iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018208

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

BRCa homolog (Tumor suppressor gene Brca1)

Genbank Nucleotide ID

BX284603

Gene Name

brc-1; C36A4.8; CELE_C36A4.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00000264	C36A4.8a	C36A4.8a

Annotation

mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16628214

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00045	21.0	21	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +kd p++  C H+f+++C+++      + +++ +CP+Cr
   Q: 21   CGICCSTYKD-PILSTCFHIFCRSCINAC----FERKRKVQCPICR 61
           9*********.99999**********999....8899999*****8 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MADVALRITE TVARLQKELK CGICCSTYKD PILSTCFHIF CRSCINACFE RKRKVQCPIC 60
RSVLDKRSCR DTYQITMAVQ NYLKLSEAFK KDIENMNTFK SLPPEKMFME SQMPLDITII 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TTGCACTGAG GATCACAGAA ACAGTGGCAC GACTGCAAAA AGAACTGAAA 60
TGTGGAATTT GGTAATTTAT TTTCAAAAAA TCAACAAAAA AACCTTAAAT TGGTTTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16589--BRCT_2
PF00097--zf-C3HC4

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0051307--P:meiotic chromosome separation
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0006289--P:nucleotide-excision repair
GO:0071158--P:positive regulation of cell cycle arrest
GO:0035066--P:positive regulation of histone acetylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0042127--P:regulation of cell proliferation

KEGG

cel:CELE_C36A4.8

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	33.70	2.00e-11	64.70
IUUC-Apl-003252	Anas platyrhynchos	32.61	5.00e-11	63.20
IUUC-Aca-005242	Anolis carolinensis	32.03	3.00e-10	58.50
IUUC-Ath-006986	Arabidopsis thaliana	31.82	2.00e-07	50.40
IUUC-Ang-009681	Aspergillus niger	34.12	5.00e-08	51.20
IUUC-Ame-011517	Astyanax mexicanus	43.48	3.00e-10	58.90
IUUC-Bta-013433	Bos taurus	32.61	6.00e-11	62.80
IUUC-Cja-019149	Callithrix jacchus	35.44	2.00e-10	61.20
IUUC-Cfa-020322	Canis familiaris	33.70	5.00e-11	63.20
IUUC-Cpo-021583	Cavia porcellus	31.18	4.00e-10	60.10
IUUC-Cre-022597	Chlamydomonas reinhardtii	29.67	1.00e-08	53.10
IUUC-Csa-024227	Chlorocebus sabaeus	33.70	2.00e-11	63.50
IUUC-Cho-024530	Choloepus hoffmanni	36.92	2.00e-08	54.70
IUUC-Cin-025364	Ciona intestinalis	28.05	9.00e-11	59.30
IUUC-Csv-026245	Ciona savignyi	33.33	4.00e-10	57.00
IUUC-Cne-026870	Cryptococcus neoformans	39.29	2.00e-07	50.10
IUUC-Dre-028398	Danio rerio	35.00	7.00e-11	60.50
IUUC-Dor-030527	Dipodomys ordii	40.68	5.00e-10	57.40
IUUC-Ete-032424	Echinops telfairi	33.33	4.00e-09	55.10
IUUC-Eca-033446	Equus caballus	31.52	2.00e-10	61.20
IUUC-Eeu-034957	Erinaceus europaeus	32.91	5.00e-07	48.10
IUUC-Fca-035991	Felis catus	32.61	2.00e-10	61.60
IUUC-Fal-036803	Ficedula albicollis	30.34	1.00e-10	62.00
IUUC-Fox-037868	Fusarium oxysporum	32.22	1.00e-09	56.20
IUUC-Gmo-039366	Gadus morhua	34.67	4.00e-11	60.80
IUUC-Gga-040969	Gallus gallus	31.03	3.00e-11	63.90
IUUC-Gac-042563	Gasterosteus aculeatus	34.69	7.00e-08	50.40
IUUC-Ggo-044740	Gorilla gorilla	33.66	7.00e-11	62.80
IUUC-Hsa-046086	Homo sapiens	33.66	7.00e-11	62.80
IUUC-Itr-048579	Ictidomys tridecemlineatus	29.66	3.00e-09	55.10
IUUC-Lch-049677	Latimeria chalumnae	39.02	7.00e-13	67.40
IUUC-Loc-052208	Lepisosteus oculatus	40.96	4.00e-12	64.70
IUUC-Laf-053648	Loxodonta africana	35.44	2.00e-10	61.20
IUUC-Mcc-055210	Macaca mulatta	34.78	2.00e-11	64.30
IUUC-Meu-056122	Macropus eugenii	40.68	8.00e-09	53.90
IUUC-Mga-060163	Meleagris gallopavo	31.03	3.00e-11	63.90
IUUC-Mvi-060412	Microbotryum violaceum	35.53	3.00e-07	48.90
IUUC-Mdo-062209	Monodelphis domestica	39.24	7.00e-12	65.90
IUUC-Mmu-063495	Mus musculus	31.75	3.00e-10	58.50
IUUC-Mpu-065825	Mustela putorius furo	32.61	6.00e-11	61.60
IUUC-Mlu-068176	Myotis lucifugus	32.61	7.00e-11	62.80
IUUC-Nle-069178	Nomascus leucogenys	33.70	3.00e-10	60.80
IUUC-Opr-070901	Ochotona princeps	30.43	1.00e-08	52.80
IUUC-Ont-071281	Oreochromis niloticus	29.76	1.00e-09	56.60
IUUC-Oan-072725	Ornithorhynchus anatinus	38.98	6.00e-08	50.80
IUUC-Ocu-074424	Oryctolagus cuniculus	35.44	1.00e-10	62.00
IUUC-Ola-086860	Oryzias latipes	30.25	5.00e-10	57.80
IUUC-Oga-088422	Otolemur garnettii	33.33	3.00e-08	52.00
IUUC-Oar-089938	Ovis aries	32.61	6.00e-11	62.80
IUUC-Ptr-090960	Pan troglodytes	33.66	8.00e-11	62.80
IUUC-Pan-091944	Papio anubis	38.98	3.00e-08	51.60
IUUC-Pma-094336	Petromyzon marinus	48.00	3.00e-09	52.80
IUUC-Pab-097982	Pongo abelii	33.70	2.00e-10	60.80
IUUC-Pca-100435	Procavia capensis	38.98	1.00e-08	53.50
IUUC-Pva-102631	Pteropus vampyrus	32.61	5.00e-11	63.20
IUUC-Rno-105879	Rattus norvegicus	34.78	1.00e-10	61.60
IUUC-Sce-106384	Saccharomyces cerevisiae	32.73	6.00e-05	41.60
IUUC-Sha-107080	Sarcophilus harrisii	30.85	1.00e-08	53.50
IUUC-Sar-113047	Sorex araneus	29.47	9.00e-08	52.40
IUUC-Ssc-115846	Sus scrofa	35.44	2.00e-10	61.20
IUUC-Tgu-116785	Taeniopygia guttata	29.55	3.00e-10	60.80
IUUC-Tru-118309	Takifugu rubripes	37.68	4.00e-10	58.20
IUUC-Tsy-118963	Tarsius syrichta	31.00	2.00e-08	52.40
IUUC-Tni-120490	Tetraodon nigroviridis	43.75	5.00e-09	54.70
IUUC-Tre-121893	Trichoderma reesei	29.17	3.00e-07	48.50
IUUC-Vpa-130216	Vicugna pacos	32.61	2.00e-10	61.20
IUUC-Xtr-132398	Xenopus tropicalis	33.33	6.00e-12	66.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence