iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G65040	AT1G65040.2	AT1G65040.2
AT1G65040	AT1G65040.5	AT1G65040.5
AT1G65040	AT1G65040.4	AT1G65040.4
AT1G65040	AT1G65040.3	AT1G65040.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.50e-08	33.9	292	330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e++    + l CgH+fh +Cl  w        ++ +CP+Cr
   Q: 292  CIICREEMTS-AKKLVCGHLFHVHCLRSW------LERQNTCPTCR 330
           ********88.999***************......**********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3A.

Protein Sequence
(Fasta)

MIQLKVYAGL STLATLVVIY HAFSSRGQFY PATVYLSTSK INLVVLLNMG LVLMLSLWNL 60
VKIVFLGSLR EAEVERLNEQ AWRELMEILF AITIFRQDFS VGFISLVVTL LLIKGLHWMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAATTTCTA AGAGAGCTTT TCTTCTTCCT CCTCCCTCTT CGTTCGTGAT TTCTCATTTC 60
CTTAACGGAA AGCTTAAGGC TTTAATCATT ATATCTCTTC TTCTACCTAT ACACGACTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

ath:AT1G65040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003404	Anas platyrhynchos	29.00	2.00e-38	153.00
IUUC-Aly-005440	Arabidopsis lyrata	91.38	0.00e+00	793.00
IUUC-Bci-013675	Botrytis cinerea	45.10	2.00e-30	127.00
IUUC-Bol-015593	Brassica oleracea	84.85	0.00e+00	707.00
IUUC-Bra-017516	Brassica rapa	85.43	0.00e+00	709.00
IUUC-Cel-018422	Caenorhabditis elegans	38.92	1.00e-68	253.00
IUUC-Cho-024889	Choloepus hoffmanni	38.28	1.00e-66	246.00
IUUC-Cin-025215	Ciona intestinalis	25.89	5.00e-35	141.00
IUUC-Cne-027002	Cryptococcus neoformans	39.78	1.00e-70	260.00
IUUC-Cme-027285	Cyanidioschyzon merolae	36.81	4.00e-58	218.00
IUUC-Ete-032962	Echinops telfairi	28.43	9.00e-33	134.00
IUUC-Eeu-034515	Erinaceus europaeus	56.45	9.00e-17	80.90
IUUC-Fal-036758	Ficedula albicollis	30.28	3.00e-35	142.00
IUUC-Fox-037902	Fusarium oxysporum	34.13	8.00e-62	231.00
IUUC-Ggr-040076	Gaeumannomyces graminis	30.67	4.00e-51	196.00
IUUC-Gga-040575	Gallus gallus	30.00	8.00e-39	154.00
IUUC-Kpa-049117	Komagataella pastoris	26.04	3.00e-27	115.00
IUUC-Lch-050491	Latimeria chalumnae	28.14	6.00e-35	141.00
IUUC-Lma-052997	Leptosphaeria maculans	32.82	1.00e-60	227.00
IUUC-Mla-059168	Melampsora laricipopulina	38.16	6.00e-72	265.00
IUUC-Mga-059937	Meleagris gallopavo	30.26	1.00e-38	153.00
IUUC-Oan-073717	Ornithorhynchus anatinus	28.79	8.00e-40	157.00
IUUC-Pma-094759	Petromyzon marinus	49.62	3.00e-36	145.00
IUUC-Pgr-103286	Puccinia graminis	38.40	6.00e-75	275.00
IUUC-Ptt-103919	Puccinia triticina	37.50	1.00e-75	276.00
IUUC-Sce-106348	Saccharomyces cerevisiae	22.78	7.00e-14	71.20
IUUC-Sja-107685	Schizosaccharomyces japonicus	31.88	1.00e-44	173.00
IUUC-Ssl-108558	Sclerotinia sclerotiorum	31.45	2.00e-41	164.00
IUUC-Sar-113397	Sorex araneus	33.33	7.00e-36	144.00
IUUC-Sre-115212	Sporisorium reilianum	38.14	5.00e-65	241.00
IUUC-Tgu-116717	Taeniopygia guttata	29.45	4.00e-37	148.00
IUUC-Tsy-118823	Tarsius syrichta	37.19	4.00e-54	204.00
IUUC-Tme-127197	Tuber melanosporum	40.73	2.00e-69	256.00
IUUC-Uma-129401	Ustilago maydis	37.77	1.00e-58	220.00
IUUC-Vpa-130483	Vicugna pacos	28.24	2.00e-33	136.00
IUUC-Yli-134552	Yarrowia lipolytica	30.23	5.00e-37	147.00
IUUC-Zma-135183	Zea mays	68.65	1.00e-149	521.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence