iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/ZnF_UBP	42.78	4.00e-83	306.00	IUUC-Hsa-046904

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Arabidopsis thaliana

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

Protein Sequence
(Fasta)

MAMAGESSGK KIGDCDGKVA GNRQRKVGLI YDETMCKHDT PDGEDHPECP DRIRVIWEKL 60
QLAGVSQRCV VLGSSKAEDK HLQLVHTKDH VNLVKSISTK QKDYRRNRIA SQLNSIYLNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCAAACCTA AAAAAAAAAA AGGAGAGAAT GAAAAAAAGA AAGAATTGAA AAGTAAAAAA 60
TACTTGGAAG CTTTAGAAGC TGAGAGCAAA GACTTGACCT TTTTCACTTC CTTCTCACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR013024--GGCT-like
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom

Pfam

PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0005634--C:nucleus
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT5G61060

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000749	Aegilops tauschii	59.87	1.00e-113	403.00
IUUC-Aml-002087	Ailuropoda melanoleuca	46.79	1.00e-85	311.00
IUUC-Atr-002745	Amborella trichopoda	53.93	0.00e+00	678.00
IUUC-Apl-003250	Anas platyrhynchos	40.25	1.00e-74	274.00
IUUC-Aca-004303	Anolis carolinensis	43.90	2.00e-84	306.00
IUUC-Aly-006432	Arabidopsis lyrata	92.88	0.00e+00	1248.00
IUUC-Ago-007972	Ashbya gossypii	38.30	1.00e-73	270.00
IUUC-Acl-008187	Aspergillus clavatus	43.15	3.00e-75	275.00
IUUC-Afl-008399	Aspergillus flavus	48.08	2.00e-42	166.00
IUUC-Afu-008954	Aspergillus fumigatus	37.27	2.00e-64	239.00
IUUC-Ani-009142	Aspergillus nidulans	39.63	4.00e-69	255.00
IUUC-Ang-009522	Aspergillus niger	36.13	4.00e-24	105.00
IUUC-Aor-010069	Aspergillus oryzae	40.60	4.00e-67	248.00
IUUC-Ate-010291	Aspergillus terreus	41.29	9.00e-79	287.00
IUUC-Ame-010780	Astyanax mexicanus	40.69	2.00e-80	293.00
IUUC-Bta-013052	Bos taurus	46.88	7.00e-80	291.00
IUUC-Bci-013789	Botrytis cinerea	39.83	7.00e-70	258.00
IUUC-Bdi-014007	Brachypodium distachyon	62.98	2.00e-141	495.00
IUUC-Bol-015468	Brassica oleracea	84.44	0.00e+00	1132.00
IUUC-Bra-016680	Brassica rapa	84.14	0.00e+00	1132.00
IUUC-Cel-018220	Caenorhabditis elegans	38.46	5.00e-73	268.00
IUUC-Cja-019473	Callithrix jacchus	42.78	4.00e-84	305.00
IUUC-Cfa-020263	Canis familiaris	47.09	7.00e-85	308.00
IUUC-Cpo-021691	Cavia porcellus	46.30	3.00e-82	299.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	48.87	2.00e-52	197.00
IUUC-Csa-024223	Chlorocebus sabaeus	42.82	3.00e-84	306.00
IUUC-Csv-026359	Ciona savignyi	44.74	4.00e-58	217.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	37.28	2.00e-68	252.00
IUUC-Cne-026978	Cryptococcus neoformans	41.48	9.00e-76	277.00
IUUC-Dre-028820	Danio rerio	41.35	7.00e-82	298.00
IUUC-Dno-029160	Dasypus novemcinctus	45.62	3.00e-82	300.00
IUUC-Dor-030859	Dipodomys ordii	45.05	7.00e-85	308.00
IUUC-Dse-031186	Dothistroma septosporum	36.79	8.00e-67	248.00
IUUC-Dme-031963	Drosophila melanogaster	41.14	5.00e-81	295.00
IUUC-Ete-032279	Echinops telfairi	39.14	1.00e-65	244.00
IUUC-Eca-033842	Equus caballus	45.96	1.00e-83	304.00
IUUC-Eeu-034487	Erinaceus europaeus	54.55	2.00e-60	226.00
IUUC-Fca-036430	Felis catus	46.18	1.00e-84	307.00
IUUC-Fox-038067	Fusarium oxysporum	35.24	1.00e-64	240.00
IUUC-Fso-038263	Fusarium solani	37.98	1.00e-69	257.00
IUUC-Gmo-038473	Gadus morhua	41.21	4.00e-68	252.00
IUUC-Ggr-040062	Gaeumannomyces graminis	39.77	2.00e-68	253.00
IUUC-Gga-040501	Gallus gallus	41.86	4.00e-74	272.00
IUUC-Gac-042335	Gasterosteus aculeatus	43.31	3.00e-75	276.00
IUUC-Gma-043738	Glycine max	62.75	0.00e+00	844.00
IUUC-Ggo-045022	Gorilla gorilla	42.78	2.00e-84	307.00
IUUC-Hsa-046904	Homo sapiens	42.78	2.00e-84	306.00
IUUC-Hvu-047285	Hordeum vulgare	64.39	3.00e-137	480.00
IUUC-Itr-048484	Ictidomys tridecemlineatus	44.78	4.00e-87	315.00
IUUC-Kpa-049281	Komagataella pastoris	41.22	2.00e-77	282.00
IUUC-Lch-050330	Latimeria chalumnae	45.18	2.00e-79	290.00
IUUC-Lpe-051214	Leersia perrieri	55.71	0.00e+00	760.00
IUUC-Loc-052231	Lepisosteus oculatus	42.71	7.00e-73	268.00
IUUC-Lma-053263	Leptosphaeria maculans	42.41	1.00e-82	300.00
IUUC-Laf-053386	Loxodonta africana	45.91	7.00e-82	298.00
IUUC-Mcc-055530	Macaca mulatta	42.78	2.00e-84	307.00
IUUC-Meu-056442	Macropus eugenii	45.96	1.00e-85	310.00
IUUC-Mor-057095	Magnaporthe oryzae	41.19	4.00e-75	275.00
IUUC-Mpo-057389	Magnaporthe poae	39.20	5.00e-68	251.00
IUUC-Mtr-058463	Medicago truncatula	62.44	0.00e+00	806.00
IUUC-Mla-059143	Melampsora laricipopulina	42.18	3.00e-77	282.00
IUUC-Mmr-060637	Microcebus murinus	46.60	1.00e-79	291.00
IUUC-Mdo-062198	Monodelphis domestica	45.03	8.00e-84	305.00
IUUC-Mmu-063346	Mus musculus	45.63	3.00e-85	309.00
IUUC-Mac-064630	Musa acuminata	58.87	0.00e+00	806.00
IUUC-Mpu-065884	Mustela putorius furo	47.09	3.00e-85	309.00
IUUC-Mlu-068117	Myotis lucifugus	42.56	2.00e-83	303.00
IUUC-Nfi-068404	Neosartorya fischeri	41.29	5.00e-76	278.00
IUUC-Ncr-068672	Neurospora crassa	37.11	9.00e-68	251.00
IUUC-Nle-069868	Nomascus leucogenys	38.34	5.00e-73	268.00
IUUC-Opr-071074	Ochotona princeps	44.51	5.00e-87	315.00
IUUC-Ont-072246	Oreochromis niloticus	43.23	2.00e-77	283.00
IUUC-Oan-073275	Ornithorhynchus anatinus	42.56	3.00e-76	279.00
IUUC-Ocu-074627	Oryctolagus cuniculus	42.75	1.00e-86	314.00
IUUC-Oba-075489	Oryza barthii	55.71	0.00e+00	674.00
IUUC-Obr-076150	Oryza brachyantha	56.30	0.00e+00	780.00
IUUC-Ogl-077437	Oryza glaberrima	54.97	0.00e+00	763.00
IUUC-Ogu-078370	Oryza glumaepatula	54.68	0.00e+00	763.00
IUUC-Oin-079210	Oryza indica	54.68	0.00e+00	763.00
IUUC-Olo-080971	Oryza longistaminata	53.91	0.00e+00	669.00
IUUC-Oni-082031	Oryza nivara	55.06	0.00e+00	751.00
IUUC-Opu-083471	Oryza punctata	55.43	0.00e+00	733.00
IUUC-Oru-084755	Oryza rufipogon	54.68	0.00e+00	763.00
IUUC-Osa-085447	Oryza sativa	54.68	0.00e+00	763.00
IUUC-Ola-087031	Oryzias latipes	43.41	1.00e-77	284.00
IUUC-Oga-089155	Otolemur garnettii	46.50	7.00e-80	291.00
IUUC-Oar-089620	Ovis aries	46.25	7.00e-80	291.00
IUUC-Ptr-091116	Pan troglodytes	42.97	3.00e-76	279.00
IUUC-Pan-092340	Papio anubis	42.82	2.00e-84	307.00
IUUC-Psi-093734	Pelodiscus sinensis	41.21	3.00e-74	273.00
IUUC-Pma-094386	Petromyzon marinus	42.50	5.00e-75	275.00
IUUC-Pno-095131	Phaeosphaeria nodorum	47.45	2.00e-72	265.00
IUUC-Ppa-095550	Physcomitrella patens	54.77	6.00e-112	397.00
IUUC-Pfo-096110	Poecilia formosa	40.64	5.00e-80	291.00
IUUC-Pab-098422	Pongo abelii	42.31	4.00e-75	276.00
IUUC-Pop-099174	Populus trichocarpa	69.09	0.00e+00	917.00
IUUC-Pca-100833	Procavia capensis	44.24	5.00e-80	292.00
IUUC-Ppe-101644	Prunus persica	66.17	0.00e+00	763.00
IUUC-Pva-102410	Pteropus vampyrus	46.25	2.00e-80	293.00
IUUC-Ptt-103841	Puccinia triticina	40.17	1.00e-72	267.00
IUUC-Pte-104383	Pyrenophora teres	41.32	3.00e-79	289.00
IUUC-Pyt-104427	Pyrenophora triticirepentis	41.32	1.00e-79	290.00
IUUC-Rno-105131	Rattus norvegicus	41.78	6.00e-89	322.00
IUUC-Sce-106274	Saccharomyces cerevisiae	40.76	8.00e-72	264.00
IUUC-Sha-106661	Sarcophilus harrisii	45.22	4.00e-77	282.00
IUUC-Sja-107915	Schizosaccharomyces japonicus	40.49	2.00e-75	276.00
IUUC-Spo-108300	Schizosaccharomyces pombe	42.47	7.00e-73	267.00
IUUC-Smo-109615	Selaginella moellendorffii	49.21	4.00e-171	593.00
IUUC-Sit-110160	Setaria italica	53.50	0.00e+00	738.00
IUUC-Sly-111164	Solanum lycopersicum	58.60	0.00e+00	790.00
IUUC-Stu-112685	Solanum tuberosum	41.01	5.00e-66	244.00
IUUC-Sar-113692	Sorex araneus	38.94	4.00e-57	216.00
IUUC-Sbi-114301	Sorghum bicolor	53.05	0.00e+00	731.00
IUUC-Sre-115013	Sporisorium reilianum	40.41	4.00e-78	285.00
IUUC-Ssc-115724	Sus scrofa	45.65	1.00e-75	277.00
IUUC-Tgu-116776	Taeniopygia guttata	40.25	2.00e-74	273.00
IUUC-Tru-117614	Takifugu rubripes	45.94	3.00e-81	296.00
IUUC-Tsy-118807	Tarsius syrichta	42.28	2.00e-73	270.00
IUUC-Tni-119809	Tetraodon nigroviridis	45.23	7.00e-81	295.00
IUUC-Tca-121312	Theobroma cacao	66.77	0.00e+00	896.00
IUUC-Tre-121930	Trichoderma reesei	38.84	6.00e-69	254.00
IUUC-Tvi-122373	Trichoderma virens	38.08	1.00e-66	247.00
IUUC-Tae-123064	Triticum aestivum	58.01	5.00e-126	443.00
IUUC-Tur-126278	Triticum urartu	32.14	1.20e+00	28.50
IUUC-Tme-127027	Tuber melanosporum	40.77	2.00e-69	255.00
IUUC-Tbe-127675	Tupaia belangeri	40.13	3.00e-22	100.00
IUUC-Ttr-128411	Tursiops truncatus	39.90	1.00e-77	284.00
IUUC-Uma-129408	Ustilago maydis	43.27	6.00e-72	264.00
IUUC-Vda-129994	Verticillium dahliae	37.60	8.00e-68	251.00
IUUC-Vpa-130525	Vicugna pacos	51.67	6.00e-14	72.40
IUUC-Vvi-131038	Vitis vinifera	64.77	0.00e+00	877.00
IUUC-Xtr-132618	Xenopus tropicalis	43.29	1.00e-84	307.00
IUUC-Xma-133730	Xiphophorus maculatus	45.06	1.00e-79	290.00
IUUC-Yli-134680	Yarrowia lipolytica	40.69	3.00e-71	262.00
IUUC-Zma-135110	Zea mays	56.88	9.00e-163	566.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence