iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049802

Ensembl Protein ID

ENSLACP00000023488.1

UniProt Accession

M3XL82; M3XL82_LATCH

Genbank Protein ID

ENSLACP00000023488

Protein Name

Muscarinic acetylcholine receptor

Genbank Nucleotide ID

AFYH01097530

Gene Name

CHRM3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000022555.1	ENSLACT00000025889.1	ENSLACP00000023488.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	23.84	8.70e-02	33.50	IUUC-Sce-106193

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Latimeria chalumnae

Functional Description
(View)

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

Protein Sequence
(Fasta)

MDFFLTCSSI CQKIKMIANY NNTSLALFPN ISFDWNENSQ RTDLHAENRS QDGSYDIFQT 60
SGTFSSITVA PNISVKQNIT YDDPLGGHTV WQVVLIALFT GILALVTIIG NILVMVSFKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTAAGGTGT GTCATGTTTC CAGTGGCAGC TCCAGACCAG GGCCAGACAG ATCCTGTGGC 60
CAAGGAAAAA TATGATGTGC CCACAATTAT GCCTTGACTC CCTTTCTGTA TGGTGCATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0297--G-protein coupled receptor
KW-0472--Membrane
KW-0628--Postsynaptic cell membrane
KW-0675--Receptor
KW-1185--Reference proteome
KW-0770--Synapse
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
IPR001183--Musac_Ach_M3_rcpt
IPR000995--Musac_Ach_rcpt

PROSITE

PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2

Pfam

PF00001--7tm_1

PRINTS

PR00237--GPCRRHODOPSN
PR00243--MUSCARINICR
PR00540--MUSCRINICM3R

Gene Ontology

GO:0030054--C:cell junction
GO:0005887--C:integral component of plasma membrane
GO:0045211--C:postsynaptic membrane
GO:0016907--F:G-protein coupled acetylcholine receptor activity
GO:0045987--P:positive regulation of smooth muscle contraction
GO:0046541--P:saliva secretion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013064	Bos taurus	25.35	6.00e-05	41.60
IUUC-Cfa-020374	Canis familiaris	20.00	3.80e-02	32.00
IUUC-Cpo-022123	Cavia porcellus	23.46	2.00e-06	46.20
IUUC-Cho-024336	Choloepus hoffmanni	27.08	2.00e-06	46.60
IUUC-Dno-029971	Dasypus novemcinctus	24.32	1.40e+00	26.90
IUUC-Itr-048148	Ictidomys tridecemlineatus	25.93	4.20e-02	32.00
IUUC-Loc-052069	Lepisosteus oculatus	32.46	4.00e-29	122.00
IUUC-Mmr-061649	Microcebus murinus	25.93	2.60e-02	32.70
IUUC-Mdo-062558	Monodelphis domestica	25.23	1.00e-15	77.00
IUUC-Mlu-067297	Myotis lucifugus	19.38	7.80e-02	31.20
IUUC-Oan-072894	Ornithorhynchus anatinus	32.98	2.00e-24	107.00
IUUC-Ola-087063	Oryzias latipes	24.18	1.00e-06	48.10
IUUC-Ptr-091524	Pan troglodytes	20.00	2.00e-03	36.60
IUUC-Pfo-096201	Poecilia formosa	29.58	1.00e-15	77.40
IUUC-Rno-106078	Rattus norvegicus	25.81	2.00e-04	39.70
IUUC-Sce-106193	Saccharomyces cerevisiae	23.84	3.00e-02	33.50
IUUC-Sha-107148	Sarcophilus harrisii	36.78	1.00e-27	116.00
IUUC-Ssc-115447	Sus scrofa	24.69	8.00e-02	31.20
IUUC-Tbe-127299	Tupaia belangeri	24.17	1.00e-04	40.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence