iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092238

Ensembl Protein ID

ENSPANP00000018885.1

UniProt Accession

A0A096P0L0; A0A096P0L0_PAPAN

Genbank Protein ID

ENSPANP00000018885

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AHZZ01061142

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000025883.1	ENSPANT00000027848.1	ENSPANP00000018885.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	36.84	4.00e-09	55.10	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Papio anubis

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVEVE FGGGAELLFD GIKKHQVTLP GQEEPWDIRN LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELLV STSGDIPPPA LALAASVGKP WASQVHIEWL GNPPPHSSPT 120

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Nucleotide Sequence
(Fasta)

ATGGCAGCGC CCTTGTCAGT GGAGGTGGAG TTCGGGTGAG TCACAGAGCT GGGGCACAAT 60
GGGGATAGAT TGAAGTCGTC GGGCTCGGAA TTCCTTTCCT TCTGCCATGG GGCCTGACAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	98.73	2.00e-41	159.00
IUUC-Atr-003089	Amborella trichopoda	56.58	1.00e-21	94.40
IUUC-Apl-003382	Anas platyrhynchos	86.96	4.00e-31	125.00
IUUC-Aca-004981	Anolis carolinensis	83.54	5.00e-36	141.00
IUUC-Aly-005517	Arabidopsis lyrata	51.47	1.00e-18	84.00
IUUC-Ath-006718	Arabidopsis thaliana	50.82	2.00e-15	73.20
IUUC-Ago-007917	Ashbya gossypii	38.16	3.00e-13	66.20
IUUC-Acl-008054	Aspergillus clavatus	77.78	1.00e-07	47.80
IUUC-Afl-008704	Aspergillus flavus	54.55	1.00e-12	63.90
IUUC-Aor-009890	Aspergillus oryzae	57.69	2.00e-17	80.50
IUUC-Bta-012448	Bos taurus	96.20	1.00e-40	156.00
IUUC-Bci-013865	Botrytis cinerea	41.77	1.00e-12	64.70
IUUC-Bdi-014980	Brachypodium distachyon	71.43	4.00e-15	72.40
IUUC-Bol-016055	Brassica oleracea	56.14	8.00e-16	74.70
IUUC-Bra-016845	Brassica rapa	56.14	8.00e-16	74.70
IUUC-Cel-018485	Caenorhabditis elegans	32.05	8.00e-06	41.60
IUUC-Cja-019587	Callithrix jacchus	98.73	2.00e-41	159.00
IUUC-Cfa-020653	Canis familiaris	96.20	2.00e-40	156.00
IUUC-Cpo-021622	Cavia porcellus	98.73	2.00e-41	159.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	46.24	3.00e-19	85.90
IUUC-Csa-023756	Chlorocebus sabaeus	96.55	2.00e-75	274.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	43.04	4.00e-13	66.20
IUUC-Cne-026953	Cryptococcus neoformans	55.00	2.00e-17	81.30
IUUC-Cme-027314	Cyanidioschyzon merolae	39.19	2.00e-09	53.50
IUUC-Dre-027884	Danio rerio	74.68	1.00e-32	130.00
IUUC-Dno-029262	Dasypus novemcinctus	69.67	2.00e-41	161.00
IUUC-Dor-030601	Dipodomys ordii	58.23	2.00e-15	73.60
IUUC-Dme-031893	Drosophila melanogaster	52.04	2.00e-22	96.70
IUUC-Ete-032773	Echinops telfairi	88.61	9.00e-36	140.00
IUUC-Eca-034187	Equus caballus	98.73	2.00e-41	159.00
IUUC-Eeu-034808	Erinaceus europaeus	94.94	6.00e-40	154.00
IUUC-Fca-036107	Felis catus	98.73	3.00e-41	159.00
IUUC-Fal-036607	Ficedula albicollis	85.51	1.00e-30	124.00
IUUC-Fox-037698	Fusarium oxysporum	44.44	2.00e-15	73.60
IUUC-Gmo-039492	Gadus morhua	74.68	9.00e-33	130.00
IUUC-Ggr-039965	Gaeumannomyces graminis	44.44	7.00e-13	66.20
IUUC-Gga-041268	Gallus gallus	86.08	1.00e-36	143.00
IUUC-Gac-042111	Gasterosteus aculeatus	75.95	3.00e-34	135.00
IUUC-Gma-043240	Glycine max	50.82	1.00e-14	70.90
IUUC-Ggo-045176	Gorilla gorilla	93.15	1.00e-63	234.00
IUUC-Hsa-046077	Homo sapiens	97.47	2.00e-32	130.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	95.52	1.00e-25	107.00
IUUC-Kpa-049157	Komagataella pastoris	43.42	7.00e-12	61.60
IUUC-Lch-049889	Latimeria chalumnae	79.75	3.00e-34	135.00
IUUC-Lpe-050783	Leersia perrieri	60.00	1.00e-15	74.30
IUUC-Loc-052400	Lepisosteus oculatus	78.48	4.00e-34	135.00
IUUC-Lma-053259	Leptosphaeria maculans	44.74	3.00e-13	66.20
IUUC-Laf-053596	Loxodonta africana	97.47	8.00e-41	157.00
IUUC-Mcc-054845	Macaca mulatta	92.11	5.00e-35	138.00
IUUC-Meu-055968	Macropus eugenii	92.31	3.00e-39	152.00
IUUC-Mor-057126	Magnaporthe oryzae	41.98	2.00e-11	61.20
IUUC-Mpo-057311	Magnaporthe poae	46.15	3.00e-14	70.50
IUUC-Mtr-058266	Medicago truncatula	49.21	7.00e-15	71.60
IUUC-Mla-058847	Melampsora laricipopulina	36.71	6.00e-06	42.70
IUUC-Mga-059468	Meleagris gallopavo	86.96	2.00e-31	125.00
IUUC-Mvi-060235	Microbotryum violaceum	31.25	4.00e-10	57.00
IUUC-Mdo-061948	Monodelphis domestica	89.74	9.00e-39	150.00
IUUC-Mmu-063946	Mus musculus	94.94	6.00e-40	154.00
IUUC-Mac-064812	Musa acuminata	60.00	8.00e-16	74.70
IUUC-Mpu-066763	Mustela putorius furo	96.20	1.00e-39	154.00
IUUC-Mlu-066970	Myotis lucifugus	98.73	5.00e-41	158.00
IUUC-Ncr-068824	Neurospora crassa	39.74	4.00e-13	65.90
IUUC-Nle-069849	Nomascus leucogenys	93.15	2.00e-71	260.00
IUUC-Opr-070227	Ochotona princeps	98.73	2.00e-41	159.00
IUUC-Ont-072530	Oreochromis niloticus	77.22	7.00e-34	134.00
IUUC-Oan-073191	Ornithorhynchus anatinus	88.06	3.00e-30	122.00
IUUC-Ocu-074460	Oryctolagus cuniculus	97.37	3.00e-39	152.00
IUUC-Oba-075499	Oryza barthii	69.05	4.00e-14	70.50
IUUC-Obr-076896	Oryza brachyantha	56.90	1.00e-13	69.30
IUUC-Ogl-077834	Oryza glaberrima	69.05	1.00e-14	70.90
IUUC-Ogu-078622	Oryza glumaepatula	69.05	1.00e-14	70.90
IUUC-Oin-079358	Oryza indica	69.05	5.00e-14	70.90
IUUC-Olo-081035	Oryza longistaminata	49.37	3.00e-15	74.30
IUUC-Oni-082425	Oryza nivara	69.05	1.00e-14	70.90
IUUC-Opu-083461	Oryza punctata	69.05	2.00e-14	71.20
IUUC-Oru-084875	Oryza rufipogon	60.42	1.00e-12	63.90
IUUC-Oga-089128	Otolemur garnettii	98.73	3.00e-41	159.00
IUUC-Oar-089896	Ovis aries	96.20	1.00e-40	156.00
IUUC-Ptr-091618	Pan troglodytes	93.15	1.00e-63	234.00
IUUC-Psi-093879	Pelodiscus sinensis	88.61	6.00e-37	145.00
IUUC-Pma-094484	Petromyzon marinus	79.75	1.00e-24	103.00
IUUC-Ppa-095801	Physcomitrella patens	58.62	2.00e-14	70.10
IUUC-Pfo-097192	Poecilia formosa	78.48	7.00e-35	138.00
IUUC-Pab-098203	Pongo abelii	96.20	3.00e-32	129.00
IUUC-Pop-099614	Populus trichocarpa	50.00	7.00e-16	75.10
IUUC-Pca-100507	Procavia capensis	97.47	7.00e-41	157.00
IUUC-Ppe-101174	Prunus persica	52.63	3.00e-20	89.70
IUUC-Pva-102735	Pteropus vampyrus	96.20	2.00e-37	146.00
IUUC-Pgr-103510	Puccinia graminis	37.97	5.00e-07	46.20
IUUC-Ptt-103918	Puccinia triticina	32.91	3.00e-05	40.00
IUUC-Pte-104173	Pyrenophora teres	45.00	6.00e-15	72.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	45.00	7.00e-15	71.60
IUUC-Rno-105820	Rattus norvegicus	96.20	2.00e-40	156.00
IUUC-Sce-106366	Saccharomyces cerevisiae	36.84	6.00e-10	55.10
IUUC-Sja-107727	Schizosaccharomyces japonicus	32.23	3.00e-11	60.10
IUUC-Spo-108074	Schizosaccharomyces pombe	34.25	2.00e-06	43.10
IUUC-Smo-108944	Selaginella moellendorffii	59.70	3.00e-18	82.40
IUUC-Sit-110277	Setaria italica	57.63	4.00e-15	72.40
IUUC-Sly-111505	Solanum lycopersicum	52.46	3.00e-16	76.30
IUUC-Stu-112076	Solanum tuberosum	54.10	9.00e-17	77.80
IUUC-Sbi-114274	Sorghum bicolor	56.36	2.00e-15	73.60
IUUC-Sre-114953	Sporisorium reilianum	55.70	1.00e-18	84.30
IUUC-Ssc-115418	Sus scrofa	96.20	9.00e-41	157.00
IUUC-Tgu-117311	Taeniopygia guttata	85.51	1.00e-30	124.00
IUUC-Tru-118598	Takifugu rubripes	82.09	7.00e-30	121.00
IUUC-Tni-120109	Tetraodon nigroviridis	75.00	1.00e-31	127.00
IUUC-Tca-120942	Theobroma cacao	52.54	2.00e-14	69.70
IUUC-Tre-122099	Trichoderma reesei	44.12	3.00e-11	59.70
IUUC-Tvi-122285	Trichoderma virens	49.37	4.00e-16	76.30
IUUC-Tae-125193	Triticum aestivum	63.83	3.00e-14	69.70
IUUC-Tur-126677	Triticum urartu	50.85	8.00e-12	62.00
IUUC-Tme-127120	Tuber melanosporum	44.44	2.00e-15	74.30
IUUC-Tbe-128050	Tupaia belangeri	63.29	8.00e-21	91.30
IUUC-Ttr-129019	Tursiops truncatus	94.94	2.00e-38	149.00
IUUC-Uma-129483	Ustilago maydis	52.50	2.00e-16	77.00
IUUC-Vda-129690	Verticillium dahliae	37.08	4.00e-09	52.80
IUUC-Vvi-131174	Vitis vinifera	55.93	9.00e-16	74.30
IUUC-Xma-133862	Xiphophorus maculatus	78.48	7.00e-35	138.00
IUUC-Yli-134398	Yarrowia lipolytica	38.30	2.00e-12	63.20
IUUC-Zma-134964	Zea mays	54.24	4.00e-14	68.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence