iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	7.50e-55	186.5	221	434

Active Site

Position(s)	Description	Evidence
418	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++C++e+  ++++++leC+h++Ck+Clk+y+e++ik+gqv++++cp+++cp+ +++ ++ke lve++l++ry++lll+++++ +a++ +
   Q: 221  CSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCPSVATPGQVKE-LVEADLFARYDRLLLQSTLDLMADVVY 309
           **************************************************************.7************************** PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeek........................eeaeskel 156
           cp+p+C+l+v++e+    + + c++c+++fC+ C+ ++H  + Ck ++ekl + ++e+                        ee+esk +
   Q: 310  CPRPCCQLPVMQEPG--GTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEKLIDLRNEYlqadeatkrfleqrygkrviqkalEEMESKDW 397
           **************6..56677999******************************999******************************** PP
   S: 157  leanskkCpkCkvyieknegCnhmtCakCkaefCwlC 193
           le+nsk+Cp+C ++i+k +gCn+mtC+ C+++fCw+C
   Q: 398  LEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWIC 434
           ************************************* PP

Organism

Mus musculus

Functional Description
(View)

Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity).

Protein Sequence
(Fasta)

MSAEDLEAQE DELLALASIY DADEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNESLQN 60
SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCGCTGG CATCCGCCCC TCTCAGCTGA CAGCTCTGGA GACGGAAGAG GCGGTGCTCA 60
GGTGCTGCGG CTGGTCTGCA GGCCTGGCCG GCAAGCGTCT GCCGAGGCCC AGTCAAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50908--RWD
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR
PF05773--RWD

SMART

SM00647--IBR
SM00591--RWD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0050681--F:androgen receptor binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0019787--F:ubiquitin-like protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:56736

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001130	Aegilops tauschii	29.85	7.00e-52	198.00
IUUC-Aml-001458	Ailuropoda melanoleuca	91.51	0.00e+00	865.00
IUUC-Atr-002560	Amborella trichopoda	29.38	4.00e-45	176.00
IUUC-Apl-003680	Anas platyrhynchos	80.17	0.00e+00	755.00
IUUC-Aca-005000	Anolis carolinensis	69.26	0.00e+00	649.00
IUUC-Aly-006288	Arabidopsis lyrata	30.80	8.00e-54	205.00
IUUC-Ath-006719	Arabidopsis thaliana	30.46	6.00e-54	205.00
IUUC-Acl-008213	Aspergillus clavatus	25.44	5.00e-31	129.00
IUUC-Afl-008433	Aspergillus flavus	23.90	9.00e-32	131.00
IUUC-Afu-008772	Aspergillus fumigatus	26.32	2.00e-33	137.00
IUUC-Ani-009249	Aspergillus nidulans	28.14	3.00e-34	140.00
IUUC-Ang-009757	Aspergillus niger	29.02	9.00e-39	154.00
IUUC-Aor-009963	Aspergillus oryzae	23.90	2.00e-31	130.00
IUUC-Ate-010460	Aspergillus terreus	25.05	1.00e-32	134.00
IUUC-Ame-011312	Astyanax mexicanus	57.21	2.00e-144	505.00
IUUC-Bgr-012052	Blumeria graminis	23.29	2.00e-28	121.00
IUUC-Bta-013529	Bos taurus	91.26	0.00e+00	870.00
IUUC-Bci-013729	Botrytis cinerea	25.11	1.00e-28	121.00
IUUC-Bdi-014940	Brachypodium distachyon	32.03	6.00e-51	195.00
IUUC-Bra-016998	Brassica rapa	29.91	4.00e-51	196.00
IUUC-Cel-018547	Caenorhabditis elegans	30.65	3.00e-50	192.00
IUUC-Cja-019791	Callithrix jacchus	88.70	0.00e+00	847.00
IUUC-Cfa-020403	Canis familiaris	91.04	0.00e+00	869.00
IUUC-Cpo-022229	Cavia porcellus	88.32	0.00e+00	826.00
IUUC-Cre-022601	Chlamydomonas reinhardtii	32.71	6.00e-29	120.00
IUUC-Csa-024115	Chlorocebus sabaeus	90.41	0.00e+00	859.00
IUUC-Cho-024911	Choloepus hoffmanni	91.26	0.00e+00	869.00
IUUC-Cin-025578	Ciona intestinalis	41.83	1.00e-96	347.00
IUUC-Csv-026355	Ciona savignyi	39.37	8.00e-83	300.00
IUUC-Cgl-026439	Colletotrichum gloeosporioides	23.81	4.00e-26	113.00
IUUC-Cne-026782	Cryptococcus neoformans	25.16	2.00e-27	117.00
IUUC-Dre-027380	Danio rerio	56.75	9.00e-153	533.00
IUUC-Dno-029640	Dasypus novemcinctus	92.34	0.00e+00	875.00
IUUC-Dor-030681	Dipodomys ordii	91.90	0.00e+00	871.00
IUUC-Dse-031208	Dothistroma septosporum	24.13	3.00e-30	127.00
IUUC-Ete-033122	Echinops telfairi	60.29	2.00e-134	472.00
IUUC-Eca-033755	Equus caballus	89.96	0.00e+00	851.00
IUUC-Eeu-035034	Erinaceus europaeus	94.52	1.00e-69	257.00
IUUC-Fca-036461	Felis catus	92.11	0.00e+00	875.00
IUUC-Fal-037516	Ficedula albicollis	78.72	0.00e+00	748.00
IUUC-Fso-038307	Fusarium solani	25.16	5.00e-25	109.00
IUUC-Gmo-039563	Gadus morhua	56.48	2.00e-145	508.00
IUUC-Ggr-039920	Gaeumannomyces graminis	25.71	5.00e-25	109.00
IUUC-Gga-040331	Gallus gallus	78.25	0.00e+00	735.00
IUUC-Gac-042164	Gasterosteus aculeatus	58.03	2.00e-156	545.00
IUUC-Gma-044080	Glycine max	31.61	7.00e-59	221.00
IUUC-Ggo-045257	Gorilla gorilla	89.98	0.00e+00	857.00
IUUC-Hsa-046887	Homo sapiens	91.32	0.00e+00	849.00
IUUC-Hvu-047317	Hordeum vulgare	29.93	7.00e-49	188.00
IUUC-Itr-048199	Ictidomys tridecemlineatus	92.54	0.00e+00	879.00
IUUC-Lch-050155	Latimeria chalumnae	62.31	2.00e-162	565.00
IUUC-Lpe-051669	Leersia perrieri	30.97	2.00e-40	160.00
IUUC-Loc-051779	Lepisosteus oculatus	58.33	3.00e-152	531.00
IUUC-Lma-052969	Leptosphaeria maculans	25.40	8.00e-32	131.00
IUUC-Laf-053488	Loxodonta africana	90.17	0.00e+00	855.00
IUUC-Mcc-054701	Macaca mulatta	91.11	0.00e+00	847.00
IUUC-Meu-056577	Macropus eugenii	77.90	1.00e-117	416.00
IUUC-Mor-057157	Magnaporthe oryzae	21.26	7.00e-27	115.00
IUUC-Mpo-057518	Magnaporthe poae	26.17	2.00e-28	121.00
IUUC-Mtr-058125	Medicago truncatula	30.11	2.00e-46	180.00
IUUC-Mga-059906	Meleagris gallopavo	78.25	0.00e+00	734.00
IUUC-Mvi-060374	Microbotryum violaceum	31.67	4.00e-31	129.00
IUUC-Mmr-061786	Microcebus murinus	92.54	0.00e+00	881.00
IUUC-Mdo-062453	Monodelphis domestica	86.21	0.00e+00	792.00
IUUC-Mac-065119	Musa acuminata	29.37	4.00e-39	155.00
IUUC-Mpu-066274	Mustela putorius furo	91.47	0.00e+00	870.00
IUUC-Mlu-067202	Myotis lucifugus	88.72	0.00e+00	810.00
IUUC-Nfi-068564	Neosartorya fischeri	25.44	4.00e-32	133.00
IUUC-Ncr-068823	Neurospora crassa	26.87	9.00e-30	125.00
IUUC-Nle-068987	Nomascus leucogenys	91.13	0.00e+00	850.00
IUUC-Opr-070453	Ochotona princeps	90.41	0.00e+00	850.00
IUUC-Ont-072611	Oreochromis niloticus	56.41	2.00e-154	539.00
IUUC-Oan-073738	Ornithorhynchus anatinus	79.39	0.00e+00	729.00
IUUC-Ocu-074396	Oryctolagus cuniculus	92.11	0.00e+00	872.00
IUUC-Oba-075472	Oryza barthii	31.88	1.00e-44	174.00
IUUC-Obr-076277	Oryza brachyantha	31.17	6.00e-47	182.00
IUUC-Ogl-077046	Oryza glaberrima	31.57	3.00e-43	170.00
IUUC-Ogu-078634	Oryza glumaepatula	31.88	8.00e-45	175.00
IUUC-Oin-080080	Oryza indica	28.03	3.00e-44	173.00
IUUC-Olo-080828	Oryza longistaminata	29.26	1.00e-41	165.00
IUUC-Ome-081387	Oryza meridionalis	28.80	3.00e-47	182.00
IUUC-Oni-082934	Oryza nivara	31.88	6.00e-45	175.00
IUUC-Opu-083719	Oryza punctata	28.27	3.00e-41	162.00
IUUC-Oru-084518	Oryza rufipogon	31.88	8.00e-45	175.00
IUUC-Ola-087312	Oryzias latipes	57.75	2.00e-152	531.00
IUUC-Olu-087661	Ostreococcus lucimarinus	29.21	2.00e-47	183.00
IUUC-Oga-089129	Otolemur garnettii	92.74	0.00e+00	878.00
IUUC-Oar-089839	Ovis aries	91.04	0.00e+00	868.00
IUUC-Ptr-091626	Pan troglodytes	91.11	0.00e+00	847.00
IUUC-Pan-092798	Papio anubis	91.11	0.00e+00	847.00
IUUC-Psi-093253	Pelodiscus sinensis	78.68	0.00e+00	754.00
IUUC-Pma-094512	Petromyzon marinus	55.39	7.00e-147	513.00
IUUC-Pno-094937	Phaeosphaeria nodorum	24.07	2.00e-29	124.00
IUUC-Ppa-095211	Physcomitrella patens	30.24	2.00e-54	207.00
IUUC-Pfo-097049	Poecilia formosa	52.29	4.00e-135	474.00
IUUC-Pab-097911	Pongo abelii	90.89	0.00e+00	846.00
IUUC-Pop-099841	Populus trichocarpa	30.95	2.00e-50	193.00
IUUC-Pca-100814	Procavia capensis	71.24	0.00e+00	632.00
IUUC-Ppe-101972	Prunus persica	30.60	3.00e-50	192.00
IUUC-Pva-103038	Pteropus vampyrus	90.83	0.00e+00	862.00
IUUC-Pgr-103277	Puccinia graminis	33.84	9.00e-39	154.00
IUUC-Ptt-103855	Puccinia triticina	31.15	2.00e-35	143.00
IUUC-Pte-104113	Pyrenophora teres	23.80	5.00e-27	115.00
IUUC-Pyt-104619	Pyrenophora triticirepentis	27.30	5.00e-28	118.00
IUUC-Rno-106003	Rattus norvegicus	94.74	0.00e+00	861.00
IUUC-Sce-106287	Saccharomyces cerevisiae	27.92	2.00e-23	103.00
IUUC-Sha-106652	Sarcophilus harrisii	85.93	0.00e+00	802.00
IUUC-Spo-108167	Schizosaccharomyces pombe	31.39	5.00e-48	185.00
IUUC-Ssl-108396	Sclerotinia sclerotiorum	24.55	6.00e-09	56.60
IUUC-Smo-109393	Selaginella moellendorffii	31.35	2.00e-48	186.00
IUUC-Sit-110529	Setaria italica	34.69	3.00e-45	176.00
IUUC-Sly-111829	Solanum lycopersicum	30.57	8.00e-53	201.00
IUUC-Stu-112811	Solanum tuberosum	31.00	1.00e-52	201.00
IUUC-Sar-113259	Sorex araneus	86.02	1.00e-130	459.00
IUUC-Sbi-114591	Sorghum bicolor	32.39	1.00e-37	150.00
IUUC-Sre-115227	Sporisorium reilianum	27.74	2.00e-34	141.00
IUUC-Ssc-115293	Sus scrofa	91.26	0.00e+00	868.00
IUUC-Tgu-117335	Taeniopygia guttata	79.78	0.00e+00	741.00
IUUC-Tru-118458	Takifugu rubripes	57.48	3.00e-155	541.00
IUUC-Tsy-119475	Tarsius syrichta	83.16	0.00e+00	761.00
IUUC-Tni-119827	Tetraodon nigroviridis	57.11	2.00e-153	535.00
IUUC-Tca-121023	Theobroma cacao	33.19	1.00e-52	201.00
IUUC-Tre-121965	Trichoderma reesei	23.64	1.00e-30	127.00
IUUC-Tvi-122564	Trichoderma virens	23.46	8.00e-28	118.00
IUUC-Tae-124793	Triticum aestivum	33.77	7.00e-42	165.00
IUUC-Tur-126258	Triticum urartu	30.31	3.00e-43	170.00
IUUC-Tbe-127227	Tupaia belangeri	71.58	5.00e-74	271.00
IUUC-Ttr-128984	Tursiops truncatus	69.51	4.00e-172	597.00
IUUC-Uma-129565	Ustilago maydis	26.38	5.00e-32	132.00
IUUC-Vpa-130301	Vicugna pacos	91.90	0.00e+00	873.00
IUUC-Vvi-131244	Vitis vinifera	30.99	1.00e-53	204.00
IUUC-Xtr-132880	Xenopus tropicalis	58.05	7.00e-158	550.00
IUUC-Xma-134055	Xiphophorus maculatus	57.20	6.00e-154	537.00
IUUC-Yli-134342	Yarrowia lipolytica	28.33	2.00e-43	170.00
IUUC-Zma-135021	Zea mays	33.24	2.00e-40	160.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence