iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018195

UUCD1 version

UUC-CaE-00043

Ensembl Protein ID

ZK287.5.1

UniProt Accession

Q23457; Q8WSQ1; RBX1_CAEEL

Genbank Protein ID

CAA94801.1; BAB83695.1

Protein Name

RING-box protein 1; Ce-rbx-1

Genbank Nucleotide ID

Z70757; AB077287

Gene Name

rbx-1; ZK287.5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00004320	ZK287.5.1	ZK287.5.1

Annotation

mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17609115

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	3.40e-09	37.4	44	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv..................lpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+++++d +++                  ++C+H+fh++C+ +w       ++++ CPl+
   Q: 44   CAICRNHIMD-LCIecqanqaaglkdectvawGNCNHAFHFHCISRW------LKTRQVCPLD 99
           ********66.44333333333333333334499*************......********97 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.

Protein Sequence
(Fasta)

MAQASDSTAM EVEEATNQTV KKRFEVKKWS AVALWAWDIQ VDNCAICRNH IMDLCIECQA 60
NQAAGLKDEC TVAWGNCNHA FHFHCISRWL KTRQVCPLDN REWEFQKYGH

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCAATATT AAGTATTTCA TTATATCATC AATGCTACTT TTGCGCTCTT ATTTTGAAAT 60
GATTACTGTT ATTCTCATTT GTATTTTTTC CAGAAATGGC CCAAGCAAGC GACAGCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2

PROSITE

PS50089--ZF_RING_2

Pfam

PF12678--zf-rbx1

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902104--P:positive regulation of metaphase/anaphase transition of meiotic cell cycle
GO:0016567--P:protein ubiquitination
GO:0051759--P:sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation

KEGG

cel:CELE_ZK287.5

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001798	Ailuropoda melanoleuca	79.28	8.00e-48	180.00
IUUC-Atr-002900	Amborella trichopoda	87.78	2.00e-46	175.00
IUUC-Apl-003762	Anas platyrhynchos	89.74	3.00e-39	151.00
IUUC-Aca-005328	Anolis carolinensis	79.28	8.00e-48	180.00
IUUC-Aly-005923	Arabidopsis lyrata	89.77	1.00e-45	173.00
IUUC-Ath-007535	Arabidopsis thaliana	87.64	4.00e-44	167.00
IUUC-Ago-007991	Ashbya gossypii	56.48	1.00e-35	139.00
IUUC-Acl-008332	Aspergillus clavatus	87.64	7.00e-45	170.00
IUUC-Afl-008537	Aspergillus flavus	88.37	2.00e-43	166.00
IUUC-Afu-008985	Aspergillus fumigatus	87.64	7.00e-45	170.00
IUUC-Ani-009342	Aspergillus nidulans	86.52	1.00e-44	169.00
IUUC-Ang-009778	Aspergillus niger	88.37	2.00e-43	166.00
IUUC-Aor-009918	Aspergillus oryzae	88.37	2.00e-43	166.00
IUUC-Ame-010814	Astyanax mexicanus	89.29	3.00e-27	111.00
IUUC-Bgr-012224	Blumeria graminis	88.89	7.00e-47	177.00
IUUC-Bta-012426	Bos taurus	79.28	1.00e-47	179.00
IUUC-Bci-013839	Botrytis cinerea	89.66	7.00e-45	170.00
IUUC-Bdi-014575	Brachypodium distachyon	88.76	1.00e-45	173.00
IUUC-Bol-015671	Brassica oleracea	91.01	9.00e-47	177.00
IUUC-Bra-017034	Brassica rapa	91.01	9.00e-47	177.00
IUUC-Cja-018788	Callithrix jacchus	78.70	2.00e-45	172.00
IUUC-Cpo-021365	Cavia porcellus	79.28	1.00e-47	179.00
IUUC-Cre-022904	Chlamydomonas reinhardtii	56.32	3.00e-25	105.00
IUUC-Csa-024198	Chlorocebus sabaeus	79.28	1.00e-47	179.00
IUUC-Cho-024344	Choloepus hoffmanni	89.09	5.00e-27	110.00
IUUC-Cin-025449	Ciona intestinalis	84.31	2.00e-48	182.00
IUUC-Cgl-026522	Colletotrichum gloeosporioides	88.76	1.00e-45	173.00
IUUC-Cne-027067	Cryptococcus neoformans	70.79	7.00e-34	134.00
IUUC-Cme-027268	Cyanidioschyzon merolae	58.93	5.00e-36	141.00
IUUC-Dre-027434	Danio rerio	80.37	6.00e-48	180.00
IUUC-Dno-029252	Dasypus novemcinctus	77.78	8.00e-45	170.00
IUUC-Dor-030861	Dipodomys ordii	61.68	1.00e-30	123.00
IUUC-Dse-031355	Dothistroma septosporum	88.76	1.00e-45	173.00
IUUC-Dme-031585	Drosophila melanogaster	80.00	1.00e-48	182.00
IUUC-Ete-032747	Echinops telfairi	44.14	5.00e-15	71.20
IUUC-Eca-033758	Equus caballus	79.28	1.00e-47	179.00
IUUC-Fca-035586	Felis catus	79.28	1.00e-47	179.00
IUUC-Fal-037097	Ficedula albicollis	88.89	6.00e-41	156.00
IUUC-Fox-037881	Fusarium oxysporum	86.42	6.00e-40	154.00
IUUC-Fso-038373	Fusarium solani	73.87	1.00e-46	176.00
IUUC-Gmo-039457	Gadus morhua	78.50	8.00e-45	170.00
IUUC-Ggr-039970	Gaeumannomyces graminis	88.51	5.00e-44	167.00
IUUC-Gga-040328	Gallus gallus	79.28	1.00e-47	179.00
IUUC-Gac-041578	Gasterosteus aculeatus	80.37	6.00e-48	180.00
IUUC-Gma-042692	Glycine max	88.64	3.00e-45	171.00
IUUC-Ggo-045249	Gorilla gorilla	56.76	3.00e-28	114.00
IUUC-Hsa-046279	Homo sapiens	79.28	1.00e-47	179.00
IUUC-Hvu-047597	Hordeum vulgare	88.76	2.00e-45	172.00
IUUC-Itr-048174	Ictidomys tridecemlineatus	79.28	1.00e-47	179.00
IUUC-Kpa-049330	Komagataella pastoris	58.41	7.00e-36	140.00
IUUC-Lch-049667	Latimeria chalumnae	80.37	9.00e-48	179.00
IUUC-Lma-053052	Leptosphaeria maculans	89.89	2.00e-45	172.00
IUUC-Laf-053827	Loxodonta africana	76.58	9.00e-46	173.00
IUUC-Mcc-055208	Macaca mulatta	79.28	1.00e-47	179.00
IUUC-Meu-056143	Macropus eugenii	90.24	3.00e-42	160.00
IUUC-Mor-057158	Magnaporthe oryzae	88.51	4.00e-44	167.00
IUUC-Mpo-057409	Magnaporthe poae	88.51	5.00e-44	167.00
IUUC-Mtr-058505	Medicago truncatula	88.64	2.00e-45	172.00
IUUC-Mla-059071	Melampsora laricipopulina	68.29	7.00e-44	167.00
IUUC-Mga-059797	Meleagris gallopavo	79.28	1.00e-47	179.00
IUUC-Mvi-060401	Microbotryum violaceum	85.26	1.00e-47	180.00
IUUC-Mmr-061077	Microcebus murinus	79.28	1.00e-47	179.00
IUUC-Mdo-062218	Monodelphis domestica	79.28	1.00e-47	179.00
IUUC-Mmu-064224	Mus musculus	79.28	1.00e-47	179.00
IUUC-Mac-064505	Musa acuminata	88.64	5.00e-45	170.00
IUUC-Mpu-066572	Mustela putorius furo	79.28	1.00e-47	179.00
IUUC-Mlu-067821	Myotis lucifugus	79.28	1.00e-47	179.00
IUUC-Nfi-068412	Neosartorya fischeri	87.64	7.00e-45	170.00
IUUC-Nle-069309	Nomascus leucogenys	79.28	1.00e-47	179.00
IUUC-Opr-070307	Ochotona princeps	79.28	1.00e-47	179.00
IUUC-Ont-071677	Oreochromis niloticus	80.00	4.00e-49	184.00
IUUC-Oan-072926	Ornithorhynchus anatinus	90.00	1.00e-40	155.00
IUUC-Oba-075405	Oryza barthii	88.76	1.00e-45	173.00
IUUC-Obr-076843	Oryza brachyantha	88.76	5.00e-46	175.00
IUUC-Ogl-077608	Oryza glaberrima	88.76	1.00e-45	173.00
IUUC-Ogu-078316	Oryza glumaepatula	88.76	1.00e-45	173.00
IUUC-Oin-079918	Oryza indica	59.23	3.00e-39	152.00
IUUC-Olo-080968	Oryza longistaminata	83.33	4.00e-24	100.00
IUUC-Ome-081246	Oryza meridionalis	87.50	5.00e-45	171.00
IUUC-Oni-082052	Oryza nivara	88.76	1.00e-45	173.00
IUUC-Opu-084035	Oryza punctata	87.64	6.00e-46	174.00
IUUC-Oru-084941	Oryza rufipogon	88.76	1.00e-45	173.00
IUUC-Osa-085800	Oryza sativa	88.76	1.00e-45	173.00
IUUC-Ola-087352	Oryzias latipes	80.37	3.00e-48	181.00
IUUC-Olu-087676	Ostreococcus lucimarinus	53.26	3.00e-27	112.00
IUUC-Oga-088880	Otolemur garnettii	79.28	1.00e-47	179.00
IUUC-Oar-089286	Ovis aries	79.28	9.00e-48	180.00
IUUC-Ptr-091402	Pan troglodytes	79.28	1.00e-47	179.00
IUUC-Pan-091687	Papio anubis	80.37	6.00e-47	177.00
IUUC-Psi-093640	Pelodiscus sinensis	80.37	4.00e-48	181.00
IUUC-Pma-094723	Petromyzon marinus	89.16	2.00e-42	161.00
IUUC-Pno-094822	Phaeosphaeria nodorum	85.26	4.00e-46	174.00
IUUC-Ppa-095730	Physcomitrella patens	88.64	2.00e-45	172.00
IUUC-Pfo-096055	Poecilia formosa	79.28	7.00e-48	180.00
IUUC-Pab-098577	Pongo abelii	79.28	1.00e-47	179.00
IUUC-Pop-099697	Populus trichocarpa	76.85	3.00e-47	178.00
IUUC-Pca-100719	Procavia capensis	79.28	1.00e-47	179.00
IUUC-Ppe-101429	Prunus persica	75.00	9.00e-47	177.00
IUUC-Pva-102885	Pteropus vampyrus	57.01	4.00e-29	118.00
IUUC-Pgr-103470	Puccinia graminis	87.64	4.00e-45	171.00
IUUC-Ptt-103909	Puccinia triticina	66.67	1.00e-26	110.00
IUUC-Pte-104144	Pyrenophora teres	81.91	2.00e-42	162.00
IUUC-Pyt-104533	Pyrenophora triticirepentis	84.21	1.00e-45	173.00
IUUC-Rno-105912	Rattus norvegicus	79.28	1.00e-47	179.00
IUUC-Sce-106407	Saccharomyces cerevisiae	63.04	2.00e-34	135.00
IUUC-Sha-107549	Sarcophilus harrisii	79.28	1.00e-47	179.00
IUUC-Sja-108003	Schizosaccharomyces japonicus	75.24	6.00e-46	174.00
IUUC-Spo-108091	Schizosaccharomyces pombe	70.75	3.00e-43	165.00
IUUC-Ssl-108634	Sclerotinia sclerotiorum	89.66	6.00e-45	171.00
IUUC-Smo-109681	Selaginella moellendorffii	88.64	4.00e-45	171.00
IUUC-Sit-110419	Setaria italica	86.52	8.00e-45	170.00
IUUC-Sly-110933	Solanum lycopersicum	74.55	2.00e-46	176.00
IUUC-Stu-112567	Solanum tuberosum	76.15	2.00e-46	175.00
IUUC-Sar-113409	Sorex araneus	56.76	6.00e-29	117.00
IUUC-Sbi-113799	Sorghum bicolor	84.21	2.00e-46	175.00
IUUC-Sre-115142	Sporisorium reilianum	74.29	7.00e-45	170.00
IUUC-Tgu-116923	Taeniopygia guttata	88.61	2.00e-39	151.00
IUUC-Tru-117710	Takifugu rubripes	80.00	7.00e-48	180.00
IUUC-Tni-119934	Tetraodon nigroviridis	80.37	2.00e-48	182.00
IUUC-Tca-121820	Theobroma cacao	89.89	2.00e-46	175.00
IUUC-Tre-122212	Trichoderma reesei	86.42	2.00e-40	155.00
IUUC-Tvi-122357	Trichoderma virens	86.52	8.00e-45	170.00
IUUC-Tae-125834	Triticum aestivum	82.29	3.00e-46	175.00
IUUC-Tur-126093	Triticum urartu	88.76	1.00e-45	172.00
IUUC-Tme-126940	Tuber melanosporum	76.92	8.00e-47	176.00
IUUC-Tbe-127918	Tupaia belangeri	90.24	3.00e-42	160.00
IUUC-Ttr-128306	Tursiops truncatus	90.24	3.00e-42	160.00
IUUC-Uma-129482	Ustilago maydis	71.70	2.00e-44	169.00
IUUC-Vda-129917	Verticillium dahliae	77.57	2.00e-46	176.00
IUUC-Vpa-130142	Vicugna pacos	75.70	2.00e-41	159.00
IUUC-Vvi-130957	Vitis vinifera	88.64	2.00e-45	172.00
IUUC-Xma-133061	Xiphophorus maculatus	79.28	7.00e-48	180.00
IUUC-Yli-134542	Yarrowia lipolytica	59.48	5.00e-39	151.00
IUUC-Zma-135466	Zea mays	88.76	1.00e-45	173.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence