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Tag Content
iUUCD ID IUUC-Ago-007740
Ensembl Protein ID AAS51162
UniProt Accession Q75CI5; ATG10_ASHGO
Genbank Protein ID AAS51162.2
Protein Name Ubiquitin-like-conjugating enzyme ATG10; Autophagy-related protein 10
Genbank Nucleotide ID AE016816
Gene Name ATG10; ACL066C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AGOS_ACL066C AAS51162 AAS51162
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E2/Autophagy_C 28.70 1.00e-05 44.30 IUUC-Sce-106162
Active Site
Position(s) Description Evidence
123 Glycyl thioester intermediate {ECO:0000250}
Organism Ashbya gossypii
Functional Description
(View)

Functional Description



     E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity).
E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity).
Protein Sequence
(Fasta)
MLSAEDFSDQ VLRLLPLLRR WRRCEHALWD PRARRLQLSV ATARNSARFD VRVDLHPLYA 60
VPQLLLRYWE PDPAVSEYEV WKLHFVDPYQ LPLWQPGRFS IALDQVPATS GSAYETWYVV 120
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Protein Fasta Sequence



>IUUC-Ago-007740|E2,E2/Autophagy_C|Ashbya gossypii
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Nucleotide Sequence
(Fasta)
ATGCTTTCCG CGGAAGACTT CTCCGACCAG GTGCTGCGGC TCCTGCCCCT GCTGCGCCGC 60
TGGCGCCGCT GCGAGCACGC GCTGTGGGAC CCACGCGCCC GTCGCCTGCA ACTCTCCGTC 120
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Nucleotide Fasta Sequence



>IUUC-Ago-007740|E2,E2/Autophagy_C|Ashbya gossypii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0436--Ligase
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR016524--Atg10
IPR007135--Autophagy-rel_prot_3

Pfam

PF03987--Autophagy_act_C

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0016874--F:ligase activity
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG ago:AGOS_ACL066C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Bol-015989 Brassica oleracea 25.37 9.60e-01 24.60
IUUC-Ete-032676 Echinops telfairi 24.53 2.50e+00 23.10
IUUC-Gmo-039312 Gadus morhua 30.23 2.80e-01 27.30
IUUC-Lpe-050882 Leersia perrieri 38.89 7.90e-01 26.20
IUUC-Opu-084128 Oryza punctata 36.11 1.20e+00 26.60
Created Date 25-Jun-2017

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