iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028440

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-specific peptidase 8

Genbank Nucleotide ID

CU928201

Gene Name

usp8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000063719.6	ENSDART00000151550.1	ENSDARP00000126067.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-105	354.5	735	1065

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n+  +++++++  ++ ++n+ n  ++kge+++++  ++++lw ++ k +sp +++ +++k++++fs+
   Q: 735  TGLRNLGNTCYMNSILQCLCNTVAMADYFNRnYYQDDINRANILGHKGEVAEEFSVVMKALWLGQYKMISPLDFKGTICKINSRFSS 821
           7******************************677889************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkk...eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           ye+qD+qE+l fl+d+l+e+l+k   ++  + ee e+ d+ ++ d a++k+k+ n+s+i+ lFqgq+ks+++c +c+++s ++e+f+
   Q: 822  YEHQDSQELLLFLMDGLHEDLNKadkRRGYKEEEIEHLDDVSAADLAWSKHKQLNESIIVALFQGQFKSTVQCMSCQHKSRTFETFM 908
           *********************8865444455556666677778888***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +l+l+   ++++   slqdcL+ f+kee+l++ n++yc++ck +++a k+++++klP++L +hLkRf+++ +   rek+++ v+fpl
   Q: 909  YLTLEMTASSKC---SLQDCLKLFHKEERLTDGNRFYCRHCKTHRDAIKRMQIWKLPPILLVHLKRFKYEGR--WREKLQTLVDFPL 990
           ***********9...****************************************************99765..567********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
             Ldls++++ p+++    kkY+L+av +H+G++++GHY+ay+kn  ++ W++fdD++V+e++ ++v +     aY++fY 
   Q: 991  DnLDLSQYVIGPKNN---LKKYNLYAVSNHYGGMDGGHYTAYCKNPMKQrWFKFDDHEVSEISSSTVRS---PAAYIFFYS 1065
           ***********9988...69*************************87777*******************...********7 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MPSVSSGLKD LYLSTSLGDL NKKAEIKPDK SSTRHYVQSA CKIFKAAEEC RLDRDEERAY 60
VLYMKYLSVY DLIKKRPDFK QQQEFFLSML GPTSFKKAIE EAEKLSESLK LRYEEVEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGTGTGTG TGTGTGTGTG TGAGACCTGA GGCTTCGGTG TCCAGCAGGA ATATGAGCTG 60
AAGATGCCGT CCGTGTCCAG CGGATTGAAG GATCTCTATC TGTCCACGTC ACTCGGAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF08969--USP8_dimer

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:565434

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	62.52	0.00e+00	736.00
IUUC-Apl-003226	Anas platyrhynchos	53.67	0.00e+00	1096.00
IUUC-Aca-004936	Anolis carolinensis	51.87	0.00e+00	989.00
IUUC-Ago-007959	Ashbya gossypii	33.61	2.00e-49	191.00
IUUC-Acl-008102	Aspergillus clavatus	30.22	8.00e-51	196.00
IUUC-Afl-008604	Aspergillus flavus	30.49	1.00e-49	192.00
IUUC-Afu-009001	Aspergillus fumigatus	30.56	2.00e-50	194.00
IUUC-Ani-009291	Aspergillus nidulans	30.77	7.00e-51	196.00
IUUC-Ang-009844	Aspergillus niger	31.94	1.00e-50	194.00
IUUC-Aor-010098	Aspergillus oryzae	30.49	1.00e-48	188.00
IUUC-Ate-010585	Aspergillus terreus	31.22	2.00e-50	194.00
IUUC-Ame-011029	Astyanax mexicanus	62.37	2.00e-92	332.00
IUUC-Bta-013008	Bos taurus	64.86	0.00e+00	744.00
IUUC-Cel-018482	Caenorhabditis elegans	31.58	8.00e-47	182.00
IUUC-Cja-019173	Callithrix jacchus	70.78	0.00e+00	732.00
IUUC-Cfa-021243	Canis familiaris	62.80	0.00e+00	736.00
IUUC-Cpo-021522	Cavia porcellus	53.10	0.00e+00	1093.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	43.02	3.00e-79	288.00
IUUC-Csa-023616	Chlorocebus sabaeus	70.99	0.00e+00	729.00
IUUC-Cho-024381	Choloepus hoffmanni	63.41	8.00e-175	608.00
IUUC-Cin-025287	Ciona intestinalis	44.02	5.00e-90	326.00
IUUC-Csv-026253	Ciona savignyi	48.16	7.00e-82	299.00
IUUC-Cne-026821	Cryptococcus neoformans	35.71	4.00e-71	263.00
IUUC-Dno-029039	Dasypus novemcinctus	70.58	0.00e+00	732.00
IUUC-Dor-031043	Dipodomys ordii	73.99	1.00e-107	385.00
IUUC-Dse-031463	Dothistroma septosporum	28.46	2.00e-44	174.00
IUUC-Dme-032089	Drosophila melanogaster	43.19	5.00e-82	299.00
IUUC-Ete-033040	Echinops telfairi	67.25	2.00e-163	569.00
IUUC-Eca-033449	Equus caballus	70.78	0.00e+00	751.00
IUUC-Eeu-034693	Erinaceus europaeus	73.99	1.00e-102	368.00
IUUC-Fca-035794	Felis catus	70.53	0.00e+00	704.00
IUUC-Fal-037322	Ficedula albicollis	70.93	0.00e+00	716.00
IUUC-Gmo-038584	Gadus morhua	61.34	0.00e+00	677.00
IUUC-Gga-041188	Gallus gallus	71.55	0.00e+00	727.00
IUUC-Gac-041850	Gasterosteus aculeatus	72.56	0.00e+00	735.00
IUUC-Ggo-045565	Gorilla gorilla	70.78	0.00e+00	734.00
IUUC-Hsa-046438	Homo sapiens	70.78	0.00e+00	733.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	54.95	0.00e+00	1114.00
IUUC-Lch-050485	Latimeria chalumnae	66.60	0.00e+00	744.00
IUUC-Loc-052769	Lepisosteus oculatus	74.85	0.00e+00	770.00
IUUC-Lma-053021	Leptosphaeria maculans	31.72	2.00e-53	204.00
IUUC-Laf-053432	Loxodonta africana	53.98	0.00e+00	1088.00
IUUC-Mcc-055823	Macaca mulatta	70.99	0.00e+00	735.00
IUUC-Meu-056099	Macropus eugenii	76.21	2.00e-132	467.00
IUUC-Mla-059089	Melampsora laricipopulina	40.62	9.00e-73	269.00
IUUC-Mga-059739	Meleagris gallopavo	70.72	0.00e+00	722.00
IUUC-Mvi-060559	Microbotryum violaceum	37.68	1.00e-75	278.00
IUUC-Mmr-061158	Microcebus murinus	70.29	0.00e+00	726.00
IUUC-Mdo-061801	Monodelphis domestica	71.19	0.00e+00	734.00
IUUC-Mmu-063665	Mus musculus	53.26	0.00e+00	1077.00
IUUC-Mpu-066738	Mustela putorius furo	70.99	0.00e+00	733.00
IUUC-Mlu-067307	Myotis lucifugus	70.49	0.00e+00	739.00
IUUC-Nfi-068410	Neosartorya fischeri	30.56	9.00e-51	196.00
IUUC-Nle-069314	Nomascus leucogenys	70.58	0.00e+00	731.00
IUUC-Opr-070378	Ochotona princeps	67.55	1.00e-101	364.00
IUUC-Ont-071545	Oreochromis niloticus	61.28	0.00e+00	1158.00
IUUC-Oan-073537	Ornithorhynchus anatinus	68.49	0.00e+00	729.00
IUUC-Ocu-074193	Oryctolagus cuniculus	55.00	0.00e+00	1130.00
IUUC-Ola-086622	Oryzias latipes	60.56	0.00e+00	773.00
IUUC-Oga-088271	Otolemur garnettii	70.70	0.00e+00	726.00
IUUC-Oar-090431	Ovis aries	64.93	0.00e+00	747.00
IUUC-Ptr-091339	Pan troglodytes	52.71	0.00e+00	1119.00
IUUC-Pan-092266	Papio anubis	71.69	2.00e-145	508.00
IUUC-Psi-093187	Pelodiscus sinensis	60.13	1.00e-104	374.00
IUUC-Pma-094626	Petromyzon marinus	52.30	4.00e-134	471.00
IUUC-Pfo-096463	Poecilia formosa	72.37	0.00e+00	759.00
IUUC-Pab-097645	Pongo abelii	70.78	0.00e+00	733.00
IUUC-Pva-103222	Pteropus vampyrus	73.00	8.00e-169	588.00
IUUC-Pgr-103408	Puccinia graminis	36.87	2.00e-57	218.00
IUUC-Ptt-103699	Puccinia triticina	44.41	1.00e-66	249.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	29.97	3.00e-50	194.00
IUUC-Rno-105510	Rattus norvegicus	53.31	0.00e+00	1117.00
IUUC-Sce-106435	Saccharomyces cerevisiae	33.51	4.00e-51	196.00
IUUC-Sha-106879	Sarcophilus harrisii	63.89	0.00e+00	734.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	33.71	6.00e-45	175.00
IUUC-Sar-113019	Sorex araneus	68.24	0.00e+00	674.00
IUUC-Sre-115031	Sporisorium reilianum	35.75	4.00e-68	253.00
IUUC-Ssc-116334	Sus scrofa	54.67	0.00e+00	1138.00
IUUC-Tgu-117062	Taeniopygia guttata	63.37	0.00e+00	718.00
IUUC-Tru-117908	Takifugu rubripes	61.68	0.00e+00	1271.00
IUUC-Tsy-118867	Tarsius syrichta	63.17	0.00e+00	632.00
IUUC-Tni-120206	Tetraodon nigroviridis	56.83	0.00e+00	1134.00
IUUC-Tme-127144	Tuber melanosporum	39.27	8.00e-76	279.00
IUUC-Tbe-127877	Tupaia belangeri	77.08	2.00e-67	251.00
IUUC-Ttr-128580	Tursiops truncatus	70.61	0.00e+00	738.00
IUUC-Uma-129340	Ustilago maydis	35.48	6.00e-71	263.00
IUUC-Vpa-130541	Vicugna pacos	61.67	0.00e+00	720.00
IUUC-Xtr-132161	Xenopus tropicalis	68.34	0.00e+00	724.00
IUUC-Xma-134271	Xiphophorus maculatus	72.76	0.00e+00	766.00
IUUC-Yli-134561	Yarrowia lipolytica	34.65	1.00e-57	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence