUC-Fal-037322	Ficedula albicollis	34.40	2.00e-53	202.00
IUUC-Fso-038082	Fusarium solani	22.77	1.00e-19	90.90
IUUC-Gmo-038584	Gadus morhua	33.63	3.00e-49	189.00
IUUC-Ggr-039986	Gaeumannomyces graminis	26.36	3.00e-23	103.00
IUUC-Gga-041188	Gallus gallus	34.69	2.00e-53	202.00
IUUC-Gac-041850	Gasterosteus aculeatus	34.43	5.00e-52	198.00
IUUC-Ggo-045565	Gorilla gorilla	33.82	3.00e-52	199.00
IUUC-Hsa-046438	Homo sapiens	33.82	4.00e-52	199.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	33.82	5.00e-52	198.00
IUUC-Kpa-049321	Komagataella pastoris	29.19	1.00e-40	160.00
IUUC-Lch-050485	Latimeria chalumnae	33.33	7.00e-52	197.00
IUUC-Loc-052769	Lepisosteus oculatus	30.90	1.00e-51	197.00
IUUC-Lma-053021	Leptosphaeria maculans	28.39	2.00e-41	163.00
IUUC-Laf-053432	Loxodonta africana	33.53	5.00e-52	198.00
IUUC-Mcc-055823	Macaca mulatta	33.82	3.00e-52	199.00
IUUC-Meu-056099	Macropus eugenii	33.46	1.00e-36	147.00
IUUC-Mor-057065	Magnaporthe oryzae	25.92	1.00e-24	107.00
IUUC-Mpo-057461	Magnaporthe poae	25.13	4.00e-22	99.40
IUUC-Mga-059739	Meleagris gallopavo	34.40	9.00e-53	201.00
IUUC-Mmr-061158	Microcebus murinus	34.40	1.00e-52	200.00
IUUC-Mdo-061801	Monodelphis domestica	34.40	3.00e-52	199.00
IUUC-Mmu-063665	Mus musculus	31.21	3.00e-52	199.00
IUUC-Mpu-066738	Mustela putorius furo	33.82	5.00e-52	198.00
IUUC-Mlu-067307	Myotis lucifugus	33.53	7.00e-51	194.00
IUUC-Nfi-068410	Neosartorya fischeri	30.35	2.00e-35	143.00
IUUC-Nle-069314	Nomascus leucogenys	33.82	6.00e-52	198.00
IUUC-Ont-071545	Oreochromis niloticus	33.15	1.00e-52	200.00
IUUC-Oan-073537	Ornithorhynchus anatinus	34.69	3.00e-51	196.00
IUUC-Ocu-074193	Oryctolagus cuniculus	33.82	8.00e-52	197.00
IUUC-Ola-086622	Oryzias latipes	32.69	2.00e-50	193.00
IUUC-Olu-087767	Ostreococcus lucimarinus	27.86	2.00e-24	104.00
IUUC-Oga-088271	Otolemur garnettii	33.82	4.00e-52	198.00
IUUC-Oar-090431	Ovis aries	34.11	2.00e-52	200.00
IUUC-Ptr-091339	Pan troglodytes	33.82	3.00e-52	199.00
IUUC-Pan-092266	Papio anubis	33.13	1.00e-46	178.00
IUUC-Psi-093243	Pelodiscus sinensis	28.66	5.00e-36	143.00
IUUC-Pma-094626	Petromyzon marinus	33.99	1.00e-54	205.00
IUUC-Pno-094986	Phaeosphaeria nodorum	27.35	4.00e-32	132.00
IUUC-Pfo-096463	Poecilia formosa	34.33	1.00e-51	197.00
IUUC-Pab-097645	Pongo abelii	33.82	3.00e-52	199.00
IUUC-Pva-103222	Pteropus vampyrus	33.43	6.00e-48	185.00
IUUC-Pte-104348	Pyrenophora teres	27.65	1.00e-32	134.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	28.00	1.00e-40	160.00
IUUC-Rno-105510	Rattus norvegicus	33.82	6.00e-52	198.00
IUUC-Sce-106435	Saccharomyces cerevisiae	31.87	9.00e-42	164.00
IUUC-Sha-106879	Sarcophilus harrisii	34.39	1.00e-51	197.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	31.25	4.00e-41	161.00
IUUC-Spo-108065	Schizosaccharomyces pombe	30.00	3.00e-33	135.00
IUUC-Sar-113019	Sorex araneus	33.63	7.00e-50	191.00
IUUC-Ssc-116334	Sus scrofa	33.82	5.00e-52	198.00
IUUC-Tgu-117062	Taeniopygia guttata	34.69	2.00e-53	203.00
IUUC-Tru-117908	Takifugu rubripes	33.24	3.00e-53	202.00
IUUC-Tsy-118867	Tarsius syrichta	30.59	4.00e-46	179.00
IUUC-Tni-120206	Tetraodon nigroviridis	32.52	2.00e-49	189.00
IUUC-Tre-122216	Trichoderma reesei	24.19	2.00e-21	96.70
IUUC-Tvi-122618	Trichoderma virens	24.78	2.00e-21	96.70
IUUC-Tme-127144	Tuber melanosporum	30.75	2.00e-42	166.00
IUUC-Ttr-128580	Tursiops truncatus	31.92	2.00e-52	200.00
IUUC-Vda-129869	Verticillium dahliae	24.03	7.00e-24	104.00
IUUC-Vpa-130541	Vicugna pacos	33.24	4.00e-48	185.00
IUUC-Xtr-132161	Xenopus tropicalis	33.24	7.00e-56	211.00
IUUC-Xma-134271	Xiphophorus maculatus	34.33	2.00e-51	196.00
IUUC-Yli-134561	Yarrowia lipolytica	27.70	1.00e-33	137.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence