iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088672

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03116574

Gene Name

WDR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000008960.2	ENSOGAT00000008965.2	ENSOGAP00000008034.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-59	193.4	127	166
UBD/Beta-Prp	9.50e-89	297.5	40	332

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ v+c++f +  +l+vsGs D ++++WD++tg++lk+
   Q: 127  GHSNYVFCCNFnPQsNLIVSGSFDESVRIWDVKTGKCLKT 166
           8***********666**********************986 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           tl gh k+v + vkfsp++++la++s+d+ ik+w + +gk+ +++sgh+ ++++v +s+d+++lv++s+D+t+k+wd+s+gkc+ tlkg
   Q: 40   TLAGHTKAVSS-VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127
           67777776666.***************************************************************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++v +++f+p+++ +vsGs d+ +r+wd++tg+cl+ tl  h++ v+ v+++ dg+l+vs+s+D+ +r+Wd ++g++l+tl  ++++
   Q: 128  HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK-TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
           **************************************.********************************************999*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           +v  ++f++ngk+++++ ld+t+klwd+++g+c++t++gh++  +++ +      ++++vsgs+D+ ++iW+l++++++++lq+h + v
   Q: 216  PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANfsvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
           **********************************************98887899*********************************** PP
   S: 268  isvavlsfgdnvlvlgse..dskvniwkl 294
           is a+ ++++n++++++   d+++++wk 
   Q: 305  ISTAC-HPTENIIASAALenDKTIKLWKS 332
           *****.*******9998888*******96 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MATEEKKPET EAVRAQPAPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 60
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGACAG AGGAGAAGAA GCCAGAGACC GAGGCTGTCA GAGCACAGCC AGCGCCTTCC 60
TCATCAGCCA CTCAAAGCAA GGTGCCTGCC CAGGGCCTCG TGGGGCACTT CCCAGGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0071339--C:MLL1 complex
GO:0044666--C:MLL3/4 complex
GO:0048188--C:Set1C/COMPASS complex
GO:0046972--F:histone acetyltransferase activity (H4-K16 specific)
GO:0043995--F:histone acetyltransferase activity (H4-K5 specific)
GO:0043996--F:histone acetyltransferase activity (H4-K8 specific)
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0043966--P:histone H3 acetylation
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0001501--P:skeletal system development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000502	Aegilops tauschii	53.02	8.00e-90	323.00
IUUC-Aml-002420	Ailuropoda melanoleuca	99.69	0.00e+00	649.00
IUUC-Atr-002439	Amborella trichopoda	69.51	2.00e-130	457.00
IUUC-Apl-003436	Anas platyrhynchos	89.52	2.00e-168	584.00
IUUC-Aca-004259	Anolis carolinensis	95.81	0.00e+00	637.00
IUUC-Aly-005723	Arabidopsis lyrata	64.45	7.00e-117	413.00
IUUC-Ath-007308	Arabidopsis thaliana	65.45	4.00e-117	414.00
IUUC-Acl-008045	Aspergillus clavatus	45.95	2.00e-83	303.00
IUUC-Afl-008596	Aspergillus flavus	44.66	8.00e-81	294.00
IUUC-Afu-009074	Aspergillus fumigatus	46.75	2.00e-83	303.00
IUUC-Ani-009318	Aspergillus nidulans	50.00	5.00e-83	301.00
IUUC-Ang-009775	Aspergillus niger	45.63	5.00e-83	301.00
IUUC-Aor-010222	Aspergillus oryzae	44.66	9.00e-81	294.00
IUUC-Ate-010583	Aspergillus terreus	48.75	8.00e-81	294.00
IUUC-Ame-011349	Astyanax mexicanus	99.02	6.00e-179	619.00
IUUC-Bgr-011968	Blumeria graminis	50.33	9.00e-85	307.00
IUUC-Bta-013016	Bos taurus	99.68	0.00e+00	629.00
IUUC-Bci-013948	Botrytis cinerea	50.79	1.00e-85	310.00
IUUC-Bdi-014263	Brachypodium distachyon	62.46	1.00e-120	425.00
IUUC-Bol-015900	Brassica oleracea	62.50	1.00e-113	402.00
IUUC-Bra-017143	Brassica rapa	62.17	1.00e-114	405.00
IUUC-Cel-018355	Caenorhabditis elegans	72.24	3.00e-132	464.00
IUUC-Cja-019936	Callithrix jacchus	99.69	0.00e+00	649.00
IUUC-Cfa-020596	Canis familiaris	99.69	0.00e+00	649.00
IUUC-Cpo-021318	Cavia porcellus	99.69	0.00e+00	649.00
IUUC-Cre-022935	Chlamydomonas reinhardtii	48.76	1.00e-79	289.00
IUUC-Csa-023053	Chlorocebus sabaeus	99.69	0.00e+00	649.00
IUUC-Cin-025495	Ciona intestinalis	87.62	4.00e-170	590.00
IUUC-Csv-025988	Ciona savignyi	91.86	4.00e-164	570.00
IUUC-Cne-027025	Cryptococcus neoformans	32.13	3.00e-53	202.00
IUUC-Cme-027119	Cyanidioschyzon merolae	50.43	1.00e-105	376.00
IUUC-Dre-027521	Danio rerio	96.11	0.00e+00	633.00
IUUC-Dno-029739	Dasypus novemcinctus	100.00	4.00e-179	620.00
IUUC-Dor-030966	Dipodomys ordii	100.00	0.00e+00	627.00
IUUC-Dse-031189	Dothistroma septosporum	48.91	6.00e-86	311.00
IUUC-Dme-031613	Drosophila melanogaster	94.72	4.00e-172	597.00
IUUC-Eca-033790	Equus caballus	99.69	0.00e+00	649.00
IUUC-Fca-035901	Felis catus	99.69	0.00e+00	649.00
IUUC-Fal-037413	Ficedula albicollis	96.71	0.00e+00	638.00
IUUC-Fox-037876	Fusarium oxysporum	46.45	3.00e-58	218.00
IUUC-Gmo-039131	Gadus morhua	93.71	4.00e-179	620.00
IUUC-Ggr-040071	Gaeumannomyces graminis	40.27	1.00e-64	241.00
IUUC-Gga-040789	Gallus gallus	96.71	0.00e+00	638.00
IUUC-Gac-042634	Gasterosteus aculeatus	91.32	3.00e-177	613.00
IUUC-Gma-043692	Glycine max	66.34	2.00e-127	447.00
IUUC-Ggo-044443	Gorilla gorilla	99.69	0.00e+00	649.00
IUUC-Hsa-046290	Homo sapiens	99.69	0.00e+00	649.00
IUUC-Hvu-047077	Hordeum vulgare	57.73	8.00e-80	289.00
IUUC-Itr-048954	Ictidomys tridecemlineatus	99.69	0.00e+00	649.00
IUUC-Kpa-049404	Komagataella pastoris	45.42	1.00e-65	243.00
IUUC-Lch-049539	Latimeria chalumnae	98.43	0.00e+00	641.00
IUUC-Lpe-051082	Leersia perrieri	61.67	3.00e-119	421.00
IUUC-Loc-051743	Lepisosteus oculatus	99.02	6.00e-179	619.00
IUUC-Lma-053188	Leptosphaeria maculans	46.73	9.00e-86	310.00
IUUC-Laf-054432	Loxodonta africana	94.93	0.00e+00	637.00
IUUC-Mcc-055603	Macaca mulatta	99.69	0.00e+00	649.00
IUUC-Meu-056440	Macropus eugenii	92.13	4.00e-156	543.00
IUUC-Mor-056965	Magnaporthe oryzae	36.71	5.00e-69	255.00
IUUC-Mpo-057333	Magnaporthe poae	41.16	3.00e-61	229.00
IUUC-Mtr-057951	Medicago truncatula	65.58	1.00e-122	432.00
IUUC-Mla-058896	Melampsora laricipopulina	43.60	3.00e-72	265.00
IUUC-Mga-060046	Meleagris gallopavo	96.41	0.00e+00	637.00
IUUC-Mvi-060453	Microbotryum violaceum	48.02	1.00e-88	320.00
IUUC-Mmr-061020	Microcebus murinus	92.22	3.00e-177	613.00
IUUC-Mdo-062204	Monodelphis domestica	95.61	0.00e+00	627.00
IUUC-Mmu-063917	Mus musculus	99.69	0.00e+00	649.00
IUUC-Mac-065310	Musa acuminata	66.22	1.00e-122	432.00
IUUC-Mpu-066072	Mustela putorius furo	99.69	0.00e+00	649.00
IUUC-Mlu-068209	Myotis lucifugus	99.69	0.00e+00	649.00
IUUC-Nfi-068538	Neosartorya fischeri	46.43	8.00e-83	301.00
IUUC-Ncr-068651	Neurospora crassa	41.36	1.00e-72	267.00
IUUC-Ont-071458	Oreochromis niloticus	92.22	2.00e-179	621.00
IUUC-Oan-073597	Ornithorhynchus anatinus	100.00	4.00e-180	623.00
IUUC-Oba-075292	Oryza barthii	54.09	1.00e-99	355.00
IUUC-Obr-076723	Oryza brachyantha	54.90	8.00e-97	346.00
IUUC-Ogl-077251	Oryza glaberrima	60.39	4.00e-117	414.00
IUUC-Ogu-078882	Oryza glumaepatula	49.86	4.00e-103	367.00
IUUC-Oin-079601	Oryza indica	54.55	2.00e-112	398.00
IUUC-Olo-080976	Oryza longistaminata	62.95	1.00e-102	365.00
IUUC-Ome-081430	Oryza meridionalis	60.78	2.00e-117	414.00
IUUC-Oni-082182	Oryza nivara	49.45	1.00e-102	366.00
IUUC-Opu-083880	Oryza punctata	60.13	2.00e-116	411.00
IUUC-Oru-084935	Oryza rufipogon	53.65	8.00e-99	353.00
IUUC-Osa-085706	Oryza sativa	60.39	4.00e-117	414.00
IUUC-Ola-087134	Oryzias latipes	94.31	2.00e-179	620.00
IUUC-Olu-087660	Ostreococcus lucimarinus	42.50	3.00e-40	157.00
IUUC-Ptr-091513	Pan troglodytes	99.69	0.00e+00	649.00
IUUC-Pan-092046	Papio anubis	99.69	0.00e+00	649.00
IUUC-Psi-093192	Pelodiscus sinensis	96.41	0.00e+00	638.00
IUUC-Pno-094881	Phaeosphaeria nodorum	48.04	9.00e-90	323.00
IUUC-Ppa-095367	Physcomitrella patens	72.58	4.00e-134	470.00
IUUC-Pfo-097434	Poecilia formosa	91.92	4.00e-179	620.00
IUUC-Pab-097773	Pongo abelii	93.51	4.00e-166	576.00
IUUC-Pop-099778	Populus trichocarpa	64.87	9.00e-122	429.00
IUUC-Pca-100281	Procavia capensis	78.67	2.00e-124	438.00
IUUC-Ppe-101341	Prunus persica	64.56	5.00e-123	433.00
IUUC-Pva-103020	Pteropus vampyrus	98.75	0.00e+00	645.00
IUUC-Pgr-103589	Puccinia graminis	39.27	8.00e-70	257.00
IUUC-Pte-104153	Pyrenophora teres	51.91	7.00e-94	337.00
IUUC-Pyt-104712	Pyrenophora triticirepentis	52.43	6.00e-79	287.00
IUUC-Rno-105858	Rattus norvegicus	99.69	0.00e+00	649.00
IUUC-Sha-107101	Sarcophilus harrisii	98.75	0.00e+00	642.00
IUUC-Sja-107858	Schizosaccharomyces japonicus	51.17	1.00e-68	253.00
IUUC-Spo-108117	Schizosaccharomyces pombe	47.98	5.00e-64	238.00
IUUC-Smo-109155	Selaginella moellendorffii	71.29	1.00e-132	465.00
IUUC-Sit-110688	Setaria italica	62.00	3.00e-119	421.00
IUUC-Sly-110891	Solanum lycopersicum	68.90	9.00e-127	446.00
IUUC-Stu-112365	Solanum tuberosum	66.13	5.00e-127	446.00
IUUC-Sbi-114284	Sorghum bicolor	62.00	2.00e-118	418.00
IUUC-Sre-115180	Sporisorium reilianum	42.57	1.00e-66	246.00
IUUC-Ssc-116204	Sus scrofa	100.00	3.00e-179	620.00
IUUC-Tgu-117172	Taeniopygia guttata	96.71	0.00e+00	638.00
IUUC-Tru-118320	Takifugu rubripes	91.62	2.00e-178	618.00
IUUC-Tni-120660	Tetraodon nigroviridis	87.84	1.00e-109	388.00
IUUC-Tca-121051	Theobroma cacao	67.53	3.00e-125	441.00
IUUC-Tre-122237	Trichoderma reesei	45.09	1.00e-85	310.00
IUUC-Tvi-122635	Trichoderma virens	46.18	4.00e-85	308.00
IUUC-Tae-125819	Triticum aestivum	60.26	8.00e-121	426.00
IUUC-Tur-126217	Triticum urartu	55.84	2.00e-76	278.00
IUUC-Tme-127061	Tuber melanosporum	56.12	4.00e-112	397.00
IUUC-Ttr-129309	Tursiops truncatus	93.73	2.00e-173	601.00
IUUC-Uma-129585	Ustilago maydis	41.64	1.00e-73	269.00
IUUC-Vda-129907	Verticillium dahliae	44.71	9.00e-79	287.00
IUUC-Vvi-131269	Vitis vinifera	66.45	7.00e-120	423.00
IUUC-Xtr-131945	Xenopus tropicalis	96.71	0.00e+00	637.00
IUUC-Xma-132997	Xiphophorus maculatus	91.92	4.00e-179	620.00
IUUC-Yli-134418	Yarrowia lipolytica	42.95	1.00e-75	276.00
IUUC-Zma-135765	Zea mays	61.67	3.00e-117	414.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence