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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018295
UUCD1 version UUC-CaE-00722
Ensembl Protein ID C25D7.8
UniProt Accession Q9XVR6; OTUBL_CAEEL
Genbank Protein ID CAB02772.1
Protein Name Ubiquitin thioesterase otubain-like; Deubiquitinating enzyme otubain-like; Ubiquitin-specific-processing protease otubain-like
Genbank Nucleotide ID Z81039
Gene Name otub-1; C25D7.8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00007718 C25D7.8 C25D7.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
PINAMentha
Protein 3D Structure
PDBMMDB
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/OTU 34.42 2.00e-40 163.00 IUUC-Hsa-046766
Active Site
Position(s) Description Evidence
85 N/A {ECO:0000250|UniProtKB:Q96DC9}
88 Nucleophile {ECO:0000250|UniProtKB:Q96DC9}
245 {ECO:0000250|UniProtKB:Q96FW1}
267 {ECO:0000250|UniProtKB:Q96DC9}
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin.
 Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin.
Protein Sequence
(Fasta)
MANEPQKSDD NGQAAEAVVT DDEIVLQDQQ LKTIEDEQKS VPLVATLAPF SILCAEYDNE 60
TSAAFLSKAT ELSEVYGEIR YIRGDGNCFY RAILVGLIEI MLKDRARLEK FIASSRDWTR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018295|DUB,OTU|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTAACAGGAA CTATGGCCAA TGAACCCCAA AAATCTGATG ATAACGGTCA GGCTGCGGAG 60
GCTGTGGTGA CTGATGACGA AATAGTTTTG CAGGACCAAC AGTTGAAGAC AATTGAAGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018295|DUB,OTU|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003323--OTU_dom
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain
PROSITE

PS50802--OTU
Pfam

PF10275--Peptidase_C65
Gene Ontology

GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0071108--P:protein K48-linked deubiquitination
KEGG cel:CELE_C25D7.8
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001871 Ailuropoda melanoleuca 35.78 2.00e-41 161.00
IUUC-Aca-004648 Anolis carolinensis 32.77 4.00e-35 140.00
IUUC-Aly-005710 Arabidopsis lyrata 37.74 8.00e-44 169.00
IUUC-Ath-007112 Arabidopsis thaliana 37.22 6.00e-43 166.00
IUUC-Ago-007842 Ashbya gossypii 43.59 1.50e-01 30.00
IUUC-Afl-008439 Aspergillus flavus 32.67 2.00e-09 54.70
IUUC-Ame-010662 Astyanax mexicanus 34.18 3.00e-39 154.00
IUUC-Bta-013533 Bos taurus 35.78 2.00e-41 160.00
IUUC-Bol-016100 Brassica oleracea 32.65 1.00e-39 155.00
IUUC-Bra-017705 Brassica rapa 33.10 7.00e-36 142.00
IUUC-Cja-019190 Callithrix jacchus 35.78 4.00e-41 160.00
IUUC-Cfa-020430 Canis familiaris 35.78 2.00e-41 160.00
IUUC-Cpo-022355 Cavia porcellus 35.78 1.00e-41 162.00
IUUC-Cre-022997 Chlamydomonas reinhardtii 32.13 4.00e-34 136.00
IUUC-Csa-023286 Chlorocebus sabaeus 35.78 1.00e-41 161.00
IUUC-Cho-024411 Choloepus hoffmanni 33.33 3.00e-15 73.60
IUUC-Cin-025507 Ciona intestinalis 31.10 4.00e-22 96.70
IUUC-Csv-026273 Ciona savignyi 34.90 7.00e-42 162.00
IUUC-Dre-027843 Danio rerio 34.30 2.00e-41 161.00
IUUC-Dno-029165 Dasypus novemcinctus 36.45 6.00e-39 152.00
IUUC-Dor-030943 Dipodomys ordii 35.78 1.00e-41 162.00
IUUC-Dme-031922 Drosophila melanogaster 35.02 7.00e-43 165.00
IUUC-Ete-032296 Echinops telfairi 35.53 1.00e-26 112.00
IUUC-Eca-033695 Equus caballus 35.78 7.00e-41 159.00
IUUC-Eeu-034775 Erinaceus europaeus 30.67 7.00e-29 119.00
IUUC-Fca-036441 Felis catus 35.78 3.00e-41 160.00
IUUC-Gmo-038908 Gadus morhua 34.18 1.00e-39 155.00
IUUC-Ggr-040020 Gaeumannomyces graminis 27.34 2.00e-22 100.00
IUUC-Gga-040460 Gallus gallus 34.91 3.00e-39 154.00
IUUC-Gac-042417 Gasterosteus aculeatus 34.69 8.00e-39 152.00
IUUC-Gma-043712 Glycine max 37.45 7.00e-44 169.00
IUUC-Ggo-045023 Gorilla gorilla 31.14 5.00e-29 119.00
IUUC-Hsa-046766 Homo sapiens 35.78 1.00e-41 161.00
IUUC-Itr-048312 Ictidomys tridecemlineatus 35.78 1.00e-41 162.00
IUUC-Lch-050602 Latimeria chalumnae 34.73 4.00e-34 136.00
IUUC-Loc-052003 Lepisosteus oculatus 31.73 1.00e-29 121.00
IUUC-Laf-053705 Loxodonta africana 35.78 1.00e-41 162.00
IUUC-Mcc-055745 Macaca mulatta 35.78 4.00e-41 160.00
IUUC-Meu-056569 Macropus eugenii 36.95 1.00e-39 155.00
IUUC-Mtr-057712 Medicago truncatula 36.50 2.00e-36 144.00
IUUC-Mla-058941 Melampsora laricipopulina 64.29 5.10e-01 27.30
IUUC-Mvi-060358 Microbotryum violaceum 27.01 7.00e-09 53.10
IUUC-Mmr-061123 Microcebus murinus 33.86 6.00e-30 123.00
IUUC-Mdo-062613 Monodelphis domestica 32.49 1.00e-34 138.00
IUUC-Mmu-063658 Mus musculus 35.78 1.00e-41 162.00
IUUC-Mac-065274 Musa acuminata 27.98 7.00e-25 106.00
IUUC-Mpu-066172 Mustela putorius furo 35.78 1.00e-41 161.00
IUUC-Mlu-066966 Myotis lucifugus 35.78 2.00e-41 160.00
IUUC-Ncr-068634 Neurospora crassa 38.46 2.10e+00 27.30
IUUC-Nle-069673 Nomascus leucogenys 31.14 4.00e-29 119.00
IUUC-Opr-070761 Ochotona princeps 28.57 2.00e-11 60.50
IUUC-Ont-071901 Oreochromis niloticus 35.92 7.00e-40 155.00
IUUC-Oan-072922 Ornithorhynchus anatinus 31.73 8.00e-29 119.00
IUUC-Ocu-074643 Oryctolagus cuniculus 31.14 4.00e-29 119.00
IUUC-Oni-082026 Oryza nivara 27.36 1.00e-11 63.20
IUUC-Oru-084761 Oryza rufipogon 27.36 1.00e-11 63.20
IUUC-Ola-087331 Oryzias latipes 33.33 9.00e-29 118.00
IUUC-Oga-088064 Otolemur garnettii 35.78 1.00e-41 161.00
IUUC-Oar-089251 Ovis aries 33.21 6.00e-41 159.00
IUUC-Ptr-091430 Pan troglodytes 35.78 3.00e-41 160.00
IUUC-Pan-091969 Papio anubis 31.14 4.00e-29 119.00
IUUC-Psi-093823 Pelodiscus sinensis 33.62 5.00e-35 139.00
IUUC-Pma-094366 Petromyzon marinus 36.55 2.00e-41 160.00
IUUC-Pfo-096734 Poecilia formosa 35.10 7.00e-37 145.00
IUUC-Pab-097919 Pongo abelii 33.86 4.00e-30 123.00
IUUC-Pop-099401 Populus trichocarpa 35.50 7.00e-42 162.00
IUUC-Pca-100252 Procavia capensis 33.33 7.00e-07 46.20
IUUC-Ppe-101977 Prunus persica 35.74 2.00e-42 164.00
IUUC-Pva-102499 Pteropus vampyrus 35.78 1.00e-41 161.00
IUUC-Pgr-103552 Puccinia graminis 33.93 1.10e-02 31.20
IUUC-Rno-105233 Rattus norvegicus 35.78 1.00e-41 162.00
IUUC-Sce-106424 Saccharomyces cerevisiae 44.74 2.20e-01 29.60
IUUC-Sha-106665 Sarcophilus harrisii 33.70 4.00e-42 163.00
IUUC-Sly-111640 Solanum lycopersicum 34.78 2.00e-40 157.00
IUUC-Sar-113295 Sorex araneus 32.02 6.00e-29 119.00
IUUC-Ssc-116202 Sus scrofa 35.78 1.00e-41 161.00
IUUC-Tru-117664 Takifugu rubripes 33.57 9.00e-38 149.00
IUUC-Tni-120440 Tetraodon nigroviridis 25.84 3.00e-19 87.00
IUUC-Tca-121467 Theobroma cacao 34.55 5.00e-44 169.00
IUUC-Tbe-128116 Tupaia belangeri 33.70 1.00e-28 118.00
IUUC-Ttr-128622 Tursiops truncatus 36.21 2.00e-42 164.00
IUUC-Uma-129443 Ustilago maydis 31.63 2.00e-23 102.00
IUUC-Vvi-131389 Vitis vinifera 34.75 4.00e-43 166.00
IUUC-Xtr-131951 Xenopus tropicalis 25.33 8.00e-25 105.00
IUUC-Xma-134191 Xiphophorus maculatus 35.51 5.00e-37 146.00
Created Date 25-Jun-2017

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