iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134668

Ensembl Protein ID

CAG79685

UniProt Accession

Q6C5H0; Q6C5H0_YARLI

Genbank Protein ID

CAG79685.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CR382131

Gene Name

YALI0_E18117g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E18117g	CAG79685	CAG79685

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-125	416.5	522	853

Active Site

Position(s)	Description	Evidence
822	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dl+krl+++f gEegld+gGv+ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr +g+a++++r+ld+++  +fyk++l+
   Q: 522  PQDLQKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGI-NPEHLNYFKFIGRCVGLAIFHRRFLDAFFIGAFYKMILK 621
           589*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+ led+e vd++++++l++ ++n   di++  ldltfsv+++++ge+ + +Lkp+G+ni+Vtn+Nk eYv+lv+e+r+ ++++eq++af +Gf+e+ip+
   Q: 622  KKVMLEDMEGVDADYHRNLEWALDN---DITDV-LDLTFSVEDDQFGEIVTIDLKPDGRNIEVTNDNKIEYVELVTEWRISKRVEEQFQAFVSGFYELIPQ 718
           ***********************99...9***8.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           el+++F+e+elelli G ++idv+d+kk+t y+g y+e++++i+wFw+++++++se+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 719  ELVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YSESDEVIKWFWQCIRSWDSEQKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKAGEAQHLPK 818
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+ +LP+Y+++e l +kL +A+eet gF++
   Q: 819  SHTCFNRVDLPPYKNYEDLVKKLSMAVEETVGFGQ 853
           *********************************96 PP

Organism

Yarrowia lipolytica

Protein Sequence
(Fasta)

MPRTTKLRLT VIAADQLYKR DVFRLPDPFA VVLVDGGQTR TTSVIKKTLN PYWNESFDVD 60
VTPSSIIVVQ IFDHKKFKKK DQGFLGVINI RVGDVLNLAQ GGDEMITKDL RKANDSLVVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCCAGGA CAACCAAGCT AAGGCTGACG GGTGAGTATG AGCCGGTGGC GTTGCGCCAC 60
GGAGCGACTG TGGCAGTCAG TCAGGGACCA GTCAGGACCA ACGGAACACT GGGTGGACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

yli:YALI0E18117g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	46.20	6.00e-157	546.00
IUUC-Apl-003893	Anas platyrhynchos	46.04	6.00e-154	536.00
IUUC-Aca-005338	Anolis carolinensis	46.33	2.00e-157	548.00
IUUC-Ago-007742	Ashbya gossypii	71.59	0.00e+00	931.00
IUUC-Acl-008273	Aspergillus clavatus	75.08	0.00e+00	958.00
IUUC-Afl-008713	Aspergillus flavus	74.92	0.00e+00	945.00
IUUC-Afu-009103	Aspergillus fumigatus	75.56	0.00e+00	965.00
IUUC-Ani-009259	Aspergillus nidulans	66.63	0.00e+00	1074.00
IUUC-Ang-009738	Aspergillus niger	66.94	0.00e+00	1082.00
IUUC-Aor-010053	Aspergillus oryzae	81.27	2.00e-148	516.00
IUUC-Ame-010601	Astyanax mexicanus	46.49	2.00e-156	544.00
IUUC-Bgr-012148	Blumeria graminis	81.82	0.00e+00	851.00
IUUC-Bta-012679	Bos taurus	46.20	3.00e-157	547.00
IUUC-Bci-013785	Botrytis cinerea	74.48	0.00e+00	942.00
IUUC-Cel-018299	Caenorhabditis elegans	43.53	2.00e-148	517.00
IUUC-Cja-018732	Callithrix jacchus	46.37	1.00e-157	548.00
IUUC-Cfa-021226	Canis familiaris	46.20	9.00e-157	545.00
IUUC-Cpo-021671	Cavia porcellus	46.20	4.00e-157	546.00
IUUC-Csa-023344	Chlorocebus sabaeus	44.90	2.00e-153	535.00
IUUC-Cho-024695	Choloepus hoffmanni	47.31	1.00e-159	555.00
IUUC-Cin-025157	Ciona intestinalis	44.30	1.00e-148	518.00
IUUC-Csv-026256	Ciona savignyi	44.72	3.00e-145	506.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	73.19	0.00e+00	928.00
IUUC-Cne-026849	Cryptococcus neoformans	68.55	0.00e+00	880.00
IUUC-Dre-028809	Danio rerio	46.49	2.00e-156	543.00
IUUC-Dno-029466	Dasypus novemcinctus	46.20	2.00e-157	548.00
IUUC-Dor-030138	Dipodomys ordii	45.73	7.00e-153	532.00
IUUC-Dse-031241	Dothistroma septosporum	68.14	0.00e+00	1135.00
IUUC-Dme-032041	Drosophila melanogaster	49.60	1.00e-140	491.00
IUUC-Ete-033145	Echinops telfairi	43.46	6.00e-143	499.00
IUUC-Eca-033445	Equus caballus	46.20	6.00e-157	546.00
IUUC-Eeu-035247	Erinaceus europaeus	51.02	7.00e-148	516.00
IUUC-Fca-035605	Felis catus	46.33	6.00e-158	549.00
IUUC-Fal-037604	Ficedula albicollis	48.52	4.00e-142	496.00
IUUC-Fox-037774	Fusarium oxysporum	73.32	0.00e+00	932.00
IUUC-Fso-038393	Fusarium solani	72.12	0.00e+00	919.00
IUUC-Gmo-039674	Gadus morhua	51.02	2.00e-145	508.00
IUUC-Ggr-040107	Gaeumannomyces graminis	72.09	0.00e+00	943.00
IUUC-Gga-040703	Gallus gallus	46.37	5.00e-154	536.00
IUUC-Gac-042020	Gasterosteus aculeatus	52.46	3.00e-145	507.00
IUUC-Ggo-045332	Gorilla gorilla	46.37	3.00e-157	547.00
IUUC-Hsa-045968	Homo sapiens	46.37	2.00e-157	548.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	46.49	3.00e-158	550.00
IUUC-Kpa-049273	Komagataella pastoris	74.36	0.00e+00	966.00
IUUC-Lch-050443	Latimeria chalumnae	45.72	6.00e-155	539.00
IUUC-Loc-052662	Lepisosteus oculatus	50.61	2.00e-141	494.00
IUUC-Lma-052980	Leptosphaeria maculans	72.88	5.00e-174	601.00
IUUC-Laf-053850	Loxodonta africana	46.20	5.00e-157	546.00
IUUC-Mcc-055821	Macaca mulatta	46.37	2.00e-157	547.00
IUUC-Meu-056436	Macropus eugenii	45.57	2.00e-120	424.00
IUUC-Mor-057097	Magnaporthe oryzae	65.36	0.00e+00	1088.00
IUUC-Mpo-057442	Magnaporthe poae	73.26	0.00e+00	879.00
IUUC-Mla-058996	Melampsora laricipopulina	69.49	0.00e+00	892.00
IUUC-Mga-059986	Meleagris gallopavo	42.11	5.00e-147	513.00
IUUC-Mvi-060395	Microbotryum violaceum	78.97	0.00e+00	833.00
IUUC-Mmr-061135	Microcebus murinus	46.66	7.00e-159	552.00
IUUC-Mdo-062173	Monodelphis domestica	44.36	6.00e-152	529.00
IUUC-Mmu-064136	Mus musculus	46.20	3.00e-157	547.00
IUUC-Mpu-066765	Mustela putorius furo	46.20	6.00e-157	546.00
IUUC-Mlu-067565	Myotis lucifugus	46.20	2.00e-156	544.00
IUUC-Nfi-068427	Neosartorya fischeri	75.56	0.00e+00	964.00
IUUC-Ncr-068918	Neurospora crassa	82.85	0.00e+00	846.00
IUUC-Nle-069244	Nomascus leucogenys	46.66	8.00e-159	551.00
IUUC-Opr-071044	Ochotona princeps	51.02	1.00e-147	515.00
IUUC-Ont-071798	Oreochromis niloticus	47.15	2.00e-157	547.00
IUUC-Oan-073497	Ornithorhynchus anatinus	42.35	1.00e-146	511.00
IUUC-Ocu-074160	Oryctolagus cuniculus	51.02	7.00e-148	516.00
IUUC-Ola-087467	Oryzias latipes	49.42	4.00e-146	510.00
IUUC-Oga-088460	Otolemur garnettii	46.20	6.00e-157	545.00
IUUC-Oar-090198	Ovis aries	46.20	6.00e-157	546.00
IUUC-Ptr-090939	Pan troglodytes	46.37	2.00e-157	548.00
IUUC-Pan-092284	Papio anubis	46.37	2.00e-157	548.00
IUUC-Psi-093645	Pelodiscus sinensis	45.63	2.00e-156	544.00
IUUC-Pma-094364	Petromyzon marinus	49.61	1.00e-143	500.00
IUUC-Pno-095118	Phaeosphaeria nodorum	65.86	0.00e+00	1094.00
IUUC-Pfo-096937	Poecilia formosa	47.47	4.00e-158	550.00
IUUC-Pab-098088	Pongo abelii	46.37	1.00e-157	548.00
IUUC-Pca-100596	Procavia capensis	47.96	2.00e-136	478.00
IUUC-Pva-102354	Pteropus vampyrus	46.04	1.00e-156	545.00
IUUC-Pgr-103620	Puccinia graminis	68.54	0.00e+00	874.00
IUUC-Ptt-103806	Puccinia triticina	78.99	0.00e+00	704.00
IUUC-Pte-104016	Pyrenophora teres	75.40	0.00e+00	960.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	75.40	0.00e+00	960.00
IUUC-Rno-105318	Rattus norvegicus	46.20	3.00e-157	547.00
IUUC-Sce-106289	Saccharomyces cerevisiae	72.07	0.00e+00	938.00
IUUC-Sha-107482	Sarcophilus harrisii	50.51	3.00e-146	510.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	76.86	0.00e+00	833.00
IUUC-Spo-108171	Schizosaccharomyces pombe	78.12	0.00e+00	855.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	74.32	0.00e+00	941.00
IUUC-Sar-113761	Sorex araneus	46.49	2.00e-157	548.00
IUUC-Sre-114929	Sporisorium reilianum	77.94	0.00e+00	832.00
IUUC-Ssc-115368	Sus scrofa	41.91	2.00e-145	508.00
IUUC-Tgu-117130	Taeniopygia guttata	50.61	5.00e-146	509.00
IUUC-Tru-118442	Takifugu rubripes	46.98	4.00e-158	550.00
IUUC-Tsy-119492	Tarsius syrichta	51.02	2.00e-146	511.00
IUUC-Tni-119993	Tetraodon nigroviridis	50.61	9.00e-142	495.00
IUUC-Tre-122203	Trichoderma reesei	64.31	0.00e+00	1031.00
IUUC-Tvi-122595	Trichoderma virens	64.60	0.00e+00	1046.00
IUUC-Tme-126897	Tuber melanosporum	72.76	0.00e+00	905.00
IUUC-Tbe-127793	Tupaia belangeri	46.73	9.00e-132	462.00
IUUC-Ttr-128235	Tursiops truncatus	51.02	2.00e-147	514.00
IUUC-Uma-129332	Ustilago maydis	77.94	0.00e+00	806.00
IUUC-Vda-129753	Verticillium dahliae	73.68	0.00e+00	932.00
IUUC-Vpa-130503	Vicugna pacos	49.79	6.00e-141	493.00
IUUC-Xtr-132859	Xenopus tropicalis	47.01	6.00e-158	549.00
IUUC-Xma-133797	Xiphophorus maculatus	51.43	1.00e-147	515.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence