iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sja-107941

Ensembl Protein ID

EEB08801

UniProt Accession

B6K5J7; B6K5J7_SCHJY

Genbank Protein ID

EEB08801.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

KE651167

Gene Name

SJAG_03970

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SJAG_03970	EEB08801	EEB08801

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-127	424.0	435	766

Active Site

Position(s)	Description	Evidence
735	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           +sdlkkrl+++f gE+gld+gG++re+++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r++d+++  sfyk++l+
   Q: 435  ASDLKKRLMIKFDGEDGLDYGGLSREYFYLLSHEMFNPFYCLFEYSSVDNYTLQINPHSGI-NPEHLNYFKFIGRVIGLAIFHRRFVDAFFVVSFYKMILK 534
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+ l+d+e++d+e+y+sl++i++n   di+++ ldltfsv+++ +ge+ +++L+p+G+ni+Vt+eNk++Yv++v+e+r++++i+ q+ af+eGf+e+ip 
   Q: 535  KKVALSDMESMDAEYYRSLMWILNN---DITDI-LDLTFSVEDNCFGEVVTVDLIPNGRNIEVTEENKQQYVEAVTEWRIQTRIQDQFRAFYEGFSELIPH 631
           ***********************99...9***9.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           el+++F+e+elelli G +eid+ed+kk t+y++ yt+++++i+wFwe +ee+++e+r+++LqF+Tg+sr+P++Gf++l+    pr+f+i+k++++++lP+
   Q: 632  ELVTVFDERELELLIGGISEIDLEDWKKYTEYRS-YTANDQVIKWFWELIEEWDNEKRSRLLQFTTGTSRIPVNGFKDLQgsdgPRKFTIEKSGEPTQLPK 731
           ********************************99.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++TCfn+L+LP+Y++k++l  kL +Aieet gF+ 
   Q: 732  AHTCFNRLDLPDYPTKQVLDAKLSLAIEETIGFGN 766
           ********************************985 PP

Organism

Schizosaccharomyces japonicus

Protein Sequence
(Fasta)

MSNSNLTRRL RVTIVAADGL YKRDVFRFPD PFAVLTVDGE QTHTTTVIKK TLNPYWNESF 60
EVTANENSTL AVQIFDQKKF KKKGQGFLGV INVRISDVLD LSVGGDEMLT RELKKSNDNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAACACTGGC GGTTACTGCA GTTATCCTTC TCCCACAGCG TATTTGTCAG AAAACCGAGC 60
TTTTCGTCTT TCACTTGTAG AATTCGCACA GAATTCTGCT GAATTGACGG ATTTTGCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0071944--C:cell periphery
GO:0005794--C:Golgi apparatus
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0060360--P:negative regulation of leucine import in response to ammonium ion
GO:0034067--P:protein localization to Golgi apparatus
GO:0051453--P:regulation of intracellular pH
GO:0034762--P:regulation of transmembrane transport
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0015857--P:uracil transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	49.74	4.00e-160	556.00
IUUC-Apl-003752	Anas platyrhynchos	47.70	2.00e-160	557.00
IUUC-Ago-007742	Ashbya gossypii	72.42	0.00e+00	887.00
IUUC-Acl-008273	Aspergillus clavatus	65.20	0.00e+00	1012.00
IUUC-Afl-008713	Aspergillus flavus	65.97	0.00e+00	1021.00
IUUC-Afu-009103	Aspergillus fumigatus	62.75	0.00e+00	983.00
IUUC-Ani-009259	Aspergillus nidulans	65.28	0.00e+00	1011.00
IUUC-Ang-009738	Aspergillus niger	65.89	0.00e+00	1030.00
IUUC-Aor-010053	Aspergillus oryzae	69.57	6.00e-131	457.00
IUUC-Ate-010529	Aspergillus terreus	66.75	0.00e+00	1029.00
IUUC-Bgr-012148	Blumeria graminis	65.39	0.00e+00	986.00
IUUC-Bta-012782	Bos taurus	50.09	3.00e-161	560.00
IUUC-Bci-013785	Botrytis cinerea	64.39	0.00e+00	1016.00
IUUC-Cja-018899	Callithrix jacchus	47.49	2.00e-160	557.00
IUUC-Cpo-022073	Cavia porcellus	50.09	3.00e-161	560.00
IUUC-Csa-023252	Chlorocebus sabaeus	46.86	9.00e-161	558.00
IUUC-Cho-024695	Choloepus hoffmanni	45.50	2.00e-160	557.00
IUUC-Cin-025126	Ciona intestinalis	39.47	2.00e-147	513.00
IUUC-Csv-026339	Ciona savignyi	39.46	4.00e-161	559.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	64.68	0.00e+00	1003.00
IUUC-Cne-026849	Cryptococcus neoformans	59.61	0.00e+00	979.00
IUUC-Dre-027650	Danio rerio	38.17	4.00e-158	550.00
IUUC-Dno-029884	Dasypus novemcinctus	47.16	1.00e-159	555.00
IUUC-Dse-031241	Dothistroma septosporum	65.19	0.00e+00	1044.00
IUUC-Eca-033793	Equus caballus	49.91	2.00e-160	557.00
IUUC-Fca-035605	Felis catus	49.65	1.00e-159	555.00
IUUC-Fal-037126	Ficedula albicollis	50.09	8.00e-160	555.00
IUUC-Fox-037774	Fusarium oxysporum	64.13	0.00e+00	999.00
IUUC-Fso-038393	Fusarium solani	63.97	0.00e+00	991.00
IUUC-Ggr-040107	Gaeumannomyces graminis	63.45	0.00e+00	1000.00
IUUC-Gga-040832	Gallus gallus	50.09	1.00e-160	558.00
IUUC-Gac-041658	Gasterosteus aculeatus	49.21	4.00e-158	550.00
IUUC-Hsa-046564	Homo sapiens	46.86	2.00e-160	558.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	49.91	2.00e-160	557.00
IUUC-Kpa-049273	Komagataella pastoris	66.11	0.00e+00	1012.00
IUUC-Lch-050398	Latimeria chalumnae	49.21	2.00e-151	528.00
IUUC-Lma-052980	Leptosphaeria maculans	60.04	2.00e-171	593.00
IUUC-Laf-054383	Loxodonta africana	49.91	1.00e-160	558.00
IUUC-Mcc-055532	Macaca mulatta	46.86	8.00e-161	558.00
IUUC-Mor-057097	Magnaporthe oryzae	65.04	0.00e+00	1028.00
IUUC-Mpo-057442	Magnaporthe poae	75.71	0.00e+00	816.00
IUUC-Mla-058996	Melampsora laricipopulina	60.55	0.00e+00	978.00
IUUC-Mga-059661	Meleagris gallopavo	50.09	1.00e-160	558.00
IUUC-Mvi-060395	Microbotryum violaceum	76.30	0.00e+00	812.00
IUUC-Mmr-061135	Microcebus murinus	47.49	4.00e-161	560.00
IUUC-Mdo-062505	Monodelphis domestica	47.32	5.00e-160	556.00
IUUC-Mmu-063375	Mus musculus	49.91	2.00e-160	557.00
IUUC-Mpu-066203	Mustela putorius furo	49.91	1.00e-160	558.00
IUUC-Mlu-067837	Myotis lucifugus	50.44	7.00e-162	562.00
IUUC-Nfi-068427	Neosartorya fischeri	65.19	0.00e+00	1017.00
IUUC-Ncr-068918	Neurospora crassa	64.38	0.00e+00	980.00
IUUC-Nle-069244	Nomascus leucogenys	46.86	1.00e-160	558.00
IUUC-Ont-072226	Oreochromis niloticus	49.38	1.00e-159	555.00
IUUC-Oan-073497	Ornithorhynchus anatinus	46.09	3.00e-151	527.00
IUUC-Ocu-074298	Oryctolagus cuniculus	50.09	7.00e-161	558.00
IUUC-Ola-087438	Oryzias latipes	49.21	7.00e-159	552.00
IUUC-Pan-092454	Papio anubis	46.86	6.00e-161	559.00
IUUC-Pno-095118	Phaeosphaeria nodorum	63.25	0.00e+00	1019.00
IUUC-Pgr-103620	Puccinia graminis	76.73	0.00e+00	818.00
IUUC-Ptt-103806	Puccinia triticina	77.37	0.00e+00	699.00
IUUC-Pte-104016	Pyrenophora teres	62.67	0.00e+00	978.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	62.67	0.00e+00	978.00
IUUC-Rno-104924	Rattus norvegicus	46.41	9.00e-161	558.00
IUUC-Sce-106289	Saccharomyces cerevisiae	64.03	0.00e+00	984.00
IUUC-Sha-107175	Sarcophilus harrisii	47.16	5.00e-160	556.00
IUUC-Spo-108171	Schizosaccharomyces pombe	80.05	0.00e+00	1257.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	66.13	0.00e+00	1015.00
IUUC-Sar-113761	Sorex araneus	49.91	6.00e-160	555.00
IUUC-Sre-114929	Sporisorium reilianum	69.05	0.00e+00	857.00
IUUC-Tru-118442	Takifugu rubripes	49.21	9.00e-161	558.00
IUUC-Tni-120151	Tetraodon nigroviridis	48.77	2.00e-154	538.00
IUUC-Tre-122203	Trichoderma reesei	64.43	0.00e+00	984.00
IUUC-Tvi-122595	Trichoderma virens	64.20	0.00e+00	993.00
IUUC-Tme-126897	Tuber melanosporum	67.71	0.00e+00	1004.00
IUUC-Vda-129753	Verticillium dahliae	62.69	0.00e+00	947.00
IUUC-Xtr-132885	Xenopus tropicalis	47.34	6.00e-160	555.00
IUUC-Yli-134668	Yarrowia lipolytica	68.01	0.00e+00	875.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence