iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15530417

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	7.70e-08	33.0	72	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...........kdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+ +f           +d+plvl+ C H+fh++C+ kw       +++++CPlCr
   Q: 72   CGICRMEFesacnmckfpgDDCPLVLGiCRHAFHRHCIDKW-IAAPTNQPRAQCPLCR 128
           999*777788888888899555888888*************.6666899********8 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis (PubMed:11861581). In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity (PubMed:15466891).

Protein Sequence
(Fasta)

MEQQIQMDEQ ENDESQGNDD QQNMSMSSSE LHTMQDDHPG ILLKTNTRMS ITVKKLHVCG 60
EWKWLQGGED TCGICRMEFE SACNMCKFPG DDCPLVLGIC RHAFHRHCID KWIAAPTNQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAATGGAG CAACAAATTC AAATGGACGA ACAGGAAAAT GATGAATCAC AGGGAAACGA 60
TGATCAACAA AATATGTCGA TGAGCAGTTC TGAACTTCAT ACTGTAAGAC ATATAAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024991--Apc11
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF12861--zf-ANAPC11

SMART

SM00184--RING

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0045132--P:meiotic chromosome segregation
GO:0007067--P:mitotic nuclear division
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_F35G12.9

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002323	Ailuropoda melanoleuca	48.28	5.00e-19	84.00
IUUC-Aly-006393	Arabidopsis lyrata	48.24	1.00e-20	89.70
IUUC-Ath-006698	Arabidopsis thaliana	48.24	1.00e-20	89.70
IUUC-Ago-007824	Ashbya gossypii	46.27	7.00e-16	75.10
IUUC-Acl-008180	Aspergillus clavatus	43.90	1.00e-19	86.70
IUUC-Afl-008622	Aspergillus flavus	45.68	9.00e-20	87.00
IUUC-Afu-008844	Aspergillus fumigatus	45.68	4.00e-20	87.80
IUUC-Ani-009260	Aspergillus nidulans	43.90	1.00e-19	86.30
IUUC-Ang-009794	Aspergillus niger	40.45	1.00e-20	93.20
IUUC-Ame-011274	Astyanax mexicanus	47.13	7.00e-18	80.10
IUUC-Bgr-012017	Blumeria graminis	38.27	1.00e-13	66.20
IUUC-Bta-012644	Bos taurus	48.28	6.00e-19	83.60
IUUC-Bci-013779	Botrytis cinerea	41.86	3.00e-18	81.60
IUUC-Bdi-014975	Brachypodium distachyon	50.60	9.00e-22	93.20
IUUC-Bol-016184	Brassica oleracea	49.38	2.00e-20	88.60
IUUC-Bra-016983	Brassica rapa	43.30	7.00e-22	94.70
IUUC-Cja-019909	Callithrix jacchus	48.28	6.00e-19	83.60
IUUC-Cfa-020306	Canis familiaris	48.28	5.00e-19	84.00
IUUC-Cpo-021773	Cavia porcellus	48.28	5.00e-19	84.00
IUUC-Cre-022961	Chlamydomonas reinhardtii	46.99	4.00e-19	84.30
IUUC-Csa-024274	Chlorocebus sabaeus	48.28	6.00e-19	83.60
IUUC-Cgl-026398	Colletotrichum gloeosporioides	41.98	9.00e-18	80.10
IUUC-Cne-027036	Cryptococcus neoformans	52.46	2.00e-16	75.90
IUUC-Cme-027263	Cyanidioschyzon merolae	51.81	2.00e-22	95.10
IUUC-Dre-027617	Danio rerio	47.13	5.00e-18	80.50
IUUC-Dse-031304	Dothistroma septosporum	50.60	3.00e-22	94.70
IUUC-Dme-031897	Drosophila melanogaster	51.16	1.00e-21	92.40
IUUC-Fca-036297	Felis catus	47.87	1.00e-20	90.10
IUUC-Fal-037228	Ficedula albicollis	48.28	1.00e-19	86.30
IUUC-Fox-037929	Fusarium oxysporum	45.61	5.00e-13	63.90
IUUC-Fso-038194	Fusarium solani	44.44	2.00e-18	81.60
IUUC-Gmo-039638	Gadus morhua	57.14	9.00e-11	56.60
IUUC-Gga-040897	Gallus gallus	47.13	7.00e-19	83.20
IUUC-Gac-041644	Gasterosteus aculeatus	57.14	9.00e-11	56.60
IUUC-Gma-043111	Glycine max	48.84	3.00e-22	95.50
IUUC-Hsa-046268	Homo sapiens	48.28	6.00e-19	83.60
IUUC-Hvu-047305	Hordeum vulgare	48.19	4.00e-22	94.40
IUUC-Itr-048453	Ictidomys tridecemlineatus	48.28	5.00e-19	84.00
IUUC-Kpa-049388	Komagataella pastoris	34.55	1.00e-16	77.40
IUUC-Lch-049838	Latimeria chalumnae	47.13	2.00e-20	88.60
IUUC-Lpe-050878	Leersia perrieri	53.12	9.00e-17	76.60
IUUC-Lma-053166	Leptosphaeria maculans	45.68	6.00e-21	90.90
IUUC-Laf-054221	Loxodonta africana	48.28	5.00e-19	84.00
IUUC-Mor-056930	Magnaporthe oryzae	43.21	3.00e-18	81.60
IUUC-Mtr-058104	Medicago truncatula	49.41	9.00e-21	89.70
IUUC-Mla-059079	Melampsora laricipopulina	33.63	5.00e-15	71.60
IUUC-Mvi-060446	Microbotryum violaceum	47.69	3.00e-14	69.70
IUUC-Mmu-064301	Mus musculus	48.28	5.00e-19	84.00
IUUC-Mac-064936	Musa acuminata	51.81	1.00e-22	96.70
IUUC-Mpu-066041	Mustela putorius furo	48.28	5.00e-19	84.00
IUUC-Mlu-067360	Myotis lucifugus	48.28	6.00e-19	83.60
IUUC-Ncr-068931	Neurospora crassa	43.21	2.00e-18	82.40
IUUC-Ont-072502	Oreochromis niloticus	48.24	1.00e-18	82.80
IUUC-Ocu-074751	Oryctolagus cuniculus	41.38	3.00e-14	68.20
IUUC-Oba-075026	Oryza barthii	49.41	6.00e-22	93.60
IUUC-Obr-076888	Oryza brachyantha	48.28	2.00e-22	96.30
IUUC-Ogl-077825	Oryza glaberrima	49.40	3.00e-21	91.30
IUUC-Ogu-078433	Oryza glumaepatula	46.24	1.00e-22	98.20
IUUC-Oin-079835	Oryza indica	49.40	3.00e-21	91.30
IUUC-Ome-081297	Oryza meridionalis	52.94	2.00e-18	84.00
IUUC-Oni-082739	Oryza nivara	46.24	4.00e-23	99.00
IUUC-Opu-083502	Oryza punctata	53.12	3.00e-17	78.20
IUUC-Oru-084838	Oryza rufipogon	46.24	7.00e-23	97.80
IUUC-Osa-086037	Oryza sativa	49.40	3.00e-21	91.30
IUUC-Ola-087572	Oryzias latipes	48.28	2.00e-18	81.60
IUUC-Olu-087765	Ostreococcus lucimarinus	45.35	3.00e-17	78.20
IUUC-Oga-088853	Otolemur garnettii	48.28	4.00e-19	84.30
IUUC-Oar-089687	Ovis aries	48.28	5.00e-19	84.00
IUUC-Ptr-091674	Pan troglodytes	48.28	6.00e-19	83.60
IUUC-Psi-093124	Pelodiscus sinensis	47.13	3.00e-19	84.70
IUUC-Pno-094852	Phaeosphaeria nodorum	45.68	5.00e-21	91.30
IUUC-Ppa-095866	Physcomitrella patens	51.90	5.00e-21	90.50
IUUC-Pfo-096410	Poecilia formosa	47.13	3.00e-18	81.60
IUUC-Pop-099204	Populus trichocarpa	45.45	8.00e-22	93.60
IUUC-Ppe-101903	Prunus persica	49.40	8.00e-22	93.20
IUUC-Pte-104160	Pyrenophora teres	45.68	5.00e-20	87.80
IUUC-Rno-104979	Rattus norvegicus	48.28	5.00e-19	84.00
IUUC-Sce-106149	Saccharomyces cerevisiae	37.25	9.00e-19	84.70
IUUC-Sja-107930	Schizosaccharomyces japonicus	43.68	1.00e-20	89.40
IUUC-Spo-108296	Schizosaccharomyces pombe	40.23	5.00e-19	84.00
IUUC-Ssl-108464	Sclerotinia sclerotiorum	33.33	7.00e-11	56.60
IUUC-Smo-109289	Selaginella moellendorffii	51.95	1.00e-20	89.00
IUUC-Sit-109777	Setaria italica	48.19	2.00e-21	91.70
IUUC-Stu-112287	Solanum tuberosum	49.38	7.00e-20	87.40
IUUC-Sbi-113803	Sorghum bicolor	48.19	2.00e-21	91.70
IUUC-Sre-115018	Sporisorium reilianum	43.18	3.00e-16	75.10
IUUC-Ssc-116403	Sus scrofa	48.78	1.00e-17	79.30
IUUC-Tgu-117375	Taeniopygia guttata	48.28	1.00e-19	86.30
IUUC-Tru-118064	Takifugu rubripes	48.19	1.00e-17	79.00
IUUC-Tni-120387	Tetraodon nigroviridis	47.13	2.00e-18	82.00
IUUC-Tca-121186	Theobroma cacao	54.39	2.00e-15	72.00
IUUC-Tre-122153	Trichoderma reesei	44.44	1.00e-18	82.80
IUUC-Tvi-122412	Trichoderma virens	44.44	1.00e-18	82.80
IUUC-Tae-125184	Triticum aestivum	48.19	2.00e-21	91.70
IUUC-Tur-126516	Triticum urartu	47.06	4.00e-21	90.90
IUUC-Tme-127121	Tuber melanosporum	44.19	3.00e-21	91.30
IUUC-Uma-129529	Ustilago maydis	42.86	4.00e-15	71.60
IUUC-Vvi-131191	Vitis vinifera	44.44	3.00e-21	92.80
IUUC-Xma-133275	Xiphophorus maculatus	47.13	4.00e-18	80.90
IUUC-Yli-134369	Yarrowia lipolytica	43.21	1.00e-19	87.00
IUUC-Zma-134869	Zea mays	48.19	1.00e-21	92.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence